Current Advances In Osteosarcoma

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Current Advances in Osteosarcoma

Author : Eugenie S. Kleinerman, M.D.
Publisher : Springer
ISBN 13 : 3319048430
Total Pages : 358 pages
Book Rating : 4.3/5 (19 download)

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Book Synopsis Current Advances in Osteosarcoma by : Eugenie S. Kleinerman, M.D.

Download or read book Current Advances in Osteosarcoma written by Eugenie S. Kleinerman, M.D. and published by Springer. This book was released on 2014-06-12 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current Advances in Osteosarcoma edited by Dr. Eugenie S. Kleinerman summarizes molecular and genetic characteristics, new therapeutic ideas, and biological characteristics that have been uncovered in the past 10 years. Osteosarcoma is an aggressive malignant neoplasm and it is also the most common histological form of bone cancer. It accounts for approximately 56% of new bone tumors, making it the most primary malignant bone tumor in children and adolescents. The lungs are the most common site of metastases and once osteosarcoma spreads to the lungs, it is very difficult to treat. To improve the outcome of this disease, the biology of osteosarcoma needs to be better understood. There are numerous investigators around the world who have made seminal discoveries about the important molecular pathways and genetic alterations that contribute to the development and metastases of osteosarcoma. Other investigators have proposed novel therapeutic strategies including some based on the molecular and genetic phenotype of the disease. Current Advances in Osteosarcoma summarizes all of these new discoveries in one singular text, which will help move the field forward.

Current Advances in Osteosarcoma

Author : Eugenie S. Kleinerman
Publisher : Springer Nature
ISBN 13 : 3030430324
Total Pages : 214 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Current Advances in Osteosarcoma by : Eugenie S. Kleinerman

Download or read book Current Advances in Osteosarcoma written by Eugenie S. Kleinerman and published by Springer Nature. This book was released on 2020-06-01 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thoroughly revised second edition complied in 2 books is an up-to-date overview of the current clinical advances in sarcoma and osteosarcoma. The new edition features detailed, in-depth discussions of microRNAs in osteosarcoma, historical perspectives of chemotherapy in the treatment of the disease, tumor targeted IL12 therapy and HER2 targeted therapy, the role of enhancer elements in regulating the prometastatic transcriptional program and more. Further, these essential volumes also includes new insights on Wnt signaling in osteosarcoma, the role of genomics, genetically modified T-cell therapy, liquid biopsy, oncolytic viruses, immunophenotyping, receptor tyrosine kinases and epigenetic-focused approaches for treatment of osteosarcoma metastases, as well as thoughts on the current standard of treatment for patients suffering from these cancers. In the years since the previous edition, there have been numerous new developments in this rapidly changing field; this new edition is both timely and urgently needed. When taken together these companion volumes, Current Clinical (Book 1) and Scientific (Book 2) Advances in Osteosarcoma, are a timely and urgently needed guide for laboratory investigators and clinical oncologists focused in sarcoma.

Current Advances in the Science of Osteosarcoma

Author : Eugenie S. Kleinerman
Publisher : Springer Nature
ISBN 13 : 3030430855
Total Pages : 233 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Current Advances in the Science of Osteosarcoma by : Eugenie S. Kleinerman

Download or read book Current Advances in the Science of Osteosarcoma written by Eugenie S. Kleinerman and published by Springer Nature. This book was released on 2020-08-07 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thoroughly revised second edition is an up-to-date overview of the new advances in the knowledge of the basic science in sarcoma and osteosarcoma. It features detailed, in-depth discussions of microRNAs in osteosarcoma, historical perspectives of chemotherapy in the treatment of the disease, tumor targeted IL12 therapy and HER2 targeted therapy, the role of enhancer elements in regulating the prometastatic transcriptional program and more. Further, this essential volume also includes new insights on Wnt signaling in osteosarcoma, the role of genomics, genetically modified T-cell therapy, liquid biopsy, oncolytic viruses, immunophenotyping, receptor tyrosine kinases and epigenetic-focused approaches for treatment of osteosarcoma metastases, as well as thoughts on the current standard of treatment for patients suffering from these cancers. In the years since the previous edition, there have been numerous new developments in this rapidly changing field; this new edition is both timely and urgently needed. When taken together these companion volumes, Current Clinical (Book 1) and Scientific (Book 2) Advances in Osteosarcoma, are a timely and urgently needed guide for laboratory investigators and clinical oncologists.

Current Advances in the Science of Osteosarcoma

Author :
Publisher :
ISBN 13 : 9783030430863
Total Pages : pages
Book Rating : 4.4/5 (38 download)

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Book Synopsis Current Advances in the Science of Osteosarcoma by :

Download or read book Current Advances in the Science of Osteosarcoma written by and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This thoroughly revised second edition is an up-to-date overview of the new advances in the knowledge of the basic science in sarcoma and osteosarcoma. It features detailed, in-depth discussions of microRNAs in osteosarcoma, historical perspectives of chemotherapy in the treatment of the disease, tumor targeted IL12 therapy and HER2 targeted therapy, the role of enhancer elements in regulating the prometastatic transcriptional program and more. Further, this essential volume also includes new insights on Wnt signaling in osteosarcoma, the role of genomics, genetically modified T-cell therapy, liquid biopsy, oncolytic viruses, immunophenotyping, receptor tyrosine kinases and epigenetic-focused approaches for treatment of osteosarcoma metastases, as well as thoughts on the current standard of treatment for patients suffering from these cancers. In the years since the previous edition, there have been numerous new developments in this rapidly changing field; this new edition is both timely and urgently needed. When taken together these companion volumes, Current Clinical (Book 1) and Scientific (Book 2) Advances in Osteosarcoma, are a timely and urgently needed guide for laboratory investigators and clinical oncologists.

Pediatric and Adolescent Osteosarcoma

Author : Norman Jaffe
Publisher : Springer Science & Business Media
ISBN 13 : 1441902848
Total Pages : 591 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Pediatric and Adolescent Osteosarcoma by : Norman Jaffe

Download or read book Pediatric and Adolescent Osteosarcoma written by Norman Jaffe and published by Springer Science & Business Media. This book was released on 2010-03-10 with total page 591 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pediatric and Adolescent Osteosarcoma provides a historical review of the nature of osteosarcoma and the conflict that accompanied the introduction of adjuvant therapy for osteosarcoma culminating in accepted and prevailing methods of current therapy. It outlines concepts in Epidemiology and Etiology, and provides chapters on pathology and radiologic characteristics of osteosarcoma, surgical therapy tailored specifically for treatment of primary tumors in pediatric/adolescent age group, treatment of pulmonary and extra pulmonary metastases and complications, as well as the role of radiation therapy. The volume concludes with a review of differences and similarities in the management of osteosarcoma in adults as compared to pediatrics / adolescents and new laboratory and animal investigations currently in progress to develop effective diagnostic and therapeutic approaches to improve the outcome. In essence the scope and intensive coverage of the book provides a historical perspective of the advances made over the past 30 years and emerging concepts and prospects for new diagnostic and therapeutic approaches. This is based upon past experiences and new discoveries. It also provides a unique opportunity for pediatric and adult medical oncologists, physicians in training, orthopedic surgeons, pathologists, radiologists, radiotherapists, oncology nurses and allied professionals involved in the care of pediatric/adolescent patients with osteosarcoma to become acquainted with prevailing methods of treatment and new and evolving concepts and developments.

Recent Advances in Bone Tumours and Osteoarthritis

Author : Hiran Amarasekera
Publisher : BoD – Books on Demand
ISBN 13 : 1839689234
Total Pages : 154 pages
Book Rating : 4.8/5 (396 download)

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Book Synopsis Recent Advances in Bone Tumours and Osteoarthritis by : Hiran Amarasekera

Download or read book Recent Advances in Bone Tumours and Osteoarthritis written by Hiran Amarasekera and published by BoD – Books on Demand. This book was released on 2021-09-01 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a combination of recent advances in two major areas of orthopaedics: Bone tumours and Osteoarthritis. All chapters are contributed by well-known researchers and surgeons in Orthopaedics working across the globe. The book is divided into two major parts for clarity. All authors have contributed their original research, their experience in the field, and the recent advances that will keep the reader well informed and up to date in our understanding of bone tumours and osteoarthritis. This is a “must have” reference book for any medical library or an individual who is keen to update and have CME (continuous medical education) points added to their learning.

Osteosarcoma in Adolescents and Young Adults: New Developments and Controversies

Author : G. Bennett Humphrey
Publisher : Springer Science & Business Media
ISBN 13 : 1461535182
Total Pages : 389 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Osteosarcoma in Adolescents and Young Adults: New Developments and Controversies by : G. Bennett Humphrey

Download or read book Osteosarcoma in Adolescents and Young Adults: New Developments and Controversies written by G. Bennett Humphrey and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: Osteosarcoma in Adolescents and Young Adults: New Developments and Controversies is the fifth volume in the series `Cancer Treatment, and Research' devoted to pediatric oncology. Like its immediate predecessor, Hodgkin's Disease in Children: Controversies and Current Practice, this volume also deals with the current state of affairs: where do researchers differ in opinions or firmly held beliefs? What does the future hold for research or for the patients who have benefited from research and are now cured? etc. The first part deals with preclinical and clinical issues that relate to the disease and the second part deals with the results of recent trials and in some cases ongoing trials. It could be argued that section B Pharmacology, Section D Radiotherapy and Section E Surgery of part one belong to part two; however in these sections we have tried to focus on one discipline and in part two, we have tried to focus on the results of multidisciplinary trials. A third part includes a few critiques and editorial comments. This volume was prepared and planned for both basic and clinical oncologists. It is hoped that the basic scientists will gain some insight into the problems of their clinical colleagues and that the clinicians will be willing to read to the more basic articles. It is not a text for students (or for that matter physicians) who want all things to be laid out in `black and white'. But it is a text for those students who want to know how vibrant this field of research is and are willing to stand in awe of how much research needs to be done.

Cancer Incidence and Survival Among Children and Adolescents

Author :
Publisher :
ISBN 13 :
Total Pages : 194 pages
Book Rating : 4.:/5 (327 download)

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Book Synopsis Cancer Incidence and Survival Among Children and Adolescents by :

Download or read book Cancer Incidence and Survival Among Children and Adolescents written by and published by . This book was released on 1999 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Osteosarcoma

Author : Takafumi Ueda
Publisher : Springer
ISBN 13 : 9784431566779
Total Pages : 0 pages
Book Rating : 4.5/5 (667 download)

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Book Synopsis Osteosarcoma by : Takafumi Ueda

Download or read book Osteosarcoma written by Takafumi Ueda and published by Springer. This book was released on 2018-04-07 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the brilliant progress made in the past three decades in clinical outcomes for osteosarcoma patients treated with a multidisciplinary approach, including limb-salvage surgery combined with neoadjuvant multidrug chemotherapy and aggressive management of pulmonary metastasis. Osteosarcoma was a miserable disease for adolescents and young adults until the early 1970s, with a survival rate that was less than 10–15% even after amputation for affected limbs because of the progression of pulmonary metastasis. With the development of neoadjuvant chemotherapy for osteosarcoma, including high-dose methotrexate, doxorubicin, cisplatin, and ifosfamide during the late 1970s and the 1980s, however, the prognosis has dramatically improved. Limb-salvage surgery for patients with extremity osteosarcoma is now a gold-standard surgical procedure for more than 90% of patients with localized disease. Additionally, aggressive pulmonary metastasectomy for patients with lung metastasis from osteosarcoma has contributed to improvement of their survival. More recently, carbon-ion radiotherapy has also been introduced for patients with unresectable osteosarcoma of the trunk, as in the spine and pelvis. In this volume the author provides valuable descriptions of an important new treatment modality for a multidisciplinary approach for osteosarcoma patients.

Osteosarcoma

Author : Kanya Honoki
Publisher : BoD – Books on Demand
ISBN 13 : 9535130951
Total Pages : 256 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Osteosarcoma by : Kanya Honoki

Download or read book Osteosarcoma written by Kanya Honoki and published by BoD – Books on Demand. This book was released on 2017-04-26 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Osteosarcoma is the most common malignant bone tumor and mainly affects children, adolescents, and young adults. Osteosarcoma shows significant genetic instability, resulting in very complex biology with multifaceted cellular and molecular mechanisms and behavior. Although clinical outcomes, both prognostic and functional, of osteosarcoma dramatically improved in the 1980s, the prognoses of the patients with relapsed and/or metastatic disease remained very poor in spite of our continuous efforts to overcome this difficulty. This book aims to delve into the current advances of basic and clinical sciences in osteosarcoma that are guiding the future directions of its research and clinical practice. The knowledge presented here will lead to further inspiration, ideas, and novel insights into the field of osteosarcoma research. Hopefully, this work will foster improvement of the prognosis for patients suffering from the disease.

Orthopaedic Oncology

Author : Terrance D. Peabody
Publisher : Springer
ISBN 13 : 3319073230
Total Pages : 224 pages
Book Rating : 4.3/5 (19 download)

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Book Synopsis Orthopaedic Oncology by : Terrance D. Peabody

Download or read book Orthopaedic Oncology written by Terrance D. Peabody and published by Springer. This book was released on 2014-07-28 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text provides a comprehensive overview of orthopaedic oncology – the field of orthopaedic surgery that specializes in the evaluation and treatment of bone and soft tissue tumors of the musculoskeletal system. The opening chapters cover musculoskeletal imaging interpretation and the principles of musculoskeletal biopsy. Assessment and treatment of the full range of tumors are then described in a series of well-illustrated chapters. Detailed consideration is given to benign tumors, osteosarcomas, Ewing sarcomas, chondrosarcomas, metastatic bone disease of the axial and appendicular skeleton, and soft tissue sarcomas. This book will be invaluable for both orthopaedic surgeons and medical oncologists, providing a framework for understanding the fundamentals of these tumors and a sound basis for their treatment.

Soft Tissue and Bone Tumours

Author : WHO Classification of Tumours Editorial Board
Publisher : WHO Classification of Tumours
ISBN 13 : 9789283245025
Total Pages : 0 pages
Book Rating : 4.2/5 (45 download)

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Book Synopsis Soft Tissue and Bone Tumours by : WHO Classification of Tumours Editorial Board

Download or read book Soft Tissue and Bone Tumours written by WHO Classification of Tumours Editorial Board and published by WHO Classification of Tumours. This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: PLEASE NOTE: Text has been accidentally deleted from page 54 of this book. Please refer to the corrigenda (PDF file) posted on the Stylus Publishing web site or email [email protected] for an updated, printable page. ****When not purchasing directly from the official sales agents of the WHO, especially at online bookshops, please note that there have been issues with counterfeited copies. Buy only from known sellers and if there are quality issues, please contact the seller for a refund.***** Soft Tissue and Bone Tumours is the third volume in the 5th edition of the WHO series on the classification of human tumours. This series (also known as the WHO Blue Books) is regarded as the gold standard for the diagnosis of tumours and comprises a unique synthesis of histopathological diagnosis with digital and molecular pathology. These authoritative and concise reference books provide indispensable international standards for anyone involved in the care of patients with cancer or in cancer research, underpinning individual patient treatment as well as research into all aspects of cancer causation, prevention, therapy, and education. This volume will be of particular interest to pathologists, oncologists, surgeons, and epidemiologists who manage or research soft tissue and bone tumours. Sections are included on all recognized neoplasms of the soft tissue and bone, as well as on genetic tumour syndromes affecting these sites. Since the previous edition, there have been changes based on recent molecular and genetic information, with impact on clinical practice.

Bone Cancer

Author : Dominique Heymann
Publisher : Academic Press
ISBN 13 : 9780123748959
Total Pages : 472 pages
Book Rating : 4.7/5 (489 download)

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Book Synopsis Bone Cancer by : Dominique Heymann

Download or read book Bone Cancer written by Dominique Heymann and published by Academic Press. This book was released on 2010 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clear presentation by bone biologists of the cellular and molecular mechanisms underlying bone tumors and bone cancer metastasis as well as the genomic and proteomic assays used in detecting cancer within given organ systems Clear presentation by oncologists and radiologists of how histopathology, imaging, and pain monitoring can lead to new therapeutic approaches Benefit Saves researchers and clinicians time in quickly accessing the very latest details on a broad range of bone cancer issues, as opposed to searching through thousands of journal articles.-

Osteosarcoma

Author : Kanya Honoki
Publisher :
ISBN 13 : 9789535148593
Total Pages : 0 pages
Book Rating : 4.1/5 (485 download)

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Book Synopsis Osteosarcoma by : Kanya Honoki

Download or read book Osteosarcoma written by Kanya Honoki and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Pediatric Surgical Oncology

Author : Lewis Spitz
Publisher : Springer Science & Business Media
ISBN 13 : 3642726437
Total Pages : 202 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Pediatric Surgical Oncology by : Lewis Spitz

Download or read book Pediatric Surgical Oncology written by Lewis Spitz and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is devoted to the overall management of solid tumors in children. Recent advances in the use of monoclonal antibodies for diagnosis and possible treatment are presented. New approaches to the complete care of the child and family as well as specific developments in the treatment of defined conditions are discussed. A particular contribution deals with congential dysplasia of soft tissue. The material analyzed for this topic was taken from a unique collections of clinical cases supplemented by detailed laboratory studies.

Sarcomas of Bone and Soft Tissues in Children and Adolescents

Author : Carola A. S. Arndt
Publisher : Springer Nature
ISBN 13 : 303051160X
Total Pages : 181 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis Sarcomas of Bone and Soft Tissues in Children and Adolescents by : Carola A. S. Arndt

Download or read book Sarcomas of Bone and Soft Tissues in Children and Adolescents written by Carola A. S. Arndt and published by Springer Nature. This book was released on 2020 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive and up-to-date compendium on all aspects of sarcomas of bone and soft tissues in childhood and adolescence. After introductory chapters on the history, epidemiology, and biology of pediatric sarcomas, treatment considerations are extensively reviewed, with emphasis on the use of risk-adjusted treatment approaches. The pathology and biology of this diverse group of tumors are extensively reviewed. Promising new treatment approaches are discussed, and strategies for the development of new agents are appraised. The major common pediatric sarcomas, including osteosarcoma, Ewing sarcoma, rhabdomyosarcoma and non-rhabdomyosarcoma soft tissue sarcoma, are covered in detail. The authors are internationally recognized experts who offer a largely evidence-based consensus on etiology, biology, and treatment. This handbook has far-reaching applicability to the clinical diagnosis and management of childhood and adolescent sarcomas and will prove invaluable to specialists, generalists, and trainees alike.

Bone and Soft Tissue Pathology

Author : Andrew L. Folpe, MD
Publisher : Elsevier Health Sciences
ISBN 13 : 0443066884
Total Pages : 477 pages
Book Rating : 4.4/5 (43 download)

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Book Synopsis Bone and Soft Tissue Pathology by : Andrew L. Folpe, MD

Download or read book Bone and Soft Tissue Pathology written by Andrew L. Folpe, MD and published by Elsevier Health Sciences. This book was released on 2009-08-04 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone and Soft Tissue Pathology: A Volume in the Diagnostic Pathology Series, by Andrew L. Folpe, MD and Carrie Y. Inwards, MD, packs today's most essential bone and soft tissue pathology know-how into a compact, high-yield format! The book's pragmatic, well-organized approach-complemented by abundant full-color, high-quality illustrations and at-a-glance tables-makes it easy to access the information you need to quickly and accurately identify pathology specimens. Best of all, Expert Consult functionality provides online access to the full text of the book, downloadable illustrations for your personal use, and more. The result is a practical, affordable reference for study and review as well as for everyday clinical practice. Includes access to the complete contents online, fully searchable, downloadable illustrations for your personal use, and more, allowing you to consult the text a quick, convenient manner. Reviews normal histology before examining abnormal findings, enabling you to conveniently compare their characteristics in one place at one time. Covers both neoplastic and non-neoplastic conditions of bone and soft tissue to equip you to meet a wide range of diagnostic challenges. Uses a consistent, user-friendly format to explore each entity's clinical features, pathologic features (gross and microscopic), ancillary studies, differential diagnoses, and prognostic and therapeutic considerations...making it easy to locate specific information on a particular entity. Features abundant boxes and tables throughout that enhance the presentation and accessibility of the material. Offers nearly 1,000 full-color, high-quality illustrations that demonstrate the key features of a wide variety of pathologic lesions to facilitate greater accuracy in identification of specimens. The Foundations in Diagnostic Pathology Series answers the call for fresh, affordable, and easy-to-use guidance. Each region-specific volume provides all of the most essential information on the pathologic entities encountered in practice. Series Editor: John R. Goldblum, MD, FACP, FASCP, FACG Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.