Basic Concepts in Pharmacology: What You Need to Know for Each Drug Class, Fourth Edition

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Author :
Publisher : McGraw Hill Professional
ISBN 13 : 0071769420
Total Pages : 254 pages
Book Rating : 4.0/5 (717 download)

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Book Synopsis Basic Concepts in Pharmacology: What You Need to Know for Each Drug Class, Fourth Edition by : Janet L. Stringer

Download or read book Basic Concepts in Pharmacology: What You Need to Know for Each Drug Class, Fourth Edition written by Janet L. Stringer and published by McGraw Hill Professional. This book was released on 2011-03-11 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: A time-saving, stress-reducing approach to learning the essential concepts of pharmacology Great for USMLE review! "This could be a very useful tool for students who struggle with understanding the most basic concepts in pharmacology for course and licensure examinations. 3 Stars."--Doody's Review Service Basic Concepts in Pharmacology provides you with a complete framework for studying -– and understanding -- the fundamental principles of drug actions. With this unique learning system, you’ll be able to identify must-know material, recognize your strengths and weaknesses, minimize memorization, streamline your study, and build your confidence. Basic Concepts in Pharmacology presents drugs by class, details exactly what you need to know about each class, and reinforces key concepts and definitions. With this innovative text you’ll be able to: Recognize the concepts you truly must know before moving on to other material Understand the fundamental principles of drug actions Organize and condense the drug information you must remember Review key information, which is presented in boxes, illustrations, and tables Identify the most important drugs in each drug class Seven sections specifically designed to simplify the learning process and help you gain an understanding of the most important concepts: General Principles Drugs That Affect the Autonomic Nervous System Drugs That Affect the Cardiovascular System Drugs That Act on the Central Nervous System Chemotherapeutic Agents Drugs That Affect the Endocrine System Miscellaneous Drugs (Includes Toxicology and Poisoning)

Core Concepts in Pharmacology

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Publisher : Prentice Hall
ISBN 13 : 9780135077597
Total Pages : 0 pages
Book Rating : 4.0/5 (775 download)

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Book Synopsis Core Concepts in Pharmacology by : Leland Norman Holland

Download or read book Core Concepts in Pharmacology written by Leland Norman Holland and published by Prentice Hall. This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive, up-to-date text introduces pharmacology from an interdisciplinary perspective, illuminating core concepts of anatomy, physiology, and pathology that make drug therapy understandable to all nursing students. Organized around body systems and diseases, it clearly places each drug in context. Its focused nursing content includes easy-to-read flowcharts that illuminate assessment, diagnosis, planning, interventions, patient education, discharge planning, and evaluation. This edition contains new chapters on the nursing process and drugs for degenerative diseases and muscles; new Safety Alerts; new coverage of weight loss surgery and drugs; revamped NCLEX-PN® questions; a brand-new glossary, and many other improvements. Some new feautres to this edition include: New! Full chapter on the nursing process New! All-new chapter on drugs for degenerative diseases and muscles New! Safety Alerts call attention to medication errors and Joint Commission safety guidelines Updated! End-of-chapter NCLEX-PN® questions completely revamped to reflect the latest practice New! Scenario-based Case Study Questions help students apply pharmacology and nursing care to specific clients and circumstances

Basic Pharmacology

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Author :
Publisher : Routledge
ISBN 13 : 1351989111
Total Pages : 388 pages
Book Rating : 4.3/5 (519 download)

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Book Synopsis Basic Pharmacology by : Maria A. Hernandez, Ph.D.

Download or read book Basic Pharmacology written by Maria A. Hernandez, Ph.D. and published by Routledge. This book was released on 2017-07-12 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intended for use in an introductory pharmacology course, Basic Pharmacology: Understanding Drug Actions and Reactions provides an in-depth discussion of how to apply the chemical and molecular pharmacology concepts, a discussion students need for more advanced study. The textbook introduces the principles of chemistry and biology necessary to understand drug interactions at the cellular level. The authors highlight chemical and physical properties of drugs, drug absorption and distribution, drug interactions with cellular receptors, and drug metabolism and elimination. The book begins with a review of chemical principles as they apply to drug molecules, focusing mainly on those for commonly prescribed drugs. The authors use drug structures to illustrate the chemical concepts learned in general and organic chemistry courses. They cover the dynamics of receptors in mediating the pharmacological effects of drugs. They clarify theories, drawn from the scientific literature, which explain drug-receptor interactions and the quantitative relationship between drug binding and its effects at the cellular level. The authors’ extensive use of drug structures for teaching chemical and molecular pharmacology principles, and their emphasis on the relevance of these principles in future professional life makes this book unique. It provides the framework for better understanding of advanced pharmacology and therapeutics topics. Blending medicinal chemistry and pharmacodynamics aspects, this textbook clearly elucidates the essential concepts that form the cornerstone for further work in pharmacology.

Concepts and Principles of Pharmacology

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Publisher : Springer Nature
ISBN 13 : 3030353621
Total Pages : 457 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Concepts and Principles of Pharmacology by : James E. Barrett

Download or read book Concepts and Principles of Pharmacology written by James E. Barrett and published by Springer Nature. This book was released on 2019-12-24 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Celebrating 100 years of HEP, this volume will discuss key pharmacological discoveries and concepts of the past 100 years. These discoveries have dramatically changed the medical treatment paradigms of many diseases and these concepts have and will continue to shape discovery of new medicinies. Newly evolving technologies will similarly be discussed as they will shape the future of the pharmacology and, accordingly, medical therapy.

Basic and Clinical Pharmacology 15e

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Publisher : McGraw Hill Professional
ISBN 13 : 1260452328
Total Pages : 1326 pages
Book Rating : 4.2/5 (64 download)

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Book Synopsis Basic and Clinical Pharmacology 15e by : Bertram G. Katzung

Download or read book Basic and Clinical Pharmacology 15e written by Bertram G. Katzung and published by McGraw Hill Professional. This book was released on 2020-11-22 with total page 1326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Master key pharmacological concepts and practices with the most comprehensive, authoritative guide available Doody's Core Titles for 2023! Presented in full-color and packed with hundreds of illustrations, Basic and Clinical Pharmacology is the wide-ranging, engaging guide students have counted on for decades. Organized to reflect the course sequence in many pharmacology courses and in integrated curricula, the guide covers the important concepts students need to know about the science of pharmacology and its application to clinical practice. This edition has been extensively updated to provide expanded coverage of transporters, pharmacogenomics, and new drugs Delivers the knowledge and insight needed to excel in every facet of pharmacology!. Encompasses all aspects of medical pharmacology, including botanicals and over-the-counter drugs Major revisions of the chapters on immunopharmacology, antiseizure, antipsychotic, antidepressant, antidiabetic, anti-inflammatory, and antiviral drugs, prostaglandins, and central nervous system neurotransmitters New chapter on the increasingly relevant topic of cannabis pharmacology Each chapter opens with a case study, covers drug groups and prototypes, and closes with summary tables and diagrams that encapsulate important information Revised full-color illustrations provide more information about drug mechanisms and effects and help clarify important concepts Trade Name/Generic Name tables are provided at end of each chapter for easy reference when writing a chart order or prescription Includes descriptions of important new drugs released through May 2019 New and updated coverage of general concepts relating to recently discovered receptors, receptor mechanisms, and drug transporters

Elements of Pharmacology

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Publisher : Cambridge University Press
ISBN 13 : 9780521280747
Total Pages : 170 pages
Book Rating : 4.2/5 (87 download)

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Book Synopsis Elements of Pharmacology by : P. J. Bentley

Download or read book Elements of Pharmacology written by P. J. Bentley and published by Cambridge University Press. This book was released on 1981-08-31 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written primarily for students of medicine, pharmacy, and pharmacology, this introductory book provides a concise summary of the principles that underlie the science of pharmacology. It presents the basic concepts required for understanding the use, mechanisms of action, toxicity and side effects, and therapeutic application of drugs in man. Thus the book may also be of interest to medical practitioners and to biological and medical scientists. Among topics covered are the sources of drugs, the way they are administered and dealt with in the body, as well as concepts about the nature of their actions. The last include their chemical interactions with components of cells and the manner in which these lead to therapeutically desirable as well as undesirable and even toxic effects. In addition, clinically related subjects, such as drug interactions, teratogenic and carcinogenic effects are discussed. The development and testing of new drugs are also described. For easy reference, at the back of the book there is a glossary of drugs named in the text.

Advanced Pharmacology for Prescribers

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Publisher : Springer Publishing Company
ISBN 13 : 0826195474
Total Pages : 659 pages
Book Rating : 4.8/5 (261 download)

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Book Synopsis Advanced Pharmacology for Prescribers by : Brent Q. Luu, PharmD, BCPS, BCACP

Download or read book Advanced Pharmacology for Prescribers written by Brent Q. Luu, PharmD, BCPS, BCACP and published by Springer Publishing Company. This book was released on 2021-01-13 with total page 659 pages. Available in PDF, EPUB and Kindle. Book excerpt: Delivers the critical information primary care providers need to be thoroughly informed prescribers This unique resource—an evidence-based pharmacology text and reference for advanced practice students and clinicians—guides users in analyzing the pharmacological foundations of drug therapy and fosters the development of sound clinical judgment in determining the appropriate medication for every patient across the lifespan. Targeting the specific needs of APRN and PA students and clinicians, the text is a “bridge” between standard, lengthy pharmacology texts and quick pocket references that lack information regarding key pharmacotherapy principles. Featuring an applied therapeutic approach to major disorders and their pharmacologic treatment, the book examines how medications act on the body and visa versa, while teaching the rationale for using specific therapeutic agents or drug classes. Each chapter includes case studies that apply the concepts discussed, relevant diagnostic studies, applicable guidelines, genomics, and important lifespan considerations. Of special interest is a chapter on pharmacogenetics explaining the basic principles underlying our current understanding of genetic variations in response to pharmacotherapy and adverse drug reactions. Easily digestible chapters include objectives and review questions. Ancillary resources include an instructor manual with learning objectives, chapter summaries, and case studies; chapter PowerPoint slides; test bank; and image bank. Key Features: Delivers an applied, evidence-based foundation on the basic science underlying prescribing Targets the specific needs of APRN and PA students and professionals and related healthcare providers Provides clinical decision-making tools and principles to support sound prescribing judgment Focuses on synthesizing drugs to manage commonly occurring disorders Includes strategies for addressing the needs of specific populations throughout the lifespan Includes abundant case studies illuminating key concepts Includes a robust instructor manual with learning objectives, chapter summaries, and case studies; PowerPoint slides; test bank; and image bank. Purchase includes access to the eBook for use on most mobile devices or computers.

Principles of Pharmacology, 2Ed

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Publisher : CRC Press
ISBN 13 : 9780412122316
Total Pages : 1800 pages
Book Rating : 4.1/5 (223 download)

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Book Synopsis Principles of Pharmacology, 2Ed by : P. Munson

Download or read book Principles of Pharmacology, 2Ed written by P. Munson and published by CRC Press. This book was released on 1998-09-04 with total page 1800 pages. Available in PDF, EPUB and Kindle. Book excerpt: University of North Carolina, Chapel Hill. Revised reprint of the comprehensive reference on pharmacology principles, fundamental concepts, mechanisms of action, and clinical applications of drugs. For students, residents, and practitioners in medicine or pharmacy. 159 contributor, 84 U.S.

Pharmacology and Physiology for Anesthesia E-Book

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Publisher : Elsevier Health Sciences
ISBN 13 : 0323568866
Total Pages : 986 pages
Book Rating : 4.3/5 (235 download)

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Book Synopsis Pharmacology and Physiology for Anesthesia E-Book by : Hugh C. Hemmings

Download or read book Pharmacology and Physiology for Anesthesia E-Book written by Hugh C. Hemmings and published by Elsevier Health Sciences. This book was released on 2018-10-19 with total page 986 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacology and physiology are the foundation of every anesthesia provider's training and clinical competency. Pharmacology and Physiology for Anesthesia: Foundations and Clinical Application, 2nd Edition, delivers the information you need in pharmacology, physiology, and molecular-cellular biology, keeping you current with contemporary training and practice. This thoroughly updated edition is your one-stop, comprehensive overview of physiology, and rational anesthetic drug selection and administration, perfect for study, review, and successful practice. - Contains new chapters on Special Populations (anesthetic pharmacology in obesity, geriatrics, and pediatrics), Oral and Non-IV Opioids, Thermoregulation, Physiology and Pharmacology of Obstetric Anesthesia, Chemotherapeutic and Immunosuppresive Drugs, and Surgical Infection and Antimicrobial Drugs. - Incorporates entirely new sections on Physics, Anatomy, and Imaging. - Includes new information on consciousness and cognition, pharmacodynamics, the immune system, and anti-inflammatory drugs. - Features user-friendly tables, figures, and algorithms (including 100 new illustrations), all presented in full color and designed to help explain complex concepts. - Helps you understand the molecular mechanism of drug actions and identify key drug interactions that may complicate anesthesia with dedicated sections on these areas.

A Framework for K-12 Science Education

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Author :
Publisher : National Academies Press
ISBN 13 : 0309214459
Total Pages : 400 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis A Framework for K-12 Science Education by : National Research Council

Download or read book A Framework for K-12 Science Education written by National Research Council and published by National Academies Press. This book was released on 2012-02-28 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Science, engineering, and technology permeate nearly every facet of modern life and hold the key to solving many of humanity's most pressing current and future challenges. The United States' position in the global economy is declining, in part because U.S. workers lack fundamental knowledge in these fields. To address the critical issues of U.S. competitiveness and to better prepare the workforce, A Framework for K-12 Science Education proposes a new approach to K-12 science education that will capture students' interest and provide them with the necessary foundational knowledge in the field. A Framework for K-12 Science Education outlines a broad set of expectations for students in science and engineering in grades K-12. These expectations will inform the development of new standards for K-12 science education and, subsequently, revisions to curriculum, instruction, assessment, and professional development for educators. This book identifies three dimensions that convey the core ideas and practices around which science and engineering education in these grades should be built. These three dimensions are: crosscutting concepts that unify the study of science through their common application across science and engineering; scientific and engineering practices; and disciplinary core ideas in the physical sciences, life sciences, and earth and space sciences and for engineering, technology, and the applications of science. The overarching goal is for all high school graduates to have sufficient knowledge of science and engineering to engage in public discussions on science-related issues, be careful consumers of scientific and technical information, and enter the careers of their choice. A Framework for K-12 Science Education is the first step in a process that can inform state-level decisions and achieve a research-grounded basis for improving science instruction and learning across the country. The book will guide standards developers, teachers, curriculum designers, assessment developers, state and district science administrators, and educators who teach science in informal environments.

Pharmacology Made Incredibly Easy!

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Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1496350472
Total Pages : 1190 pages
Book Rating : 4.4/5 (963 download)

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Book Synopsis Pharmacology Made Incredibly Easy! by : Lippincott Williams & Wilkins

Download or read book Pharmacology Made Incredibly Easy! written by Lippincott Williams & Wilkins and published by Lippincott Williams & Wilkins. This book was released on 2016-06-07 with total page 1190 pages. Available in PDF, EPUB and Kindle. Book excerpt: Get all the basics on drug therapies—and administer drugs confidently and accurately—with the newly updated Pharmacology Made Incredibly Easy, 4th Edition. Written in the enjoyable, award-winning Incredibly Easy style, this easy-to-follow, fully illustrated guide offers step-by-step direction on the medication process, from assessing patient needs, to planning care, to implementation and positive outcomes. Strengthen your understanding of your class materials, get ready for the NCLEX® or certification exam, and administer drug therapies—safely and effectively! Build a strong platform of pharmacology knowledge and skills with. . . NEW and updated content on the newest approved medications and dosages and NEW tables listing: NEW vaccines and treatment for biological weapons exposure NEW treatment and antidotes for chemical weapons exposure NEW herbal drugs content NEW icons and images that clarify content Revised and updated content on the concepts of pharmacokinetics, pharmacodynamics, and pharmacotherapeutics Pharmacology basics – How drugs are derived, developed, classified, and administered; classes of drugs by body system; their uses and mechanisms “Nurse Joy” and “Nurse Jake” illustrated characters offering tips and insights throughout Quick-scan format with concise, bulleted content Hundreds of illustrations and diagrams explaining key concepts and providing clear direction on administering drugs; drug distribution, absorption, and metabolism; potential drug interactions; adverse reactions; how different classes of drugs work in different body systems Special chapter features: Just the facts – A quick summary of chapter content Advice from the experts – Experienced practitioners’ insights Prototype pro – Actions, indications, and nursing considerations for common prototype drugs Nursing process – Patient assessment, diagnosis, outcome goals, implementation, and evaluation for each type and class of drug Pharm function – Illustrating how drugs act in the body; recognizing and treating adverse reactions Before you give that drug – Warnings to consider before you administer a drug Education edge – Information to share with your patient Quick quiz – End-of-chapter questions with answers/explanations, to help you remember the essentials End-of-book multiple-choice Q&A; Quick Guides to Medication Safety, Ophthalmic and Dermatologic Drugs, and Abbreviations to Avoid; Glossary of essential pharmacology terms.

Dale's Pharmacology Condensed E-Book

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Publisher : Elsevier Health Sciences
ISBN 13 : 0702078190
Total Pages : 179 pages
Book Rating : 4.7/5 (2 download)

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Book Synopsis Dale's Pharmacology Condensed E-Book by : Clive P. Page

Download or read book Dale's Pharmacology Condensed E-Book written by Clive P. Page and published by Elsevier Health Sciences. This book was released on 2019-12-25 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering the essential basic science and principles of pharmacology using concise text and diagrams, Dale's Pharmacology Condensed, 3rd Edition, presents the key facts and concepts that are key to understanding how drugs work and their underlying pathophysiological processes. Each of the 50 short chapters provides an organized, consistent approach to efficient learning and retention of complex information. This concise text is an ideal companion volume to Rang and Dale's Pharmacology, as well as a stand-alone condensed textbook or review book for exams. - All content has been thoroughly revised and updated, with new coverage of fast-moving therapeutic areas such as cancer treatments, dermatology and immune mediated diseases, and new developments in pharmacological principles such as biased agonism. - Each two-page (or less) chapter condenses key information from Rang and Dale's Pharmacology to provide the necessary core knowledge, as well as essential therapeutic information. - New editors are experienced teachers who provide a clear focus on what today's students need to know. - Ideal for exam preparation with explanatory diagrams throughout, important drugs identified with bold type, and 50 multiple choice questions for self-assessment and review.

The Flesh and Bones of Medical Pharmacology

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Publisher : Elsevier Health Sciences
ISBN 13 : 0723437165
Total Pages : 152 pages
Book Rating : 4.7/5 (234 download)

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Book Synopsis The Flesh and Bones of Medical Pharmacology by : Domenico Spina

Download or read book The Flesh and Bones of Medical Pharmacology written by Domenico Spina and published by Elsevier Health Sciences. This book was released on 2008-01-08 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: A concise, accessible account of pharmacology and covers all the key concepts med students need with no gaps! Perfect as an introduction to a topic, or as a revision aid. Big Picture Section - you can relate detail to the subject as a whole High Return Facts - fills large gaps in your knowledge. Can be used as a revision tool. Reinforces the major points Cartoon-strip illustrations - you can visualise difficult concepts in a step-by-step format - information is chunked into 'student-friendly' sizes Double-page overviews - read topic summaries without cross-referencing to other pages - they're all laid out in one spread!

Key Concepts in Medical Sociology

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Publisher : SAGE
ISBN 13 : 9780761974420
Total Pages : 278 pages
Book Rating : 4.9/5 (744 download)

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Book Synopsis Key Concepts in Medical Sociology by : Jonathan Gabe

Download or read book Key Concepts in Medical Sociology written by Jonathan Gabe and published by SAGE. This book was released on 2004-04-10 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: This title provides a systematic and accessible introduction to medical sociology, beginning each 1500 word entry with a definition of the concept, then examines its origins, development, strengths and weaknesses, offering further reading guidance for independent learning, and drawing on international literature and examples.

Lippincott NCLEX-RN Pharmacology Review

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Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1975109848
Total Pages : 464 pages
Book Rating : 4.9/5 (751 download)

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Book Synopsis Lippincott NCLEX-RN Pharmacology Review by : Rebecca Hill

Download or read book Lippincott NCLEX-RN Pharmacology Review written by Rebecca Hill and published by Lippincott Williams & Wilkins. This book was released on 2019-08-14 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Master the Pharmacology Concepts You’ll Encounter on Your Licensure Exam! Reinforce your understanding and ready yourself for success with this comprehensive review of critical pharmacology content covered on the NCLEX-RN®. Lippincott® Pharmacology Review for NCLEX-RN® summarizes core medication classes and their associated conditions in an easy-to-use format accompanied by ample practice questions to help you excel on your exams and make a confident transition to clinical practice. Streamlined, bulleted format reinforces key information at a glance. NCLEX-style review questions test your retention of essential concepts and familiarize you with the exam experience. Detailed answer key offers instant remediation including full rationales, Bloom’s Taxonomy levels and Client Need categories for each question. Free 7-day Lippincott® PassPoint trial provides personalized, adaptive online test preparation to enhance your test-taking confidence.

From Neurons to Neighborhoods

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Publisher : National Academies Press
ISBN 13 : 0309069882
Total Pages : 610 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis From Neurons to Neighborhoods by : National Research Council

Download or read book From Neurons to Neighborhoods written by National Research Council and published by National Academies Press. This book was released on 2000-11-13 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: How we raise young children is one of today's most highly personalized and sharply politicized issues, in part because each of us can claim some level of "expertise." The debate has intensified as discoveries about our development-in the womb and in the first months and years-have reached the popular media. How can we use our burgeoning knowledge to assure the well-being of all young children, for their own sake as well as for the sake of our nation? Drawing from new findings, this book presents important conclusions about nature-versus-nurture, the impact of being born into a working family, the effect of politics on programs for children, the costs and benefits of intervention, and other issues. The committee issues a series of challenges to decision makers regarding the quality of child care, issues of racial and ethnic diversity, the integration of children's cognitive and emotional development, and more. Authoritative yet accessible, From Neurons to Neighborhoods presents the evidence about "brain wiring" and how kids learn to speak, think, and regulate their behavior. It examines the effect of the climate-family, child care, community-within which the child grows.

Atkinson's Principles of Clinical Pharmacology

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Author :
Publisher : Academic Press
ISBN 13 : 0128198842
Total Pages : 764 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Atkinson's Principles of Clinical Pharmacology by : Shiew-Mei Huang

Download or read book Atkinson's Principles of Clinical Pharmacology written by Shiew-Mei Huang and published by Academic Press. This book was released on 2021-10-16 with total page 764 pages. Available in PDF, EPUB and Kindle. Book excerpt: **Selected for Doody's Core Titles® 2024 in Pharmacology**Atkinson's Principles of Clinical Pharmacology, Fourth Edition is the essential reference on the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This well-regarded survey continues to focus on the basics of clinical pharmacology for the development, evaluation and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the fourth edition has been thoroughly updated to provide readers with an ideal reference on the wide range of important topics impacting clinical pharmacology. - Presents the essential knowledge for effective practice of clinical pharmacology - Includes a new chapter and extended discussion on the role of personalized and precision medicine in clinical pharmacology - Offers an extensive regulatory section that addresses US and international issues and guidelines - Provides extended coverage of earlier chapters on transporters, pharmacogenetics and biomarkers, along with further discussion on "Phase 0" studies (microdosing) and PBPK