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Collagen Self Assembly
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Book Synopsis Collagen Self-assembly by : Darren Anderson
Download or read book Collagen Self-assembly written by Darren Anderson and published by . This book was released on 2006 with total page 698 pages. Available in PDF, EPUB and Kindle. Book excerpt: Collagen is the major structural protein in mammals, and forms the basis of a variety of tissues essential for animal life, including bone, skin, teeth, cornea, tendon, and others. It self-assembles---both in vivo and in vitro---into a variety of biologically important structures, and this self-assembly process is highly dependent on solution pH, ionic strength, and the concentration of the collagen monomer. Kinetic studies demonstrating these dependencies are presented for the formation of the most important aggregate, native type collagen. The cold dissociation of collagen that does not contain complete non-helical telopeptide regions is also demonstrated. Based on these studies, five different types of collagen intermediates are identified and a partially hierarchical fibrillogenesis mechanism is proposed, along with a detailed kinetic model. In order to further understand collagen fibrillogenesis at a molecular level, a previously predicted structure of the collagen monomer is completely relaxed using condensed phase molecular dynamics simulations. For validation purposes, several experimentally solved model collagen structures are simulated in the same way, and the simulation results agree with the crystal structures to within the experimental error. Therefore, a structure of the collagen monomer is proposed that comprises the most complete model currently developed. This model forms the basis for two sets of simulations aimed at explaining the formation of several of the polymorphisms of collagen. First, a three-dimensional analysis of the interactions between collagen monomers in fibrillar aggregates is presented, including hydrophobic-hydrophobic and electrostatic interactions. An examination of these interactions as a function of overlap between monomers demonstrates the origin of the topological regularity in native type collagen. Second, a detailed molecular model for formation of segmental long spacing crystallites of collagen is presented, involving bridging of in-register collagen monomers by nucleotide triphosphate moieties at colocalized acidic and basic residues. The proposed model is confirmed using molecular mechanics and dynamics simulations.
Book Synopsis The Mechanism of Collagen Self-assembly by : Yuping Li
Download or read book The Mechanism of Collagen Self-assembly written by Yuping Li and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The acceleration of fibrillogenesis rate with increasing pH from 6.6 to 9.2 is consistent with a reduction of surface net charge since the isoelectric point of soluble collagen is approaching. The native D-periodicity of 62 nm was found except at pH 7.1 where collagen molecules form short banding of 50-60 nm in the early stage of fibrillogenesis which might be caused by unusual alignment of collagen molecules in fibrils. We also introduced different monovalent and divalent electrolytes into fibril formation instead of PBS buffer. It was found the fibril formation was facilitated by divalent ions. Divalent ions can shift the isoelectric point of collagen by adsorption. We proposed the adsorbed divalent ions form the salt bridges between collagen which facilitate fibril formation. The unusual periodicities along the collagen fibril were also found which might be come from altered alignment of molecules due to the change of surface charge. These studies provide new insight on understanding the basis for collagen fibril formation and help for designing new biomaterials.
Book Synopsis Collagen Self-assembly, Induced Alignment and Quantitative Image Analysis by : Julian Haffegee
Download or read book Collagen Self-assembly, Induced Alignment and Quantitative Image Analysis written by Julian Haffegee and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Extracellular Matrix Assembly and Structure by : Peter D. Yurchenco
Download or read book Extracellular Matrix Assembly and Structure written by Peter D. Yurchenco and published by Academic Press. This book was released on 2013-10-22 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: The complex and critical process of extracellular matrix (ECM) assembly is described in this book. Assembly may involve molecules interacting with molecules of the same matrix class, such as in collagen, or interactions between different ECM molecules, such as in basement membranes. The text shows how this is driven by structural information within the matrix monomer. This information will be of interest to cell, developmental, and molecular biologists, biochemists, biophysicists, and biomedical researchers involved in macromolecular assembly, biological macromolecules, and extracellular matrix. Addresses assembly of most of the known classes of extracellular matrix macromolecules Discusses higher order structures produced by ECM Gives important concepts in ECM and cell-matrix interactions, Protein structure and protein-protein interactions, Development and tissue remodeling
Download or read book Collagen written by Marcel E. Nimni and published by CRC Press. This book was released on 2018-01-18 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: This series was conceived with the idea of integrating current aspects of ongoing research in the collagen field. The book consists of a spectrum of papers which discus divers aspects such as X-ray structure, the thermodynamics and mechanism of fibrillogenesis, and the use of collagen as a biomaterial for the manufacturing of many implantable, sometimes lifesaving, devises.
Book Synopsis Self Assembly of Type IV Collagen on PTFE by : Colin Michael Yoder
Download or read book Self Assembly of Type IV Collagen on PTFE written by Colin Michael Yoder and published by . This book was released on 2006 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Collagen written by Peter Fratzl and published by Springer Science & Business Media. This book was released on 2008-05-10 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Not only does this book provide a comprehensive review of current research advances in collagen structure and mechanics, it also explores this biological macromolecule’s many applications in biomaterials and tissue engineering. Readers gain an understanding of the structure and mechanical behavior of type I collagen and collagen-based tissues in vertebrates across all length scales, from the molecular (nano) to the organ (macro) level.
Book Synopsis Multi-scale Extracellular Matrix Mechanics and Mechanobiology by : Yanhang Zhang
Download or read book Multi-scale Extracellular Matrix Mechanics and Mechanobiology written by Yanhang Zhang and published by . This book was released on 2020 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the current state of knowledge in the field of multi-scale ECM mechanics and mechanobiology with a focus on experimental and modelling studies in biomechanical characterization, advanced optical microscopy and imaging, as well as computational modeling. This book also discusses the scale dependency of ECM mechanics, translation of mechanical forces from tissue to cellular level, and advances and challenges in improving our understanding of cellular mechanotransduction in the context of living tissues and organisms.
Book Synopsis Investigating Type I Collagen Self-Assembly Processes and End Products by : Calvin Chia-Hung Cheng
Download or read book Investigating Type I Collagen Self-Assembly Processes and End Products written by Calvin Chia-Hung Cheng and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Self-Assembly of Collagen-Related Peptides by Metal-Histidine Coordination by : 鄭琬蓉
Download or read book Self-Assembly of Collagen-Related Peptides by Metal-Histidine Coordination written by 鄭琬蓉 and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Ultrastructure of the Connective Tissue Matrix by : P. Motta
Download or read book Ultrastructure of the Connective Tissue Matrix written by P. Motta and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the techniques of electron microscopy have developed so widely and rapidly that they now cover the fields of research once the unique ll:panage of sister research techniques such as biochemistry, physiology, immunology, X-ray diffraction, etc. It is now possible to reach molecular and submolecular levels, making this technique indispensable in every type of research. Electron microscopy alone often provides enough information to solve given problems. In the field of the connective tissue matrix, knowledge of the molecular structure of collagen, pro teoglycans and elastin and their interaction has been to a large extent elucidated by electron microscopy. The field over which electron microscopy ranges in the investigation of the connective tissue matrix is so wide that the aim of this volume is to collect the main ultrastructural acquisitions disseminated in various journals and monographs in one book. The intent ofthis volume is to: (a) integrate different and new microscopic methods and review the results of such an integrative approach; (b) present a comprehensive ultrastructural account of selected aspects of the field; (c) point out gaps or controversial topics in our knowledge; (d) outline pertinent future research and expansion of the subject.
Book Synopsis Self-assembly of Mineralized Collagen Composoites by : Fu-Zhai Cui
Download or read book Self-assembly of Mineralized Collagen Composoites written by Fu-Zhai Cui and published by . This book was released on 2007 with total page 37 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Role of the Telopeptides of Collagen in Directing in Vitro Self-assembly by : Donald Lawrence Helseth
Download or read book The Role of the Telopeptides of Collagen in Directing in Vitro Self-assembly written by Donald Lawrence Helseth and published by . This book was released on 1981 with total page 686 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Effects of PH and Temperature on the Self-assembly of A Type I Collagen System by : Eric Kai Huang
Download or read book Effects of PH and Temperature on the Self-assembly of A Type I Collagen System written by Eric Kai Huang and published by . This book was released on 1997 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Effects of Backbone Modifications on Collagen Self-assembly by : Yitao Zhang
Download or read book Effects of Backbone Modifications on Collagen Self-assembly written by Yitao Zhang and published by . This book was released on 2016 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: Unnatural amino acid substitutions can provide a wealth of information about protein and peptide folding events. Collagen, the most abundant protein in the animal kingdom, has served as an important model system for unnatural amino acid substitutions due to its broad importance in human disease and its use in constructing synthetic biomaterials. Recently, we incorporated the unnatural amino acid aza-proline into a collagen model peptide (CMP) and demonstrated its utility as a stereodynamic replacement for proline to provide key insights into collagen peptide folding and recognition processes. Replacement of a proline stereocenter with a nitrogen atom in a CMP resulted in stereochemical mimicry and a surprisingly stable triple helix structure. For the first time, this single result demonstrated the effect of stereodynamics in the context of biopolymer self-assembly.
Book Synopsis Self-assembly of Mineralized Collagen Composites by : Yan Li
Download or read book Self-assembly of Mineralized Collagen Composites written by Yan Li and published by . This book was released on 2007 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Characterizing Collagen Mimetic Peptides for Orthogonal Self-assembly by : Sandeep Vishwanath Belure
Download or read book Characterizing Collagen Mimetic Peptides for Orthogonal Self-assembly written by Sandeep Vishwanath Belure and published by . This book was released on 2017 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt:
