Co Registration Of Fluorescence Diffuse Optical Tomography Fdot With Positron Emission Tomography Pet And Development Of Multi Angle Fdot

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Co-registration of Fluorescence Diffuse Optical Tomography (fDOT) with Positron Emission Tomography (PET) and Development of Multi-angle FDOT

Author : Xiao Tong
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (835 download)

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Book Synopsis Co-registration of Fluorescence Diffuse Optical Tomography (fDOT) with Positron Emission Tomography (PET) and Development of Multi-angle FDOT by : Xiao Tong

Download or read book Co-registration of Fluorescence Diffuse Optical Tomography (fDOT) with Positron Emission Tomography (PET) and Development of Multi-angle FDOT written by Xiao Tong and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis concerns the image processing of fluorescence diffuse optical tomography (fDOT), following two axes: FDOT image co-registration with PET (positron emission tomography) image and improvement of fDOT image reconstructions using mirrors to collect additional projections. It is presented in two parts:In the first part, an automatic method to co-register the fDOT images with PET images has been developed to correlate all the information from each modality. This co-registration method is based on automatic detection of fiducial markers (FM) present in both modalities. The particularity of this method is the use of optical surface image obtained in fDOT imaging system, which serves to identify the Z position of FM in optical images. We tested this method on a model of mice bearing tumor xenografts of MEN2A cancer cells that mimic a human medullary thyroid carcinoma, after a double injection of radiotracer [18F] 2-fluoro-2-Deoxy-D-glucose ( FDG) for PET imaging and optical fluorescent infrared tracer Sentidye. With the accuracy of our method, we can demonstrate that the signal of Sentidye is present both in the tumor and surrounding vessels.The fDOT reconstruction image quality is degraded along the Z axis due to a limited number of projections for reconstruction. In the second part, the work is oriented towards a new method of fDOT image reconstruction with a new multi-angle data acquisition system in placing two mirrors on each side of the animal. This work was conducted in collaboration with the CS Department of University College London (UCL), a partner of the European project FMT-XCT. TOAST software developed by this team was used as source code for the reconstruction algorithm, and was modified to adapt to the concerned problem. After several tests on the adjustment of program parameters, we applied this method on a phantom that simulating the biological tissue and on mice. The results showed an improvement in the reconstructed image of a semi-cylindrical phantom and the image of mouse kidney, for which the reconstruction of the mirrors geometry is better than that of conventional geometry without mirror. Nevertheless, we observed that the results were very sensitive to certain parameters, where the performance of reconstruction varies from one case to another. Future prospectives concern the optimization of parameters in order to generalize the multi-angle approach.

Diffuse Optical Tomography and Fluorescence Diffuse Optical Tomography

Author : Baohong Yuan
Publisher :
ISBN 13 :
Total Pages : 270 pages
Book Rating : 4.:/5 (71 download)

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Book Synopsis Diffuse Optical Tomography and Fluorescence Diffuse Optical Tomography by : Baohong Yuan

Download or read book Diffuse Optical Tomography and Fluorescence Diffuse Optical Tomography written by Baohong Yuan and published by . This book was released on 2006 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Diffuse Optical Tomography

Author : Huabei Jiang
Publisher : CRC Press
ISBN 13 : 1439847584
Total Pages : 366 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Diffuse Optical Tomography by : Huabei Jiang

Download or read book Diffuse Optical Tomography written by Huabei Jiang and published by CRC Press. This book was released on 2018-09-03 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by an authority involved in the field since its nascent stages, Diffuse Optical Tomography: Principles and Applications is a long-awaited profile of a revolutionary imaging method. Diffuse Optical Tomography (DOT) provides spatial distributions of intrinsic tissue optical properties or molecular contrast agents through model-based reconstruction algorithms using NIR measurements along or near the boundary of tissue. Despite the practical value of DOT, many engineers from electrical or applied mathematics backgrounds do not have a sufficient understanding of its vast clinical applications and portability value, or its uncommon advantages as a tool for obtaining functional, cellular, and molecular parameters. A collection of the author’s research and experience, this book fuses historical perspective and experiential anecdotes with fundamental principles and vital technical information needed to successfully apply this technology—particularly in medical imaging. This reference finally outlines how to use DOT to create experimental image systems and adapt the results of laboratory studies for use in clinical applications including: Early-stage detection of breast tumors and prostate cancer "Real-time" functional brain imaging Joint imaging to treat progressive diseases such as arthritis Monitoring of tumor response New contrast mechanisms and multimodality methods This book covers almost every aspect of DOT—including reconstruction algorithms based on nonlinear iterative Newton methods, instrumentation and calibration methods in both continuous-wave and frequency domains, and important issues of imaging contrast and spatial resolution. It also addresses phantom experiments and the development of various image-enhancing schemes, and it describes reconstruction methods based on contrast agents and fluorescence DOT. Offering a concise description of the particular problems involved in optical tomography, this reference illustrates DOT’s fundamental foundations and the principle of image reconstruction. It thoroughly explores computational methods, forward mathematical models, and inverse strategies, clearly illustrating solutions to key equations.

Positron Emission Tomography

Author : Timothy H. Witney
Publisher : Springer Nature
ISBN 13 : 1071634992
Total Pages : 454 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Positron Emission Tomography by : Timothy H. Witney

Download or read book Positron Emission Tomography written by Timothy H. Witney and published by Springer Nature. This book was released on 2023-11-25 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume explores key concepts and experimental design related to Positron Emission Tomography (PET) imaging that have revolutionized our understanding of human biology. The first part focuses on recent advances in radiotracer probe development to enable the detection of materials, from large macromolecules to complicated drug-like structures. The next section describes how key physiological and pathophysiological processes can be interrogated and quantifiably measured with this imaging technique. Finally, chapters examine important technological developments in the field that are revolutionizing the way these innovative PET probes are utilized in the clinic. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Positron Emission Tomography: Methods and Protocols serves as an ideal guide for researchers looking to use imaging to revolutionize the way we diagnose and treat disease.

Development and Validation of Time-domain Diffuse Optical Tomographic Imaging and Multiplexed Fluorescence Mediated Tomography

Author : Ying Mu
Publisher :
ISBN 13 :
Total Pages : 104 pages
Book Rating : 4.:/5 (15 download)

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Book Synopsis Development and Validation of Time-domain Diffuse Optical Tomographic Imaging and Multiplexed Fluorescence Mediated Tomography by : Ying Mu

Download or read book Development and Validation of Time-domain Diffuse Optical Tomographic Imaging and Multiplexed Fluorescence Mediated Tomography written by Ying Mu and published by . This book was released on 2016 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diffuse optical tomography (DOT) and fluorescence molecule tomography (FMT) are emerging as important optical imaging tools for clinical and biomedical research. Two major outstanding challenge in DOT and FMT are i) the relatively low imaging resolution, which results from the high degree of photon scatter through biological tissue, and ii) the inability to image multiple fluorescent targets in deep tissue ("multiplexing") due to the relatively narrow wavelength region within which light is less attenuated and effectively transmitted through bulk tissue. In this dissertation, we explored the use of time-domain DOT and FMT imaging to address these problems. First, time-resolved (TR) measurement of early arriving photons from a pulse laser was studied as a method for improving resolution in diffuse optical imaging. The underlying concept is photons that arrive first ("early") at a detector from a pulsed laser incident on bulk tissue have experienced fewer scattering events and taken relatively straight paths. We developed and tested a time-domain diffuse optical imaging system consisting of a femetosecond titanium: sapphire laser and fast, single photon avalanche photodiode (SPAD) detectors, that had an extremely fast temporal response time of 59 ps. We validated that the SPAD allowed measurement of photon-density sensitivity function that were 65% narrower than the temporally un-gated case at very early times. This exceeded the performance achieved previously with photomultiplier-based systems and approached the theoretical maximum predicted by time-resolved Monte Carlo simulations. Following this work, we then developed a complete SPAD-based DOT scanner, in which an array of SPADs were used. We validated performance of the system in cylindrical and irregular shaped optical phantoms of approximately small animal size. We were able to accurately reconstruct the size and position of up to 4 absorbing inclusions in diffusive media for the first time, with increasing image quality at earlier times. Next, we developed a time-resolved multiplexed fluorescence tomography system, which allowed us to measure extremely rich multi-spectral and temporal fluorescence data sets from diffusing media. In combination with a recently developed two-stage de-mixing and image reconstruction algorithm we are able to simultaneously image as many as four (and in theory 5) red and near-infrared fluorophores with closely overlapping spectral and temporal profiles, doubling the information throughput of FMT systems. This instrument also allowed us to account for the wavelength-dependency of optical properties in bulk biological tissue, which is a major challenge in biological imaging. The unique multiplexing imaging capabilities of this technology will allow us to study development of gliomas in small animal models in ongoing work in our group.

Positron Emission Tomography

Author : Dale L. Bailey
Publisher : Springer Science & Business Media
ISBN 13 : 1846280079
Total Pages : 381 pages
Book Rating : 4.8/5 (462 download)

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Book Synopsis Positron Emission Tomography by : Dale L. Bailey

Download or read book Positron Emission Tomography written by Dale L. Bailey and published by Springer Science & Business Media. This book was released on 2006-07-06 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essential for students, science and medical graduates who want to understand the basic science of Positron Emission Tomography (PET), this book describes the physics, chemistry, technology and overview of the clinical uses behind the science of PET and the imaging techniques it uses. In recent years, PET has moved from high-end research imaging tool used by the highly specialized to an essential component of clinical evaluation in the clinic, especially in cancer management. Previously being the realm of scientists, this book explains PET instrumentation, radiochemistry, PET data acquisition and image formation, integration of structural and functional images, radiation dosimetry and protection, and applications in dedicated areas such as drug development, oncology, and gene expression imaging. The technologist, the science, engineering or chemistry graduate seeking further detailed information about PET, or the medical advanced trainee wishing to gain insight into the basic science of PET will find this book invaluable. This book is primarily repackaged content from the Basic Science section of the 'big' Valk book on PET. It contains new, completely revised and unchanged chapters covering the "basic sciences" section of the main book - total 18 chapters: 2 new (chapters 1, 16) 8 completely revised (chapters 4, 5, 8, 13, 14, 15, 17, 18) 3 minor corrections (chapters 2, 6, 11) 5 unchanged (chapters 3, 7, 9, 10, 12)

Three-dimensional Image Co-registration of Positron Emission Tomography [PET] Images

Author : Nagesh Mallugari
Publisher :
ISBN 13 :
Total Pages : 160 pages
Book Rating : 4.:/5 (493 download)

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Book Synopsis Three-dimensional Image Co-registration of Positron Emission Tomography [PET] Images by : Nagesh Mallugari

Download or read book Three-dimensional Image Co-registration of Positron Emission Tomography [PET] Images written by Nagesh Mallugari and published by . This book was released on 2000 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Small Animal Imaging

Author : Fabian Kiessling
Publisher : Springer
ISBN 13 : 3319422022
Total Pages : 871 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Small Animal Imaging by : Fabian Kiessling

Download or read book Small Animal Imaging written by Fabian Kiessling and published by Springer. This book was released on 2017-05-22 with total page 871 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook is a practical guide to the use of small animal imaging in preclinical research that will assist in the choice of imaging modality and contrast agent and in study design, experimental setup, and data evaluation. All established imaging modalities are discussed in detail, with the assistance of numerous informative illustrations. While the focus of the new edition remains on practical basics, it has been updated to encompass a variety of emerging imaging modalities, methods, and applications. Additional useful hints are also supplied on the installation of a small animal unit, study planning, animal handling, and cost-effective performance of small animal imaging. Cross-calibration methods and data postprocessing are considered in depth. This new edition of Small Animal Imaging will be an invaluable aid for researchers, students, and technicians involved in research into and applications of small animal imaging.

Future Trends in Biomedical and Health Informatics and Cybersecurity in Medical Devices

Author : Kang-Ping Lin
Publisher : Springer
ISBN 13 : 9783030306359
Total Pages : 439 pages
Book Rating : 4.3/5 (63 download)

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Book Synopsis Future Trends in Biomedical and Health Informatics and Cybersecurity in Medical Devices by : Kang-Ping Lin

Download or read book Future Trends in Biomedical and Health Informatics and Cybersecurity in Medical Devices written by Kang-Ping Lin and published by Springer. This book was released on 2019-09-28 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gathers the proceedings of the IV International Conference on Biomedical and Health Informatics (ICBHI 2019), held on 17-20 April, 2019, in Taipei, Taiwan. Contributions span a range of topics, including medical imaging, biosignal processing, biodata management and analytics, public and personalized health systems, mobile health applications and many more. The IV conference edition gave a special emphasis to cybersecurity issues and cutting-edge medical devices, as it is reflected in this book, which provides academics and professionals with extensive knowledge on and a timely snapshot of cutting-edge research and developments in the field of biomedical and health informatics.

Aptamers for Medical Applications

Author : Yiyang Dong
Publisher : Springer Nature
ISBN 13 : 9813348380
Total Pages : 470 pages
Book Rating : 4.8/5 (133 download)

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Book Synopsis Aptamers for Medical Applications by : Yiyang Dong

Download or read book Aptamers for Medical Applications written by Yiyang Dong and published by Springer Nature. This book was released on 2021-03-25 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book outlines comprehensively the main medical uses of aptamers, from diagnosis to therapeutics in fourteen chapters. Pioneering topics covered include aptamer pharmaceuticals, aptamers for malign tumors, aptamers for personalized therapeutics and aptamers for point-of-care testing. The book offers an essential guide for medical scientists interested in developing aptamer-based schemes for better theranostics. It is therefore of interest for not only academic researchers, but also practitioners and medical researchers in various fields of medical science, medical research and bio-analytical chemistry.

Comprehensive Biomedical Physics

Author :
Publisher : Newnes
ISBN 13 : 0444536337
Total Pages : 4052 pages
Book Rating : 4.4/5 (445 download)

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Book Synopsis Comprehensive Biomedical Physics by :

Download or read book Comprehensive Biomedical Physics written by and published by Newnes. This book was released on 2014-07-25 with total page 4052 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Biomedical Physics, Ten Volume Set is a new reference work that provides the first point of entry to the literature for all scientists interested in biomedical physics. It is of particularly use for graduate and postgraduate students in the areas of medical biophysics. This Work is indispensable to all serious readers in this interdisciplinary area where physics is applied in medicine and biology. Written by leading scientists who have evaluated and summarized the most important methods, principles, technologies and data within the field, Comprehensive Biomedical Physics is a vital addition to the reference libraries of those working within the areas of medical imaging, radiation sources, detectors, biology, safety and therapy, physiology, and pharmacology as well as in the treatment of different clinical conditions and bioinformatics. This Work will be valuable to students working in all aspect of medical biophysics, including medical imaging and biomedical radiation science and therapy, physiology, pharmacology and treatment of clinical conditions and bioinformatics. The most comprehensive work on biomedical physics ever published Covers one of the fastest growing areas in the physical sciences, including interdisciplinary areas ranging from advanced nuclear physics and quantum mechanics through mathematics to molecular biology and medicine Contains 1800 illustrations, all in full color

Biomedical Engineering in Gastrointestinal Surgery

Author : Armin Schneider
Publisher : Academic Press
ISBN 13 : 0128032316
Total Pages : 592 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Biomedical Engineering in Gastrointestinal Surgery by : Armin Schneider

Download or read book Biomedical Engineering in Gastrointestinal Surgery written by Armin Schneider and published by Academic Press. This book was released on 2017-06-27 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical Engineering in Gastrointestinal Surgery is a combination of engineering and surgical experience on the role of engineering in gastrointestinal surgery. There is currently no other book that combines engineering and clinical issues in this field, while engineering is becoming more and more important in surgery. This book is written to a high technical level, but also contains clear explanations of clinical conditions and clinical needs for engineers and students. Chapters covering anatomy and physiology are comprehensive and easy to understand for non-surgeons, while technologies are put into the context of surgical disease and anatomy for engineers. The authors are the two most senior members of the Institute for Minimally Invasive Interdisciplinary Therapeutic Interventions (MITI), which is pioneering this kind of collaboration between engineers and clinicians in minimally invasive surgery. MITI is an interdisciplinary platform for collaborative work of surgeons, gastroenterologists, biomedical engineers and industrial companies with mechanical and electronic workshops, dry laboratories and comprehensive facilities for animal studies as well as a fully integrated clinical "OR of the future". - Written by the head of the Institute of Minimally Invasive Interdisciplinary Therapeutic Intervention (TUM MITI) which focusses on interdisciplinary cooperation in visceral medicine - Provides medical and anatomical knowledge for engineers and puts technology in the context of surgical disease and anatomy - Helps clinicians understand the technology, and use it safely and efficiently

Biophotonics for Medical Applications

Author : Igor Meglinski
Publisher : Elsevier
ISBN 13 : 0857096745
Total Pages : 402 pages
Book Rating : 4.8/5 (57 download)

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Book Synopsis Biophotonics for Medical Applications by : Igor Meglinski

Download or read book Biophotonics for Medical Applications written by Igor Meglinski and published by Elsevier. This book was released on 2015-06-29 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biophotonics for Medical Applications presents information on the interface between laser optics and cell biology/medicine. The book discusses the development and application of photonic techniques that aid the diagnosis and therapeutics of biological tissues in both healthy and diseased states. Chapters cover the fundamental technologies used in biophotonics and a wide range of therapeutic and diagnostic applications. - Presents information on the interface between laser optics and cell biology/medicine - Discusses the development and application of photonic techniques which aid the diagnosis and therapeutics of biological tissues in both healthy and diseased states - Presents the fundamental technologies used in biophotonics and a wide range of therapeutic and diagnostic applications

Scientific and Technical Aerospace Reports

Author :
Publisher :
ISBN 13 :
Total Pages : 296 pages
Book Rating : 4.:/5 (3 download)

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Book Synopsis Scientific and Technical Aerospace Reports by :

Download or read book Scientific and Technical Aerospace Reports written by and published by . This book was released on 1991 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Medical Optical Tomography

Author : Gerhard J. Müller
Publisher : SPIE-International Society for Optical Engineering
ISBN 13 :
Total Pages : 668 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis Medical Optical Tomography by : Gerhard J. Müller

Download or read book Medical Optical Tomography written by Gerhard J. Müller and published by SPIE-International Society for Optical Engineering. This book was released on 1993 with total page 668 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Protocol Handbook for Cancer Biology

Author : Gauri Misra
Publisher : Academic Press
ISBN 13 : 0323898173
Total Pages : 222 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Protocol Handbook for Cancer Biology by : Gauri Misra

Download or read book Protocol Handbook for Cancer Biology written by Gauri Misra and published by Academic Press. This book was released on 2021-02-12 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protocol Handbook for Cancer Biology brings together a comprehensive collection of the methods used for cancer assessment, diagnostics, and therapeutics. Various protocols are discussed along with alternative strategies, including the advantages and limitations of techniques that have been used in labs globally. These protocols are presented by cancer biology experts based on their real-world experience. The protocols in this book will be a valuable resource for cancer researchers and graduate students, who can utilize the techniques described to conduct research more efficiently and successfully. Presents comprehensive protocols used for cancer assessment, diagnostics, and therapeutics all in one place Encompasses alternative strategies considering the requirements of the end user and taking into consideration diverse research settings Discusses limitations and advantages of each method in experimental design and execution, thus saving time during the research process

Imaging of Head and Neck Cancer

Author : A. T. Ahuja
Publisher : Cambridge University Press
ISBN 13 : 9781841100906
Total Pages : 240 pages
Book Rating : 4.1/5 (9 download)

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Book Synopsis Imaging of Head and Neck Cancer by : A. T. Ahuja

Download or read book Imaging of Head and Neck Cancer written by A. T. Ahuja and published by Cambridge University Press. This book was released on 2003-01-06 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This concise integrated handbook looks at all available imaging methods for head and neck cancer, highlighting the strengths and weaknesses of each method. The information is provided in a clinical context and will guide radiologists as to the information the clinician actually needs when managing a patient with head and neck cancer. It will also provide the clinician with the advantages and limitations of imaging. The text therefore deals with Ultrasound, CT and MRI. The initial chapters aim to give the reader a core knowledge, which can be used in imaging by the various methods described. The subsequent chapters are directed towards clinical problems and deal with the common cancers in a logical order.