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Complement In Health And Disease
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Book Synopsis The Human Complement System in Health and Disease by : John E. Volanakis
Download or read book The Human Complement System in Health and Disease written by John E. Volanakis and published by CRC Press. This book was released on 1998-02-25 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative, single-source reference provides comprehensive examinations of the complement system-offering recent findings in basic science on the structure, biology, physiology, and pathophysiology of complement proteins and the latest therapeutic approaches towards the control of complement-mediated diseases. Written by over 40 international experts from North America, Europe, and Asia, The Human Complement System in Health and Disease describes the molecular architecture of the complement system details the structure of complement genes discusses gene organization as well as the topology and chemistry of ligand-binding sites and catalytic centers of complement proteins analyzes complement organization and activation, including phylogeny and the newly discovered lectin pathway elucidates the regulation of complement gene expression and the structure and function of bioactive peptides explicates opsonic and immunoregulatory properties of complement fragments, endothelial responses, and interactions with viruses and bacteria and more!
Book Synopsis The Complement System by : Janos Szebeni
Download or read book The Complement System written by Janos Szebeni and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a phylogenetically old system complement is now regarded as a part of innate immunity. But it is much more than that. It bridges innate and adapted immunity, participates not only in host defense but also in many essential physiological processes, old and new diseases and adverse conditions. Indeed, complement became a term that almost defies categorization. What was for a long time a subject for a limited number of specialists has now moved into the mainstream of experimental and clinical immunology. In 1973 I visited the Basel Institute of Immunology and met its director, the eminent scientist and Nobel laureate Nils Jerne. When I entered his office he greeted me with the following words: “Complement, does that really exist?” I was never certain whether he wanted only to tease me or whether he sincerely believed that the complement system was an unimportant biological curiosity, a misstep of evolution. But, of course, missteps do not survive the evolutionary process. Little did I foresee the dramatic developments of recent years when Hans J. Müller-Eberhard and I started to unravel the specifics of the action of the cobra venom factor on the complement system in 1968 and defined a new pathway to its activation. An elucidation of the role of the system in diseases and its control for therapeutic reasons is now getting closer to actual realization in the clinic although many problems, in particular those of highly specificinhibition free of side effects, have still to be resolved.
Book Synopsis Complement Regulatory Proteins by : B. Paul Morgan
Download or read book Complement Regulatory Proteins written by B. Paul Morgan and published by Academic Press. This book was released on 1999-02-18 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: From small beginnings in the early 1970s, the study of complement regulatory proteins has grown in the last decade to the point where it dominates the complement field. This growth has been fueled by the discovery of new regulators, the cloning of old and new regulators, the discovery that many of the regulators are structurally and evolutionarily related to each other and the development of recombinant forms for use in therapy. There are now more proteins known to be involved in controlling the complement system than there are components of the system and the list continues to grow. The time is ripe for a comprehensive review of our current knowledge of these intriguing proteins. This book does just that. The first few chapters discuss the "nuts-and-bolts" of the complement regulators, describing their structures, functional roles and modes of action. The roles of the complement regulators in vivo are then described, focusing on the consequences of deficiency, roles in the reproductive system, interactions with pathogens and exploitation for therapy. The interesting developments in defining the complement regulators expressed in other species are also discussed. The book is written as a monograph, albeit by two people. The text is as readable as possible without compromising on scientific accuracy and completeness. The conversational style very evident in some sections is deliberate! Placing all references in a single bibliography at the end of the text further improves readability. The reader will go to the book to discover a specific fact but be persuaded to read more and derive pleasure from the process. The authors' enthusiasm for the subject comes over strongly in the text, and this enthusiasm proves infectious. - Complement regulators--structure, functional roles and mode of action - Comprehensive reviews of each of the individual regulators - Roles of Complement regulators in vivo,in health and disease: - Consequences of deficiency - Roles in the reproductive system - Interactions with pathogens - Exploitation for therapy - Complement regulators in other species
Book Synopsis Complementary and Alternative Medicine in the United States by : Institute of Medicine
Download or read book Complementary and Alternative Medicine in the United States written by Institute of Medicine and published by National Academies Press. This book was released on 2005-04-13 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integration of complementary and alternative medicine therapies (CAM) with conventional medicine is occurring in hospitals and physicians offices, health maintenance organizations (HMOs) are covering CAM therapies, insurance coverage for CAM is increasing, and integrative medicine centers and clinics are being established, many with close ties to medical schools and teaching hospitals. In determining what care to provide, the goal should be comprehensive care that uses the best scientific evidence available regarding benefits and harm, encourages a focus on healing, recognizes the importance of compassion and caring, emphasizes the centrality of relationship-based care, encourages patients to share in decision making about therapeutic options, and promotes choices in care that can include complementary therapies where appropriate. Numerous approaches to delivering integrative medicine have evolved. Complementary and Alternative Medicine in the United States identifies an urgent need for health systems research that focuses on identifying the elements of these models, the outcomes of care delivered in these models, and whether these models are cost-effective when compared to conventional practice settings. It outlines areas of research in convention and CAM therapies, ways of integrating these therapies, development of curriculum that provides further education to health professionals, and an amendment of the Dietary Supplement Health and Education Act to improve quality, accurate labeling, research into use of supplements, incentives for privately funded research into their efficacy, and consumer protection against all potential hazards.
Book Synopsis Janeway's Immunobiology by : Kenneth Murphy
Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Book Synopsis Disease Control Priorities in Developing Countries by : Dean T. Jamison
Download or read book Disease Control Priorities in Developing Countries written by Dean T. Jamison and published by World Bank Publications. This book was released on 2006-04-02 with total page 1449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on careful analysis of burden of disease and the costs ofinterventions, this second edition of 'Disease Control Priorities in Developing Countries, 2nd edition' highlights achievable priorities; measures progresstoward providing efficient, equitable care; promotes cost-effectiveinterventions to targeted populations; and encourages integrated effortsto optimize health. Nearly 500 experts - scientists, epidemiologists, health economists,academicians, and public health practitioners - from around the worldcontributed to the data sources and methodologies, and identifiedchallenges and priorities, resulting in this integrated, comprehensivereference volume on the state of health in developing countries.
Book Synopsis Neuroinflammation in Stroke by : Ulrich Dirnagl
Download or read book Neuroinflammation in Stroke written by Ulrich Dirnagl and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: The successful treatment of acute stroke remains one of the major challenges in clinical medicine. Over the last decades, the understanding of stroke pathophysiology has greatly improved, while the therapeutic options in stroke therapy remain very limited. Today, hyperacute mechanisms of damage, such as excitotoxicity, can be discriminated from delayed ones, such as inflammation and apoptosis. Targeting of inflammation has already been successfully applied in various stroke models, but translation into a clinically efficacious strategy has not been achieved so far. In this book, leading experts in basic cerebrovascular research as well as stroke treatment review the current evidence for and against an important role for inflammation in stroke, and explore the potential of treating or modulating inflammation in stroke therapy.
Book Synopsis The Interface Between Innate and Acquired Immunity by : M.D. Cooper
Download or read book The Interface Between Innate and Acquired Immunity written by M.D. Cooper and published by Springer Science & Business Media. This book was released on 2002-03-26 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: All multicellular organisms may possess innate immunity mediated by defense mechanisms with which the organism is born. In recent years much has been learned about the diversity of innate immune mechanisms. A large array of naturally produced antimicrobial peptides has been de fined. A variety of cell surface receptors that recognize common patterns displayed by infectious organisms have been identified along with the intracellular pathways that these receptors use to activate cellular defense functions. Cell surface receptors on natural killer (NK) cells have been shown to sense microbial invasion in neighboring cells, thereby setting into motion their elimination by cy totoxic mechanisms. Other receptors have been found to facilitate phagocytosis and intracellular killing of microbes by phagocytic cells. These and other natural defense mechanisms have traditionally been viewed as the first line of body defense in vertebrate species that also possess the capacity for acquired or adaptive immunity. Sharks and all of the other jawed vertebrates generate large repertoires of T and B lymphocyte clones that display different antigen specific receptors in the form ofT cell receptors (TCR) and immunoglobulins (Ig) that allow them to recognize and respond to antigens in collaboration with antigen-present ing cells. Memory T and B cells are then generated to allow faster and heightened cellular and humoral immune re sponses on secondary antigen encounter. In recent years it has also become obvious that innate immune responses can directly influence adaptive immune responses in ways that will enhance body defense.
Book Synopsis The Role of Complement in Health and Disease by : Maciej Cedzyński
Download or read book The Role of Complement in Health and Disease written by Maciej Cedzyński and published by Frontiers Media SA. This book was released on 2019-11-18 with total page 631 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Global Health written by Kevin McCracken and published by Routledge. This book was released on 2012 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: The health of human populations around the world is constantly changing and the health profiles of most nations in the early twenty-first century global health landscape are unrecognizable compared with those of just a century ago. This book examines and explains these health changes and considers likely future patterns and changes. While the overall picture charted is one of progress and improvement, certain unfortunate regressions and stubbornly persistent health inequalities are equally shown to be part of the evolving patterns of global health. The chapters of the book are organized in three major parts: The first part introduces readers to the principal concepts of global health, and to the idea of populations having distinctive health profiles. In particular, it explores how those profiles can be measured, and how they change, using the umbrella concepts and theories of epidemiological and health transition. Building on the first section, the second part focuses on the evolution of health states, as well as paying particular attention to the reasons for the many subnational inequalities in global health. It also examines health challenges such as the continuing infectious disease burden and current emerging 'epidemics'. The final part transports readers from the current health scene to future possible and probable health scenarios, acknowledging the challenges presented by global environmental change, as well as issues centred around geopolitics and human security. Using clear and original explanations of complex issues, this text makes extensive use of boxed case studies and international examples, with thought-provoking discussion questions posed for readers at the end of each chapter. Global Health is essential reading for students of global health, public health and development studies.
Book Synopsis Endotoxin in Health and Disease by : Helmut Brade
Download or read book Endotoxin in Health and Disease written by Helmut Brade and published by CRC Press. This book was released on 2020-10-28 with total page 968 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering a basis for further research into the interactions of hosts and pathogens, this work gathers up-to-date findings, and details basic structures, functions and immunology. It provides descriptions of a variety of experimental endotoxin neutralizing agents, as well as a guide to clinical research initiatives and the latest treatments.
Book Synopsis The Control of Communicable Diseases by : American Public Health Association
Download or read book The Control of Communicable Diseases written by American Public Health Association and published by . This book was released on 1940 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Origin and Evolution of the Vertebrate Immune System by : L. Du Pasquier
Download or read book Origin and Evolution of the Vertebrate Immune System written by L. Du Pasquier and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: The comparative approach to immunology can be traced to the era of Pasteur and Metchnikov in which observations regarding foreign recognition in invertebrates was a factor in the develop ment of the principal concepts that created the foundation of what now is the broad field of immunology. With each major experimental and conceptual breakthrough, the classical, albeit essential, question has been asked "are the immune systems of phylogenetically primitive vertebrates and invertebrates similar to that of mammals?" Somewhat surprisingly for the jawed verte brates, the general answer has been a qualified form of "yes", whereas for agnathans and invertebrate phyla it has been "no" so far. The apparent abruptness in the appearance of the immune system of vertebrates is linked to the introduction of the somatic generation of the diversity of its antigen specific receptors. Therefore the questions regarding the origin and evolution of the specific immune system revolve around this phenomenon. With respect to the origin of the system (aside from the or igin of the rearranging machinery itself, the study of which is still in its infancy) one can ask questions about the cellular and mo lecular contexts in which the mechanism was introduced.
Book Synopsis Eosinophils in Health and Disease by : James J. Lee
Download or read book Eosinophils in Health and Disease written by James J. Lee and published by Academic Press. This book was released on 2012-11-02 with total page 679 pages. Available in PDF, EPUB and Kindle. Book excerpt: Eosinophils in Health and Disease provides immunology researchers and students with a comprehensive overview of current thought and cutting-edge eosinophil research, providing chapters on basic science, disease-specific issues, therapeutics, models for study and areas of emerging importance.
Book Synopsis Exercise Physiology by : Stanley P. Brown
Download or read book Exercise Physiology written by Stanley P. Brown and published by Lippincott Williams & Wilkins. This book was released on 2006 with total page 695 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bridging the gap between exercise physiology principles and clinical practice, this text provides comprehensive coverage of both traditional basic science and clinical exercise physiology principles. The book presents clinical applications and examples that connect theory to practice. More than 500 full-color illustrations and numerous graphs and tables complement the text. Reader-friendly features including Perspective Boxes, Research Highlights, Biography Boxes, and Case Studies engage readers and reinforce key concepts. A bonus three-dimensional interactive anatomy CD-ROM from Primal Pictures and a Student Resource CD-ROM accompany the book. LiveAdvise online faculty support and student tutoring services are available free with the text.
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis An Integrative Metaregression Framework for Descriptive Epidemiology by : Abraham D. Flaxman
Download or read book An Integrative Metaregression Framework for Descriptive Epidemiology written by Abraham D. Flaxman and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: To provide the tools and knowledge needed in efforts to improve the health of the world's populations, researchers collaborated on the Global Burden of Diseases, Injuries, and Risk Factors Study 2010. The study produced comprehensive estimates of over 200 diseases and health risk factors in 187 countries over two decades, results that will be used by governments and non-governmental agencies to inform priorities for global health research, policies, and funding. Integrated Meta-Regression Framework for Descriptive Epidemiology is the first book-length treatment of model-based meta-analytic methods for descriptive epidemiology used in the Global Burden of Disease Study 2010. In addition to collecting the prior work on compartmental modeling of disease, this book significantly extends the model, by formally connecting the system dynamics model of disease progression to a statistical model of epidemiological rates and demonstrates how the two models were combined to allow researchers to integrate relevant data. Practical applications of the model to meta-analysis of more than a dozen different diseases complement the theoretical foundations of the integrative systems modeling of disease in populations. The book concludes with a detailed description of the future directions for research in model-based meta-analysis of descriptive epidemiological data. Abraham Flaxman is assistant professor of global health in the Institute for Health Metrics and Evaluation at the University of Washington.
