Computer Aided Design Of Antimicrobial Lipopeptides As Prospective Drug Candidates

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Computer-Aided Design of Antimicrobial Lipopeptides as Prospective Drug Candidates

Author : Jujjvarapu Satya Eswari
Publisher : CRC Press
ISBN 13 : 1351018299
Total Pages : 130 pages
Book Rating : 4.3/5 (51 download)

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Book Synopsis Computer-Aided Design of Antimicrobial Lipopeptides as Prospective Drug Candidates by : Jujjvarapu Satya Eswari

Download or read book Computer-Aided Design of Antimicrobial Lipopeptides as Prospective Drug Candidates written by Jujjvarapu Satya Eswari and published by CRC Press. This book was released on 2019-09-24 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: Increase in antibiotic resistance has forced researchers to develop new drugs against microorganisms. Lipopeptides are produced as secondary metabolites by some microorganisms. Computer-aided Design of Antimicrobial Lipopeptides as Prospective Drug Candidates provides the identification of novel ligands for different antimicrobial lipopeptides. Along with identification, it also provides some of the in silico drug design processes, namely homology modelling, molecular docking, QSAR studies, drug ADMET studies and pharmacophore studies to check the ligand-lipopeptide interaction. Some lipopeptides have shown anti-cancerous properties too, and this book discusses the required templates to design new drugs using computational techniques. Key Features: Focuses on the use lipopeptides as new antimicrobial compounds Presents the basics of in silico modelling for design and development of new drug molecules, and is therefore of interest to beginners in the field Provides a step-by-step process for identification of drug molecules and testing its efficacy in silico Couples with courses on patents and intellectual property rights

Microbial Surfactants

Author : R.Z. Sayyed
Publisher : CRC Press
ISBN 13 : 1000415651
Total Pages : 326 pages
Book Rating : 4.0/5 (4 download)

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Book Synopsis Microbial Surfactants by : R.Z. Sayyed

Download or read book Microbial Surfactants written by R.Z. Sayyed and published by CRC Press. This book was released on 2021-11-30 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biosurfactants are the surface-active biomolecules produced by microorganisms. Biosurfactants have gained commercial significance due to their unique properties, such as high surface activity, high specificity, low toxicity, tolerance to pH, temperature and ionic strength, biodegradability, excellent emulsifying and demulsifying ability, antimicrobial activity, ability to work under extreme conditions, and relative ease of preparation. Biosurfactants are used in several industries, including organic chemicals, petroleum, petrochemicals, mining, metallurgy (mainly bioleaching), agrochemicals, fertilizers, foods, beverages, cosmetics, pharmaceuticals and many others. The aim of this book is to highlight key aspects from basics to advanced concepts, classifications, production and applications in various fields such as agriculture, health, bioremediation, industries, pharmaceutical, oil recovery, environment, and nanotechnology. It also serves as an excellent and expansive literature on fermentation, recovery, genomics, and metagenomics of biosurfactant production. The book focuses on the biosurfactant production from bacteria, the diversity of biosurfactant producing bacteria, and industrial need of biosurfactant.

Biotechnological Applications in Human Health

Author : Provash Chandra Sadhukhan
Publisher : Springer Nature
ISBN 13 : 9811534535
Total Pages : 117 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Biotechnological Applications in Human Health by : Provash Chandra Sadhukhan

Download or read book Biotechnological Applications in Human Health written by Provash Chandra Sadhukhan and published by Springer Nature. This book was released on 2020-05-08 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book compiles selected articles presented at the International Conference on Biotechnology & Biological Sciences, BIOSPECTRUM 2017, organized by the Department of Biotechnology, University of Engineering & Management, Kolkata. Focusing on biotechnology-based analysis and intervention to address certain human diseases, the book includes a holistic discourse on disease profiling, molecular level analysis of diseases, and non-invasive medical interventions. It features articles on non-invasive treatment of iron deficiency anemia with iron nanoparticles; novel diagnosis methods based on microarray data; analysis using machine learning techniques like artificial neural network for early detection and treatment of cancer; and drug discovery for preventing the growth of human leukemic cells. Further, the book sheds light on in silico drug design using lipopeptides, and identifying the binding sites for their corresponding ligands. Presenting the concepts of the design of potent and safe antimicrobial compounds to fight multi drug resistant pathogens, it also includes interesting reviews on the design and development of various non-invasive methods, such as multi NIR wavelength probes to identify the risk areas in the diabetic foot at an early stage; and a low-cost cochlear implant prototype designed and developed from commercial off the-shelf components to empower the hearing impaired. The book appeals to students, academics and researchers in a wide range of subject areas, including biotechnology, life sciences, medicine and cancer research.

Computer-Aided Drug Design: Drug Discovery, Computational Modelling, and Artificial Intelligence

Author : Fei Ye
Publisher : Frontiers Media SA
ISBN 13 : 2889767841
Total Pages : 205 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Computer-Aided Drug Design: Drug Discovery, Computational Modelling, and Artificial Intelligence by : Fei Ye

Download or read book Computer-Aided Drug Design: Drug Discovery, Computational Modelling, and Artificial Intelligence written by Fei Ye and published by Frontiers Media SA. This book was released on 2022-08-17 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Endemic Plants: Experimental and Theoretical Insights Into Properties of Bioactive Metabolites With Therapeutic Potential

Author : Carolina Otero
Publisher : Frontiers Media SA
ISBN 13 : 2889718727
Total Pages : 67 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Endemic Plants: Experimental and Theoretical Insights Into Properties of Bioactive Metabolites With Therapeutic Potential by : Carolina Otero

Download or read book Endemic Plants: Experimental and Theoretical Insights Into Properties of Bioactive Metabolites With Therapeutic Potential written by Carolina Otero and published by Frontiers Media SA. This book was released on 2021-12-29 with total page 67 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Biogeography and Taxonomy of Honeybees

Author : Friedrich Ruttner
Publisher : Springer Science & Business Media
ISBN 13 : 3642726496
Total Pages : 292 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Biogeography and Taxonomy of Honeybees by : Friedrich Ruttner

Download or read book Biogeography and Taxonomy of Honeybees written by Friedrich Ruttner and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Honeybees are as small as flies or as large as hornets, nesting in nar row cavities of trees and rocks or in the open on large limbs of trees 30 m above ground. They occur in tropical zones and in the forests of the Ural mountains, they survive seven months of winter and even longer periods of drought and heat. Historically, they lived through a extended time of stagnation in the tropics from the mid-Tertiary, but then experienced an explosive evolution during the Pleistocene, re sulting in the conquest of huge new territories and the origin of two dozen subspecies in Apis mellifera. This vast geographic and ecologic diversification of the genus Apis was accompanied by a rich morphological variation, less on the level of species than at the lowest rank, the subspecies level. Variation being exclusively of a quantitative kind at this first step of speciation, tradi tional descriptive methods of systematics proved to be unsatisfactory, and honeybee taxonomy finally ended up in a confusing multitude of inadequately described units. Effective methods of morphometric-sta tistical analysis of honeybee popUlations, centered on limited areas, have been developed during the last decades. Only the numerical characterization of the populations, together with the description of behavior, shows the true geographic variability and will end current generalizations and convenient stereotypes.

Host Defense Peptides and Their Potential as Therapeutic Agents

Author : Richard M. Epand
Publisher : Springer
ISBN 13 : 3319329499
Total Pages : 323 pages
Book Rating : 4.3/5 (193 download)

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Book Synopsis Host Defense Peptides and Their Potential as Therapeutic Agents by : Richard M. Epand

Download or read book Host Defense Peptides and Their Potential as Therapeutic Agents written by Richard M. Epand and published by Springer. This book was released on 2016-05-06 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers an overview of our current understanding of host defense peptides and their potential for clinical applications as well as some of the obstacles to this. The chapters, written by leading experts in the field, detail the number and diversity of host defense peptides, and discuss the therapeutic potential not only of antibacterial, but also of antifungal, antiviral, plant antimicrobial and anticancer host defense peptides. The authors provide new insights into their mechanisms of action and their immunomodulatory properties, and review recent advances in the design of novel therapeutic molecules. Lastly, their potential to prevent preterm births and Staphylococcus aureus infections is highlighted. The book is of interest to researchers, industry and clinicians alike.

Penicillins and Cephalosporins

Author : Robert B. Morin
Publisher : Academic Press
ISBN 13 : 1483277194
Total Pages : 594 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Penicillins and Cephalosporins by : Robert B. Morin

Download or read book Penicillins and Cephalosporins written by Robert B. Morin and published by Academic Press. This book was released on 2014-05-10 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemistry and Biology of ?-Lactam Antibiotics, Volume 1: Penicillins and Cephalosporins provides information pertinent to the study of antibiotics containing the ?-lactam moiety. This book discusses the occurrence of a group of ?-lactam antibiotics structurally related to cephalosporin C. Organized into five chapters, this volume begins with an overview of the mechanism of action of ?-lactam antibiotics that caused many microbiologists to develop screening tools for the detection of the ?-lactam moiety. This text then discusses the discovery of the nocardicins, the thienamycins, and olivanic acids. Other chapters provide a summary of the essential penicillin sulfoxide chemistry that gave rise to many compounds. This book discusses as well the ability of chemists to predict the level of biological activity of a compound from knowledge of its structure through theoretical and physicochemical studies. The final chapter deals with quantitative structure–activity relationships. This book is a valuable resource for microbiologists, chemists, and scientists.

Biotechnological Applications in Human Health

Author : Provash Chandra Sadhukhan
Publisher : Springer
ISBN 13 : 9789811534522
Total Pages : 114 pages
Book Rating : 4.5/5 (345 download)

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Book Synopsis Biotechnological Applications in Human Health by : Provash Chandra Sadhukhan

Download or read book Biotechnological Applications in Human Health written by Provash Chandra Sadhukhan and published by Springer. This book was released on 2020-05-09 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book compiles selected articles presented at the International Conference on Biotechnology & Biological Sciences, BIOSPECTRUM 2017, organized by the Department of Biotechnology, University of Engineering & Management, Kolkata. Focusing on biotechnology-based analysis and intervention to address certain human diseases, the book includes a holistic discourse on disease profiling, molecular level analysis of diseases, and non-invasive medical interventions. It features articles on non-invasive treatment of iron deficiency anemia with iron nanoparticles; novel diagnosis methods based on microarray data; analysis using machine learning techniques like artificial neural network for early detection and treatment of cancer; and drug discovery for preventing the growth of human leukemic cells. Further, the book sheds light on in silico drug design using lipopeptides, and identifying the binding sites for their corresponding ligands. Presenting the concepts of the design of potent and safe antimicrobial compounds to fight multi drug resistant pathogens, it also includes interesting reviews on the design and development of various non-invasive methods, such as multi NIR wavelength probes to identify the risk areas in the diabetic foot at an early stage; and a low-cost cochlear implant prototype designed and developed from commercial off the-shelf components to empower the hearing impaired. The book appeals to students, academics and researchers in a wide range of subject areas, including biotechnology, life sciences, medicine and cancer research.

Nanocarrier Technologies

Author : M. Reza Mozafari
Publisher : Springer Science & Business Media
ISBN 13 : 1402050410
Total Pages : 238 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Nanocarrier Technologies by : M. Reza Mozafari

Download or read book Nanocarrier Technologies written by M. Reza Mozafari and published by Springer Science & Business Media. This book was released on 2006-09-24 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designed as an advanced survey of the field, this book describes the key research parameters of nanocarrier technologies. It is the first book with this topic. It comprises a collection of scientific articles from top research people in the field and provides an up-to-date source containing recent citation and bibliography. The book is an indispensable source of information for new researchers and scientists.

Antibiotic Discovery and Development

Author : Thomas J. Dougherty
Publisher : Springer Science & Business Media
ISBN 13 : 1461414008
Total Pages : 1119 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Antibiotic Discovery and Development by : Thomas J. Dougherty

Download or read book Antibiotic Discovery and Development written by Thomas J. Dougherty and published by Springer Science & Business Media. This book was released on 2011-12-18 with total page 1119 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers all aspects of the antibiotic discovery and development process through Phase II/III. The contributors, a group of highly experienced individuals in both academics and industry, include chapters on the need for new antibiotic compounds, strategies for screening for new antibiotics, sources of novel synthetic and natural antibiotics, discovery phases of lead development and optimization, and candidate compound nominations into development. Beyond discovery , the handbook will cover all of the studies to prepare for IND submission: Phase I (safety and dose ranging), progression to Phase II (efficacy), and Phase III (capturing desired initial indications). This book walks the reader through all aspects of the process, which has never been done before in a single reference. With the rise of antibiotic resistance and the increasing view that a crisis may be looming in infectious diseases, there are strong signs of renewed emphasis in antibiotic research. The purpose of the handbook is to offer a detailed overview of all aspects of the problem posed by antibiotic discovery and development.

Antimicrobial Resistance

Author : Donald L. Jungkind
Publisher : Springer Science & Business Media
ISBN 13 : 1475792034
Total Pages : 247 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Antimicrobial Resistance by : Donald L. Jungkind

Download or read book Antimicrobial Resistance written by Donald L. Jungkind and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: Development and Implications of Antimicrobial Resistance One of the most ominous trends in the field of antimicrobial chemotherapy over the past decade has been the increasing pace of development of antimicrobial resistance among microbial pathogens. The hypothesis that man can discover a magic bullet to always cure a particular infection has proved false. Physicians are now seeing and treating patients for which there are few therapeutic alternatives, and in some cases, none at all. Until recently there was little concern that physicians might be losing the war in our ability to compete with the evolving resistance patterns of microbial pathogens. Now the general public is very aware of the threat to them if they become infected, thanks to cover story articles in major magazines such as Time, Newsweek, newspapers, and other news sources. Antimicrobial resistance is not a novel problem. Shortly after the widespread introduction of penicillin in the early 1940s, the first strains of penicillin-resistant staphylococci were described. Today it is an uncommon event for a clinical laboratory to isolate an S. aureus that is sensitive to penicillin. Other gram-positive strains of bacteria have become resistant, including the exquisitely sensitive Streptococcus pneumoniae. Sensitivity to vancomycin was once so uniform that it was used in routine clinical laboratories as a surrogate marker for whether an organism should be classified as a gram-positive. That criterion can no longer be relied upon because of emerging resistance among some species. Gram-negative bacteria, viruses, fungi, and parasites all have succeeded in developing resistance.

Antimicrobial Peptides

Author : Katsumi Matsuzaki
Publisher : Springer
ISBN 13 : 9811335885
Total Pages : 304 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Antimicrobial Peptides by : Katsumi Matsuzaki

Download or read book Antimicrobial Peptides written by Katsumi Matsuzaki and published by Springer. This book was released on 2019-04-12 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an overview of antimicrobial peptides (AMPs), their mechanisms of antimicrobial action, other activities, and various problems that must still be overcome regarding their clinical application. Divided into four major parts, the book begins with a general overview of AMPs (Part I), and subsequently discusses the various mechanisms of antimicrobial action and methods for researching them (Part 2). It then addresses a range of activities other than antimicrobial action, such as cell penetration, antisepsis, anticancer, and immunomodulatory activities (Part 3), and explores the prospects of clinical application from various standpoints such as the selective toxicity, design, and discovery of AMPs (Part 4). A huge number of AMPs have been discovered in plants, insects, and vertebrates including humans, and constitute host defense systems against invading pathogenic microorganisms. Consequently, many attempts have been made to utilize AMPs as antibiotics. AMPs could help to solve the urgent problem of drug-resistant bacteria, and are also promising with regard to sepsis and cancer therapy. Gathering a wealth of information, this book will be a bible for all those seeking to develop antibiotics, anti-sepsis, or anticancer agents based on AMPs.

Descriptive Inorganic Chemistry

Author : James E. House
Publisher : Academic Press
ISBN 13 : 0080916775
Total Pages : 585 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Descriptive Inorganic Chemistry by : James E. House

Download or read book Descriptive Inorganic Chemistry written by James E. House and published by Academic Press. This book was released on 2010-09-22 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: Descriptive Inorganic Chemistry, Second Edition, covers the synthesis, reactions, and properties of elements and inorganic compounds for courses in descriptive inorganic chemistry. This updated version includes expanded coverage of chemical bonding and enhanced treatment of Buckminster Fullerenes, and incorporates new industrial applications matched to key topics in the text. It is suitable for the one-semester (ACS-recommended) course or as a supplement in general chemistry courses. Ideal for majors and non-majors, the book incorporates rich graphs and diagrams to enhance the content and maximize learning. Includes expanded coverage of chemical bonding and enhanced treatment of Buckminster Fullerenes Incorporates new industrial applications matched to key topics in the text

Polymyxin Antibiotics

Author : Jian Li (Pharmacologist)
Publisher :
ISBN 13 : 9783030163723
Total Pages : pages
Book Rating : 4.1/5 (637 download)

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Book Synopsis Polymyxin Antibiotics by : Jian Li (Pharmacologist)

Download or read book Polymyxin Antibiotics written by Jian Li (Pharmacologist) and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: It is our wish that readers discover the importance of polymyxin structure in relation to the mechanisms of activity, resistance and toxicity. We emphasized that reliable analytic methods for polymyxins are critical when investigating their pharmacokinetics (PK) and pharmacodynamics (PD). The complicated dose definitions and different pharmacopoeial standards have already compromised the safe use of polymyxins in patients. Therefore, informed by the latest pharmacological information, scientifically-based dosing recommendations have been proposed for intravenous polymyxins. Considering the PK/PD limitations and potential development of resistance, polymyxin combinations are encouraged; however, the current literature has not shown definite microbiological benefits, possibly because most clinical studies to date overlooked key PK/PD principles. Nephrotoxicity is the major dose-limiting factor and it is imperative to elucidate the mechanisms and develop novel approaches to minimize polymyxin-associated toxicities. In addition, the anti-endotoxin effect of polymyxins supports their clinical use to treat Gram-negative sepsis. Fortunately, the discovery of new-generation polymyxins with wider therapeutic windows has benefited from the latest achievements in polymyxin research.

Handbook of Algal Science, Technology and Medicine

Author : Ozcan Konur
Publisher : Academic Press
ISBN 13 : 0128183063
Total Pages : 738 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Handbook of Algal Science, Technology and Medicine by : Ozcan Konur

Download or read book Handbook of Algal Science, Technology and Medicine written by Ozcan Konur and published by Academic Press. This book was released on 2020-03-28 with total page 738 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Algal Science, Microbiology, Technology and Medicine provides a concise introduction to the science, biology, technology and medical use of algae that is structured on the major research fronts of the last four decades, such as algal structures and properties, algal biomedicine, algal genomics, algal toxicology, and algal bioremediation, algal photosystems, algal ecology, algal bioenergy and biofuels. It also covers algal production for biomedicine, algal biomaterials, and algal medicinal foods within these primary sections. All chapters are authored by the leading researchers in their respective research fields. Our society currently faces insurmountable challenges in the areas of biomedicine and energy in the face of increasing global population and diminishing natural resources as well as the growing environmental and economic concerns, such as global warming, greenhouse gas emissions and climate change. Algae offer a way to deal with these challenges and concerns for both sustainable and environment friendly bioenergy production and in biomedicine through the development of crucial biotechnology. Provides an essential interdisciplinary introduction and handbook for all the stakeholders engaged in science, technology and medicine of algae Covers the major research streams of the last four decades, ranging from algal structures, to algal biomedicine and algal bioremediation Fills a significant market opening for an interdisciplinary handbook on algal science, technology and medicine

Targeted Drug Delivery : Concepts and Design

Author : Padma V. Devarajan
Publisher : Springer
ISBN 13 : 3319113550
Total Pages : 788 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Targeted Drug Delivery : Concepts and Design by : Padma V. Devarajan

Download or read book Targeted Drug Delivery : Concepts and Design written by Padma V. Devarajan and published by Springer. This book was released on 2014-12-08 with total page 788 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative volume explores the fundamental concepts and numerous applications of targeted delivery of drugs to the body. This compilation has been divided into eight sections comprised of the basic principles of drug targeting, disease and organ/organelle-based targeting, passive and active targeting strategies, and various advanced drug delivery tools such as functionalized lipidic, polymeric and inorganic nanocarriers. Together, the twenty-three chapters cover a wide range of topics in the field, including tumor and hepatic targeting, polymer-drug conjugates, nanoemulsion, physical and biophysical characteristics of nanoparticles, and in vivo imaging techniques, among others. The book also examines advanced characterization techniques, regulatory hurdles and toxicity-related issues that are key features for successful commercialization of targeted drug delivery system products. Targeted Drug Delivery is a comprehensive reference guide for drug delivery researchers, both beginners and those already working in the field.