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Author : Doris D. Wang
Publisher : Frontiers Media SA
ISBN 13 : 2889762459
Total Pages : 165 pages
Book Rating : 4.8/5 (897 download)
Download or read book Closing the Loop on Neuromodulation for Neurological Diseases written by Doris D. Wang and published by Frontiers Media SA. This book was released on 2022-05-27 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Won Kim
Publisher : Elsevier Health Sciences
ISBN 13 : 0323264018
Total Pages : 233 pages
Book Rating : 4.3/5 (232 download)
Download or read book Advances in Neuromodulation, An Issue of Neurosurgery Clinics of North America, An Issue of Neurosurgery Clinics written by Won Kim and published by Elsevier Health Sciences. This book was released on 2014-01-28 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Neurosurgery Clinics of North America is devoted to "Advances in Neuromodulation." Editors Won Kim, MD, Antonio De Salles, MD, and Nader Pouratian, MD have assembled the top experts to review topics such as: peripheral nerve stimulation; spinal cord stimulation for gait reanimation and vascular pathology; deep brain stimulation for Tourettes, OCD, depression, Parkinson’s disease, eating disorders, dystonia, and headache; and techniques for image-guided deep brain stimulation, advanced imaging for targeting, and closed loop neuromodulation.
Author : Hariprasad Chandrakumar
Publisher :
ISBN 13 :
Total Pages : 182 pages
Book Rating : 4.:/5 (14 download)
Download or read book Implantable Neural Recording Front-Ends for Closed-Loop Neuromodulation Systems written by Hariprasad Chandrakumar and published by . This book was released on 2018 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of neuromodulation is to alter neural activity through targeted delivery of a stimulus to specific sites in the body. A prominent example of neuromodulation is deep brain stimulation (DBS), which has proved effective in mitigating the effects of certain neurological conditions. However, existing neuromodulation treatments lack real-time feedback (simultaneous sensing) to adapt stimulation parameters in response to brain dynamics. Hence, neuroscientists and clinicians aim to perform closed-loop neuromodulation, where stimulation can be optimally controlled in real time for better treatment outcomes. In recent years, the community has emphasized closed-loop neuromodulation as a highly desirable tool for administering therapy in patients suffering from drug-resistant neurological ailments. A miniaturized autonomous implant would be instrumental in ensuring that neuromodulation achieves its full potential. A key requirement for any closed-loop neuromodulation system is the ability to record neural signals while concurrently performing stimulation. However, neural stimulation generates large differential and common-mode artifacts at the recording sites, which easily saturate existing implantable recording front-ends due to their limited linear input range. To observe the neural response during stimulation, the front-end must faithfully digitize neural signals in the presence of large stimulation artifacts. The front-end must also satisfy strict constraints on power consumption, noise and input impedance, while achieving a small form-factor. State-of-the-art neural recording front-ends do not meet these requirements. This work presents a recording front-end that can digitize neural signals in the presence of 200mVpp differential artifacts and 700mVpp common-mode artifacts. The front-end consists of a chopper amplifier and a 15.2b-ENOB continuous-time delta-sigma ADC. In the design of the chopper amplifier, new techniques have been proposed that introduce immunity to common-mode interference, increase the DC input impedance (Zin) of the chopper amplifier to 1.5G , and enable the realization of large resistances (90G ) on-chip in a small area for filtering electrode offsets. In the design of the delta-sigma ADC, a modified loop-filter is used along with new linearization techniques to significantly reduce power consumption in the ADC. These techniques enable our recording front-end to achieve a dynamic range of 90dB (14b ENOB) in 1Hz - 200Hz, and 81dB (12.7b ENOB) in 1Hz - 5kHz. Implemented in a 40nm CMOS process, the prototype occupies an area of 0.113mm2/channel, consumes 7.3i W from a 1.2V supply, and can digitize neural signals from 1Hz to 5kHz. The input-referred noise is 1.8i Vrms (1Hz - 200Hz) and 6.35i Vrms (1Hz - 5kHz). The total harmonic distortion for a 200mVpp input at 1kHz is 81dB. Compared to state-of-the-art neural recording front-ends, this work improves Zin by 24.2x (for chopped front-ends), the linear-input range by 2x, the signal bandwidth (BW) by 10x, the dynamic range by 12.6dB, and tolerance to common-mode interferers by 6.5x, while maintaining comparable power and noise performance. The ADC alone consumes 4.5i W, has Zin of 20M , BW of 5kHz, and achieves a peak SNDR of 93.5dB for a 1.77Vpp differential input at 1kHz. The ADC's Schreier FOM (using SNDR) is 184dB, which is 6dB higher than the state-of-the-art in high-resolution ADCs.
Author : Timothée Levi
Publisher : Frontiers Media SA
ISBN 13 : 2889454665
Total Pages : 326 pages
Book Rating : 4.8/5 (894 download)
Download or read book Closed-Loop Systems for Next-Generation Neuroprostheses written by Timothée Levi and published by Frontiers Media SA. This book was released on 2018-04-26 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Millions of people worldwide are affected by neurological disorders which disrupt the connections within the brain and between brain and body causing impairments of primary functions and paralysis. Such a number is likely to increase in the next years and current assistive technology is yet limited. A possible response to such disabilities, offered by the neuroscience community, is given by Brain-Machine Interfaces (BMIs) and neuroprostheses. The latter field of research is highly multidisciplinary, since it involves very different and disperse scientific communities, making it fundamental to create connections and to join research efforts. Indeed, the design and development of neuroprosthetic devices span/involve different research topics such as: interfacing of neural systems at different levels of architectural complexity (from in vitro neuronal ensembles to human brain), bio-artificial interfaces for stimulation (e.g. micro-stimulation, DBS: Deep Brain Stimulation) and recording (e.g. EMG: Electromyography, EEG: Electroencephalography, LFP: Local Field Potential), innovative signal processing tools for coding and decoding of neural activity, biomimetic artificial Spiking Neural Networks (SNN) and neural network modeling. In order to develop functional communication with the nervous system and to create a new generation of neuroprostheses, the study of closed-loop systems is mandatory. It has been widely recognized that closed-loop neuroprosthetic systems achieve more favorable outcomes for users then equivalent open-loop devices. Improvements in task performance, usability, and embodiment have all been reported in systems utilizing some form of feedback. The bi-directional communication between living neurons and artificial devices is the main final goal of those studies. However, closed-loop systems are still uncommon in the literature, mostly due to requirement of multidisciplinary effort. Therefore, through eBook on closed-loop systems for next-generation neuroprostheses, we encourage an active discussion among neurobiologists, electrophysiologists, bioengineers, computational neuroscientists and neuromorphic engineers. This eBook aims to facilitate this process by ordering the 25 contributions of this research in which we highlighted in three different parts: (A) Optimization of different blocks composing the closed-loop system, (B) Systems for neuromodulation based on DBS, EMG and SNN and (C) Closed-loop BMIs for rehabilitation.
Author : Markus Christen
Publisher : Frontiers Media SA
ISBN 13 : 2889453731
Total Pages : 84 pages
Book Rating : 4.8/5 (894 download)
Download or read book The Clinical and Ethical Practice of Neuromodulation – Deep Brain Stimulation and Beyond written by Markus Christen and published by Frontiers Media SA. This book was released on 2018-01-15 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuromodulation is among the fastest-growing areas of medicine, involving many diverse specialties and affecting hundreds of thousands of patients with numerous disorders worldwide. It can briefly be described as the science of how electrical, chemical, and mechanical interventions can modulate the nervous system function. A prominent example of neuromodulation is deep brain stimulation (DBS), an intervention that reflects a fundamental shift in the understanding of neurological and psychiatric diseases: namely as resulting from a dysfunctional activity pattern in a defined neuronal network that can be normalized by targeted stimulation. The application of DBS has grown remarkably and more than 130,000 patients worldwide have obtained a DBS intervention in the past 30 years—most of them for treating movement disorders. This Frontiers Research Topics provides an overview on the current discussion beyond basic research in DBS and other brain stimulation technologies. Researchers from various disciplines, who are working on broader clinical, ethical and social issues related to DBS and related neuromodulation technologies, have contributed to this research topic.
Author :
Publisher : Academic Press
ISBN 13 : 0128222999
Total Pages : 290 pages
Book Rating : 4.1/5 (282 download)
Download or read book Emerging Horizons in Neuromodulation: New Frontiers in Brain and Spine Stimulation written by and published by Academic Press. This book was released on 2021-08-24 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: International Review of Neurobiology serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the International Review of Neurobiology series
Author : Vahagn Hokhikyan
Publisher :
ISBN 13 :
Total Pages : 119 pages
Book Rating : 4.:/5 (14 download)
Download or read book Design and Verification of a Closed-loop-ready High-channel-count Neuromodulation Unit written by Vahagn Hokhikyan and published by . This book was released on 2017 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: According to a report by the World Health Organization (WHO), neuropsychiatric disorders affect about one billion people worldwide and are the leading cause of disability in the U.S.. To address this global epidemic, neuroscientific initiatives are being developed globally. Deep brain stimulation (DBS) has been successful alternate treatment modality for some neuropsychiatric disorders (Parkinson's disease, essential tremor, dystonia, and obsessive-compulsive disorder) when traditional treatment options failed (resection, medication, and psychotherapy). According to one long term study targeting Parkinson's disease, patients' motor function and daily activity-scores improve about 50% while off medication and receiving only DBS therapy. This therapy is delivered through large electrodes in the form of fixed-frequency rectangular stimulation pulses in an always-on, open-loop fashion - ignoring the disease state, medication status, or side effects. In this work, we present a more advanced neural implant which, while being backward compatible with traditional DBS therapy, 1) is capable of sensing neural signals while delivering stimulation, 2) has high-channel-count, and 3) can generate non-rectangular stimulation waveforms. These key features are enabled by our custom-designed neural sensing and stimulation integrated circuits (ICs), which along with a few passive components, a miniature printed circuit board, and our user-friendly graphical interface comprise a capable neuromodulation system. Our sensing IC's ability to capture neural signals and stimulation artifacts without saturation at implant-level power is unique. Sampled local field potential (LFP) signals can be used to close the knowledge gap about the disease biomarkers and be fed into closed-loop algorithms for automatic tuning of stimulation parameters based on the disease state. The resulting autonomy will reduce or eliminate the need for periodic clinical visits for re-adjusting stimulation parameters to ameliorate neural network's habituation effects. Our high-channel-count stimulation IC, when paired with high-density probes, will substantially increase the spatial resolution of DBS, which can improve the therapeutic index and potentially result in lower power consumption for achieving the same therapeutic benefits. Also, the ability of our stimulation IC to generate custom, non-rectangular waveforms can lead to increased implant battery life, as some non-rectangular waveforms seem to be more energy efficient. We believe that the proposed system has the potential to improve the quality of patient care and to further our understanding of neuropsychiatric disorders, and we hope that it will soon find an increased use in various clinical and research environments.
Author :
Publisher : Elsevier
ISBN 13 : 0444635475
Total Pages : 317 pages
Book Rating : 4.4/5 (446 download)
Download or read book Computational Neurostimulation written by and published by Elsevier. This book was released on 2015-11-16 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational Neurostimulation, the latest volume in the Progress in Brain Research series provides an introduction to a nascent field with contributions from leading researchers. In addition, it addresses a very timely and relevant issue which has long been known to require more treatment. Part of a well-established international series that examines major areas of basic and clinical research within neuroscience, as well as emerging subfields Provides an introduction to a nascent field with contributions from leading researchers
Author : BAHMAN. ZOHURI
Publisher :
ISBN 13 : 9781774634905
Total Pages : 550 pages
Book Rating : 4.6/5 (349 download)
Download or read book Electrical Brain Stimulation for the Treatment of Neurological Disorders written by BAHMAN. ZOHURI and published by . This book was released on 2021-03-31 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, Electrical Brain Stimulation for the Treatment of Neurological Disorders, the authors present their embodiment for a closed loop, feedback controlled, non-invasive application of electrical stimulation of the brain to enhance individual/group performance or to treat neurological disorders. Using a combination of modeling and experimental work, the authors have developed a unique approach to the field in combination with new technology from the perspectives of electro-magnetic and electrical engineering, computation of image processing, machine learning and neural networking, and in conjunction with the medicine of neurology and understanding of neuron behavior. They claim that non-invasive brain stimulation (NIBS) will provide new treatment methods with much greater simplicity, lower cost, improved safety, and in some cases, possibly greater effectiveness than well-established pharmacological methods or more recent invasive electrical deep brain stimulation (DBS) techniques. The authors explain their techniques and the results of their experimental studies and assert that the application of tailored and individualized control of their approach can be combined with other therapy methods to treat neurological disorders while minimizing or even eliminating the use of pharmaceuticals.
Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (136 download)
Download or read book Closed-Loop Systems for Next-Generation Neuroprostheses written by and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Millions of people worldwide are affected by neurological disorders which disrupt the connections within the brain and between brain and body causing impairments of primary functions and paralysis. Such a number is likely to increase in the next years and current assistive technology is yet limited. A possible response to such disabilities, offered by the neuroscience community, is given by Brain-Machine Interfaces (BMIs) and neuroprostheses. The latter field of research is highly multidisciplinary, since it involves very different and disperse scientific communities, making it fundamental to create connections and to join research efforts. Indeed, the design and development of neuroprosthetic devices span/involve different research topics such as: interfacing of neural systems at different levels of architectural complexity (from in vitro neuronal ensembles to human brain), bio-artificial interfaces for stimulation (e.g. micro-stimulation, DBS: Deep Brain Stimulation) and recording (e.g. EMG: Electromyography, EEG: Electroencephalography, LFP: Local Field Potential), innovative signal processing tools for coding and decoding of neural activity, biomimetic artificial Spiking Neural Networks (SNN) and neural network modeling. In order to develop functional communication with the nervous system and to create a new generation of neuroprostheses, the study of closed-loop systems is mandatory. It has been widely recognized that closed-loop neuroprosthetic systems achieve more favorable outcomes for users then equivalent open-loop devices. Improvements in task performance, usability, and embodiment have all been reported in systems utilizing some form of feedback. The bi-directional communication between living neurons and artificial devices is the main final goal of those studies. However, closed-loop systems are still uncommon in the literature, mostly due to requirement of multidisciplinary effort. Therefore, through eBook on closed-loop systems for next-generation neuroprostheses, we encourage an active discussion among neurobiologists, electrophysiologists, bioengineers, computational neuroscientists and neuromorphic engineers. This eBook aims to facilitate this process by ordering the 25 contributions of this research in which we highlighted in three different parts: (A) Optimization of different blocks composing the closed-loop system, (B) Systems for neuromodulation based on DBS, EMG and SNN and (C) Closed-loop BMIs for rehabilitation.
Author : AHMED FAHAD A ALZUHAIR
Publisher :
ISBN 13 :
Total Pages : 101 pages
Book Rating : 4.:/5 (112 download)
Download or read book Theta Phase-Specific Closed-Loop Stimulation in Implantable Neuromodulation Devices written by AHMED FAHAD A ALZUHAIR and published by . This book was released on 2019 with total page 101 pages. Available in PDF, EPUB and Kindle. Book excerpt: Deep brain stimulation (DBS) is increasingly used to mitigate a variety of brain disorders, which is driving the interest in understanding and creating the optimal conditions for delivery of stimulation pulses. Generally, therapeutic DBS is open loop, with limited sensing in epilepsy devices. Epilepsy monitoring is a welcoming clinical environment to study science of human memory, where encoding and retrieval of information occur at a specific phase of Theta-band brain waves. Beside treating epilepsy, there is a growing interest in using DBS for memory restoration. Stimulation could be more efficacious if we incorporate knowledge of the memory encoding or recall state to inform the stimulation decision process [1]. It was shown that DBS enhances or inhibits memory when delivered at specific phases of the Theta rhythm [2-4]. Early Theta phase-locked (or phase-specific) (PL) experiments were fully supervised in the lab, and methods inaccuracies were overcome by repeated experiments. Later, efforts were made to realize real-time PL in software; these methods are supervised, requiring subject-specific complex optimization and manual settings, in addition to the high computational complexity [5, 6]. This work enables unsupervised, implantable size and power, phase-specific stimulation, closing the gap between implantable analog front-ends (AFE) and stimulation engines for smarter closed-loop control. Furthermore, compared to continuous stimulation, delivering stimulation pulses only when it matters results in an overall system power savings. This is crucial to implantable devices, since it translates to a smaller battery-size requirement or less frequent surgery for battery replacement. To facilitate clinical studies and accelerate IC validation towards an implantable system, the PL IC was integrated with an AFE and a stimulation IC's in a small-scale hand-held portable platform. The closed-loop platform functionality was verified in-vitro in preparation for clinical studies, which have been recently approved by the UCLA institutional review board. The platform features a graphical user interface for clinicians to design the closed-loop stimulation protocol parameters, such as targeted phase and the stimulation intensity for Theta-synchronized stimulation delivery. Therefore, facilitating a wide range of experiments that can, hopefully, bring us a step closer to restoring and enhancing memory.
Author : Valentin A. Pavlov
Publisher : Perspectives Cshl
ISBN 13 : 9781621823025
Total Pages : 350 pages
Book Rating : 4.8/5 (23 download)
Download or read book Bioelectronic Medicine written by Valentin A. Pavlov and published by Perspectives Cshl. This book was released on 2019 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Cold Spring Harbor perspectives in medicine."
Author : Nitish V. Thakor
Publisher : Springer Nature
ISBN 13 : 9811655405
Total Pages : 3686 pages
Book Rating : 4.8/5 (116 download)
Download or read book Handbook of Neuroengineering written by Nitish V. Thakor and published by Springer Nature. This book was released on 2023-02-02 with total page 3686 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Handbook serves as an authoritative reference book in the field of Neuroengineering. Neuroengineering is a very exciting field that is rapidly getting established as core subject matter for research and education. The Neuroengineering field has also produced an impressive array of industry products and clinical applications. It also serves as a reference book for graduate students, research scholars and teachers. Selected sections or a compendium of chapters may be used as “reference book” for a one or two semester graduate course in Biomedical Engineering. Some academicians will construct a “textbook” out of selected sections or chapters. The Handbook is also meant as a state-of-the-art volume for researchers. Due to its comprehensive coverage, researchers in one field covered by a certain section of the Handbook would find other sections valuable sources of cross-reference for information and fertilization of interdisciplinary ideas. Industry researchers as well as clinicians using neurotechnologies will find the Handbook a single source for foundation and state-of-the-art applications in the field of Neuroengineering. Regulatory agencies, entrepreneurs, investors and legal experts can use the Handbook as a reference for their professional work as well.
Author : Daniel Laskowitz
Publisher : CRC Press
ISBN 13 : 1498766579
Total Pages : 388 pages
Book Rating : 4.4/5 (987 download)
Download or read book Translational Research in Traumatic Brain Injury written by Daniel Laskowitz and published by CRC Press. This book was released on 2016-04-21 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme
Author : Clement Hamani
Publisher : John Wiley & Sons
ISBN 13 : 1118801040
Total Pages : 518 pages
Book Rating : 4.1/5 (188 download)
Download or read book Neuromodulation in Psychiatry written by Clement Hamani and published by John Wiley & Sons. This book was released on 2016-01-26 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by an expert multidisciplinary team, Neuromodulation in Psychiatry is the first reference guide to address both invasive and non-invasive neuromodulation strategies used in psychiatry. Covers basic principles, technical aspects, clinical applications and ethical considerations Presents up-to-date evidence in comprehensive summaries suitable for all levels of experience Each technique is clearly explained along with its implications for real-world clinical practice Allows psychiatrists to make informed decisions regarding neuromodulation for their patients
Author : Gordon H. Baltuch
Publisher : CRC Press
ISBN 13 : 1420019759
Total Pages : 374 pages
Book Rating : 4.4/5 (2 download)
Download or read book Deep Brain Stimulation for Parkinson's Disease written by Gordon H. Baltuch and published by CRC Press. This book was released on 2007-03-19 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Considered the largest breakthrough in the treatment of Parkinson's disease in the past 40 years, Deep Brain Stimulation (DBS) is a pioneering procedure of neurology and functional neurosurgery, forging enormous change and growth within the field. The first comprehensive text devoted to this surgical therapy, Deep Brain Stimulation for Parkinson's
Author : Kim J Burchiel
Publisher : Elsevier Health Sciences
ISBN 13 : 0323496105
Total Pages : 400 pages
Book Rating : 4.3/5 (234 download)
Download or read book Functional Neurosurgery and Neuromodulation written by Kim J Burchiel and published by Elsevier Health Sciences. This book was released on 2018-05-30 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offers expert guidance on functional neurosurgery and neuromodulation, lists of requirements, and the instruments needed to perform these procedures. Answers practical questions such as "What do I need when performing a thermal procedure?", "What do I need to bear in mind when assembling a device?", and "What do I need to remember with regards to voltages, electrodes, percutaneous leads, RF generators, imaging, and micro instruments?" Consolidates today’s available information and guidance in this timely area into one convenient resource. Functional Neurosurgery and Neuromodulation provides comprehensive coverage of this emerging, minimally invasive area of health care. Recent advances in these areas have proven effective for pain relief, memory loss, addiction, and much more. This practical resource by Drs. Kim J. Burchiel and Ahmed Raslan brings you up to date with what’s new in the field and how it can benefit your patients.
