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Cyclic Nucleotide Phosphodiesterases In Health And Disease
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Book Synopsis Cyclic Nucleotide Phosphodiesterases in Health and Disease by : Joseph A. Beavo
Download or read book Cyclic Nucleotide Phosphodiesterases in Health and Disease written by Joseph A. Beavo and published by CRC Press. This book was released on 2006-12-05 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the field. There is great need for a centralized source for key information in this burgeoning and therapeutically important area of medical research. Cyclic Nucleotide Phosph
Book Synopsis Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System by : Nicholas J. Brandon
Download or read book Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System written by Nicholas J. Brandon and published by John Wiley & Sons. This book was released on 2014-03-07 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews advances in understanding phosphodiesterases within the central nervous system and their therapeutic applications. A range of expert authors from both academia and industry describe these, then focus on the areas of greatest scientific and medical interest to provide more detailed coverage. Therapeutic and drug discovery applications are covered for diseases including Alzheimer's, Parkinson's, schizophrenia, erectile dysfunction, and spinal cord injuries. There is also a chapter on drug discovery tools such as in vitro assays and X-ray structures for medicinal chemistry studies.
Book Synopsis Phosphodiesterases: CNS Functions and Diseases by : Han-Ting Zhang
Download or read book Phosphodiesterases: CNS Functions and Diseases written by Han-Ting Zhang and published by Springer. This book was released on 2017-09-26 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: PDEs are a family of enzymes that catalyze the hydrolysis of intracellular cyclic nucleotides. They are implicated in a number of disorders and dysfunctions and PDE inhibitors have already proven to be effective therapies for erectile dysfunction, COPD, and psoriatic arthritis. This family of enzymes also plays a role in diseases and disorders of the CNS such as depression, anxiety, schizophrenia, and Alzheimer's Disease. Unfortunately no effective PDE inhibitors have been developed for the treatment of these diseases. The proposed book will be a comprehensive overview of the current state of basic and translational research on PDE inhibitors written by internationally recognized experts. Authors will also discuss potential PDE subtypes and splice variants in the hopes that this will spur more creative approaches to PDE targeting drugs.
Book Synopsis Cyclic Nucleotide Phosphodiesterases by : Joe Beavo
Download or read book Cyclic Nucleotide Phosphodiesterases written by Joe Beavo and published by . This book was released on 1990-11-30 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Second volume in a series addressing topical areas important to the understanding of the control of biological processes. This volume focuses on the structure and molecular biology of isoenzymes and their role in signal transduction processes necessary for co-ordinating cellular functioning.
Book Synopsis Cyclic Nucleotide Signaling by : XiaoDong Cheng
Download or read book Cyclic Nucleotide Signaling written by XiaoDong Cheng and published by CRC Press. This book was released on 2021-03-30 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Showcasing the recent progresses of the field, Cyclic Nucleotide Signaling covers the major tools and methodologies used in various areas of research. The majority of the chapters are protocol oriented, with the goal of providing clear directions for laboratory use. Students and investigators new to the field will find this book particularly informative, as will scientists already actively researching nucleotide signaling.
Book Synopsis The Biology of Cyclic Nucleotide Phosphodiesterases by : Samuel J. Strada
Download or read book The Biology of Cyclic Nucleotide Phosphodiesterases written by Samuel J. Strada and published by . This book was released on 1992 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cyclic Nucleotides in the Nervous System by : John Daly
Download or read book Cyclic Nucleotides in the Nervous System written by John Daly and published by Springer. This book was released on 1977-03 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: The elucidation of the cellular and molecular bases underlying the inte grated function of the central nervous system, both in disease and in health, must ultimately come from the combined efforts of scientists from many disciplines, including biology, chemistry, histology, pathology, physiology, pharmacology, and psychology. Communication between scientists from these various disciplines-vital to the advancement of our understanding of the function of the nervous system-has become more and more difficult in recent years. Both increasing specialization and the incredible increases in publications pertinent to brain research in a wide spectrum of journals, in symposium volumes, in monographs, in abstracts, and in reviews contrib ute to the problems of cross-communication and even of communication within a scientific discipline. Research on the significance of cyclic nucleo tides to the function of nervous systems is particularly illustrative of the communication problem. Since the initial publications by Sutherland, Rall, and Butcher in the late fifties and early sixties on high levels of adenylate cyclase, phosphodiesterases, and cyclic AMP in brain, the ensuing litera ture of this field has expanded exponentially. At the present time, from five to ten publications relevant to cyclic nucleotides and the nervous system appear each week. Indeed, these are minimal numbers based mainly on examination of literature titles and key index words. Many articles concerned with some aspect of central function contain, buried within their text, experiments with or related to cyclic nucleotides.
Book Synopsis Cyclic nucleotide phosphodiesterase in human ureter by : Akmal Taher
Download or read book Cyclic nucleotide phosphodiesterase in human ureter written by Akmal Taher and published by . This book was released on 1992 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Microdomains in the Cardiovascular System by : Viacheslav Nikolaev
Download or read book Microdomains in the Cardiovascular System written by Viacheslav Nikolaev and published by Springer. This book was released on 2017-09-19 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book comprehensively presents new findings in cardiovascular research related to signaling microdomains in health and disease. Important second messengers such as cAMP, cGMP, calcium and their role in microdomain signaling are discussed. The book offers and explains methodical approaches and technical ways how to successfully analyze microdomain signaling, also in the context of disease. It further provides scientific perspectives and strategies that are based on the concept of signaling within microdomains and that can revolutionize pharmacology and eventually lead to the effective treatment of cardiovascular diseases in future.This book is written for scientists in cardiovascular research, pharmacology, molecular and cellular biology as well as medical doctors in cardiology, angiology and nephrology.
Book Synopsis Phosphodiesterase Methods and Protocols by : Claire Lugnier
Download or read book Phosphodiesterase Methods and Protocols written by Claire Lugnier and published by Humana. This book was released on 2005-06-22 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research leaders in the PDE field describe new concepts and techniques for investigating the role of PDEs in orchestrating normal and pathophysiological responses. Presented in step-by-step detail, these readily reproducible methods allow the measurement of cyclic nucleotide variations in living cells, as well as their visualization in a spatio-temporal manner, the localization and characterization of their activities in tissues and living cells, and the assessment of targeted PDEs in creating specific tools and drugs. Additional chapters discuss the generation of PDE4 knockout mice to demonstrate not only the potential role of targeted PDEs, but also their use in further studies of the central role of PDE regulation in intracellular signaling control. These techniques offer clinicians a way to find new therapies for numerous pathologies whose molecular origins are unknown and whose treatment is symptomatic. Alterations of intracellular signaling related to PDE deregulation in such pathologies as inflammation, neurodegeneration, and cancer may explain the difficulties observed in their prevention and treatment.
Book Synopsis Adipose Tissue Protocols by : Gérard Ailhaud
Download or read book Adipose Tissue Protocols written by Gérard Ailhaud and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adipose tissue is recognized to be exquisitely sensitive to hormone action, and is also now recognized as a secretory and endocrine organ required for reproduction and good health. Adipocytes are “smart” cells able within the tissue to communicate with surrounding cells, but also with various organs, particularly via leptin acting on the central nervous system. Brown adipose tissue (BAT) and white adipose tissue (WAT) are known to be distinct tissues, whereas the heterogeneity of WAT depots is well est- lished. Unfortunately, excess WAT leads to obesity, which is the most common health problem in industrialized countries. Therefore, from both a scientific and a technical point of view, the time has come to create a survey of adipose tissues and their neglected adipocytes. In Adipose Tissue Protocols, I have attempted to gather together chapters from all areas of adipose tissue research—from in vivo to in vitro studies—and to provide methods covering a wide variety of techniques, including the choice of adipose tissue depot and of morphological techniques for the study of BAT and WAT; the isolation, subcellular fractionation, and transfection of adipocytes where the low density of these cells must be taken into account; assays of nutrient and ion fluxes and the metabolic aspects of nutrient uptake; assays of lipid-related enzymes; biopsies and quantification of lipid-related mRNAs; cultures of adipose precursor cells from WAT and BAT of various species, including human tissue; measurements of adipose secretory products; and assessment of WAT metabolism in vivo.
Book Synopsis Cyclic Nucleotide Phosphodiesterases by : Samuel J. Strada
Download or read book Cyclic Nucleotide Phosphodiesterases written by Samuel J. Strada and published by Raven Press (ID). This book was released on 1984 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Targeted Biomarker Quantitation by LC-MS by : Naidong Weng
Download or read book Targeted Biomarker Quantitation by LC-MS written by Naidong Weng and published by John Wiley & Sons. This book was released on 2017-07-31 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first book to offer a blueprint for overcoming the challenges to successfully quantifying biomarkers in living organisms The demand among scientists and clinicians for targeted quantitation experiments has experienced explosive growth in recent years. While there are a few books dedicated to bioanalysis and biomarkers in general, until now there were none devoted exclusively to addressing critical issues surrounding this area of intense research. Target Biomarker Quantitation by LC-MS provides a detailed blueprint for quantifying biomarkers in biological systems. It uses numerous real-world cases to exemplify key concepts, all of which were carefully selected and presented so as to allow the concepts they embody to be easily expanded to future applications, including new biomarker development. Target Biomarker Quantitation by LC-MS primarily focuses on the assay establishment for biomarker quantitation—a critical issue rarely treated in depth. It offers comprehensive coverage of three core areas of biomarker assay establishment: the relationship between the measured biomarkers and their intended usage; contemporary regulatory requirements for biomarker assays (a thorough understanding of which is essential to producing a successful and defendable submission); and the technical challenges of analyzing biomarkers produced inside a living organism or cell. Covers the theory of and applications for state-of-the-art mass spectrometry and chromatography and their applications in biomarker analysis Features real-life examples illustrating the challenges involved in target biomarker quantitation and the innovative approaches which have been used to overcome those challenges Addresses potential obstacles to obtain effective biomarker level and data interpretation, such as specificity establishment and sample collection Outlines a tiered approach and fit-for-purpose assay protocol for target biomarker quantitation Highlights the current state of the biomarker regulatory environment and protocol standards Target Biomarker Quantitation by LC-MS is a valuable resource for bioanalytical scientists, drug metabolism and pharmacokinetics scientists, clinical scientists, analytical chemists, and others for whom biomarker quantitation is an important tool of the trade. It also functions as an excellent text for graduate courses in pharmaceutical, biochemistry and chemistry.
Book Synopsis Pancreatic Beta Cell in Health and Disease by : Susumu Seino
Download or read book Pancreatic Beta Cell in Health and Disease written by Susumu Seino and published by Springer Science & Business Media. This book was released on 2008-04-08 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: The beta cells of the pancreatic islets of Langerhans are the only cells in the body that produce and secrete insulin. This metabolic hormone plays a central role in the maintenance of glucose homeostasis. This book provides a comprehensive review of the beta cell in health and disease. The book’s primary aim is to encourage investigators to become actively involved in diabetes research and the search for new approaches to prevent and treat diabetes.
Book Synopsis Cyclic Nucleotide Phosphodiesterase from Beef Heart by : Elihu Norman Goren
Download or read book Cyclic Nucleotide Phosphodiesterase from Beef Heart written by Elihu Norman Goren and published by . This book was released on 1971 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mechanisms of Neuroinflammation by : Gonzalo Emiliano Aranda Abreu
Download or read book Mechanisms of Neuroinflammation written by Gonzalo Emiliano Aranda Abreu and published by BoD – Books on Demand. This book was released on 2017-08-23 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Mechanisms of Neuroinflammation" book explains how the neuronal cells become swollen at the moment of the blood-brain barrier disruption and how they lose their immunological isolation. A cascade of cytokines and immune cells from the bloodstream enters the nervous system, inflaming neurons and activating the glia. This produces a neuroinflammatory process that can generate different neurodegenerative diseases. Better understanding of mechanisms that are activated at the time when the damage to the brain occurs could lead to the development of suitable therapies that revert the neuronal inflammation and thus prevent further damage to the nervous system.
Book Synopsis Isolation and Characterization of Cyclic Nucleotide Phosphodiesterase from Human Placenta by : angeliki Stavrinoudis
Download or read book Isolation and Characterization of Cyclic Nucleotide Phosphodiesterase from Human Placenta written by angeliki Stavrinoudis and published by . This book was released on 1991 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt:
