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Author : Hillary Keeney
Publisher :
ISBN 13 : 9781934442432
Total Pages : 0 pages
Book Rating : 4.4/5 (424 download)
Download or read book Circular Therapeutics written by Hillary Keeney and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Christoph Dieterich
Publisher : Humana Press
ISBN 13 : 9781493975617
Total Pages : 220 pages
Book Rating : 4.9/5 (756 download)
Download or read book Circular RNAs written by Christoph Dieterich and published by Humana Press. This book was released on 2018-01-10 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides established approaches for identifying, characterizing, and manipulating circRNAs in vitro, in vivo, and in silico. Chapters highlight the breakthroughs and the challenges in this new field of research. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Circular RNAs: Methods and Protocols aims to useful and informative for further study into this vital field.
Author : Robert Chen (Researcher of circular RNA translation)
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (128 download)
Download or read book Principles of Circular RNA Translation and Immunity written by Robert Chen (Researcher of circular RNA translation) and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The rapid development of Covid-19 mRNA therapeutics was enabled by an upfront investment in mRNA platform technology, built on a fundamental understanding of mRNA biology. Decades of mechanistic work have uncovered key drivers of mRNA translation such as the cap, untranslated regions, and poly(A) tail. Additionally, the use of nucleoside modifications such as N1-methylpseudouridine enabled in vivo translation by suppressing innate immune responses to mRNA. Circular RNAs (circRNAs) are single-stranded covalently-closed RNAs whose translation is driven by internal ribosome entry sites (IRESs) and whose structure confers stability advantages over mRNAs. My dissertation defense will describe the circRNA assembly platform I built, its use in uncovering principals behind circRNA translation, and the study of the mechanism of immune sensing of nucleoside modification N6-methyladenosine (m6A) on circRNAs. In order to elucidate principles for driving strong circRNA translation, I built a platform for rapid and robust assembly of vectors and subsequent synthesis of circRNAs. Using this modular system, I identified an optimum format for circRNAs and systematically tested sequence elements that enhanced circRNA translation. I screened 100 viral IRESs, discovered a set with greatly improved translation across cell types, then created novel synthetic IRESs through both rational engineering and random mutagenesis. Further, I characterized a set of nucleoside modifications that improve circRNA translation. We decided to focus on one such modification, m6A, the most abundant post-transcriptional RNA modification on endogenous RNAs. Investigating the interaction behind m6A and anti-circRNA innate immunity, I found that circRNAs without nucleoside modifications activate the antiviral RNA sensor RIG-I in the presence of lysine-63-linked polyubiquitin chains to trigger a downstream interferon response. m6A blunts this response in an m6A reader YTHDF2-dependent manner. Viewed broadly, my findings characterize a mechanism behind self versus non-self recognition of circRNAs. Taken together, my circRNA development platform and the numerous discoveries made with it have pushed circRNAs forward as a promising class of RNA therapeutics.
Author : Vadim V. Demidov
Publisher : Springer
ISBN 13 : 331942226X
Total Pages : 180 pages
Book Rating : 4.3/5 (194 download)
Download or read book Rolling Circle Amplification (RCA) written by Vadim V. Demidov and published by Springer. This book was released on 2016-11-09 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the latest developments in rolling circle amplification (RCA) technology with applications in clinical diagnostic tests and molecular medicine. Topics covered include new enzymes useful in RCA, techniques involving RCA for enhanced signal amplification, novel RCA diagnostics, sensors for expediting RCA detection, and prospective RCA-based therapeutics. This is a valuable book for university professors and students in the field of biomedical engineering and biomolecular pharmacology as well as R&D managers of biotechnology and biopharmaceutical companies. Specifically, this book: Reviews prospective RCA-based therapeutics, including RCA-derived DNA nanoparticles that strongly bind to cancer cells Expands readers’ understanding of sensor systems for expediting detection of RCA products by using probe-tagged magnetic nanobeads Maximizes reader insights into novel RCA diagnostics, such as PNA openers-assisted RCA for detection of single target cells and in situ RCA diagnosis of cancer cells and malignant tissues Presents innovative methods for quasi-exponential enhancement of RCA-generated signals, such as nicking enzyme-assisted cascade RCA and RCA coupled with loop-mediated amplification Advance Praise for Rolling Circle Amplification (RCA): “This book provides a badly needed compendium of innovative RCA methods and applications. It should help further increase the community of scientists that have employed RCA in research and diagnostic programs.”— Charles Cantor, Professor Emeritus of Biomedical Engineering, Boston University Executive Director, Retrotope Inc. (USA) “In this new book Vadim Demidov has assembled an enticing menu of articles that illustrate the evolution of the RCA field, including improved protein parts for building superior DNA nanomachines, enhanced modalities of amplification and detection, diagnostic applications, and even a sampling of potential therapeutic applications. The reader will appreciate that while RCA has come of age, there is no lack of exciting surprises, turns, and twists in the continuing evolution of the technology.”— Paul Lizardi, Professor of Pathology, Yale University School of Medicine (retired) Investigator, University of Granada, Spain, President, PetaOmics, Inc., San Marcos, Texas.
Author : Anna Zampetaki
Publisher : Frontiers Media SA
ISBN 13 : 2889638820
Total Pages : 98 pages
Book Rating : 4.8/5 (896 download)
Download or read book Entering the RNA Wonderland: Opportunities and Challenges for RNA Therapeutics in the Cardiovascular System written by Anna Zampetaki and published by Frontiers Media SA. This book was released on 2020-07-22 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Saghir Akhtar
Publisher : CRC Press
ISBN 13 : 9780849347788
Total Pages : 324 pages
Book Rating : 4.3/5 (477 download)
Download or read book Delivery Strategies for Antisense Oligonucleotide Therapeutics written by Saghir Akhtar and published by CRC Press. This book was released on 1995-06-26 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions from leading experts, this book is the first to focus solely on addressing the problems and reviewing the strategies currently being used to improve the delivery of antisense nucleic acids. Important delivery issues, such as improving biological stability, improving cell-specific targeting and cellular uptake, manipulating subcellular distribution and producing liposomal delivery systems for antisense agents are comprehensively covered in this volume. This book links review-type articles with contributions that contain exciting never-before-published data on the cellular delivery of oligonucleotides. It stimulates reading for both established researchers and newcomers to the antisense field.
Author :
Publisher : Academic Press
ISBN 13 : 0128007974
Total Pages : 404 pages
Book Rating : 4.1/5 (28 download)
Download or read book Plant Cyclotides written by and published by Academic Press. This book was released on 2015-11-24 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Botanical Research publishes in-depth and up-to-date reviews on a wide range of topics in plant sciences. Currently in its 76th volume, the series features several reviews by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology and ecology. Publishes in-depth and up-to-date reviews on a wide range of topics in plant sciences Contains commentary by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology, and ecology This volume features reviews of the fast moving field of plant cyclotides
Author : Patrick Arbuthnot
Publisher : Academic Press
ISBN 13 : 0124114520
Total Pages : 391 pages
Book Rating : 4.1/5 (241 download)
Download or read book Gene Therapy for Viral Infections written by Patrick Arbuthnot and published by Academic Press. This book was released on 2015-06-01 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gene Therapy for Viral Infections provides a comprehensive review of the broader field of nucleic acid and its use in treating viral infections. The text bridges the gap between basic science and important clinical applications of the technology, providing a systematic, integrated review of the advances in nucleic acid-based antiviral drugs and the potential advantages of new technologies over current treatment options. Coverage begins with the fundamentals, exploring varying topics, including harnessing RNAi to silence viral gene expression, antiviral gene editing, viral gene therapy vectors, and non-viral vectors. Subsequent sections include detailed coverage of the developing use of gene therapy for the treatment of specific infections, the principles of rational design of antivirals, and the hurdles that currently face the further advancement of gene therapy technology. Provides coverage of gene therapy for a variety of infections, including HBV, HCV, HIV, hemorrhagic fever viruses, and respiratory and other viral infections Bridges the gap between the basic science and the important medical applications of this technology Features a broad approach to the topic, including an essential overview and the applications of gene therapy, synthetic RNA, and other antiviral strategies that involve nucleic acid engineering Presents perspectives on the future use of nucleic acids as a novel class of antiviral drugs Arms the reader with the cutting-edge information needed to stay abreast of this developing field
Author : Junjie Xiao
Publisher : Springer
ISBN 13 : 9789811346323
Total Pages : 0 pages
Book Rating : 4.3/5 (463 download)
Download or read book Circular RNAs written by Junjie Xiao and published by Springer. This book was released on 2018-12-29 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an essential overview of the rapidly advancing field of circular RNAs – newly discovered RNAs that are generated by back-splicing precursor mRNA and perform regulatory functions in many biological processes. Although many aspects of circular RNAs’ biology and mechanisms of gene regulation remain unclear, they have been found to be abundant, evolutionally conserved, and stable in cells; further, they have numerous potential functions. The book consists of eight parts:1) An overview of circular RNAs, 2) Bioinformatics for circular RNAs, 3) Biogenesis of circular RNAs, 4) Molecular mechanisms and gene regulation of circular RNAs, 5) Circular RNAs as potential disease biomarkers, 6) Circular RNAs and human diseases, 7) Circular RNAs in Plants and in Archaea, and 8) Future prospects. Given its focus, the book will be especially useful for researchers and students in the fields of biochemistry, molecular biology, cell biology, and medicine.
Author : Jill Hayes
Publisher : Jessica Kingsley Publishers
ISBN 13 : 0857006495
Total Pages : 242 pages
Book Rating : 4.8/5 (57 download)
Download or read book Soul and Spirit in Dance Movement Psychotherapy written by Jill Hayes and published by Jessica Kingsley Publishers. This book was released on 2013-06-28 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using a contemporary synthesis of Jungian and Post-Jungian imaginal perspectives, animate ecological phenomenology, somatics and recent scholarship in dance movement and progressive spiritualities, this unique book discusses how the promotion of a fluid relationship between imagination and movement can bring the mover back into relationship with soul and spirit. This connection with soul and spirit is considered as an essential and powerful resource in mental health. The book provides a rich digest of theory and produces a clear framework for the application of transpersonal theories to Dance Movement Psychotherapy (DMP) practice, writing and research, illustrating the use and value of transpersonal perspectives through detailed case studies. Providing spiritual, soulful and mythological perspectives on DMP rooted in theory and practice, this book will be essential reading for dance movement psychotherapists, drama psychotherapists, expressive arts therapists, and dance movement psychotherapy students, drama psychotherapy students and arts therapy students.
Author : Robert Knox
Publisher :
ISBN 13 :
Total Pages : 258 pages
Book Rating : 4.A/5 ( download)
Download or read book Radio-therapeutics written by Robert Knox and published by . This book was released on 1919 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Yuan-Chuan Chen
Publisher : BoD – Books on Demand
ISBN 13 : 183880031X
Total Pages : 212 pages
Book Rating : 4.8/5 (388 download)
Download or read book Gene Expression and Phenotypic Traits written by Yuan-Chuan Chen and published by BoD – Books on Demand. This book was released on 2020-04-01 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gene expression is the most fundamental level at which genotype gives rise to phenotype, which is an obvious, observable, and measurable trait. Phenotype is dependent on genetic makeup of the organism and influenced by environmental conditions. This book explores the significance, mechanism, function, characteristic, determination, and application of gene expression and phenotypic traits.
Author :
Publisher :
ISBN 13 :
Total Pages : 528 pages
Book Rating : 4.3/5 (47 download)
Download or read book The Journal of Pharmacology and Experimental Therapeutics written by and published by . This book was released on 1921 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Daniel H. Pink
Publisher : Penguin
ISBN 13 : 1101524383
Total Pages : 275 pages
Book Rating : 4.1/5 (15 download)
Download or read book Drive written by Daniel H. Pink and published by Penguin. This book was released on 2011-04-05 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: The New York Times bestseller that gives readers a paradigm-shattering new way to think about motivation from the author of When: The Scientific Secrets of Perfect Timing Most people believe that the best way to motivate is with rewards like money—the carrot-and-stick approach. That's a mistake, says Daniel H. Pink (author of To Sell Is Human: The Surprising Truth About Motivating Others). In this provocative and persuasive new book, he asserts that the secret to high performance and satisfaction-at work, at school, and at home—is the deeply human need to direct our own lives, to learn and create new things, and to do better by ourselves and our world. Drawing on four decades of scientific research on human motivation, Pink exposes the mismatch between what science knows and what business does—and how that affects every aspect of life. He examines the three elements of true motivation—autonomy, mastery, and purpose-and offers smart and surprising techniques for putting these into action in a unique book that will change how we think and transform how we live.
Author : Enrico Mihich
Publisher : Springer Science & Business Media
ISBN 13 : 1489913521
Total Pages : 351 pages
Book Rating : 4.4/5 (899 download)
Download or read book The Biology of Tumors written by Enrico Mihich and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Ninth Annual Pezcoller Symposium entitled "The Biology of Tumors" was held in Rovereto, Italy, June 4-7, 1997. It focused on the genetic mechanisms underlying het erogeneity of tumor cell populations and tumor cell differentiation, on interactions be tween tumor cells and cells of host defenses, and the mechanisms of angiogenesis. With presentations at the cutting edge of progress and stimulating discussions, this symposium addressed issues related to phenomena concerned with cell regulation and cell interactions as determined by activated genes through the appropriate and timely media tion of gene products. Important methodologies that would allow scientists to measure dif ferentially genes and gene products and thus validate many of the mechanisms of control currently proposed were considered, as were the molecular basis of tumor recognition by the immune system, interactions between cells and molecular mechanisms of cell regula tion as they are affected by or implemented through these interactions. The molecular and cellular mechanisms of tumor vascularization were also discussed. It was recognized that angiogenesis provides a potential site of therapeutic intervention and this makes it even more important to understand the mechanisms underlying it. We wish to thank the participants in the symposium for their substantial contribu tions and their participation in the spirited discussions that followed. We would also like to thank Drs.
Author :
Publisher :
ISBN 13 :
Total Pages : 822 pages
Book Rating : 4.3/5 (91 download)
Download or read book Druggists' Circular written by and published by . This book was released on 1909 with total page 822 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : You Zhou
Publisher : Frontiers Media SA
ISBN 13 : 2889745678
Total Pages : 514 pages
Book Rating : 4.8/5 (897 download)
Download or read book RNA Modification in Human Cancers: Roles and Therapeutic Implications written by You Zhou and published by Frontiers Media SA. This book was released on 2022-04-26 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt:
