Cone Beam X Ray Phase Contrast Tomography For The Observation Of Single Cells In Whole Organs

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Cone-beam x-ray phase-contrast tomography for the observation of single cells in whole organs

Author : Martin Krenkel
Publisher : Göttingen University Press
ISBN 13 : 3863952510
Total Pages : 238 pages
Book Rating : 4.8/5 (639 download)

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Book Synopsis Cone-beam x-ray phase-contrast tomography for the observation of single cells in whole organs by : Martin Krenkel

Download or read book Cone-beam x-ray phase-contrast tomography for the observation of single cells in whole organs written by Martin Krenkel and published by Göttingen University Press. This book was released on 2015 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: X-ray imaging enables the nondestructive investigation of interior structures in otherwise opaque samples. In particular the use of computed tomography (CT) allows for arbitrary virtual slices through the object and 3D information about intricate structures can be obtained. However, when it comes to image very small structures like single cells, the classical CT approach is limited by the weak absorption of soft-tissue. The use of phase information, encoded in measureable intensity images by free-space propagation of coherent x-rays, allows a huge increase in contrast, which enables 3D reconstructions at higher resolutions. In this work the application of propagation-based phase-contrast tomography to lung tissue samples is demonstrated in close to in vivo conditions. Reconstructions of the lung structure of whole mice at down to 5 μm resolution are obtained at a selfbuilt CT setup, which is based on a liquid-metal jet x-ray source. To reach even higher resolutions, synchrotron radiation in combination with suitable holographic phase-retrieval algorithms is employed. Due to optimized cone-beam geometry, field of view and resolution can be varied over a wide range of parameters, so that information on different length scales can be achieved, covering several millimeters field of view down to a 3D resolution of 50 nm. Thus, the sub-cellular 3D imaging of single cells embedded in large pieces of tissue is enabled, which paves the way for future biomedical research.

Nanoscale Photonic Imaging

Author : Tim Salditt
Publisher : Springer Nature
ISBN 13 : 3030344134
Total Pages : 634 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Nanoscale Photonic Imaging by : Tim Salditt

Download or read book Nanoscale Photonic Imaging written by Tim Salditt and published by Springer Nature. This book was released on 2020-06-09 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book, edited and authored by a team of world-leading researchers, provides a broad overview of advanced photonic methods for nanoscale visualization, as well as describing a range of fascinating in-depth studies. Introductory chapters cover the most relevant physics and basic methods that young researchers need to master in order to work effectively in the field of nanoscale photonic imaging, from physical first principles, to instrumentation, to mathematical foundations of imaging and data analysis. Subsequent chapters demonstrate how these cutting edge methods are applied to a variety of systems, including complex fluids and biomolecular systems, for visualizing their structure and dynamics, in space and on timescales extending over many orders of magnitude down to the femtosecond range. Progress in nanoscale photonic imaging in Göttingen has been the sum total of more than a decade of work by a wide range of scientists and mathematicians across disciplines, working together in a vibrant collaboration of a kind rarely matched. This volume presents the highlights of their research achievements and serves as a record of the unique and remarkable constellation of contributors, as well as looking ahead at the future prospects in this field. It will serve not only as a useful reference for experienced researchers but also as a valuable point of entry for newcomers.

3d virtual histology of neuronal tissue by propagation-based x-ray phase-contrast tomography

Author : Mareike Töpperwien
Publisher : Göttingen University Press
ISBN 13 : 3863953649
Total Pages : 286 pages
Book Rating : 4.8/5 (639 download)

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Book Synopsis 3d virtual histology of neuronal tissue by propagation-based x-ray phase-contrast tomography by : Mareike Töpperwien

Download or read book 3d virtual histology of neuronal tissue by propagation-based x-ray phase-contrast tomography written by Mareike Töpperwien and published by Göttingen University Press. This book was released on 2018 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Deciphering the three-dimensional (3d) cytoarchitecture of neuronal tissue is an important step towards understanding the connection between tissue function and structure and determining relevant changes in neurodegenerative diseases. The gold standard in pathology is histology, in which the tissue is examined under a light microscope after serial sectioning and subsequent staining. It is an invasive and labor-intensive technique which is prone to artifacts due to the slicing procedure. While it provides excellent results on the 2d slices, the 3d anatomy can only be determined after aligning the individual sections, leading to a non-isotropic resolution within the tissue. X-ray computed tomography (CT) offers a promising alternative due to its potential resolution and large penetration depth which allows for non-invasive imaging of the sample's 3d density distribution. In classical CT, contrast formation is based on absorption of the x-rays as they pass through the sample. However, weakly absorbing samples like soft tissue from the central nervous system give nearly no contrast. By exploiting the much stronger phase shifts for contrast formation, which the sample induces in a (partially) coherent wavefront, it can be substantially increased. During free-space propagation behind the sample, these phase shifts are converted to a measurable intensity image by interference of the disturbed wave fronts. In this thesis, 3d virtual histology is performed by means of propagation-based x-ray phase-contrast tomography on tissue from the central nervous system of humans and mice. A combination of synchrotron-based and laboratory setups is used to visualize the 3d density distribution on varying lengths scales from the whole organ down to single cells. By comparing and optimizing different preparation techniques and phase-retrieval approaches, even sub-cellular resolution can be reached in mm-sized tissue blocks. The development of an automatic cell segmentation workflow provides access to the 3d cellular distribution within the tissue, enabling the quantification of the cellular arrangement and allowing for extensive statistical analysis based on several thousands to millions of cells. This paves the way for biomedical studies aimed at changes in cellular distribution, e.g., in the course of neurodegenerative diseases such as multiple sclerosis, Alzheimer's disease or ischemic stroke.

Biomedical Imaging

Author : Tim Salditt
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110426692
Total Pages : 358 pages
Book Rating : 4.1/5 (14 download)

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Book Synopsis Biomedical Imaging by : Tim Salditt

Download or read book Biomedical Imaging written by Tim Salditt and published by Walter de Gruyter GmbH & Co KG. This book was released on 2017-10-23 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering both physical as well as mathematical and algorithmic foundations, this graduate textbook provides the reader with an introduction into modern biomedical imaging and image processing and reconstruction. These techniques are not only based on advanced instrumentation for image acquisition, but equally on new developments in image processing and reconstruction to extract relevant information from recorded data. To this end, the present book offers a quantitative treatise of radiography, computed tomography, and medical physics. Contents Introduction Digital image processing Essentials of medical x-ray physics Tomography Radiobiology, radiotherapy, and radiation protection Phase contrast radiography Object reconstruction under nonideal conditions

Multiscale X-Ray Analysis of Biological Cells and Tissues by Scanning Diffraction and Coherent Imaging

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Author : Jan-David Nicolas
Publisher : Göttingen University Press
ISBN 13 : 3863954203
Total Pages : 183 pages
Book Rating : 4.8/5 (639 download)

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Book Synopsis Multiscale X-Ray Analysis of Biological Cells and Tissues by Scanning Diffraction and Coherent Imaging by : Jan-David Nicolas

Download or read book Multiscale X-Ray Analysis of Biological Cells and Tissues by Scanning Diffraction and Coherent Imaging written by Jan-David Nicolas and published by Göttingen University Press. This book was released on 2019 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the intricate details of muscle contraction has a long-standing tradition in biophysical research. X-ray diffraction has been one of the key techniques to resolve the nanometer-sized molecular machinery involved in force generation. Modern, powerful X-ray sources now provide billions of X-ray photons in time intervals as short as microseconds, enabling fast time-resolved experiments that shed further light on the complex relationship between muscle structure and function. Another approach harnesses this power by repeatedly performing such an experiment at different locations in a sample. With millions of repeated exposures in a single experiment, X-ray diffraction can seamlessly be turned into a raster imaging method, neatly combining real- and reciprocal space information. This thesis has focused on the advancement of this scanning scheme and its application to soft biological tissue, in particular muscle tissue. Special emphasis was placed on the extraction of meaningful, quantitative structural parameters such as the interfilament distance of the actomyosin lattice in cardiac muscle. The method was further adapted to image biological samples on a range of scales, from isolated cells to millimeter-sized tissue sections. Due to the ‘photon-hungry’ nature of the technique, its full potential is often exploited in combination with full-field imaging techniques. From the vast set of microscopic tools available, coherent full-field X-ray imaging has proven to be particularly useful. This multimodal approach allows to correlate two- and three-dimensional images of cells and tissue with diffraction maps of structure parameters. With the set of tools developed in this thesis, scanning X-ray diffraction can now be efficiently used for the structural analysis of soft biological tissues with overarching future applications in biophysical and biomedical research.

Cone Beam Computed Tomography

Author : Chris C. Shaw
Publisher : Taylor & Francis
ISBN 13 : 1439846278
Total Pages : 266 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Cone Beam Computed Tomography by : Chris C. Shaw

Download or read book Cone Beam Computed Tomography written by Chris C. Shaw and published by Taylor & Francis. This book was released on 2014-02-14 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conventional computed tomography (CT) techniques employ a narrow array of x-ray detectors and a fan-shaped x-ray beam to rotate around the patient to produce images of thin sections of the patient. Large sections of the body are covered by moving the patient into the rotating x-ray detector and x-ray source gantry. Cone beam CT is an alternative te

Total Marrow Irradiation

Author : Jeffrey Y. C. Wong
Publisher : Springer
ISBN 13 : 9783030386948
Total Pages : 0 pages
Book Rating : 4.3/5 (869 download)

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Book Synopsis Total Marrow Irradiation by : Jeffrey Y. C. Wong

Download or read book Total Marrow Irradiation written by Jeffrey Y. C. Wong and published by Springer. This book was released on 2021-03-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, written by a team of international experts, concisely reviews the rationale and clinical application of image-guided total marrow irradiation, a rapidly emerging area in radiation oncology and hematopoietic cell transplantation. The aim is to provide the practicing radiation oncologist, hematologist, medical physicist, and bone marrow transplant researcher with a fundamental understanding of key aspects and an appreciation of the increasing significance of total marrow irradiation as conditioning for bone marrow transplantation. Detailed attention is paid to the impacts of recent advances in radiation therapy technology, functional PET and MRI, and understanding of the response of bone marrow to radiation. Full consideration is also given to the ways in which technological advances in image-guided radiation therapy have created new opportunities to treat bone marrow transplant patients with limited transplant options due to advanced disease, age, or co-morbidities. Further topics covered include the ways in which cancer stem cells and the marrow microenvironment influence response to radiation therapy and the implementation of new-generation predictive radiobiologic factors in the clinic.

Coherent X-Ray Optics

Author : David Paganin
Publisher : Oxford University Press on Demand
ISBN 13 : 0198567286
Total Pages : 424 pages
Book Rating : 4.1/5 (985 download)

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Book Synopsis Coherent X-Ray Optics by : David Paganin

Download or read book Coherent X-Ray Optics written by David Paganin and published by Oxford University Press on Demand. This book was released on 2006-01-12 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: X-ray optics is undergoing a renaissance, which may be paralleled to that experienced by visible-light optics following the invention of the laser. The associated surge of activity in "coherent" x-ray optics has been documented in this monograph, the first of its type in the field.

X-ray waveguide optics

Author : Sarah Hoffmann-Urlaub
Publisher : Göttingen University Press
ISBN 13 : 3863953088
Total Pages : 134 pages
Book Rating : 4.8/5 (639 download)

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Book Synopsis X-ray waveguide optics by : Sarah Hoffmann-Urlaub

Download or read book X-ray waveguide optics written by Sarah Hoffmann-Urlaub and published by Göttingen University Press. This book was released on 2017 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern x-ray sources and analysis techniques such as lens less imaging combined with phase retrieval algorithms allow for resolving structure sizes in the nanometer range. For this purpose optics have to be employed, ensuring small focal spot dimensions simultaneously with high photon densities. Furthermore, the wave front behind the optics is required to be smooth enabling for high resolution imaging. Combining all these properties, x-ray waveguides are well suited to perform this task, since the intensity distribution behind the guide is restricted in two dimensions serving as a secondary quasi point-source without wave-front aberrations, showing also a high divergence, suitable for resolving fine features. Importantly, the radiation provided by the waveguide reveals a high degree of coherence, required by many imaging techniques. The waveguide itself consists of an air-filled channel embedded in a solid matrix; typical materials are silicon, germanium or quartz. While the entrance area is nano-sized, the channel length is in the millimeter-range, this way posing challenges to fabricate high aspect ratio geometries. Since the functioning of x-ray waveguides is based on the total reflection at small incident angles, the surface roughness of the channel walls must be as low as possible to avoid scattering and hence loss of intensity. To fulfill these demanding conditions, a process scheme involving spin-coating, electron beam lithography, wet development, reactive ion etching and wafer bonding is optimized within this work. To gain deeper insights into the principle of wave guiding finite difference simulations are performed, also opening access for advanced design considerations such as gratings, tapered and curved channels, or beamsplitters, enabling for constructing novel x-ray tools as for example time delay devices or interferometers. Waveguides in all geometries are tested at synchrotron sources, accomplishing new benchmarks in x-ray optical performance. Here, the x-ray beam leaving the channel, propagates out to a pixel array detector in the far-field region. From the recorded data the intensity distribution in the near-field directly behind the waveguide is reconstructed, revealing an outstanding agreement with the simulations and electron micrographs. Since the radiation field of the waveguide is well-characterized and also tunable to meet the requirements of both the measurement setup and the sample, they are suited of a broad field of applications in coherent x-ray imaging.

Springer Handbook of Microscopy

Author : Peter W. Hawkes
Publisher : Springer Nature
ISBN 13 : 3030000699
Total Pages : 1561 pages
Book Rating : 4.0/5 (3 download)

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Book Synopsis Springer Handbook of Microscopy by : Peter W. Hawkes

Download or read book Springer Handbook of Microscopy written by Peter W. Hawkes and published by Springer Nature. This book was released on 2019-11-02 with total page 1561 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book features reviews by leading experts on the methods and applications of modern forms of microscopy. The recent awards of Nobel Prizes awarded for super-resolution optical microscopy and cryo-electron microscopy have demonstrated the rich scientific opportunities for research in novel microscopies. Earlier Nobel Prizes for electron microscopy (the instrument itself and applications to biology), scanning probe microscopy and holography are a reminder of the central role of microscopy in modern science, from the study of nanostructures in materials science, physics and chemistry to structural biology. Separate chapters are devoted to confocal, fluorescent and related novel optical microscopies, coherent diffractive imaging, scanning probe microscopy, transmission electron microscopy in all its modes from aberration corrected and analytical to in-situ and time-resolved, low energy electron microscopy, photoelectron microscopy, cryo-electron microscopy in biology, and also ion microscopy. In addition to serving as an essential reference for researchers and teachers in the fields such as materials science, condensed matter physics, solid-state chemistry, structural biology and the molecular sciences generally, the Springer Handbook of Microscopy is a unified, coherent and pedagogically attractive text for advanced students who need an authoritative yet accessible guide to the science and practice of microscopy.

Medical Imaging Systems

Author : Andreas Maier
Publisher : Springer
ISBN 13 : 3319965204
Total Pages : 263 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Medical Imaging Systems by : Andreas Maier

Download or read book Medical Imaging Systems written by Andreas Maier and published by Springer. This book was released on 2018-08-02 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book gives a complete and comprehensive introduction to the fields of medical imaging systems, as designed for a broad range of applications. The authors of the book first explain the foundations of system theory and image processing, before highlighting several modalities in a dedicated chapter. The initial focus is on modalities that are closely related to traditional camera systems such as endoscopy and microscopy. This is followed by more complex image formation processes: magnetic resonance imaging, X-ray projection imaging, computed tomography, X-ray phase-contrast imaging, nuclear imaging, ultrasound, and optical coherence tomography.

MicroComputed Tomography

Author : Stuart R. Stock
Publisher : CRC Press
ISBN 13 : 1420058770
Total Pages : 366 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis MicroComputed Tomography by : Stuart R. Stock

Download or read book MicroComputed Tomography written by Stuart R. Stock and published by CRC Press. This book was released on 2008-12-23 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to the availability of commercial laboratory systems and the emergence of user facilities at synchrotron radiation sources, studies of microcomputed tomography or microCT have increased exponentially. MicroComputed Technology provides a complete introduction to the technology, describing how to use it effectively and understand its results. The first part of the book focuses on methodology, covering experimental methods, data analysis, and visualization approaches. The second part addresses various microCT applications, including porous solids, microstructural evolution, soft tissue studies, multimode studies, and indirect analyses. The author presents a sufficient amount of fundamental material so that those new to the field can develop a relative understanding of how to design their own microCT studies. One of the first full-length references dedicated to microCT, this book provides an accessible introduction to field, supplemented with application examples and color images.

Computed Tomography

Author : Willi A. Kalender
Publisher : John Wiley & Sons
ISBN 13 : 3895786446
Total Pages : 372 pages
Book Rating : 4.8/5 (957 download)

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Book Synopsis Computed Tomography by : Willi A. Kalender

Download or read book Computed Tomography written by Willi A. Kalender and published by John Wiley & Sons. This book was released on 2011-07-07 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book offers a comprehensive and user-oriented description of the theoretical and technical system fundamentals of computed tomography (CT) for a wide readership, from conventional single-slice acquisitions to volume acquisition with multi-slice and cone-beam spiral CT. It covers in detail all characteristic parameters relevant for image quality and all performance features significant for clinical application. Readers will thus be informed how to use a CT system to an optimum depending on the different diagnostic requirements. This includes a detailed discussion about the dose required and about dose measurements as well as how to reduce dose in CT. All considerations pay special attention to spiral CT and to new developments towards advanced multi-slice and cone-beam CT. For the third edition most of the contents have been updated and latest topics like dual source CT, dual energy CT, flat detector CT and interventional CT have been added. The enclosed CD-ROM again offers copies of all figures in the book and attractive case studies, including many examples from the most recent 64-slice acquisitions, and interactive exercises for image viewing and manipulation. This book is intended for all those who work daily, regularly or even only occasionally with CT: physicians, radiographers, engineers, technicians and physicists. A glossary describes all the important technical terms in alphabetical order. The enclosed DVD again offers attractive case studies, including many examples from the most recent 64-slice acquisitions, and interactive exercises for image viewing and manipulation. This book is intended for all those who work daily, regularly or even only occasionally with CT: physicians, radiographers, engineers, technicians and physicists. A glossary describes all the important technical terms in alphabetical order.

Small Animal Imaging

Author : Fabian Kiessling
Publisher : Springer
ISBN 13 : 3319422022
Total Pages : 871 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Small Animal Imaging by : Fabian Kiessling

Download or read book Small Animal Imaging written by Fabian Kiessling and published by Springer. This book was released on 2017-05-22 with total page 871 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook is a practical guide to the use of small animal imaging in preclinical research that will assist in the choice of imaging modality and contrast agent and in study design, experimental setup, and data evaluation. All established imaging modalities are discussed in detail, with the assistance of numerous informative illustrations. While the focus of the new edition remains on practical basics, it has been updated to encompass a variety of emerging imaging modalities, methods, and applications. Additional useful hints are also supplied on the installation of a small animal unit, study planning, animal handling, and cost-effective performance of small animal imaging. Cross-calibration methods and data postprocessing are considered in depth. This new edition of Small Animal Imaging will be an invaluable aid for researchers, students, and technicians involved in research into and applications of small animal imaging.

Handbook of Single-Molecule Biophysics

Author : Peter Hinterdorfer
Publisher : Springer Science & Business Media
ISBN 13 : 0387764976
Total Pages : 634 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Handbook of Single-Molecule Biophysics by : Peter Hinterdorfer

Download or read book Handbook of Single-Molecule Biophysics written by Peter Hinterdorfer and published by Springer Science & Business Media. This book was released on 2009-12-24 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook describes experimental techniques to monitor and manipulate individual biomolecules, including fluorescence detection, atomic force microscopy, and optical and magnetic trapping. It includes single-molecule studies of physical properties of biomolecules such as folding, polymer physics of protein and DNA, enzymology and biochemistry, single molecules in the membrane, and single-molecule techniques in living cells.

The Handbook of Medical Image Perception and Techniques

Author : Ehsan Samei
Publisher : Cambridge University Press
ISBN 13 : 1108168817
Total Pages : 1478 pages
Book Rating : 4.1/5 (81 download)

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Book Synopsis The Handbook of Medical Image Perception and Techniques by : Ehsan Samei

Download or read book The Handbook of Medical Image Perception and Techniques written by Ehsan Samei and published by Cambridge University Press. This book was released on 2018-12-13 with total page 1478 pages. Available in PDF, EPUB and Kindle. Book excerpt: A state-of-the-art review of key topics in medical image perception science and practice, including associated techniques, illustrations and examples. This second edition contains extensive updates and substantial new content. Written by key figures in the field, it covers a wide range of topics including signal detection, image interpretation and advanced image analysis (e.g. deep learning) techniques for interpretive and computational perception. It provides an overview of the key techniques of medical image perception and observer performance research, and includes examples and applications across clinical disciplines including radiology, pathology and oncology. A final chapter discusses the future prospects of medical image perception and assesses upcoming challenges and possibilities, enabling readers to identify new areas for research. Written for both newcomers to the field and experienced researchers and clinicians, this book provides a comprehensive reference for those interested in medical image perception as means to advance knowledge and improve human health.

X-Ray Computed Tomography in Biomedical Engineering

Author : Robert Cierniak
Publisher : Springer Science & Business Media
ISBN 13 : 0857290274
Total Pages : 320 pages
Book Rating : 4.8/5 (572 download)

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Book Synopsis X-Ray Computed Tomography in Biomedical Engineering by : Robert Cierniak

Download or read book X-Ray Computed Tomography in Biomedical Engineering written by Robert Cierniak and published by Springer Science & Business Media. This book was released on 2011-01-06 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computed Tomography gives a detailed overview of various aspects of computed tomography. It discusses X-ray CT tomography from a historical point of view, the design and physical operating principles of computed tomography apparatus, the algorithms of image reconstruction and the quality assessment criteria of tomography scanners. Algorithms of image reconstruction from projections, a crucial problem in medical imaging, are considered in depth. The author gives descriptions of the reconstruction methods related to tomography scanners with a parallel X-ray beam, trough solutions with fan-shaped beam and successive modifications of spiral scanners. Computed Tomography contains a dedicated chapter for those readers who are interested in computer simulations based on studies of reconstruction algorithms. The information included in this chapter will enable readers to create a simulation environment in which virtual tomography projections can be obtained in all basic projection systems. This monograph is a valuable study on computed tomography that will be of interest to advanced students and researchers in the fields of biomedical engineering, medical electronics, computer science and medicine.