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Control Of Breast Cancer Cell Replication In Vitro By Estrogens And Antiestrogens
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Book Synopsis Control of Breast Cancer Cell Replication in Vitro by Estrogens and Antiestrogens by : Catherine Sue Murphy
Download or read book Control of Breast Cancer Cell Replication in Vitro by Estrogens and Antiestrogens written by Catherine Sue Murphy and published by . This book was released on 1990 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Estrogen/antiestrogen Action and Breast Cancer Therapy by : Virgil Craig Jordan
Download or read book Estrogen/antiestrogen Action and Breast Cancer Therapy written by Virgil Craig Jordan and published by Univ of Wisconsin Press. This book was released on 1986 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book marks one of the achievements of the "Estrogen and Antiestrogen Action: Basic and Clinical Aspects" Wisconsin Clinical Cancer Center conference in June 1984. It is not intended to be a recount of the meeting proceedings but is, rather, a historical review of the development of this field of endeavor during the past 30 years. The chapters have been written by many of the leading experts in the field who were asked to recount the development of a particular area or laboratory idea in which they had been personally involved. The book is intended to provide both scientists and clinicians with a single-volume overview of both the basic principles of hormonal control of breast cancer and the recent clinical results from cooperative groups around the world.
Book Synopsis Estrogen and Antiestrogen Regulation of Breast Cancer Cell Growth by : Shunyuan Jiang
Download or read book Estrogen and Antiestrogen Regulation of Breast Cancer Cell Growth written by Shunyuan Jiang and published by . This book was released on 1991 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Estrogens, Estrogen Receptor and Breast Cancer by : Fritz F. Parl
Download or read book Estrogens, Estrogen Receptor and Breast Cancer written by Fritz F. Parl and published by IOS Press. This book was released on 2000 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Estrogens have been implicated to play a role in the development of breast cancer. The purpose of this book is to provide a comprehensive analysis of experimental, clinical and epidemiological evidence in support of the carcinogenicity of estrogens.
Book Synopsis Estrogen and Antiestrogen Regulation of Breast Cancer Cell Growth by : Shun-Yuan Jiang
Download or read book Estrogen and Antiestrogen Regulation of Breast Cancer Cell Growth written by Shun-Yuan Jiang and published by . This book was released on 1991 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Growth Regulation of Human Breast Cancer Cells by Estrogens and Antiestrogens by : Anne E. Lykkesfeldt
Download or read book Growth Regulation of Human Breast Cancer Cells by Estrogens and Antiestrogens written by Anne E. Lykkesfeldt and published by . This book was released on 1997 with total page 79 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Tamoxifen written by John A. Kellen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tamoxifen has persisted as a widely accepted and administered drug for almost 25 years. Following the many scientific papers and books on the subject, it has remained a very intriguing substance. This, perhaps, is the reason for another monograph on Tamoxifen. It is regrettably true that overviews, even when up to date after exhaustive research - the shibboleth of our cultures -, rapidly lose relevance with the passage of time. Scientists can sometimes be pictured as deep sea divers, who plunge into the unknown in search of a hitherto unknown world. Their descent is exciting, but eventually they must come up for air and integrate their experiences with others who also had to resurface. This book intends to collect and, where possible, to collate recent, but sometimes seemingly unrelated information. To quote Stephane Mallarme: "Everything in the world exists to end up in a book". Even if this is a tad cynical, it might not be far from the truth. If a little knowledge is a dangerous commodity, one can also add - tongue in cheek - that a vast amount of knowledge can be truly hazardous. It is likely that what might seem as entangled data is confusing, especially for those satisfied with the comfortable interpretation of Tamoxifen as an antiestrogen which has long been found insufficient. The complexity of its mechanisms and effects defies simple explanations and may even seem capricious, but only because of our ignorance.
Book Synopsis Development of Estrogen Independence and Antiestrogen Resistance in Breast Cancer Cells in Culture by : Ethel M. Cormier
Download or read book Development of Estrogen Independence and Antiestrogen Resistance in Breast Cancer Cells in Culture written by Ethel M. Cormier and published by . This book was released on 1988 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Effects of Estrogen Deprivations on Hormone Responsive Breast Cancer Cell Lines by : John J. Pink
Download or read book Effects of Estrogen Deprivations on Hormone Responsive Breast Cancer Cell Lines written by John J. Pink and published by . This book was released on 1995 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Phytochemical Regulation of Estrogen Responsiveness and Proliferation of Human Breast Cancer Cells by : Shyam Narayan Sundar
Download or read book Phytochemical Regulation of Estrogen Responsiveness and Proliferation of Human Breast Cancer Cells written by Shyam Narayan Sundar and published by . This book was released on 2006 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Regulation of Estrogen Receptor-alpha Mediated Gene Expression and Endocrine Resistance Through Estrogen Receptor-alpha Phosphorylation and Micro-RNA in Breast Cancer by : Kyuri Kim
Download or read book Regulation of Estrogen Receptor-alpha Mediated Gene Expression and Endocrine Resistance Through Estrogen Receptor-alpha Phosphorylation and Micro-RNA in Breast Cancer written by Kyuri Kim and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Estrogens are associated with the development and progression of breast cancer in addition to their role in normal reproductive physiology, and estrogen receptors (ER) mediate the actions of estrogen in target tissues by regulating the expression of numerous biologically important target genes. The progression of human breast cancer and the development of resistance to endocrine therapies are thought to be associated with ER phosphorylation. We generated multiple combinations of ER phospho-mutants, at residues serine 104, 106, 118, 167, 236, and 305, and examined their impact on receptor half-life, the agonist and antagonist balance of selective estrogen receptor modulators (SERMs) and selective estrogen receptor downregulators (SERDs), the regulation of ER transcriptional activity, and stimulation of cell proliferation in response to estradiol and SERMs/SERD. We showed that changes in ER affecting the phosphorylation status of the receptor greatly impact receptor function and differential SERM and SERD modulated cellular responses that could contribute to resistance to endocrine therapies in breast cancer. We also studied the regulation of microRNAs (miRNAs) by estradiol and growth factors through ER and extracellular signal-regulated kinase 2 (ERK2) in order to understand their physiological impact on breast cancer. We identified nine miRNA- encoding genes harboring overlapping ER and ERK2 binding sites close to their transcription start sites, which require ER and ERK2 for transcriptional induction as well as estradiol- mediated miRNA regulation. We then identified TP63, a target of miR-101, miR-190 and miR- 196a2, and showed that TP63 plays an important role in estradiol- or growth factor-mediated cellular response in breast cancer cells (MCF-7 and MDA-MB-231) by increasing tumor cell growth and in vitro invasion mainly controlled by miR-196a2 action. These results suggest a tumor-suppressive role of miR-196a2 in regulating TP63 expression and the aggressive behavior of breast cancers.
Book Synopsis Drug and Hormonal Resistance in Breast Cancer by : Robert Brent Dickson
Download or read book Drug and Hormonal Resistance in Breast Cancer written by Robert Brent Dickson and published by Prentice Hall PTR. This book was released on 1995 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Featuring contributions from expert authors of international standing, this book explores emerging studies on the success and/or failure of chemotherapy in breast cancer. Covers the clinical resistance of breast cancer to treatment; chemo-hormonal reactions; anti-hormonal resistance; multidrug resistance; and fu/antimetabolites. For cancer and hormonal researchers and development scientists in pharmaceuticals and biomedicine. Previously announced in 7/93 PTR Catalog.
Book Synopsis Estradiol Stimulation and Androgen Inhibiton of the Growth of Human Breast Cancer Cell Lines by : Constance Clark Reese
Download or read book Estradiol Stimulation and Androgen Inhibiton of the Growth of Human Breast Cancer Cell Lines written by Constance Clark Reese and published by . This book was released on 1989 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Estrogen and Antiestrogen Regulation of Genes in Human Endometrial and Breast Cancer Cell Lines by : Emely Castro Rivera
Download or read book Estrogen and Antiestrogen Regulation of Genes in Human Endometrial and Breast Cancer Cell Lines written by Emely Castro Rivera and published by . This book was released on 2001 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Antiestrogen Resistance and G1 Phase Cdk Regulation in Human Breast Cancer Cells by : Andrew John Skildum
Download or read book Antiestrogen Resistance and G1 Phase Cdk Regulation in Human Breast Cancer Cells written by Andrew John Skildum and published by . This book was released on 2002 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Aspects of Antiestrogen Resistance and Autophagy in Breast Cancer Cells by : Irina Nayvelt
Download or read book Molecular Aspects of Antiestrogen Resistance and Autophagy in Breast Cancer Cells written by Irina Nayvelt and published by . This book was released on 2009 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: The major objective of this thesis was to examine the molecular aspects of estrogenic growth and autophagy in estrogen receptor [alpha] (ER[alpha])-positive breast cancer cells. We first examined the role of autophagy mediator, Beclin 1, in estrogenic signaling and antiestrogen resistance in Beclin 1-overexpressing MCF-7 cells. We found that a potential interaction between ER[alpha] and Beclin 1 rendered Beclin 1-transfected cells less sensitive to estradiol (E2)-induced growth stimulation, and to antiestrogen-mediated growth inhibition. Thus, a novel function for Beclin 1 might involve down-regulation of the action of ER[alpha], contributing to resistance of breast cancer cells to antiestrogens. In an attempt to develop novel therapeutic agents for breast cancer, we explored the effect of the polyamine analogue, 1,15-bis(ethylamino)-4,8,12-triazapentadecane (BE-3-3-3-3), on MCF-7 cell growth in the presence and absence of E2. BE-3-3-3-3 caused growth inhibition in the presence of E2. However, it mimicked estradiol and stimulated cell growth in the absence of E2, and induced growth response genes, such as c-fos, c-jun, and c-myc. This also induced autophagy, and increased levels of autophagy-related proteins, Beclin 1 and MAP LC3-II. In another approach to introduce gene therapy for breast cancer treatment, we explored the physico-chemical aspects of DNA nanoparticle formation. In an effort to optimize gene delivery systems, we investigated DNA condensation to nanoparticles in the presence of [alpha], [alpha]'-methylated spermine analogues, and characterized the size, shape and stability of the resultant nanoparticles. Although some analogues proved more efficacious DNA condensing agents than spermine, hydrodynamic radii of nanoparticles produced by analogues were comparable to those produced by spermine. We also compared the DNA condensing abilities of poly-L-lysine (PLL) and oligolysines, and characterized the physico-chemical properties of their condensates. PLL was a more effective condensing agent than oligolysines, and produced more stable nanoparticles. We conclude that PLL and oligolysines bind and condense DNA through different mechanisms. In summary, our research provides new insights into the mechanism of antiestrogen resistance and autophagy in breast cancer. We also provide mechanistic insight into DNA nanoparticle formation in the presence of polyamine analogues and lysines.
Book Synopsis Estrogen Receptors in Human Breast Cancer by : William L. McGuire
Download or read book Estrogen Receptors in Human Breast Cancer written by William L. McGuire and published by . This book was released on 1975 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt:
