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Author : Diane E. Duffy
Publisher :
ISBN 13 :
Total Pages : 34 pages
Book Rating : 4.E/5 ( download)
Download or read book Confidence Intervals for a Binomial Parameter Based on Multistage Tests written by Diane E. Duffy and published by . This book was released on 1986 with total page 34 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Technical Report written by and published by . This book was released on 1986 with total page 34 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : B.K. Ghosh
Publisher : CRC Press
ISBN 13 : 9780824784089
Total Pages : 672 pages
Book Rating : 4.7/5 (84 download)
Download or read book Handbook of Sequential Analysis written by B.K. Ghosh and published by CRC Press. This book was released on 1991-04-24 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sequential analysis refers to the body of statistical theory and methods where the sample size may depend in a random manner on the accumulating data. A formal theory in which optimal tests are derived for simple statistical hypotheses in such a framework was developed by Abraham Wald in the early 1
Author : John Crowley
Publisher : CRC Press
ISBN 13 : 142002776X
Total Pages : 642 pages
Book Rating : 4.4/5 (2 download)
Download or read book Handbook of Statistics in Clinical Oncology written by John Crowley and published by CRC Press. This book was released on 2005-12-01 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt: A compendium of cutting-edge statistical approaches to solving problems in clinical oncology, Handbook of Statistics in Clinical Oncology, Second Edition focuses on clinical trials in phases I, II, and III, proteomic and genomic studies, complementary outcomes and exploratory methods. Cancer Forum called the first edition a
Author : Susan Halabi
Publisher : CRC Press
ISBN 13 : 1351620967
Total Pages : 701 pages
Book Rating : 4.3/5 (516 download)
Download or read book Textbook of Clinical Trials in Oncology written by Susan Halabi and published by CRC Press. This book was released on 2019-04-24 with total page 701 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is an increasing need for educational resources for statisticians and investigators. Reflecting this, the goal of this book is to provide readers with a sound foundation in the statistical design, conduct, and analysis of clinical trials. Furthermore, it is intended as a guide for statisticians and investigators with minimal clinical trial experience who are interested in pursuing a career in this area. The advancement in genetic and molecular technologies have revolutionized drug development. In recent years, clinical trials have become increasingly sophisticated as they incorporate genomic studies, and efficient designs (such as basket and umbrella trials) have permeated the field. This book offers the requisite background and expert guidance for the innovative statistical design and analysis of clinical trials in oncology. Key Features: Cutting-edge topics with appropriate technical background Built around case studies which give the work a "hands-on" approach Real examples of flaws in previously reported clinical trials and how to avoid them Access to statistical code on the book’s website Chapters written by internationally recognized statisticians from academia and pharmaceutical companies Carefully edited to ensure consistency in style, level, and approach Topics covered include innovating phase I and II designs, trials in immune-oncology and rare diseases, among many others
Author : Christopher Jennison
Publisher : CRC Press
ISBN 13 : 9781584888581
Total Pages : 416 pages
Book Rating : 4.8/5 (885 download)
Download or read book Group Sequential Methods with Applications to Clinical Trials written by Christopher Jennison and published by CRC Press. This book was released on 1999-09-15 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Group sequential methods answer the needs of clinical trial monitoring committees who must assess the data available at an interim analysis. These interim results may provide grounds for terminating the study-effectively reducing costs-or may benefit the general patient population by allowing early dissemination of its findings. Group sequential methods provide a means to balance the ethical and financial advantages of stopping a study early against the risk of an incorrect conclusion. Group Sequential Methods with Applications to Clinical Trials describes group sequential stopping rules designed to reduce average study length and control Type I and II error probabilities. The authors present one-sided and two-sided tests, introduce several families of group sequential tests, and explain how to choose the most appropriate test and interim analysis schedule. Their topics include placebo-controlled randomized trials, bio-equivalence testing, crossover and longitudinal studies, and linear and generalized linear models. Research in group sequential analysis has progressed rapidly over the past 20 years. Group Sequential Methods with Applications to Clinical Trials surveys and extends current methods for planning and conducting interim analyses. It provides straightforward descriptions of group sequential hypothesis tests in a form suited for direct application to a wide variety of clinical trials. Medical statisticians engaged in any investigations planned with interim analyses will find this book a useful and important tool.
Author : Peter F. Thall
Publisher : Springer Science & Business Media
ISBN 13 : 1461520096
Total Pages : 263 pages
Book Rating : 4.4/5 (615 download)
Download or read book Recent Advances in Clinical Trial Design and Analysis written by Peter F. Thall and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical trials have two purposes -- to treat the patients in the trial, and to obtain information which increases our understanding of the disease and especially how patients respond to treatment. Statistical design provides a means to achieve both these aims, while statistical data analysis provides methods for extracting useful information from the trial data. Recent advances in statistical computing have enabled statisticians to implement very rapidly a broad array of methods which previously were either impractical or impossible. Biostatisticians are now able to provide much greater support to medical researchers working in both clinical and laboratory settings. As our collective toolkit of techniques for analyzing data has grown, it has become increasingly difficult for biostatisticians to keep up with all the developments in our own field. Recent Advances in Clinical Trial Design and Analysis brings together biostatisticians doing cutting-edge research and explains some of the more recent developments in biostatistics to clinicians and scientists who work in clinical trials.
Author : Thomas J. Santner
Publisher : Springer Science & Business Media
ISBN 13 : 1461210178
Total Pages : 381 pages
Book Rating : 4.4/5 (612 download)
Download or read book The Statistical Analysis of Discrete Data written by Thomas J. Santner and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Statistical Analysis of Discrete Data provides an introduction to cur rent statistical methods for analyzing discrete response data. The book can be used as a course text for graduate students and as a reference for researchers who analyze discrete data. The book's mathematical prereq uisites are linear algebra and elementary advanced calculus. It assumes a basic statistics course which includes some decision theory, and knowledge of classical linear model theory for continuous response data. Problems are provided at the end of each chapter to give the reader an opportunity to ap ply the methods in the text, to explore extensions of the material covered, and to analyze data with discrete responses. In the text examples, and in the problems, we have sought to include interesting data sets from a wide variety of fields including political science, medicine, nuclear engineering, sociology, ecology, cancer research, library science, and biology. Although there are several texts available on discrete data analysis, we felt there was a need for a book which incorporated some of the myriad recent research advances. Our motivation was to introduce the subject by emphasizing its ties to the well-known theories of linear models, experi mental design, and regression diagnostics, as well as to describe alterna tive methodologies (Bayesian, smoothing, etc. ); the latter are based on the premise that external information is available. These overriding goals, to gether with our own experiences and biases, have governed our choice of topics.
Author : Shein-Chung Chow
Publisher : CRC Press
ISBN 13 : 135111025X
Total Pages : 4031 pages
Book Rating : 4.3/5 (511 download)
Download or read book Encyclopedia of Biopharmaceutical Statistics - Four Volume Set written by Shein-Chung Chow and published by CRC Press. This book was released on 2018-09-03 with total page 4031 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the publication of the first edition in 2000, there has been an explosive growth of literature in biopharmaceutical research and development of new medicines. This encyclopedia (1) provides a comprehensive and unified presentation of designs and analyses used at different stages of the drug development process, (2) gives a well-balanced summary of current regulatory requirements, and (3) describes recently developed statistical methods in the pharmaceutical sciences. Features of the Fourth Edition: 1. 78 new and revised entries have been added for a total of 308 chapters and a fourth volume has been added to encompass the increased number of chapters. 2. Revised and updated entries reflect changes and recent developments in regulatory requirements for the drug review/approval process and statistical designs and methodologies. 3. Additional topics include multiple-stage adaptive trial design in clinical research, translational medicine, design and analysis of biosimilar drug development, big data analytics, and real world evidence for clinical research and development. 4. A table of contents organized by stages of biopharmaceutical development provides easy access to relevant topics. About the Editor: Shein-Chung Chow, Ph.D. is currently an Associate Director, Office of Biostatistics, U.S. Food and Drug Administration (FDA). Dr. Chow is an Adjunct Professor at Duke University School of Medicine, as well as Adjunct Professor at Duke-NUS, Singapore and North Carolina State University. Dr. Chow is the Editor-in-Chief of the Journal of Biopharmaceutical Statistics and the Chapman & Hall/CRC Biostatistics Book Series and the author of 28 books and over 300 methodology papers. He was elected Fellow of the American Statistical Association in 1995.
Author : Sin-Ho Jung
Publisher : CRC Press
ISBN 13 : 1439871868
Total Pages : 236 pages
Book Rating : 4.4/5 (398 download)
Download or read book Randomized Phase II Cancer Clinical Trials written by Sin-Ho Jung and published by CRC Press. This book was released on 2013-05-02 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: In cancer research, a traditional phase II trial is designed as a single-arm trial that compares the experimental therapy to a historical control. This simple trial design has led to several adverse issues, including increased false positivity of phase II trial results and negative phase III trials. To rectify these problems, oncologists and biosta
Download or read book Exact Tests and Exact Confidence Intervals for the Ratio of Two Binomial Proportions written by and published by . This book was released on 2003 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Testing for the ratio of binomial proportions (often called the relative risk) is quite common in clinical trials and epidemiology study or more generally in the pharmaceutical setting. Although this is an easy problem when we have large sample sizes, it becomes more challenging when sample sizes are small to moderate. In this type of situations asymptotic methods often lead to tests that are very liberal, i.e., have a very high Type I error. Hence one has to resort to exact methods. Although one can use Fisher's exact test if testing for unity relative risk, for the more general problem of testing for non-unity relative risk the only form of exact inference possible is by using exact unconditional tests. The standard exact unconditional test used for this problem is quite conservative, i.e., results in tests with very low power. We have proposed a test for this problem (based on the method suggested by Berger and Boos) which not only maintains the nominal size but is uniformly more powerful than the standard test (in most of the cases). A detailed comparison has been done between the two tests and various examples (from the pharmaceutical setting) have been used to compare the two methods. Along with testing for the relative risk, researchers are also interested in obtaining confidence intervals for this parameter. Again due to small sample sizes the asymptotic methods often result in intervals that have poor coverage. We compare the confidence intervals generated from inverting the standard exact test and the test that we are proposing. Since both these tests are exact they result in intervals that are guaranteed to maintain the nominal coverage. We show that the standard intervals are quite conservative and our intervals in general have shorter lengths and coverage probabilities closer to the nominal coverage. Although exact tests are desirable, it is often hard to implement them in practice because of computational complexities. In the last Chapter we compare th.
Author : Julian Louis Epstein
Publisher :
ISBN 13 :
Total Pages : 122 pages
Book Rating : 4.E/5 ( download)
Download or read book Upper Confidence Limits on the Product of Two Binomial Parameters written by Julian Louis Epstein and published by . This book was released on 1967 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : John Crowley
Publisher : CRC Press
ISBN 13 : 1439862001
Total Pages : 661 pages
Book Rating : 4.4/5 (398 download)
Download or read book Handbook of Statistics in Clinical Oncology, Third Edition written by John Crowley and published by CRC Press. This book was released on 2012-03-26 with total page 661 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many new challenges have arisen in the area of oncology clinical trials. New cancer therapies are often based on cytostatic or targeted agents, which pose new challenges in the design and analysis of all phases of trials. The literature on adaptive trial designs and early stopping has been exploding. Inclusion of high-dimensional data and imaging techniques have become common practice, and statistical methods on how to analyse such data have been refined in this area. A compilation of statistical topics relevant to these new advances in cancer research, this third edition of Handbook of Statistics in Clinical Oncology focuses on the design and analysis of oncology clinical trials and translational research. Addressing the many challenges that have arisen since the publication of its predecessor, this third edition covers the newest developments involved in the design and analysis of cancer clinical trials, incorporating updates to all four parts: Phase I trials: Updated recommendations regarding the standard 3 + 3 and continual reassessment approaches, along with new chapters on phase 0 trials and phase I trial design for targeted agents. Phase II trials: Updates to current experience in single-arm and randomized phase II trial designs. New chapters include phase II designs with multiple strata and phase II/III designs. Phase III trials: Many new chapters include interim analyses and early stopping considerations, phase III trial designs for targeted agents and for testing the ability of markers, adaptive trial designs, cure rate survival models, statistical methods of imaging, as well as a thorough review of software for the design and analysis of clinical trials. Exploratory and high-dimensional data analyses: All chapters in this part have been thoroughly updated since the last edition. New chapters address methods for analyzing SNP data and for developing a score based on gene expression data. In addition, chapters on risk calculators and forensic bioinformatics have been added. Accessible to statisticians and oncologists interested in clinical trial methodology, the book is a single-source collection of up-to-date statistical approaches to research in clinical oncology.
Author :
Publisher :
ISBN 13 :
Total Pages : 516 pages
Book Rating : 4.E/5 ( download)
Download or read book Technical Reports Awareness Circular : TRAC. written by and published by . This book was released on 1989 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Malay Ghosh
Publisher : John Wiley & Sons
ISBN 13 : 1118165918
Total Pages : 504 pages
Book Rating : 4.1/5 (181 download)
Download or read book Sequential Estimation written by Malay Ghosh and published by John Wiley & Sons. This book was released on 2011-09-09 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: The only comprehensive guide to the theory and practice of one oftoday's most important probabilistic techniques The past 15 years have witnessed many significant advances insequential estimation, especially in the areas of three-stage andnonparametric methodology. Yet, until now, there were no referencesdevoted exclusively to this rapidly growing statisticalfield. Sequential Estimation is the first, single-source guide to thetheory and practice of both classical and modern sequentialestimation techniques--including parametric and nonparametricmethods. Researchers in sequential analysis will appreciate theunified, logically integrated treatment of the subject, as well ascoverage of important contemporary procedures not covered in moregeneral sequential analysis texts, such as: * Shrinkage estimation * Empirical and hierarchical Bayes procedures * Multistage sampling and accelerated sampling procedures * Time-sequential estimation * Sequential estimation in finite population sampling * Reliability estimation and capture-recapture methodologiesleading to sequential tagging schemes An indispensable resource for researchers in sequential analysis,Sequential Estimation is an ideal graduate-level text as well.
Author :
Publisher :
ISBN 13 :
Total Pages : 294 pages
Book Rating : 4.:/5 (31 download)
Download or read book Research in Progress written by and published by . This book was released on 1987 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Stephen L. George
Publisher : CRC Press
ISBN 13 : 1315354330
Total Pages : 374 pages
Book Rating : 4.3/5 (153 download)
Download or read book Cancer Clinical Trials written by Stephen L. George and published by CRC Press. This book was released on 2016-08-19 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Clinical Trials: Current and Controversial Issues in Design and Analysis provides statisticians with an understanding of the critical challenges currently encountered in oncology trials. Well-known statisticians from academic institutions, regulatory and government agencies (such as the U.S. FDA and National Cancer Institute), and the pharmaceutical industry share their extensive experiences in cancer clinical trials and present examples taken from actual trials. The book covers topics that are often perplexing and sometimes controversial in cancer clinical trials. Most of the issues addressed are also important for clinical trials in other settings. After discussing general topics, the book focuses on aspects of early and late phase clinical trials. It also explores personalized medicine, including biomarker-based clinical trials, adaptive clinical trial designs, and dynamic treatment regimes.
