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Conduite Dessais Cliniques Pediatriques Dans Les Troubles Du Spectre De Lautisme
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Book Synopsis Conduite d'essais cliniques pédiatriques dans les troubles du spectre de l'autisme by : Emilie Boudet
Download or read book Conduite d'essais cliniques pédiatriques dans les troubles du spectre de l'autisme written by Emilie Boudet and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Les troubles du spectre de l'autisme (TSA) sont des troubles d'origine neurodéveloppementaux caractérisés par un déficit de la communication et des interactions sociales et par le caractère restreint et répétitif des comportements et des centres d'intérêts. Ce handicap touche environ 1% de la population mondiale, apparait durant la petite enfance et se présente sous différentes formes cliniques. Du fait de la diversité des formes cliniques, la prise en charge des personnes présentant ce trouble est personnalisée et s'articule autour de thérapies comportementales, développementales et éducatives ainsi que de traitements médicamenteux pour le management des symptômes associés aux TSA. L'origine multifactorielle de ce trouble représente une difficulté dans le développement de traitements médicamenteux, c'est pourquoi aucun traitement de fond n'est disponible à ce jour. Cependant, un enjeu majeur des promoteurs d'essais cliniques est le développement d'un traitement permettant une amélioration de la sociabilisation, l'apprentissage et le quotidien de ces personnes. Néanmoins, le développement clinique d'un médicament dans l'autisme se heurte à des problématiques. Les difficultés rencontrées peuvent être le fruit des réglementations applicables aux essais cliniques, de la pathologie ou bien des différences culturelles entre les pays. Les promoteurs doivent donc anticiper ces problématiques et mettre en place des solutions, qui sont le plus souvent le fruit d'une collaboration entre associations de patients, centres investigateurs et promoteurs.
Book Synopsis Mesure de l'efficacité clinique d'une intervention précoce dans une population d'enfants avec un Trouble du Spectre de l'Autisme by : Marie-Maude Geoffray
Download or read book Mesure de l'efficacité clinique d'une intervention précoce dans une population d'enfants avec un Trouble du Spectre de l'Autisme written by Marie-Maude Geoffray and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intervenir précocement pour diminuer la sévérité du Trouble du Spectre de l'Autisme (TSA) est à ce jour une évidence. En revanche, le type d'intervention précoce à appliquer ne fait pas consensus . Certaines interventions montrent une efficacité d'intensité faible à modérée dans des essais randomisés contrôlés. Mais ces derniers comportent de nombreux biais méthodologiques qui remettent en question la validité du résultat. Nous avons fait l'hypothèse qu'une intervention précoce avec le modèle de Denver (Early Start Denver Model-ESDM) permettrait de diminuer la sévérité de la symptomatologie d'enfants avec TSA âgés de moins de 3 ans. Dans l'étude pilote, l'objectif était d'évaluer l'effet d'une intervention ESDM 12 heures par semaine pendant 1 an dans une population de 19 enfants avec TSA. Le résultat montrait une amélioration significative du développement global avant après intervention. La taille d'effet en langage réceptif était la plus importante avec un d de Cohen à 0.72. Ces résultats étaient comparables avec ceux d'études publiées précédemment. La majorité des professionnels et des parents étaient satisfaits de cette intervention. L'adhérence au traitement en termes de dose était de 8.3±1.2 heures au lieu de 12 heures par semaine dans cette étude pilote. Cette diminution de dose était majoritairement due à l'absence des professionnels. Nous discutons, ici, le choix de notre critère de jugement principal pour mesurer l'efficacité clinique réelle de l'intervention. Ce choix était difficile du fait du manque d'outils qui mesurent avec précision le changement dans la symptomatologie ou le handicap dans le TSA . Pour confirmer ou infirmer notre hypothèse, un essai randomisé contrôlé multicentrique comparant 2 bras en parallèle a été mis en place. Le groupe expérimental recevait une intervention ESDM, conduite majoritairement par une équipe pluridisciplinaire, 12 heures par semaine, pendant 2 ans. Le groupe contrôle recevait les interventions habituellement proposées dans la communauté. L'essai a été conçu pour avoir une puissance élevée et être à haut niveau de preuve selon les recommandations Cochrane . Nous avons pour cela mesuré le nombre nécessaire de sujet de notre population à partir d'une différence de 15 points à l'échelle de Mullen entre nos deux groupes, un risque alpha de 0,5 et un risque bêta à 90%. Étant limités par le nombre de places disponibles en intervention ESDM, nous avons mis en place une randomisation 1:2. La phase d'inclusion s'est terminée en mars 2019. 61 enfants ont été inclus dans le groupe ESDM et 119 enfants dans le groupe contrôle. Nous discutons la validité interne et externe ainsi que la pertinence clinique selon les différents résultats possibles. Si nous montrons une efficacité, une étude coût-conséquence permettra une mesure de l'efficience de ce traitement. Une étude de suivi a par ailleurs débuté et mesurera l'effet à 5 ans, d'une intervention ESDM précocement reçue, sur la symptomatologie TSA et le niveau scolaire des enfants. Il est bien évidemment essentiel de mesurer l'efficacité clinique et l'efficience à long terme des interventions mais la recherche interventionnelle implique également d'autres mesures et observations. Ainsi, la connaissance des facteurs médiateurs de l'effet de l'intervention, comme celle des facteurs modérateurs permettra d'aller vers des interventions personnalisées, qui agissent précisément sur les processus physiopathologiques impliqués dans le TSA. Une meilleure connaissance de ces facteurs mais aussi de tous les potentiels obstacles ou facilitateurs au transfert dans d'autres contextes de l'intervention permettra de plus de développer des interventions transférables et durables. Nous concluons sur l'importance de prévoir des temps de phase pilote suffisants pour estimer les différents facteurs impliqués et modifier l'intervention initialement prévue si nécessaire, avant de réaliser des essais d'efficacité ou d'efficience coûteux.
Book Synopsis The TEACCH Approach to Autism Spectrum Disorders by : Gary B. Mesibov
Download or read book The TEACCH Approach to Autism Spectrum Disorders written by Gary B. Mesibov and published by Springer Science & Business Media. This book was released on 2010-02-23 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: - Professionals can be trained in the program and its methods - Translates scientific knowledge so that practitioners and parents can easily understand the current state of knowledge - Offers strategies that can be tailored to an individual's unique developmental and functional level - Advises parents on how to become involved in all phases of intervention as collaborators, co-therapists, and advocates. - Details how the program can be introduced and adapted for individuals of all ages, from preschooler to adult
Book Synopsis Handbook of (central) Auditory Processing Disorder: Auditory neuroscience and diagnosis by : Frank E. Musiek
Download or read book Handbook of (central) Auditory Processing Disorder: Auditory neuroscience and diagnosis written by Frank E. Musiek and published by Plural Publishing. This book was released on 2007 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume II covers rehabilitative and professional issues, detailing practical intervention strategies for children and adults. The chapters in this volume cover auditory neuroscience and acoustic foundations of intervention, evidence-based practice, multidisciplinary approaches, and emerging and future directions in intervention.
Book Synopsis An Early Start for Your Child with Autism by : Sally J. Rogers
Download or read book An Early Start for Your Child with Autism written by Sally J. Rogers and published by Guilford Press. This book was released on 2012-05-21 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents strategies for helping children with autism interact with others and achieve their potential, covering such areas as back-and-forth interactions, nonverbal communication, and imitation.
Download or read book ADI-R written by Michael Rutter and published by . This book was released on 2013 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Oral Speech Mechanism Screening Examination (OSMSE) by : Kenneth O. St. Louis
Download or read book Oral Speech Mechanism Screening Examination (OSMSE) written by Kenneth O. St. Louis and published by . This book was released on 1981 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although speech-language pathologists are expected to be able to administer and interpret oral examinations, there are currently no screening tests available that provide careful administration instructions and data for intra-examiner and inter-examiner reliability. The Oral Speech Mechanism Screening Examination (OSMSE) is designed primarily for use by clinical speech-language pathologists. The examination could also serve, however, as a useful tool for oral myofunctional therapists, as well as physical therapists, dentists, and orthodontists interested specifically in speech. It is reliable, relatively easy and quick to administer, and appropriate for children and adults in either diagnostic or therapy settings. The OSMSE is intended to assess those anatomical structures and physiological functions that are most often considered to be potentially related to speech or language disorders. Structural and/or functional judgments included are organized on the OSMSE test form under categories of: lips, tongue, jaw, teeth, hard palate, soft palate, pharynx, breathing, and diadochokinesis. Results of a preliminary study with normal speaking subjects indicated that the OSMSE had satisfactory intra- and inter-examiner reliability after minimal training. The time required to administer the examination typically ranged from 5 to 10 minutes. (Author/GK)
Book Synopsis Gender Issues and AD/HD by : Patricia O. Quinn
Download or read book Gender Issues and AD/HD written by Patricia O. Quinn and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bringing together many highly regarded specialists in the field of AD/HD, Drs. Nadeau and Quinn have organized an in-depth resource for clinicians. Several important topics unique to women that have received little attention elsewhere are addressed, including the need to rethink DSM-IV diagnostic criteria, the impact of hormones upon AD/HD in women, the use of medications during pregnancy, and the range of coexisting conditions that complicate and often mask AD/HD in women.
Book Synopsis Phonology for Communication Disorders by : Martin J. Ball
Download or read book Phonology for Communication Disorders written by Martin J. Ball and published by Psychology Press. This book was released on 2014-02-25 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook describes the approaches to phonology that are most relevant to communication disorders. It examines schools of thought in theoretical phonology, and their relevance to description, explanation and remediation in the clinical context. A recurring theme throughout the book is the distinction between phonological theories that attempt elegant, parsimonious descriptions of phonological data, and those that attempt to provide a psycholinguistic model of speech production and perception. This book introduces all the relevant areas of phonology to the students and practitioners of speech-language pathology and is a companion volume to the authors’ Phonetics for Communication Disorders.
Book Synopsis Choral Pedagogy and the Older Singer by : Brenda Smith
Download or read book Choral Pedagogy and the Older Singer written by Brenda Smith and published by Plural Publishing. This book was released on 2012-03-30 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Thickening Fat written by May Friedman and published by Routledge. This book was released on 2019-08-30 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thickening Fat: Fat Bodies, Intersectionality, and Social Justice seeks to explore the multiple, variable, and embodied experiences of fat oppression and fat activisms. Moving beyond an analysis of fat oppression as singular, this book will aim to unpack the volatility of fat—the mutability of fat embodiments as they correlate with other embodied subjectivities, and the threshold where fat begins to be reviled, celebrated, or amended. In addition, Thickening Fat explores the full range of intersectional and liminal analyses that push beyond the simple addition of two or more subjectivities, looking instead at the complex alchemy of layered and unstable markers of difference and privilege. Cognizant that the concept of intersectionality has been filled out in a plurality of ways, Thickening Fat poses critical questions around how to render analysis of fatness intersectional and to thicken up intersectionality, where intersectionality is attenuated to the shifting and composite and material dimensions to identity, rather than reduced to an “add difference and stir” approach. The chapters in this collection ask what happens when we operationalize intersectionality in fat scholarship and politics, and we position difference at the centre and start of inquiry.
Book Synopsis Time and Memory by : Christoph Hoerl
Download or read book Time and Memory written by Christoph Hoerl and published by Oxford University Press. This book was released on 2001 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: The capacity to represent and think about time, and the capacity to recollect the past are two of the most fundamental and least understood aspects of human cognition and consciousness. This book throws new light on central issues in the study of the mind by uniting, for the first time,psychological and philosophical approaches dealing with the connection between temporal representation and memory. Fifteen specially written essays by leading psychologists and philosophers investigate the way in which time is represented in memory, and the role memory plays in our ability to reasonabout time. They offer insights into current theories of memory processes and of the mechanisms and cognitive abilities underlying temporal judgements, and draw out fundamental issues concerning the phenomenology and epistemology of memory and our understanding of time. The chapters are arrangedinto four sections, each focused on one area of current research: I Keeping Track of Time, and Temporal Representation; II Memory, Awareness and the Past; III Memory and Experience; IV Knowledge and the Past: The Epistemology and Metaphysics of Time. A general introduction gives an overview of thetopics discussed and makes explicit central themes which unify the different philosophical and psychological approaches.
Book Synopsis Controversial Therapies for Developmental Disabilities by : John W. Jacobson
Download or read book Controversial Therapies for Developmental Disabilities written by John W. Jacobson and published by CRC Press. This book was released on 2005-01-15 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: What approaches to early intervention, education, therapy, and remediation really help those with mental retardation and developmental disabilities improve their functioning and adaptation? This book brings together leading behavioral scientists and practitioners to focus light on the major controversies surrounding such questions.
Book Synopsis Yoga for Children with Autism Spectrum Disorders by : Dion Betts
Download or read book Yoga for Children with Autism Spectrum Disorders written by Dion Betts and published by Jessica Kingsley Publishers. This book was released on 2006-03-28 with total page 101 pages. Available in PDF, EPUB and Kindle. Book excerpt: Having successfully used yoga to combat the stress of their own busy lives, Dion and Stacey Betts discovered its potential for their son Joshua, who has Asperger Syndrome. This fully-illustrated book combines the authors' professional expertise with their experience of parenting, offering a range of gentle and fun yoga positions and breathing techniques that are effective in dealing with the increased levels of anxiety, disorientation and tactile sensitivity often found in children with autism spectrum disorders (ASDs). The authors give step-by-step descriptions of warming-up, strengthening, calming, and tension-releasing exercises that are suitable for reducing coping mechanisms, such as hand-flapping, and increasing muscle tone, muscle strength and body awareness. They also offer a range of short and long sequences that can be tailored to fit the needs of the individual child. Yoga for Children with Autism Spectrum Disorders is ideal for parents and caregivers who want to use simple yoga techniques to help children with ASDs overcome some of the symptoms of the disorder.
Book Synopsis Autistic Community and the Neurodiversity Movement by : Steven K. Kapp
Download or read book Autistic Community and the Neurodiversity Movement written by Steven K. Kapp and published by Springer Nature. This book was released on 2019-11-07 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book marks the first historical overview of the autism rights branch of the neurodiversity movement, describing the activities and rationales of key leaders in their own words since it organized into a unique community in 1992. Sandwiched by editorial chapters that include critical analysis, the book contains 19 chapters by 21 authors about the forming of the autistic community and neurodiversity movement, progress in their influence on the broader autism community and field, and their possible threshold of the advocacy establishment. The actions covered are legendary in the autistic community, including manifestos such as “Don’t Mourn for Us”, mailing lists, websites or webpages, conferences, issue campaigns, academic project and journal, a book, and advisory roles. These actions have shifted the landscape toward viewing autism in social terms of human rights and identity to accept, rather than as a medical collection of deficits and symptoms to cure.
Download or read book Toward Peace-building written by and published by . This book was released on 1987 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Communicating Partners by : James David MacDonald
Download or read book Communicating Partners written by James David MacDonald and published by Jessica Kingsley Publishers. This book was released on 2004 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annotation Communicating Partners offers an innovative approach to working with late talking children that focuses on developing relationships through mutual understanding. Providing detailed maps of what children and their life partners need to do to ensure effecti
