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Author : Saravanan Subramaniam
Publisher : Frontiers Media SA
ISBN 13 : 2832528716
Total Pages : 138 pages
Book Rating : 4.8/5 (325 download)
Download or read book COVID-19 and thrombo-inflammatory responses written by Saravanan Subramaniam and published by Frontiers Media SA. This book was released on 2023-07-04 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Beate Heissig
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (135 download)
Download or read book COVID-19 Severity and Thrombo-inflammatory Response Linked to Ethnicity written by Beate Heissig and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Although there is strong evidence that SARS-CoV-2 infection is associated with adverse outcomes in certain ethnic groups, the association of disease severity and risk factors such as comorbidities and biomarkers with racial disparities remains undefined. This retrospective study between March 2020 and February 2021 explores COVID-19 risk factors as predictors for patients' disease progression through country comparison. Disease severity predictors in Germany and Japan were cardiovascular-associated comorbidities, dementia, and age. We adjusted age, sex, body mass index, and history of cardiovascular disease comorbidity in the country cohorts using a propensity score matching (PSM) technique to reduce the influence of differences in sample size and the surprisingly young, lean Japanese cohort. Analysis of the 170 PSM pairs confirmed that 65.29% of German and 85.29% of Japanese patients were in the uncomplicated phase. More German than Japanese patients were admitted in the complicated and critical phase. Ethnic differences were identified in patients without cardiovascular comorbidities. Japanese patients in the uncomplicated phase presented a suppressed inflammatory response and coagulopathy with hypocoagulation. In contrast, German patients exhibited a hyperactive inflammatory response and coagulopathy with hypercoagulation. These differences were less pronounced in patients in the complicated phase or with cardiovascular diseases. Coagulation/fibrinolysis-associated biomarkers rather than inflammatory-related biomarkers predicted disease severity in patients with cardiovascular comorbidities: platelet counts were associated with severe illness in German patients. In contrast, high D-dimer and fibrinogen levels predicted disease severity in Japanese patients. Our comparative study indicates that ethnicity influences COVID-19-associated biomarker expression linked to the inflammatory and coagulation (thrombo-inflammatory) response. Future studies will be necessary to determine whether these differences contributed to the less severe disease progression observed in Japanese COVID-19 patients compared with those in Germany
Author : Paolo Gresele
Publisher : Springer
ISBN 13 : 3319474626
Total Pages : 1402 pages
Book Rating : 4.3/5 (194 download)
Download or read book Platelets in Thrombotic and Non-Thrombotic Disorders written by Paolo Gresele and published by Springer. This book was released on 2017-03-08 with total page 1402 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews current science and applications in fields including thrombosis and hemostasis, signal transduction, and non-thrombotic conditions such as inflammation, allergy and tumor metastasis. It is a detailed, up-to-date, highly referenced text for clinical scientists and physicians, including recent developments in this rapidly expanding field. More than a scientific resource, this is also an authoritative reference and guide to the diagnosis.
Author : Marco Ranucci
Publisher : Springer Nature
ISBN 13 : 3030829383
Total Pages : 215 pages
Book Rating : 4.0/5 (38 download)
Download or read book The Coagulation Labyrinth of Covid-19 written by Marco Ranucci and published by Springer Nature. This book was released on 2021-12-07 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is devoted to COVID-19 associated coagulopathy, one of the main determinants of mortality. The volume, intended as a guide, will lead the reader in a pathway starting from pathophysiology and passing through laboratory data, clinical aspects, imaging, and therapeutic options. Written in the middle of the second wave, the book is the first addressing the topic and summarizing the results of studies and articles meanwhile published, thus representing a unique tool for clinicians fighting the disease. The Coagulation Labyrinth of Covid-19 is intended for clinicians working with acute and sub-acute ARDS cases: intensivists, anesthesiologists, cardiologists, hematologists, who will find in it an essential guide to manage the COVID-19 pandemic.
Author : Tessa Barrett
Publisher : Frontiers Media SA
ISBN 13 : 2832531334
Total Pages : 129 pages
Book Rating : 4.8/5 (325 download)
Download or read book Thromboinflammation: Crosstalk between thrombosis and inflammation in cardiovascular disease written by Tessa Barrett and published by Frontiers Media SA. This book was released on 2023-08-02 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Shaker A. Mousa
Publisher : Humana
ISBN 13 :
Total Pages : 340 pages
Book Rating : 4.F/5 ( download)
Download or read book Anticoagulants, Antiplatelets, and Thrombolytics written by Shaker A. Mousa and published by Humana. This book was released on 2010-08-17 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past decade, remarkable progress has been made in the development of newer drugs to prevent and treat thromboembolic disorders, such as oral direct anti-Xa and anti-IIa antagonists, as well as oral antiplatelet ADP antagonists with rapid onset and offset. In addition, there has been concentrated effort aimed at identifying novel uses of traditional antithrombotic drugs, such as aspirin, heparin, and oral anticoagulants, as well as combinations of agents, such as more than one antiplatelet, antiplatelet with anticoagulant, antiplatelet with or without thrombolytic. Anticoagulants, Antiplatelets, and Thrombolytics, Second Edition provides updates on various strategies in thrombosis, experimental models, and clinical and recent advances in the discovery and development of novel antithrombotics. As a volume in the highly successful Methods in Molecular BiologyTM series, this collection provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Easy to use and up to date, Anticoagulants, Antiplatelets, and Thrombolytics, Second Edition is an ideal guide for researchers aiming for the future of this vital field, focusing on the prevention of thromboembolic disorders and the protection of the vascular endothelium.
Author : Alma LaVoy Wilson
Publisher :
ISBN 13 :
Total Pages : 494 pages
Book Rating : 4.:/5 (31 download)
Download or read book Summary of Publications written by Alma LaVoy Wilson and published by . This book was released on 1926 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Viroj Wiwanitkit
Publisher : Nova Publishers
ISBN 13 : 9781600213236
Total Pages : 214 pages
Book Rating : 4.2/5 (132 download)
Download or read book Thrombohemostatic Disease Research written by Viroj Wiwanitkit and published by Nova Publishers. This book was released on 2006-08 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thrombohemostatic disorder is a common haematological problem. This book focuses on the "thrombohemostatic disorder" in several aspects including summative data from the molecular to the population scales, as well as additional metanalysis for important topics.
Author : Mohamed Boutjdir
Publisher : Frontiers Media SA
ISBN 13 : 2889633977
Total Pages : 263 pages
Book Rating : 4.8/5 (896 download)
Download or read book Cardioimmunology: Inflammation and Immunity in Cardiovascular Disease written by Mohamed Boutjdir and published by Frontiers Media SA. This book was released on 2020-01-30 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : John Martin
Publisher : Springer Science & Business Media
ISBN 13 : 1447117638
Total Pages : 276 pages
Book Rating : 4.4/5 (471 download)
Download or read book Platelet Heterogeneity written by John Martin and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Battle is a practical and sometimes lasting way of solving man's problems. It relies on the strength of the combatants and ignores the truth of the dispute. Discussion face to face can dissolve attitudes which have incorrectly determined judgements. The most striking example of this that I know is a Battle in Ireland in the eleventh century, where the king of Leinster fought a Viking prince. The Icelanders had raided Ireland for several generations in search of women, which they lacked since most of the population of Iceland were men who had arrived there by rowing long-boats from Norway. The prince was leading such a raid for the first time. Standing in the prow of the leading boat he saw Irish cavalry galloping along the beach to meet them. As they approached the shore the Irish king rode out of the band to challenge single combat. The Icelander jumped into the surf to meet him. As they raised their swords each realized that the other's face was like his own. When the Irish king spoke the other recognized the language. It had been spoken in Iceland by his grandmother who had been captured and taken there from Ireland. Swords were dropped and replaced by drinking horns. It was soon established that they were cousins. The battle gave way to a life-time of close co-operation.
Author : Lucas G. Chase
Publisher : Springer Science & Business Media
ISBN 13 : 1627032002
Total Pages : 458 pages
Book Rating : 4.6/5 (27 download)
Download or read book Mesenchymal Stem Cell Therapy written by Lucas G. Chase and published by Springer Science & Business Media. This book was released on 2012-12-12 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.
Author : Akbar Dorgalaleh
Publisher : Springer
ISBN 13 : 3319767232
Total Pages : 397 pages
Book Rating : 4.3/5 (197 download)
Download or read book Congenital Bleeding Disorders written by Akbar Dorgalaleh and published by Springer. This book was released on 2018-07-25 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes in detail the clinical presentation, diagnosis, and management of a wide range of congenital bleeding disorders. It will assist readers in overcoming the significant challenges involved in clinical and laboratory diagnosis and in providing effective clinical care that makes optimal use of new products, including recombinant factor concentrate. The coverage ranges from hemophilia A and B and von Willebrand disease to rare bleeding disorders such as congenital factor V, factor X, factor XI, and factor XIII deficiency and inherited platelet function disorders. The exceptional attention to rarer conditions is of particular importance given the considerable risk of overlooking them during diagnosis, with potential consequences for disease-related morbidity and mortality. The authors are acknowledged specialists in the field from across the world who have particular expertise in the disorder that they discuss. The book will be of value to hematologists, oncologists, pediatricians, laboratory specialists and technicians, general physicians, and trainees.
Author : Maria Dorobantu
Publisher : Springer
ISBN 13 : 9783030281984
Total Pages : 298 pages
Book Rating : 4.2/5 (819 download)
Download or read book Microcirculation written by Maria Dorobantu and published by Springer. This book was released on 2019-11-18 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive reference book of coronary microcirculation broadly covers theoretical aspects, clinical cases and therapeutic considerations from an innovative perspective. Topics covered include: ischemic heart disease, silent cerebral damage, heart failure, left ventricular hypertrophy arrhythmias, and cerebral and renal microcirculation. Microcirculation: From Bench to Bedside underlines the clinical importance of addressing coronary microcirculation with relevant clinical examples that are often encountered by practitioners. It therefore provides a critical resource on microcirculation for both specialist and non-specialist practitioners.
Author : Roy Bicknell
Publisher : Cambridge University Press
ISBN 13 : 9780521559904
Total Pages : 156 pages
Book Rating : 4.5/5 (599 download)
Download or read book Endothelial Cell Culture written by Roy Bicknell and published by Cambridge University Press. This book was released on 1996-09-28 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of the Handbooks in Practical Animal Cell Biology is to provide practical workbooks for those involved in primary cell culture. Each volume addresses a different cell lineage, and contains an introductory section followed by individual chapters on the culture of specific differentiated cell types. The authors of each chapter are leading researchers in their fields and use their first-hand experience to present reliable techniques in a clear and thorough manner. Endothelial Cell Culture contains chapters on endothelial cells derived from 1) lung, 2) bone marrow, 3) brain, 4) mammary glands, 5) skin, 6) adipose tissue, 7) female reproductive system, and 8) synovium.
Author : Rudolf Ludwig Karl Virchow
Publisher :
ISBN 13 :
Total Pages : 182 pages
Book Rating : 4.F/5 ( download)
Download or read book Post-mortem examinations written by Rudolf Ludwig Karl Virchow and published by . This book was released on 1891 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Rebecca Lever
Publisher : Springer Science & Business Media
ISBN 13 : 3642230563
Total Pages : 457 pages
Book Rating : 4.6/5 (422 download)
Download or read book Heparin - A Century of Progress written by Rebecca Lever and published by Springer Science & Business Media. This book was released on 2012-05-08 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heparins remain amongst the most commonly used drugs in clinical practice. Almost 100 years have passed since the initial discovery of this complex substance and, during this time, understanding of the nature and uses of heparin and related molecules has grown dramatically. The aim of this volume is to summarise the developments that have led to the current status of both heparins as drugs and the field of heparin research, with a focus on the particularly rapid progress that has been made over the past three decades. Individual sections are dedicated to the nature of heparin as a biological molecule, the current approaches and techniques that are used to ensure the safety and reliability of heparin as a medicine, the clinical pharmacology of heparin as an anticoagulant drug, effects and potential applications of heparin aside of those involving haemostasis and, finally, the nature and potential uses of heparin-like materials from both natural and synthetic sources.
Author : Theodore Warkentin
Publisher : CRC Press
ISBN 13 : 0824758846
Total Pages : 660 pages
Book Rating : 4.8/5 (247 download)
Download or read book Heparin-Induced Thrombocytopenia written by Theodore Warkentin and published by CRC Press. This book was released on 2003-12-05 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: Taking stock of advances in clinical recognition, laboratory testing, and pharmacologic therapy as well as basic aspects of pathogenesis, the Third Edition of Heparin-Induced Thrombocytopenia reinforces its standing as the leading guide to accurate diagnosis and effective management of this complex condition. Featuring added chapters on bivalirudin
