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Author : Sudha Kumari
Publisher : Frontiers Media SA
ISBN 13 : 2889719405
Total Pages : 267 pages
Book Rating : 4.8/5 (897 download)
Download or read book Cytoskeletal Regulation of Immune Response written by Sudha Kumari and published by Frontiers Media SA. This book was released on 2022-01-04 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (92 download)
Download or read book Cell Signaling and Cytoskeletal Regulation in Neutrophil Cell Migration in Vivo written by and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neutrophils are the most abundant white blood cells and their recruitment to sites of injury or infection is essential for host defense. Abnormal infiltration of neutrophils is the hallmark of inflammatory disease. The activation and regulation of neutrophil chemotaxis must be precise in order to prevent abnormal situations leading to disease states. In this dissertation, I use zebrafish as an italicin vivoitalic model to delineate the cell signaling and cytoskeletal regulation of neutrophil interstitial migration and innate immune response. In particular, I elucidate two negative regulators of neutrophil motility, the SH2-domain-containing inositol 5-phosphatase (SHIP) and microtubules. Phosphoinositide 3-kinase (PI3K), which generates the phosphatidylinositol (3,4,5)-trisphosphate [PI(3,4,5)P(3)], is necessary for neutrophil motility italicin vivoitalic; however, the role of SHIP enzymes, which hydrolyze PI(3,4,5)P(3) to phosphatidylinositol 3,4-bisphosphate [PI(3,4)P(2)], is not well understood. In Chapter 2, I demonstrate that SHIPs control neutrophil inflammation and limit neutrophil motility by modulating PI3K signaling. The role of microtubules in regulating leukocyte migration is also not clear. In Chapter 3, I illustrate that microtubule depolymerization inhibits polarized PI3K activation at the leading edge of neutrophils, inducing PI3K independent motility but negatively impacting neutrophil directional migration. Our data also suggest that microtubules exert their effects on neutrophil polarity and motility at least in part by the negative regulation of both Rho and Rac activities. Next, in Chapter 4, I demonstrate that the routine heat shock method used for inducible gene expression in animal models with common heat shock promoters can alter neutrophil function in zebrafish. My findings suggest that caution must be taken when employing a heat shock-dependent inducible system to study the innate immune response and that data arising from such experiments need to be carefully scrutinized. Together, my thesis research provides a better understanding of the signaling mechanisms involved in regulating neutrophil migration and function italicin vivoitalic.
Author : Martin Becker
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (14 download)
Download or read book Cytoskeletal Regulation of B Cell Antigen Receptor Signaling written by Martin Becker and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Signaling through the B cell antigen receptor (BCR) is essential for several processes of B cell biology, such as proliferation, differentiation and homeostasis. Accordingly, the signaling events emanating from the BCR have to be tightly regulated in order to ensure an effective immune response and at the same time avoid pathological conditions like autoimmunity and lymphomagenesis. Mature B cells express two different BCR isotypes, IgM and IgD, which reside in distinct, isotype-specific protein islands on the B cell surface. These structures dependent on the actin cytoskeleton, the disruption of which induces robust BCR signaling, even in the absence of antigen. We here have studied the isotype-specific regulation of the BCR by the cytoskeleton. Using several different genetically engineered mouse models we found that cytoskeleton disruption induced signaling (CDIS) is mediated by the IgD-BCR and the co-receptor CD19. CDIS differs from canonical, antigen-induced BCR signaling in many facets including a lack of BCR proximal tyrosine phosphorylation and induction of a calcium flux originating exclusively from the extracellular space. CDIS can also be enhanced by anti-CD19 stimulation in the absence of a complete IgD- BCR structure as long as the Ig[beta] signaling subunit of the BCR is still expressed on the B cell surface. Together these findings reveal a functional difference between the IgM-BCR and IgD-BCR as well as Ig[alpha] and Ig[beta] in their interactions with CD19 and the actin cytoskeleton. Furthermore, our results provide explanations for the multitude of immunological phenotypes observed in mutants of actin-binding proteins
Author : Jose C. Jimenez-Lopez
Publisher : BoD – Books on Demand
ISBN 13 : 9535131699
Total Pages : 344 pages
Book Rating : 4.5/5 (351 download)
Download or read book Cytoskeleton written by Jose C. Jimenez-Lopez and published by BoD – Books on Demand. This book was released on 2017-05-17 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cytoskeleton is a highly dynamic intracellular platform constituted by a three-dimensional network of proteins responsible for key cellular roles as structure and shape, cell growth and development, and offering to the cell with "motility" that being the ability of the entire cell to move and for material to be moved within the cell in a regulated fashion (vesicle trafficking). The present edition of Cytoskeleton provides new insights into the structure-functional features, dynamics, and cytoskeleton's relationship to diseases. The authors' contribution in this book will be of substantial importance to a wide audience such as clinicians, researches, educators, and students interested in getting updated knowledge about molecular basis of cytoskeleton, such as regulation of cell vital processes by actin-binding proteins as cell morphogenesis, motility, their implications in cell signaling, as well as strategies for clinical trial and alternative therapies based in multitargeting molecules to tackle diseases, that is, cancer.
Author : Brigitte M. Jockusch
Publisher : Springer
ISBN 13 : 3319463713
Total Pages : 356 pages
Book Rating : 4.3/5 (194 download)
Download or read book The Actin Cytoskeleton written by Brigitte M. Jockusch and published by Springer. This book was released on 2017-01-03 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Actin is one of the most abundant proteins and ubiquitously expressed in all eukaryotes. In recent years, the analysis of structure and function of such complexes has shed new light on actin's role in cellular and tissue morphogenesis, locomotion and various forms of intracellular motility, but also on its role in nuclear processes like chromatin architecture and transcription. Progress in understanding these different physiological phenomena, but also in unravelling the basis of actin-based pathophysiological processes has been made by combining video microscopy, molecular biology, genetics and biochemistry. Thus, the current research on actin, as ongoing in many international laboratories, is a "hot spot" in basic and translational research in life sciences. In this book on "The Actin Cytoskeleton", twelve internationally renowned authors present specific chapters that cover their recent work concerned with the various roles of actin mentioned above. This comprehensive volume is therefore an attractive handbook for teachers and students in many fields of medicine and pharmacology.
Author :
Publisher : Academic Press
ISBN 13 : 0128212837
Total Pages : 330 pages
Book Rating : 4.1/5 (282 download)
Download or read book Actin Cytoskeleton in Cancer Progression and Metastasis - Part B written by and published by Academic Press. This book was released on 2020-10-26 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Actin Cytoskeleton in Cancer Progression and Metastasis (Part B), Volume 356 in the International Review of Cell and Molecular Biology series, provides an overview on the roles of the actin cytoskeleton and its key structural regulators, including WASp, Paxillin, Myosin, Testin, L-Plastin and profilin, and in central processes underlying cancer progression and metastasis, such as changes in cell morphology and gene expression, acquisition of migratory and invasive capabilities, and evasion from the immune response. Specific chapters in this release cover Actin dynamics during tumor cell dissemination, Actin cytoskeleton remodeling during cancer cell migration, Cytoskeletal Mechanics Drives Heterogeneity in Epithelial Ovarian Cancer, and much more. Provides comprehensive and timely reviews on actin cytoskeleton and its regulators in cancer biology Offers a wide range of perspectives for basic and translational research Discusses opportunities and challenges for translating knowledge of tumor cell actin cytoskeleton into clinical applications
Author : Patrice Boquet
Publisher : Springer Science & Business Media
ISBN 13 : 9783540238652
Total Pages : 216 pages
Book Rating : 4.2/5 (386 download)
Download or read book Bacterial Virulence Factors and Rho GTPases written by Patrice Boquet and published by Springer Science & Business Media. This book was released on 2005-04-01 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pathogenic bacteria for human and animals have developed sophisticated weapons, termed virulence factors, to ensure their replication and persistence into their hosts. The authors in this volume show a synthesis on how the various host cellular Rho GTPases activities are manipulated by bacteria to fulfil their virulence.
Author : Kenneth Murphy
Publisher : Garland Science
ISBN 13 : 9780815344575
Total Pages : pages
Book Rating : 4.3/5 (445 download)
Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author : Sujeeve Jeganathan
Publisher :
ISBN 13 :
Total Pages : 414 pages
Book Rating : 4.:/5 (658 download)
Download or read book The Regulation of Phospholipid Signaling and Actin Cytoskeletal Remodeling by the Eukaryotic Translation Elongation Factor EEF1A2 written by Sujeeve Jeganathan and published by . This book was released on 2008 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Cosima T. Baldari
Publisher : Humana
ISBN 13 : 9781071631379
Total Pages : 0 pages
Book Rating : 4.6/5 (313 download)
Download or read book The Immune Synapse written by Cosima T. Baldari and published by Humana. This book was released on 2024-04-28 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new collection features the most up-to-date essential protocols that are currently being used to study the immune synapse. Beginning with methods for making biophysical measurements, the volume continues by covering the cell biology of synapses, methods for advanced substrate engineering, mechanobiology topics, new technologies to describe and manipulate synaptic components, as well as methods related to sites of action and immunotherapy. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and fully updated, The Immune Synapse: Methods and Protocols, Second Edition serves as an ideal practical guide for researchers working in this dynamic field. Chapters 5, 11,18, 27, 30, and 32 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Author : Helder Maiato
Publisher : Humana
ISBN 13 : 9781071602188
Total Pages : 0 pages
Book Rating : 4.6/5 (21 download)
Download or read book Cytoskeleton Dynamics written by Helder Maiato and published by Humana. This book was released on 2019-12-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume details comprehensive state-of-the-art methods on actin microfilaments and microtubules and how they work to achieve different cellular functions in different cellular contexts. Chapters guide readers through protein purification, in vitro reconstitution of several cytoskeleton properties, analyses of microtubule- and actin-based structures, functional dissection of post-translational modifications, and roles in several biological processes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Cytoskeleton Dynamics: Methods and Protocols aims to provide a wide range of experimental approaches and be an invaluable resource for present and future generations of cytoskeleton researchers. The chapter “Visualization and Functional Analysis of Spindle Actin and Chromosome Segregation in Mammalian Oocytes” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Author : Alexis J Torres
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (613 download)
Download or read book Investigating Cytoskeletal Regulation of IgE Receptor Signaling by Micropatterned Ligand Arrays written by Alexis J Torres and published by . This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The high affinity immunoglobulin E (IgE ) receptor (Fc[epsilon]RI) is a member of a family of related antigen receptors with conserved structure and similar roles in initiating intracellular signaling in response to an outside stimulus. In mammalian cells, Fc[epsilon]RI is found primarily on the surface of mast cells and basophils. Activation of this receptor by multivalent antigen triggers a series of intracellular signaling events that ultimately lead to the secretion of preformed mediators, such as histamine and serotonin, which are responsible for allergic reactions. Our recent efforts in the study of immunoreceptor signaling have focused on the participation of the plasma membrane and the actin cytoskeleton. However, tools for investigating biomolecular dynamics and interactions that occur within close proximity to the plasma membrane of living cells are somewhat limited. Micro-fabricated surfaces have been used for applications in cell and tissue engineering, although their full potential has not been explored, particularly in the area of molecular cell biology. We have recently developed a polymer lift-off method for localizing the initial stimulus to micron size patches of antigens such that assembly of signaling components could be visualized with selective fluorescent labeling and confocal microscopy. Employing these technologies we have investigated fundamental mechanisms in immune cell signaling, specifically IgE receptor (Fc[epsilon]RI) signaling involved in allergic responses on mast cells. In past years, our group has observed spatially and temporally resolved responses, including receptor phosphorylation, selective accumulation of Lyn kinase and other membrane components. In this work, I have applied these tools to investigate functional and structural implications of the actin cytoskeleton regulation of Fc[epsilon]RI signaling and the cytoskeletal dependence of activated receptor internalization. I have shown that particular actin binding proteins, paxillin, talin and vinculin co-redistribute at the patterned antigen and clustered receptors in a similar time course as polymerized actin. These proteins have been extensively characterized in the context of integrin signaling and focal adhesion assembly, but little is known about their involvement in immune cell signaling. Our biochemical data suggests that these proteins have functional relevance in some of the early and late events of the signaling cascade. In addition, I show that the GTPase dynamin 2, which is commonly associated with receptor endocytosis, is selectively recruited to the sites of receptor clustering. Protein knockdown of dynamin 2 decreases the accumulation of F-actin at the clustered receptors, implicating dynamin in the regulation of Fc[epsilon]RI mediated actin redistribution. These results point a possible role for dynamin-actin interactions in regulating activated IgEFc[epsilon]RI internalization.
Author : Robert C. Bast, Jr.
Publisher : John Wiley & Sons
ISBN 13 : 111900084X
Total Pages : 2004 pages
Book Rating : 4.1/5 (19 download)
Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Author : Julianne Zedalis
Publisher :
ISBN 13 : 9781947172401
Total Pages : 1923 pages
Book Rating : 4.1/5 (724 download)
Download or read book Biology for AP ® Courses written by Julianne Zedalis and published by . This book was released on 2017-10-16 with total page 1923 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biology for AP® courses covers the scope and sequence requirements of a typical two-semester Advanced Placement® biology course. The text provides comprehensive coverage of foundational research and core biology concepts through an evolutionary lens. Biology for AP® Courses was designed to meet and exceed the requirements of the College Board’s AP® Biology framework while allowing significant flexibility for instructors. Each section of the book includes an introduction based on the AP® curriculum and includes rich features that engage students in scientific practice and AP® test preparation; it also highlights careers and research opportunities in biological sciences.
Author :
Publisher : Academic Press
ISBN 13 : 0080962823
Total Pages : 423 pages
Book Rating : 4.0/5 (89 download)
Download or read book Primary Cilia written by and published by Academic Press. This book was released on 2009-11-30 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the role of cilia in the study of health, development and disease has been increasingly clear, and new discoveries have made this an exciting and important field of research. This comprehensive volume, a complement to the new three-volume treatment of cilia and flagella by King and Pazour, presents easy-to-follow protocols and detailed background information for researchers working with cilia and flagella. - Covers protocols for primary cilia across several systems and species - Both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time - Relevant to clinicians and scientists working in a wide range of fields
Author : Bo Liu
Publisher : Springer Science & Business Media
ISBN 13 : 1441909877
Total Pages : 333 pages
Book Rating : 4.4/5 (419 download)
Download or read book The Plant Cytoskeleton written by Bo Liu and published by Springer Science & Business Media. This book was released on 2010-11-23 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant cells house highly dynamic cytoskeletal networks of microtubules and actin microfilaments. They constantly undergo remodeling to fulfill their roles in supporting cell division, enlargement, and differentiation. Following early studies on structural aspects of the networks, recent breakthroughs have connected them with more and more intracellular events essential for plant growth and development. Advanced technologies in cell biology (live-cell imaging in particular), molecular genetics, genomics, and proteomics have revolutionized this field of study. Stories summarized in this book may inspire enthusiastic scientists to pursue new directions toward understanding functions of the plant cytoskeleton. The Plant Cytoskeleton is divided into three sections: 1) Molecular Basis of the Plant Cytoskeleton; 2) Cytoskeletal Reorganization in Plant Cell Division; and 3) The Cytoskeleton in Plant Growth and Development. This book is aimed at serving as a resource for anyone who wishes to learn about the plant cytoskeleton beyond ordinary textbooks.
