Current Problems In Drug Toxicology

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Improving and Accelerating Therapeutic Development for Nervous System Disorders

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309292492
Total Pages : 107 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Improving and Accelerating Therapeutic Development for Nervous System Disorders by : Institute of Medicine

Download or read book Improving and Accelerating Therapeutic Development for Nervous System Disorders written by Institute of Medicine and published by National Academies Press. This book was released on 2014-02-06 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt: Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.

Pharmaceutical Toxicology in Practice

Author : Alberto Lodola
Publisher : John Wiley & Sons
ISBN 13 : 0470922729
Total Pages : 280 pages
Book Rating : 4.4/5 (79 download)

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Book Synopsis Pharmaceutical Toxicology in Practice by : Alberto Lodola

Download or read book Pharmaceutical Toxicology in Practice written by Alberto Lodola and published by John Wiley & Sons. This book was released on 2011-03-31 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes, with references to key source materials, the background to, and conduct of, the principal nonclinical studies that are central to drug development. The chapters provide an understanding of the key components of the preclinical phase of drug development with a hands-on description, with core chapters addressing study conduct, types, and reporting. As such, it is a practical guide through toxicology testing and an up-to-date reference on current issues, new developments, and future directions in toxicology. Opening with a practical description of toxicology and its role in the development of pharmaceuticals, the book proceeds to detail international regulations (including the impact of the new REACH standards for chemical safety), interdisciplinary interactions among scientists in drug development, steps in toxicity testing, and risk management. Further, the book covers the methods of genetic toxicology (assays, genomics, in vivo screening) as a complement to “traditional” toxicology in the risk assessment and risk management of pharmaceuticals.

Current Problems in Drug Toxicology

Author : G Zbinden (Ed)
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (985 download)

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Book Synopsis Current Problems in Drug Toxicology by : G Zbinden (Ed)

Download or read book Current Problems in Drug Toxicology written by G Zbinden (Ed) and published by . This book was released on 1983 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Current Problems in Drug Toxicology

Author : Gerhard Zbinden
Publisher :
ISBN 13 :
Total Pages : 344 pages
Book Rating : 4.:/5 (311 download)

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Book Synopsis Current Problems in Drug Toxicology by : Gerhard Zbinden

Download or read book Current Problems in Drug Toxicology written by Gerhard Zbinden and published by . This book was released on 1983 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Issues in Drug Management, Toxicology, Monitoring, Resistance, and Safety: 2011 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464967083
Total Pages : 552 pages
Book Rating : 4.4/5 (649 download)

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Book Synopsis Issues in Drug Management, Toxicology, Monitoring, Resistance, and Safety: 2011 Edition by :

Download or read book Issues in Drug Management, Toxicology, Monitoring, Resistance, and Safety: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: Issues in Drug Management, Toxicology, Monitoring, Resistance, and Safety: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Drug Management, Toxicology, Monitoring, Resistance, and Safety. The editors have built Issues in Drug Management, Toxicology, Monitoring, Resistance, and Safety: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Drug Management, Toxicology, Monitoring, Resistance, and Safety in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Drug Management, Toxicology, Monitoring, Resistance, and Safety: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Current Problems in Drug Toxicology

Author : G. Zbinden
Publisher :
ISBN 13 :
Total Pages : 328 pages
Book Rating : 4.:/5 (598 download)

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Book Synopsis Current Problems in Drug Toxicology by : G. Zbinden

Download or read book Current Problems in Drug Toxicology written by G. Zbinden and published by . This book was released on 1983 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Current Problems in Nutrition, Pharmacology & Toxicology

Author : Allan McLean
Publisher :
ISBN 13 :
Total Pages : 260 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Current Problems in Nutrition, Pharmacology & Toxicology by : Allan McLean

Download or read book Current Problems in Nutrition, Pharmacology & Toxicology written by Allan McLean and published by . This book was released on 1988 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Current Topics in Nonclinical Drug Development

Author : Pritam S. Sahota
Publisher : CRC Press
ISBN 13 : 0429651139
Total Pages : 337 pages
Book Rating : 4.4/5 (296 download)

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Book Synopsis Current Topics in Nonclinical Drug Development by : Pritam S. Sahota

Download or read book Current Topics in Nonclinical Drug Development written by Pritam S. Sahota and published by CRC Press. This book was released on 2020-12-22 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: The inaugural volume in the Current Topics in Nonclinical Drug Development Series explores the critical issues and current topics in nonclinical drug development. This first volume covers individual topics and strategies in drug development from compound characterization to drug registration. Written by a variety of experts in the field, recent and rapid advances in technologies and associated changes in regulatory guidance are discussed. Additional features include: Deals with day-to-day issues in study design, evaluation of findings, and presentation of data. Explains new approaches in the development of medical devices. Includes dedicated chapters on the use of bioinformatics in drug development. Addresses strategies for photosafety testing of drugs. Current Topics in Nonclinical Drug Development, Volume I will aid toxicologists, toxicologic pathologists, consultants, regulators, Study Directors, and nonclinical scientists dealing with day-to-day issues in study design, evaluation of findings, and presentation of data. In addition, the book will be a valuable reference for academicians and graduate students pursuing research related to nonclinical drug development.

First International Symposium On Current Issues of Drug Abuse Testing

Author : Jordi Segura
Publisher : CRC Press
ISBN 13 : 9780849342837
Total Pages : 312 pages
Book Rating : 4.3/5 (428 download)

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Book Synopsis First International Symposium On Current Issues of Drug Abuse Testing by : Jordi Segura

Download or read book First International Symposium On Current Issues of Drug Abuse Testing written by Jordi Segura and published by CRC Press. This book was released on 1991-10-29 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book elaborates on the topics covered by top experts in the field of drug testing at an international symposium held in March, 1990. The book is an excellent reference for all professionals involved in the set up, performance and interpretation of results for drug testing programs using biological fluids (especially urine). U.S. and European perspectives are presented in relation to workplace testing. Organizational aspects for reliability of drug testing include topics ranging from sample collection, chain of custody, and laboratory strategies to legal and regulatory aspects. Critical reviews of analytical methodology involve descriptions and critical issues for the major presumptive and confirmatory techniques, including immunological and gas chromatographic-mass spectrometric methodologies. The book's interpretation of results takes into account the metabolic, pharmacokinetic, pharmacodynamic and clinical aspects. The final chapters of the book include topics addressing aspects for potential international harmonization.

Issues in Drug Management, Toxicology, Monitoring, Resistance, and Safety: 2013 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 149010917X
Total Pages : 394 pages
Book Rating : 4.4/5 (91 download)

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Book Synopsis Issues in Drug Management, Toxicology, Monitoring, Resistance, and Safety: 2013 Edition by :

Download or read book Issues in Drug Management, Toxicology, Monitoring, Resistance, and Safety: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-05-01 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: Issues in Drug Management, Toxicology, Monitoring, Resistance, and Safety: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Drug Testing and Analysis. The editors have built Issues in Drug Management, Toxicology, Monitoring, Resistance, and Safety: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Drug Testing and Analysis in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Drug Management, Toxicology, Monitoring, Resistance, and Safety: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology

Author : Seth Kwabena Amponsah
Publisher : Springer Nature
ISBN 13 : 3031123980
Total Pages : 384 pages
Book Rating : 4.0/5 (311 download)

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Book Synopsis Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology by : Seth Kwabena Amponsah

Download or read book Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology written by Seth Kwabena Amponsah and published by Springer Nature. This book was released on 2022-10-25 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives an overview of therapeutic drug monitoring (TDM) and its clinical application. It also highlights recent advances in toxicological studies, as they relate to therapeutic drug monitoring. This is one of the few books available on the market that covers TDM. Therapeutic drug monitoring (TDM) is a clinical decision-making tool that enables dosage regimen adjustments based on clinical and laboratory measurements. TDM not only involves the measuring of drug concentrations but also interpretation of the results. There is a strong correlation between drug concentrations in body fluids and outcome than between dose and outcome. The chapters include coverage of analytical techniques, pharmacokinetics, therapeutic indices, artificial intelligence and recent advances in toxicological studies. The book fills a gap in published literature and provides reliable information on; Analytical techniques in TDM and clinical toxicology TDM and pharmacokinetic studies TDM of drugs with narrow therapeutic indices Artificial intelligence in TDM and clinical toxicology Future directions and challenges

Current Concepts in Drug Metabolism and Toxicology

Author : Gabrielle M. Hawksworth
Publisher : Academic Press
ISBN 13 : 0123983398
Total Pages : 302 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Current Concepts in Drug Metabolism and Toxicology by : Gabrielle M. Hawksworth

Download or read book Current Concepts in Drug Metabolism and Toxicology written by Gabrielle M. Hawksworth and published by Academic Press. This book was released on 2012-06-12 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Advances in Pharmacology explores the current concepts in drug metabolism and toxicology. Chapters cover the Keap1-Nrf2 cell defense pathway, animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modeling metabolism and toxicity. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike. Explores the current concepts in drug metabolism and toxicology Chapters cover such areas as the Keap1-Nrf2 cell defense pathway, animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modeling metabolism and toxicity An essential resource for pharmacologists, immunologists and biochemists alike

Forensic Toxicology

Author : W. Lowry
Publisher : Springer Science & Business Media
ISBN 13 : 1468434446
Total Pages : 455 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Forensic Toxicology by : W. Lowry

Download or read book Forensic Toxicology written by W. Lowry and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the rapid spread of drug use and abuse in this country over the last decade, events relating to drugs have become increasingly prominent in the court of law as well as in society in general. It is anticipated that throughout the 1980s this problem will continue to be one of the major social problems in the United States. With the complexity of the Federal and state laws and their interrelationships, and with the increasing demand for the expert chemist or toxicologist, or both, in the courtroom, more education for these people relating to drugs must be implemented. The prosecuting and defense attorneys are also in need of accurate toxicological information to adequately handle cases in which drugs playa role. This book is intended to be a practical as well as an educational book-a resource tool for the active forensic chemist, as well as for the student. It is with the forensic chemist in mind that the material on controlled substances and substances found in cases of drug abuse has been arranged in a systematic order for quick and easy reference. This section includes synonyms, pharma ceutical preparations, biochemistry and/or pharmacognosy, toxicology and/or pharmacology, and how the substance is controlled under Federal law. Under the concept of scientific consideration as compared with the Federal law, this book enables one to deal with some of the major conflicts in the American legal system concerning scientific evidence and how it is presented in a court of law.

Human Toxicology

Author : J. Descotes
Publisher : Elsevier
ISBN 13 : 0080534228
Total Pages : 859 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Human Toxicology by : J. Descotes

Download or read book Human Toxicology written by J. Descotes and published by Elsevier. This book was released on 1996-09-02 with total page 859 pages. Available in PDF, EPUB and Kindle. Book excerpt: This excellent volume was designed and edited with two major ideas in mind: firstly, the field of clinical toxicology is changing and an acknowledgement of these changes is warranted; secondly, no comprehensive compilation of recently published case reports of, and clinical studies on, human poisonings is available, which is in sharp contrast to the closely related field of drug-induced side-effects. The book focusses on issues of recent concern, or issues poorly documented in the past. It is important that clinical toxicologists gain a better knowledge of all the available techniques of toxicological analysis. A better understanding of the way a sound interpretation of results should be conducted for the benefit of the patient's management, and a comprehensive set of data on the kinetics of the most common pharmaceutical drugs and many chemicals is required. Human Toxicology is a timely reference work which will be welcomed by a broad audience of toxicology professionals.

Mechanisms of Drug Toxicity

Author : H. Rašková
Publisher : Elsevier
ISBN 13 : 1483157202
Total Pages : 113 pages
Book Rating : 4.4/5 (831 download)

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Book Synopsis Mechanisms of Drug Toxicity by : H. Rašková

Download or read book Mechanisms of Drug Toxicity written by H. Rašková and published by Elsevier. This book was released on 2013-10-22 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanisms of Drug Toxicity, Volume 4 presents the proceedings of the 3rd International Pharmacological Meeting held in Sao Paulo, Brazil in 1966. The book discusses the drug-induced pathobiotic effects; the mechanisms of adverse reactions; and enzyme induction in the mechanism of chronic toxicity. The text also describes the influence of inducing substances on the growth of liver and microsomal electron transport systems; the quantitative aspects of chronic toxicity; and the facts and fallacies in predicting drug effects in human.

New Horizons in Predictive Toxicology

Author : Alan G. E. Wilson
Publisher : Royal Society of Chemistry
ISBN 13 : 1849730512
Total Pages : 711 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis New Horizons in Predictive Toxicology by : Alan G. E. Wilson

Download or read book New Horizons in Predictive Toxicology written by Alan G. E. Wilson and published by Royal Society of Chemistry. This book was released on 2012 with total page 711 pages. Available in PDF, EPUB and Kindle. Book excerpt: The sophistication of modelling and simulation technologies have improved dramatically over the past decade and their applications in toxicity prediction and risk assessment are of critical importance. The integration of predictive toxicology approaches will become increasingly necessary as industrial chemicals advance and as new pharmaceuticals enter the market. In this comprehensive discussion of predictive toxicology and its applications, leading experts express their views on the technologies currently available and the potential for future developments. The book covers a wide range of topics including in silico, in vitro and in vivo approaches that are being used in the safety assessment of chemical substances. It reflects the growing and urgent need to strengthen and improve our ability to predict the safety and risks posed by industrial and pharmaceutical chemicals in humans. The reader will find extensive information on the use of current animal models used for various toxicities and target mediated toxicities. Also discussed are the recent regulatory initiatives to improve the safety assessment of chemicals. The book provides an expert and comprehensive discussion on the current status and future directions of predictive toxicology and its application. The various chapters in the book also reflect the growing need for improvements in our technologies and abilities to predict toxicities of pharmaceutical and industrial chemicals to ensure product safety and protect public health.

Advanced Issue Resolution in Safety Pharmacology

Author : Mary Jeanne Kallman
Publisher : Academic Press
ISBN 13 : 9780128122068
Total Pages : 0 pages
Book Rating : 4.1/5 (22 download)

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Book Synopsis Advanced Issue Resolution in Safety Pharmacology by : Mary Jeanne Kallman

Download or read book Advanced Issue Resolution in Safety Pharmacology written by Mary Jeanne Kallman and published by Academic Press. This book was released on 2018-09-07 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Issue Resolution in Safety Pharmacology not only discusses unique issues that may emerge during the development of new medicines, but also provides detailed insights on how to resolve them. The book employs a valuable strategy that integrates preclinical findings with the clinical resolution of those findings. In addition, it introduces key interdisciplinary topics in an accessible and systematic format. Edited and written by leaders in the field of safety pharmacology, this book considerably advances the discussion on issue resolution topics, thus raising them to the next level of importance by providing scientists with an indispensable resource on solving safety issues.