Computational Epigenomics

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Computational Epigenetics and Diseases

Author :
Publisher : Academic Press
ISBN 13 : 0128145145
Total Pages : 452 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Computational Epigenetics and Diseases by :

Download or read book Computational Epigenetics and Diseases written by and published by Academic Press. This book was released on 2019-02-06 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational Epigenetics and Diseases, written by leading scientists in this evolving field, provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases. In particular, the major computational tools, databases, and strategies for computational epigenetics analysis, for example, DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA, are summarized, in the context of human diseases. This book discusses bioinformatics methods for epigenetic analysis specifically applied to human conditions such as aging, atherosclerosis, diabetes mellitus, schizophrenia, bipolar disorder, Alzheimer disease, Parkinson disease, liver and autoimmune disorders, and reproductive and respiratory diseases. Additionally, different organ cancers, such as breast, lung, and colon, are discussed. This book is a valuable source for graduate students and researchers in genetics and bioinformatics, and several biomedical field members interested in applying computational epigenetics in their research. - Provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases - Summarizes the major computational tools, databases, and strategies for computational epigenetics analysis, such as DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA - Covers the major milestones and future directions of computational epigenetics in various kinds of human diseases such as aging, atherosclerosis, diabetes, heart disease, neurological disorders, cancers, blood disorders, liver diseases, reproductive diseases, respiratory diseases, autoimmune diseases, human imprinting disorders, and infectious diseases

Computational Epigenomics and Epitranscriptomics

Author : Pedro H. Oliveira
Publisher : Springer Nature
ISBN 13 : 107162962X
Total Pages : 267 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Computational Epigenomics and Epitranscriptomics by : Pedro H. Oliveira

Download or read book Computational Epigenomics and Epitranscriptomics written by Pedro H. Oliveira and published by Springer Nature. This book was released on 2023-02-01 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume details state-of-the-art computational methods designed to manage, analyze, and generally leverage epigenomic and epitranscriptomic data. Chapters guide readers through fine-mapping and quantification of modifications, visual analytics, imputation methods, supervised analysis, and integrative approaches for single-cell data. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Computational Epigenomics and Epitranscriptomics aims to provide an overview of epiomic protocols, making it easier for researchers to extract impactful biological insight from their data.

Epigenetics Methods

Author : Trygve O Tollefsbol
Publisher : Academic Press
ISBN 13 : 0128194154
Total Pages : 740 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Epigenetics Methods by : Trygve O Tollefsbol

Download or read book Epigenetics Methods written by Trygve O Tollefsbol and published by Academic Press. This book was released on 2020-07-08 with total page 740 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the field of epigenetics has grown significantly, driving new understanding of human developmental processes and disease expression, as well as advances in diagnostics and therapeutics. As the field of epigenetics continues to grow, methods and technologies have multiplied, resulting in a wide range of approaches and tools researchers might employ. Epigenetics Methods offers comprehensive instruction in methods, protocols, and experimental approaches applied in field of epigenetics. Here, across thirty-five chapters, specialists offer step-by-step overviews of methods used to study various epigenetic mechanisms, as employed in basic and translational research. Leading the reader from fundamental to more advanced methods, the book begins with thorough instruction in DNA methylation techniques and gene or locus-specific methylation analyses, followed by histone modification methods, chromatin evaluation, enzyme analyses of histone methylation, and studies of non-coding RNAs as epigenetic modulators. Recently developed techniques and technologies discussed include single-cell epigenomics, epigenetic editing, computational epigenetics, systems biology epigenetic methods, and forensic epigenetic approaches. Epigenetics methods currently in-development, and their implication for future research, are also considered in-depth. In addition, as with the wider life sciences, reproducibility across experiments, labs, and subdisciplines is a growing issue for epigenetics researchers. This volume provides consensus-driven methods instruction and overviews. Tollefsbol and contributing authors survey the range of existing methods; identify best practices, common themes, and challenges; and bring unity of approach to a diverse and ever-evolving field. - Includes contributions by leading international investigators involved in epigenetic research and clinical and therapeutic application - Integrates technology and translation with fundamental chapters on epigenetics methods, as well as chapters on more novel and advanced epigenetics methods - Written at verbal and technical levels that can be understood by scientists and students alike - Includes chapters on state-of-the-art techniques such as single-cell epigenomics, use of CRISPR/Cas9 for epigenetic editing, and epigenetics methods applied to forensics

Bioinformatics: Sequences, Structures, Phylogeny

Author : Asheesh Shanker
Publisher : Springer
ISBN 13 : 9811315620
Total Pages : 402 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Bioinformatics: Sequences, Structures, Phylogeny by : Asheesh Shanker

Download or read book Bioinformatics: Sequences, Structures, Phylogeny written by Asheesh Shanker and published by Springer. This book was released on 2018-10-13 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the concepts and approaches used for sequence, structure, and phylogenetic analysis. Starting with an introduction to the subject and intellectual property protection for bioinformatics, it guides readers through the latest sequencing technologies, sequence analysis, genomic variations, metagenomics, epigenomics, molecular evolution and phylogenetics, structural bioinformatics, protein folding, structure analysis and validation, drug discovery, reverse vaccinology, machine learning, application of R programming in biological data analysis, and the use of Linux in handling large data files.

Computational Epigenetics in Human Diseases, Cell Differentiation, and Cell Reprogramming, Volume II

Author : Yongchun Zuo
Publisher : Frontiers Media SA
ISBN 13 : 2889747778
Total Pages : 366 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Computational Epigenetics in Human Diseases, Cell Differentiation, and Cell Reprogramming, Volume II by : Yongchun Zuo

Download or read book Computational Epigenetics in Human Diseases, Cell Differentiation, and Cell Reprogramming, Volume II written by Yongchun Zuo and published by Frontiers Media SA. This book was released on 2022-03-31 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Multi-omics, Epigenomics and Computational Analysis of Neurodegenerative Disorders

Author : Manoj Kumar Jaiswal
Publisher : Frontiers Media SA
ISBN 13 : 2889766918
Total Pages : 133 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Multi-omics, Epigenomics and Computational Analysis of Neurodegenerative Disorders by : Manoj Kumar Jaiswal

Download or read book Multi-omics, Epigenomics and Computational Analysis of Neurodegenerative Disorders written by Manoj Kumar Jaiswal and published by Frontiers Media SA. This book was released on 2022-08-03 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Computational Epigenetics in Human Diseases, Cell Differentiation, and Cell Reprogramming, Volume I

Author : Jianzhong Su
Publisher : Frontiers Media SA
ISBN 13 : 2889665046
Total Pages : 465 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Computational Epigenetics in Human Diseases, Cell Differentiation, and Cell Reprogramming, Volume I by : Jianzhong Su

Download or read book Computational Epigenetics in Human Diseases, Cell Differentiation, and Cell Reprogramming, Volume I written by Jianzhong Su and published by Frontiers Media SA. This book was released on 2021-02-24 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Epigenetic Regulation and Epigenomics

Author : Robert A. Meyers
Publisher : John Wiley & Sons
ISBN 13 : 3527668624
Total Pages : 1259 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Epigenetic Regulation and Epigenomics by : Robert A. Meyers

Download or read book Epigenetic Regulation and Epigenomics written by Robert A. Meyers and published by John Wiley & Sons. This book was released on 2012-10-02 with total page 1259 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics is a term in biology referring to heritable traits that do not involve changes in the underlying DNA sequence of the organism. Epigenetic traits exist on top of or in addition to the traditional molecular basis for inheritance. The "epigenome" is a parallel to the word "genome," and refers to the overall epigenetic state of a cell. Cancer and stem cell research have gradually focused attention on these genome modifications. The molecular basis of epigenetics involves modifications to DNA and the chromatin proteins that associate with it. Methylation, for example, can silence a nearby gene and seems to be involved in some cancers. Epigenetics is beginning to form and take shape as a new scientific discipline, which will have a major impact on Medicine and essentially all fields of biology. Increasingly, researchers are unearthing links between epigenetics and a number of diseases. Although in recent years cancer has been the main focus of epigenetics, recent data suggests that epigenetic plays a critical role in psychology and psychopathology. It is being realized that normal behaviors such as maternal care and pathologies such as Schizophrenia and Alzheimer's might have an epigenetic basis. It is also becoming clear that nutrition and life experiences have epigenetic consequences. Discover more online content in the Encyclopedia of Molecular Cell Biology and Molecular Medicine.

Environmental Epigenetics

Author : L. Joseph Su
Publisher : Springer
ISBN 13 : 1447166787
Total Pages : 327 pages
Book Rating : 4.4/5 (471 download)

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Book Synopsis Environmental Epigenetics by : L. Joseph Su

Download or read book Environmental Epigenetics written by L. Joseph Su and published by Springer. This book was released on 2015-05-18 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.

The Epigenetics Revolution

Author : Nessa Carey
Publisher : Columbia University Press
ISBN 13 : 0231530714
Total Pages : 353 pages
Book Rating : 4.2/5 (315 download)

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Book Synopsis The Epigenetics Revolution by : Nessa Carey

Download or read book The Epigenetics Revolution written by Nessa Carey and published by Columbia University Press. This book was released on 2012-03-06 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics can potentially revolutionize our understanding of the structure and behavior of biological life on Earth. It explains why mapping an organism's genetic code is not enough to determine how it develops or acts and shows how nurture combines with nature to engineer biological diversity. Surveying the twenty-year history of the field while also highlighting its latest findings and innovations, this volume provides a readily understandable introduction to the foundations of epigenetics. Nessa Carey, a leading epigenetics researcher, connects the field's arguments to such diverse phenomena as how ants and queen bees control their colonies; why tortoiseshell cats are always female; why some plants need cold weather before they can flower; and how our bodies age and develop disease. Reaching beyond biology, epigenetics now informs work on drug addiction, the long-term effects of famine, and the physical and psychological consequences of childhood trauma. Carey concludes with a discussion of the future directions for this research and its ability to improve human health and well-being.

Epigenomics

Author : Gurbachan Singh Miglani
Publisher : I K International Pvt Ltd
ISBN 13 : 9390620724
Total Pages : 710 pages
Book Rating : 4.3/5 (96 download)

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Book Synopsis Epigenomics by : Gurbachan Singh Miglani

Download or read book Epigenomics written by Gurbachan Singh Miglani and published by I K International Pvt Ltd. This book was released on 2023-06-13 with total page 710 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenomics deals in detail with the concepts, principles, procedures, developments, limitations, advantages, applications and future prospects of different areas of epigenomics in a comprehensive manner. It provides concise yet complete knowledge on the many aspects of the basic and most recent methods and applications in epigenomics, a branch of epigenetics that deals with the mechanisms such as DNA modifications, histone modifications, RNA modifications, small and long non-coding RNAs, chromatin remodeling, which are involved in epigenetic control of gene expression without involving variations in DNA sequences. These regulatory mechanisms lead to phenotypic variations. These epigenetic mechanisms can be exploited for crop improvement and cure of human diseases. Epigenomics strives to understand the role of epigenetic marks (chemical tags) in the development of phenotype. This understanding provides epigeneticists to apply epigenomics in medicine and agriculture. Self-explanatory adequately labelled figures have been the special emphasis throughout. This book is primarily designed for senior undergraduate and graduate level (M.Sc. and Ph.D.) students studying epigenetics in conventional, agricultural and medicinal universities. This book will be a useful reference text for teachers and researcher in any discipline of life sciences, agricultural sciences, medicine, and biotechnology.

Next Generation Sequencing

Author : Jerzy Kulski
Publisher : BoD – Books on Demand
ISBN 13 : 9535122401
Total Pages : 466 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Next Generation Sequencing by : Jerzy Kulski

Download or read book Next Generation Sequencing written by Jerzy Kulski and published by BoD – Books on Demand. This book was released on 2016-01-14 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Next generation sequencing (NGS) has surpassed the traditional Sanger sequencing method to become the main choice for large-scale, genome-wide sequencing studies with ultra-high-throughput production and a huge reduction in costs. The NGS technologies have had enormous impact on the studies of structural and functional genomics in all the life sciences. In this book, Next Generation Sequencing Advances, Applications and Challenges, the sixteen chapters written by experts cover various aspects of NGS including genomics, transcriptomics and methylomics, the sequencing platforms, and the bioinformatics challenges in processing and analysing huge amounts of sequencing data. Following an overview of the evolution of NGS in the brave new world of omics, the book examines the advances and challenges of NGS applications in basic and applied research on microorganisms, agricultural plants and humans. This book is of value to all who are interested in DNA sequencing and bioinformatics across all fields of the life sciences.

DNA Modifications

Author : Alexey Ruzov
Publisher : Humana
ISBN 13 : 9781071608753
Total Pages : 495 pages
Book Rating : 4.6/5 (87 download)

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Book Synopsis DNA Modifications by : Alexey Ruzov

Download or read book DNA Modifications written by Alexey Ruzov and published by Humana. This book was released on 2020-08-22 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of methods and experimental protocols that are currently used to analyze the presence and abundance of non-canonical DNA nucleotides in different biological systems. Focusing particularly on the newly discovered and less studied DNA modifications that are enzymatically produced and are likely to play specific roles in various biological processes, the volume explores chromatography- and mass spectrometry-based techniques for the detection and quantification of DNA modifications, antibody-based approaches to study their spatial distribution in different cells and tissues, and methods to analyze their genomic distribution with the help of bioinformatics tools that interrogate the corresponding datasets. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and comprehensive, DNA Modifications: Methods and Protocols serves as an ideal guide to research scientists and PhD students in this rapidly developing discipline, and, thus, will ultimately contribute to deciphering the roles of non-canonical DNA nucleotides in different biological systems.

Toxicology and Epigenetics

Author : Saura C. Sahu
Publisher : John Wiley & Sons
ISBN 13 : 1118349067
Total Pages : 822 pages
Book Rating : 4.1/5 (183 download)

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Book Synopsis Toxicology and Epigenetics by : Saura C. Sahu

Download or read book Toxicology and Epigenetics written by Saura C. Sahu and published by John Wiley & Sons. This book was released on 2012-08-23 with total page 822 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics is the study of both heritable and non-heritable changes in the regulation of gene activity and expression that occur without an alteration in the DNA sequence. This dynamic and rapidly developing discipline is making its impact across the biomedical sciences, in particular in toxicology where epigenetic differences can mean that different individuals respond differently to the same drug or chemical. Toxicology and Epigenetics reflects the multidimensional character of this emerging area of toxicology, describing cutting-edge molecular technologies to unravel epigenetic changes, the use of in vivo and in vitro models, as well as the potential use of toxicological epigenetics in regulatory environments. An international team of experts consider the interplay between epigenetics and toxicology in a number of areas, including environmental, nutritional, pharmacological, and computational toxicology, nanomaterials, proteomics and metabolomics, and cancer research. Topics covered include: environment, epigenetics and diseases DNA methylation and toxicogenomics chromatin at the intersection of disease and therapy epigenomic actions of environmental arsenicals environment, epigenetics and cardiovascular health toxicology, epigenetics and autoimmunity ocular epigenomics: potential sites of environmental impact in development and disease nuclear RNA silencing and related phenomena in animals epigenomics – impact for drug safety sciences methods of global epigenomic profiling transcriptomics: applications in epigenetic toxicology Toxicology and Epigenetics is an essential insight into the current trends and future directions of research in this rapidly expanding field for investigators, toxicologists, risk assessors and regulators in academia, industry and government.

Evolution of Translational Omics

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309224187
Total Pages : 354 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Evolution of Translational Omics by : Institute of Medicine

Download or read book Evolution of Translational Omics written by Institute of Medicine and published by National Academies Press. This book was released on 2012-09-13 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.

Toxicoepigenetics

Author : Shaun D. McCullough
Publisher : Academic Press
ISBN 13 : 0128124342
Total Pages : 430 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Toxicoepigenetics by : Shaun D. McCullough

Download or read book Toxicoepigenetics written by Shaun D. McCullough and published by Academic Press. This book was released on 2018-11-02 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxicoepigenetics: Core Principles and Applications examines the core aspects of epigenetics, including chromatin biology, DNA methylation, and non-coding RNA, as well as fundamental techniques and considerations for studying each of these mechanisms of epigenetic regulation. Although its integration into the field of toxicology is in its infancy, epigenetics have taken center stage in the study of diseases such as cancer, diabetes, and neurodegeneration. Increasing the presence of epigenetics in toxicological research allows for a more in-depth understanding of important aspects of toxicology such as the role of the environment and lifestyle influencing the individual susceptibility to these effects and the trans-generational transmission of these health effects and susceptibilities. Methods chapters are included to help improve efficacy and efficiency of protocols in both the laboratory and the classroom. Toxicoepigenetics: Core Principles and Applications is an essential book for researchers and academics using epigenetics in toxicology research and study. - Introduces the fundamental principles and practices for understanding the role of the epigenome in toxicology - Presents the foundation of epigenetics for toxicologists with a broad range of backgrounds - Discusses the incorporation of epigenetics and epigenomics into current toxicological studies and interpretation of epigenetic data in toxicological applications

Handbook of Epigenetics

Author : Trygve O Tollefsbol
Publisher : Academic Press
ISBN 13 : 0128054778
Total Pages : 684 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Handbook of Epigenetics by : Trygve O Tollefsbol

Download or read book Handbook of Epigenetics written by Trygve O Tollefsbol and published by Academic Press. This book was released on 2017-07-10 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Epigenetics: The New Molecular and Medical Genetics, Second Edition, provides a comprehensive analysis of epigenetics, from basic biology, to clinical application. Epigenetics is considered by many to be the new genetics in that many biological phenomena are controlled, not through gene mutations, but rather through reversible and heritable epigenetic processes. These epigenetic processes range from DNA methylation to prions. The biological processes impacted by epigenetics are vast and encompass effects in lower organisms and humans that include tissue and organ regeneration, X-chromosome inactivation, stem cell differentiation, genomic imprinting, and aging. The first edition of this important work received excellent reviews; the second edition continues its comprehensive coverage adding more current research and new topics based on customer and reader reviews, including new discoveries, approved therapeutics, and clinical trials. From molecular mechanisms and epigenetic technology, to discoveries in human disease and clinical epigenetics, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics, to therapeutic interventions for epigenetic-based disorders. - Timely and comprehensive collection of fully up-to-date reviews on epigenetics that are organized into one volume and written by leading figures in the field - Covers the latest advances in many different areas of epigenetics, ranging from basic aspects, to technologies, to clinical medicine - Written at a verbal and technical level that can be understood by scientists and college students - Updated to include new epigenetic discoveries, newly approved therapeutics, and clinical trials