Connectomics

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Connectome

Author : Sebastian Seung
Publisher : HMH
ISBN 13 : 0547508174
Total Pages : 389 pages
Book Rating : 4.5/5 (475 download)

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Book Synopsis Connectome by : Sebastian Seung

Download or read book Connectome written by Sebastian Seung and published by HMH. This book was released on 2012-02-07 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Accessible, witty . . . an important new researcher, philosopher and popularizer of brain science . . . on par with cosmology’s Brian Greene and the late Carl Sagan” (The Plain Dealer). One of the Wall Street Journal’s 10 Best Nonfiction Books of the Year and a Publishers Weekly “Top Ten in Science” Title Every person is unique, but science has struggled to pinpoint where, precisely, that uniqueness resides. Our genome may determine our eye color and even aspects of our character. But our friendships, failures, and passions also shape who we are. The question is: How? Sebastian Seung is at the forefront of a revolution in neuroscience. He believes that our identity lies not in our genes, but in the connections between our brain cells—our particular wiring. Seung and a dedicated group of researchers are leading the effort to map these connections, neuron by neuron, synapse by synapse. It’s a monumental effort, but if they succeed, they will uncover the basis of personality, identity, intelligence, memory, and perhaps disorders such as autism and schizophrenia. Connectome is a mind-bending adventure story offering a daring scientific and technological vision for understanding what makes us who we are, as individuals and as a species. “This is complicated stuff, and it is a testament to Dr. Seung’s remarkable clarity of exposition that the reader is swept along with his enthusiasm, as he moves from the basics of neuroscience out to the farthest regions of the hypothetical, sketching out a spectacularly illustrated giant map of the universe of man.” —TheNew York Times “An elegant primer on what’s known about how the brain is organized and how it grows, wires its neurons, perceives its environment, modifies or repairs itself, and stores information. Seung is a clear, lively writer who chooses vivid examples.” —TheWashington Post

Micro-, Meso- and Macro-Connectomics of the Brain

Author : Henry Kennedy
Publisher : Springer
ISBN 13 : 3319277774
Total Pages : 173 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Micro-, Meso- and Macro-Connectomics of the Brain by : Henry Kennedy

Download or read book Micro-, Meso- and Macro-Connectomics of the Brain written by Henry Kennedy and published by Springer. This book was released on 2016-03-10 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book has brought together leading investigators who work in the new arena of brain connectomics. This includes ‘macro-connectome’ efforts to comprehensively chart long-distance pathways and functional networks; ‘micro-connectome’ efforts to identify every neuron, axon, dendrite, synapse, and glial process within restricted brain regions; and ‘meso-connectome’ efforts to systematically map both local and long-distance connections using anatomical tracers. This book highlights cutting-edge methods that can accelerate progress in elucidating static ‘hard-wired’ circuits of the brain as well as dynamic interactions that are vital for brain function. The power of connectomic approaches in characterizing abnormal circuits in the many brain disorders that afflict humankind is considered. Experts in computational neuroscience and network theory provide perspectives needed for synthesizing across different scales in space and time. Altogether, this book provides an integrated view of the challenges and opportunities in deciphering brain circuits in health and disease.

Connectomic Deep Brain Stimulation

Author : Andreas Horn
Publisher : Academic Press
ISBN 13 : 0128218622
Total Pages : 602 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Connectomic Deep Brain Stimulation by : Andreas Horn

Download or read book Connectomic Deep Brain Stimulation written by Andreas Horn and published by Academic Press. This book was released on 2021-09-10 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: Connectomic Deep Brain Stimulation (DBS) covers this highly efficacious treatment option for movement disorders such as Parkinson’s Disease, Essential Tremor and Dystonia. The book examines its impact on distributed brain networks that span across the human brain in parallel with modern-day neuroimaging concepts and the connectomics of the brain. It asks several questions, including which cortical areas should DBS electrodes be connected in order to generate the highest possible clinical improvement? Which connections should be avoided? Could these connectomic insights be used to better understand the mechanism of action of DBS? How can they be transferred to individual patients, and more. This book is suitable for neuroscientists, neurologists and functional surgeons studying DBS. It provides practical advice on processing strategies and theoretical background, highlighting and reviewing the current state-of-the-art in connectomic surgery. Written to provide a "hands-on" approach for neuroscience graduate students, as well as medical personnel from the fields of neurology and neurosurgery Includes preprocessing strategies (such as co-registration, normalization, lead localization, VTA estimation and fiber-tracking approaches) Presents references (key articles, books and protocols) for additional detailed study Provides data analysis boxes in each chapter to help with data interpretation

Connectomics

Author : Brent C. Munsell
Publisher : Academic Press
ISBN 13 : 9780128138380
Total Pages : 0 pages
Book Rating : 4.1/5 (383 download)

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Book Synopsis Connectomics by : Brent C. Munsell

Download or read book Connectomics written by Brent C. Munsell and published by Academic Press. This book was released on 2018-09-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Connectomics: Applications to Neuroimaging is unique in presenting the frontier of neuro-applications using brain connectomics techniques. The book describes state-of-the-art research that applies brain connectivity analysis techniques to a broad range of neurological and psychiatric disorders (Alzheimer's, epilepsy, stroke, autism, Parkinson's, drug or alcohol addiction, depression, bipolar, and schizophrenia), brain fingerprint applications, speech-language assessments, and cognitive assessment. With this book the reader will learn: Basic mathematical principles underlying connectomics How connectomics is applied to a wide range of neuro-applications What is the future direction of connectomics techniques. This book is an ideal reference for researchers and graduate students in computer science, data science, computational neuroscience, computational physics, or mathematics who need to understand how computational models derived from brain connectivity data are being used in clinical applications, as well as neuroscientists and medical researchers wanting an overview of the technical methods. Features: Combines connectomics methods with relevant and interesting neuro-applications Covers most of the hot topics in neuroscience and clinical areas Appeals to researchers in a wide range of disciplines: computer science, engineering, data science, mathematics, computational physics, computational neuroscience, as well as neuroscience, and medical researchers interested in the technical methods of connectomics

Fundamentals of Brain Network Analysis

Author : Alex Fornito
Publisher : Academic Press
ISBN 13 : 0124081185
Total Pages : 496 pages
Book Rating : 4.1/5 (24 download)

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Book Synopsis Fundamentals of Brain Network Analysis by : Alex Fornito

Download or read book Fundamentals of Brain Network Analysis written by Alex Fornito and published by Academic Press. This book was released on 2016-03-04 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamentals of Brain Network Analysis is a comprehensive and accessible introduction to methods for unraveling the extraordinary complexity of neuronal connectivity. From the perspective of graph theory and network science, this book introduces, motivates and explains techniques for modeling brain networks as graphs of nodes connected by edges, and covers a diverse array of measures for quantifying their topological and spatial organization. It builds intuition for key concepts and methods by illustrating how they can be practically applied in diverse areas of neuroscience, ranging from the analysis of synaptic networks in the nematode worm to the characterization of large-scale human brain networks constructed with magnetic resonance imaging. This text is ideally suited to neuroscientists wanting to develop expertise in the rapidly developing field of neural connectomics, and to physical and computational scientists wanting to understand how these quantitative methods can be used to understand brain organization. Winner of the 2017 PROSE Award in Biomedicine & Neuroscience and the 2017 British Medical Association (BMA) Award in Neurology Extensively illustrated throughout by graphical representations of key mathematical concepts and their practical applications to analyses of nervous systems Comprehensively covers graph theoretical analyses of structural and functional brain networks, from microscopic to macroscopic scales, using examples based on a wide variety of experimental methods in neuroscience Designed to inform and empower scientists at all levels of experience, and from any specialist background, wanting to use modern methods of network science to understand the organization of the brain

Discovering the Human Connectome

Author : Olaf Sporns
Publisher : MIT Press
ISBN 13 : 0262304805
Total Pages : 253 pages
Book Rating : 4.2/5 (623 download)

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Book Synopsis Discovering the Human Connectome by : Olaf Sporns

Download or read book Discovering the Human Connectome written by Olaf Sporns and published by MIT Press. This book was released on 2012-09-07 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: A pioneer in the field outlines new empirical and computational approaches to mapping the neural connections of the human brain. Crucial to understanding how the brain works is connectivity, and the centerpiece of brain connectivity is the connectome, a comprehensive description of how neurons and brain regions are connected. In this book, Olaf Sporns surveys current efforts to chart these connections—to map the human connectome. He argues that the nascent field of connectomics has already begun to influence the way many neuroscientists collect, analyze, and think about their data. Moreover, the idea of mapping the connections of the human brain in their entirety has captured the imaginations of researchers across several disciplines including human cognition, brain and mental disorders, and complex systems and networks. Discovering the Human Connectome offers the first comprehensive overview of current empirical and computational approaches in this rapidly developing field.

Changing Connectomes

Author : Marcus Kaiser
Publisher : MIT Press
ISBN 13 : 0262360810
Total Pages : 271 pages
Book Rating : 4.2/5 (623 download)

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Book Synopsis Changing Connectomes by : Marcus Kaiser

Connectomics

Author : Alison Calder
Publisher :
ISBN 13 : 9780993124594
Total Pages : 0 pages
Book Rating : 4.1/5 (245 download)

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Book Synopsis Connectomics by : Alison Calder

Download or read book Connectomics written by Alison Calder and published by . This book was released on 2017-01-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Poems that bridge both art and science inspired by that unique organ, the human brain.

Connectomics

Author : Brent C. Munsell
Publisher : Academic Press
ISBN 13 : 0128138394
Total Pages : 236 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Connectomics by : Brent C. Munsell

Download or read book Connectomics written by Brent C. Munsell and published by Academic Press. This book was released on 2018-09-08 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Connectomics: Applications to Neuroimaging is unique in presenting the frontier of neuro-applications using brain connectomics techniques. The book describes state-of-the-art research that applies brain connectivity analysis techniques to a broad range of neurological and psychiatric disorders (Alzheimer’s, epilepsy, stroke, autism, Parkinson’s, drug or alcohol addiction, depression, bipolar, and schizophrenia), brain fingerprint applications, speech-language assessments, and cognitive assessment. With this book the reader will learn: Basic mathematical principles underlying connectomics How connectomics is applied to a wide range of neuro-applications What is the future direction of connectomics techniques. This book is an ideal reference for researchers and graduate students in computer science, data science, computational neuroscience, computational physics, or mathematics who need to understand how computational models derived from brain connectivity data are being used in clinical applications, as well as neuroscientists and medical researchers wanting an overview of the technical methods. Features: Combines connectomics methods with relevant and interesting neuro-applications Covers most of the hot topics in neuroscience and clinical areas Appeals to researchers in a wide range of disciplines: computer science, engineering, data science, mathematics, computational physics, computational neuroscience, as well as neuroscience, and medical researchers interested in the technical methods of connectomics Combines connectomics methods with relevant and interesting neuro-applications Presents information that will appeal to researchers in a wide range of disciplines, including computer science, engineering, data science, mathematics, computational physics, computational neuroscience, and more Includes a mathematics primer that formulates connectomics from an applied point-of-view, thus avoiding difficult to understand theoretical perspective Lists publicly available neuro-imaging datasets that can be used to construct structural and functional connectomes

Brain Connectivity in Autism

Author : Rajesh K. Kana
Publisher : Frontiers E-books
ISBN 13 : 2889192822
Total Pages : 265 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Brain Connectivity in Autism by : Rajesh K. Kana

Download or read book Brain Connectivity in Autism written by Rajesh K. Kana and published by Frontiers E-books. This book was released on 2014-09-23 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain's ability to process information crucially relies on connectivity. Understanding how the brain processes complex information and how such abilities are disrupted in individuals with neuropsychological disorders will require an improved understanding of brain connectivity. Autism is an intriguingly complex neurodevelopmental disorder with multidimensional symptoms and cognitive characteristics. A biological origin for autism spectrum disorders (ASD) had been proposed even in the earliest published accounts (Kanner, 1943; Asperger, 1944). Despite decades of research, a focal neurobiological marker for autism has been elusive. Nevertheless, disruptions in interregional and functional and anatomical connectivity have been a hallmark of neural functioning in ASD. Theoretical accounts of connectivity perceive ASD as a cognitive and neurobiological disorder associated with altered functioning of integrative circuitry. Neuroimaging studies have reported disruptions in functional connectivity (synchronization of activated brain areas) during cognitive tasks and during task-free resting states. While these insights are valuable, they do not address the time-lagged causality and directionality of such correlations. Despite the general promise of the connectivity account of ASD, inconsistencies and methodological differences among studies call for more thorough investigations. A comprehensive neurological account of ASD should incorporate functional, effective, and anatomical connectivity measures and test the diagnostic utility of such measures. In addition, questions pertaining to how cognitive and behavioral intervention can target connection abnormalities in ASD should be addressed. This research topic of the Frontiers in Human Neuroscience addresses “Brain Connectivity in Autism” primarily from cognitive neuroscience and neuroimaging perspectives.

An Internet in Your Head

Author : Daniel Graham
Publisher : Columbia University Press
ISBN 13 : 0231551614
Total Pages : 428 pages
Book Rating : 4.2/5 (315 download)

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Book Synopsis An Internet in Your Head by : Daniel Graham

Download or read book An Internet in Your Head written by Daniel Graham and published by Columbia University Press. This book was released on 2021-05-04 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Whether we realize it or not, we think of our brains as computers. In neuroscience, the metaphor of the brain as a computer has defined the field for much of the modern era. But as neuroscientists increasingly reevaluate their assumptions about how brains work, we need a new metaphor to help us ask better questions. The computational neuroscientist Daniel Graham offers an innovative paradigm for understanding the brain. He argues that the brain is not like a single computer—it is a communication system, like the internet. Both are networks whose power comes from their flexibility and reliability. The brain and the internet both must route signals throughout their systems, requiring protocols to direct messages from just about any point to any other. But we do not yet understand how the brain manages the dynamic flow of information across its entire network. The internet metaphor can help neuroscience unravel the brain’s routing mechanisms by focusing attention on shared design principles and communication strategies that emerge from parallel challenges. Highlighting similarities between brain connectivity and the architecture of the internet can open new avenues of research and help unlock the brain’s deepest secrets. An Internet in Your Head presents a clear-eyed and engaging tour of brain science as it stands today and where the new paradigm might take it next. It offers anyone with an interest in brains a transformative new way to conceptualize what goes on inside our heads.

Machine Learning and Medical Imaging

Author : Guorong Wu
Publisher : Academic Press
ISBN 13 : 0128041145
Total Pages : 514 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Machine Learning and Medical Imaging by : Guorong Wu

Download or read book Machine Learning and Medical Imaging written by Guorong Wu and published by Academic Press. This book was released on 2016-08-11 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: Machine Learning and Medical Imaging presents state-of- the-art machine learning methods in medical image analysis. It first summarizes cutting-edge machine learning algorithms in medical imaging, including not only classical probabilistic modeling and learning methods, but also recent breakthroughs in deep learning, sparse representation/coding, and big data hashing. In the second part leading research groups around the world present a wide spectrum of machine learning methods with application to different medical imaging modalities, clinical domains, and organs. The biomedical imaging modalities include ultrasound, magnetic resonance imaging (MRI), computed tomography (CT), histology, and microscopy images. The targeted organs span the lung, liver, brain, and prostate, while there is also a treatment of examining genetic associations. Machine Learning and Medical Imaging is an ideal reference for medical imaging researchers, industry scientists and engineers, advanced undergraduate and graduate students, and clinicians. Demonstrates the application of cutting-edge machine learning techniques to medical imaging problems Covers an array of medical imaging applications including computer assisted diagnosis, image guided radiation therapy, landmark detection, imaging genomics, and brain connectomics Features self-contained chapters with a thorough literature review Assesses the development of future machine learning techniques and the further application of existing techniques

Decoding Neural Circuit Structure and Function

Author : Arzu Çelik
Publisher : Springer
ISBN 13 : 3319573632
Total Pages : 517 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Decoding Neural Circuit Structure and Function by : Arzu Çelik

Download or read book Decoding Neural Circuit Structure and Function written by Arzu Çelik and published by Springer. This book was released on 2017-07-24 with total page 517 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers representative examples from fly and mouse models to illustrate the ongoing success of the synergistic, state-of-the-art strategy, focusing on the ways it enhances our understanding of sensory processing. The authors focus on sensory systems (vision, olfaction), which are particularly powerful models for probing the development, connectivity, and function of neural circuits, to answer this question: How do individual nerve cells functionally cooperate to guide behavioral responses? Two genetically tractable species, mice and flies, together significantly further our understanding of these processes. Current efforts focus on integrating knowledge gained from three interrelated fields of research: (1) understanding how the fates of different cell types are specified during development, (2) revealing the synaptic connections between identified cell types (“connectomics”) using high-resolution three-dimensional circuit anatomy, and (3) causal testing of how iden tified circuit elements contribute to visual perception and behavior.

Multiscale Models of Brain Disorders

Author : Vassilis Cutsuridis
Publisher : Springer Nature
ISBN 13 : 3030188302
Total Pages : 222 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Multiscale Models of Brain Disorders by : Vassilis Cutsuridis

Download or read book Multiscale Models of Brain Disorders written by Vassilis Cutsuridis and published by Springer Nature. This book was released on 2019-10-11 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on our current understanding of brain dynamics in various brain disorders (e.g. epilepsy, Alzheimer’s and Parkinson’s disease) and how the multi-scale, multi-level tools of computational neuroscience can enhance this understanding. In recent years, there have been significant advances in the study of the dynamics of the disordered brain at both the microscopic and the macroscopic levels. This understanding can be furthered by the application of multi-scale computational models as integrative principles that may link single neuron dynamics and the dynamics of local and distant brain regions observed using human EEG, ERPs, MEG, LFPs and fMRI. Focusing on the computational models that are used to study movement, memory and cognitive disorders as well as epilepsy and consciousness related diseases, the book brings together physiologists and anatomists investigating cortical circuits; cognitive neuroscientists studying brain dynamics and behavior by means of EEG and functional magnetic resonance imaging (fMRI); and computational neuroscientists using neural modeling techniques to explore local and large-scale disordered brain dynamics. Covering topics that have a significant impact on the field of medicine, neuroscience and computer science, the book appeals to a diverse group of investigators.

Connectomics in NeuroImaging

Author : Guorong Wu
Publisher : Springer
ISBN 13 : 3030007553
Total Pages : 147 pages
Book Rating : 4.0/5 (3 download)

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Book Synopsis Connectomics in NeuroImaging by : Guorong Wu

Download or read book Connectomics in NeuroImaging written by Guorong Wu and published by Springer. This book was released on 2018-09-14 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the Second International Workshop on Connectomics in NeuroImaging, CNI 2018, held in conjunction with MICCAI 2018 in Granada, Spain, in September 2018. The 15 full papers presented were carefully reviewed and selected from 20 submissions. The papers deal with new advancements in network construction, analysis, and visualization techniques in connectomics and their use in clinical diagnosis and group comparison studies as well as in various neuroimaging applications.

Changing Connectomes

Author : Marcus Kaiser
Publisher : MIT Press
ISBN 13 : 0262044617
Total Pages : 271 pages
Book Rating : 4.2/5 (62 download)

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Book Synopsis Changing Connectomes by : Marcus Kaiser

Download or read book Changing Connectomes written by Marcus Kaiser and published by MIT Press. This book was released on 2020-09-08 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: An up-to-date overview of the field of connectomics, introducing concepts and mechanisms underlying brain network change at different stages. The human brain undergoes massive changes during its development, from early childhood and the teenage years to adulthood and old age. Across a wide range of species, from C. elegans and fruit flies to mice, monkeys, and humans, information about brain connectivity (connectomes) at different stages is now becoming available. New approaches in network neuroscience can be used to analyze the topological, spatial, and dynamical organization of such connectomes. In Changing Connectomes, Marcus Kaiser provides an up-to-date overview of the field of connectomics and introduces concepts and mechanisms underlying brain network changes during evolution and development. Drawing on a range of results from experimental, clinical, and computational studies, Kaiser describes changes during healthy brain maturation and during brain network disorders (including such neurodevelopmental conditions as schizophrenia and depression), brain injury, and neurodegenerative disorders including dementia. He argues that brain stimulation is an area where understanding connectome development could help in assessing long-term effects of interventions. Changing Connectomes is a suitable starting point for researchers who are new to the field of connectomics, and also for researchers who are interested in the link between brain network organization and brain and cognitive development in health and disease. Matlab/Octave code examples available at the MIT Press website will allow computational neuroscience researchers to understand and extend the shown mechanisms of connectome development.

Reliability and Reproducibility in Functional Connectomics

Author : Xi-Nian Zuo
Publisher : Frontiers Media SA
ISBN 13 : 2889458210
Total Pages : 185 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Reliability and Reproducibility in Functional Connectomics by : Xi-Nian Zuo

Download or read book Reliability and Reproducibility in Functional Connectomics written by Xi-Nian Zuo and published by Frontiers Media SA. This book was released on 2019-05-15 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional connectomics enables researchers to monitor interactions among thousands of units within the whole brain simultaneously by using various vivo imaging technologies. For example, resting-state functional magnetic resonance imaging can image low-frequency fluctuations in the spontaneous brain activities, representing a popular tool for macro-scale functional connectomics to characterize individual differences in normal brain function, mind-brain associations, and the various disorders. Reliability and reproducibility represents the most fundamental and critical aspect for the human brain functional connectomics to both research and clinical practice. Unfortunately, lacking a data platform for researchers to rigorously explore the reliability and reproducibility of the functional connectome indices has been a bottleneck of further development of clinically oriented imaging markers in the field. Recent efforts on open neuroscience, such as Consortium for Reliability and Reproducibility, Human Connectome Project and OpenFMRI, provide the data for the field to refine and evaluate reliability and reproducibility of novel methods as well as those with widespread usage but without sufficient consideration of reliability. This Frontiers Research Topic aims at bringing together contributions from researchers in brain imaging, neuroscience, computer sciences, applied mathematics, psychology and related fields from an interdisciplinary perspective. By focusing on cutting-edge research across these fields, this topic will create new agenda on quantifying the reliability and reproducibility of the myriad connectomics-based measures and informing expectations regarding the potential of biomarker discovery.