Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Circadian Pharmacokinetics
Download Circadian Pharmacokinetics full books in PDF, epub, and Kindle. Read online Circadian Pharmacokinetics ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis Circadian Pharmacokinetics by : Baojian Wu
Download or read book Circadian Pharmacokinetics written by Baojian Wu and published by Springer Nature. This book was released on 2020-10-28 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes the recent advances for the understanding of circadian clock system in the regulation of drug metabolism and pharmacokinetics. Basic knowledge in the field of circadian clock and pharmacokinetics are systemically introduced to make it easier for readers to understand the entire book's contents. The rhythmic expression of DMEs (drug-metabolizing enzymes) and transporters are summarized, and the underlying mechanisms thereof (i.e., regulation by circadian oscillators) are discussed. Typically, evidence for the DME- and transporter-mediated chronopharmacokinetics, chronotoxicity and chronoefficacy are highlighted in this book.
Book Synopsis Circadian Rhythms and Metabolism by : Etienne Challet
Download or read book Circadian Rhythms and Metabolism written by Etienne Challet and published by Frontiers Media SA. This book was released on 2017-09-18 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the major breakthroughs of the last decade in the understanding of energy homeostasis is the identification of a reciprocal control between circadian rhythmicity and cellular metabolism. Circadian rhythmicity is a fundamental endogenous process of almost every organism living on Earth. For instance, the alternation of hunger and satiety is not continuous over 24 h, but is instead structured in time along the light/dark cycle. In mammals, the temporal organization of metabolism, physiology and behavior around 24 h is controlled by a network of multiple cellular clocks, synchronized via neuronal and hormonal signals by a master clock located in the suprachiasmatic nuclei of the hypothalamus. This central circadian conductor in the brain is mainly reset by ambient light perceived by the retina, while secondary circadian clocks in other brain areas and peripheral organs can be reset by meal timing. Chronic disruption of circadian rhythms, as seen in human shift-workers (up to 20% of the active population), has been associated with the development of a number of adverse mental and metabolic conditions. Understanding of the functional links between circadian desynchronization and overall health in animal models and humans, however, is still scarce. Interactions between circadian clocks and metabolism can occur at different levels: the molecular clockwork, internal synchronization via neuro-hormonal signals, or external synchronization via photic or feeding cues. This Research Topic comprises a number of reviews as well as research and methods articles that feature recent advancements in the mechanisms linking circadian clocks with energy metabolism, and the pathophysiological implications of these interactions for metabolic health.
Book Synopsis Chronotherapeutics by : P. H. Redfern
Download or read book Chronotherapeutics written by P. H. Redfern and published by Pharmaceutical Press. This book was released on 2003 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: In nature, many physical processes are governed by the passage of time. The study of these processes - chronobiology - reveals rhythmic patterns which may be yearly, monthly, daily or more frequent. Novel drug delivery systems are currently being delivered that will release varying quantities of a drug at optimum times to coincide with these rhythmic patterns.Chronotherapeutics considers the pharmaceutical and therapeutic implications associated with biological clocks. The book presents a comprehensive discussion of specific diseases that are time dependent, and the drugs and new drug formulations that can be used as treatments.Written by leading international experts in the field, Chronotherapeutics provides up-to-date information on chronobiology for non-chronobiologists in pharmaceutical and medical sciences. Peter Redfern is Professor of Pharmacology at the University of Bath, UK.
Book Synopsis Biologic Rhythms in Clinical and Laboratory Medicine by : Yvan Touitou
Download or read book Biologic Rhythms in Clinical and Laboratory Medicine written by Yvan Touitou and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 747 pages. Available in PDF, EPUB and Kindle. Book excerpt: Everyone has heard of nature's "biological clocks", the phenomenon of periodic activity in plants, animals and humans. But what does chronobiology have to do with modern medicine? This book presents in a concise but comprehensive fashion the basic principles of chronobiology and their application to clinical medicine. The chapters are written by specialists in the field; they summarize the physiology, pathophysiology and pathology of the human time structure and outline the application of chronobiologic principles and techniques for diagnosis and treatment.
Book Synopsis Chronopharmacology by : Björn Lemmer
Download or read book Chronopharmacology written by Björn Lemmer and published by Marcel Dekker. This book was released on 1989 with total page 752 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronopharmacology is the study of time-dependent variations in the pharmacokinetics, effects, and side and toxic effects of drugs. After three chapters on basic aspects, the remaining 46 contributions cover various types of drugs and discuss the regulatory issues related to circadian mechanisms and the predictive aspects of the science. Annotation(c) 2003 Book News, Inc., Portland, OR (booknews.com)
Book Synopsis Biopharmaceutics and Pharmacokinetics Considerations by :
Download or read book Biopharmaceutics and Pharmacokinetics Considerations written by and published by Academic Press. This book was released on 2021-07-07 with total page 754 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biopharmaceutics and Pharmacokinetics Considerations examines the history of biopharmaceutics and pharmacokinetics. The book provides a biopharmaceutics and pharmacokinetics approach to addressing issues in formulation development and ethical considerations in handling animals. Written by experts in the field, this volume within the Advances in Pharmaceutical Product Development and Research series deepens understanding of biopharmaceutics and pharmacokinetics within drug discovery and drug development. Each chapter delves into a particular aspect of this fundamental field to cover the principles, methodologies and technologies employed by pharmaceutical scientists, researchers and pharmaceutical industries to study the chemical and physical properties of drugs and the biological effects they produce. - Examines the most recent developments in biopharmaceutics and pharmacokinetics for pharmaceutical sciences - Covers the principles, methodologies and technologies of biopharmaceutics and pharmacokinetics - Focuses on the pharmaceutical sciences, but also encompasses aspects of toxicology, neuroscience, environmental sciences and nanotechnology
Book Synopsis Physiology and Pharmacology of Biological Rhythms by : Peter H. Redfern
Download or read book Physiology and Pharmacology of Biological Rhythms written by Peter H. Redfern and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: Measured by any criteria, research in chronobiology in general and chronopharmacology in particular has expanded rapidly in recent years. This expansion has been paralleled by an increasing recognition by those outside the field of the relevance and significance of recent developments in chronobiology. Advances in two areas have been chiefly responsible. First, application of the full range of modern techniques in behavioral, neurochemical, and molecular biology have greatly improved our understanding of basic clock mechanisms. In several species the genetic basis of the circadian clock is being progressively delineated. A complete picture of the neurochemical and neuroanatomical structure of the mammalian clock is emerging and the complex pattern of control mechanisms involving endogenous clock mechan isms and photic and nonphotic zeitgebers is being built up as a result of behavioral studies. Secondly, in parallel with these exciting developments in basic science, clinical applications are being convincingly demonstrated in the general fields of pharmacology and medicine as well as in specific areas, e.g., jet lag, shiftwork maladaption syndrome, blindness, and cardiovascular system. It is therefore an opportune time to review progress in the field of chronopharmacology and to introduce some of the exciting developments and prospects to a readership beyond the confines of the chronobiological cognoscenti. This volume is therefore aimed primarily at the pharmacologist - whether basic, applied, or clinical-who is not a specialist in chronobiology.
Download or read book Circadian Clocks written by Achim Kramer and published by Springer Science & Business Media. This book was released on 2013-04-18 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the reader with a contemporary and comprehensive overview about the molecular, cellular and system-wide principles of circadian clock regulation. Emphasis is placed on the importance of circadian clocks for the timing of therapeutic interventions.
Book Synopsis Military Strategies for Sustainment of Nutrition and Immune Function in the Field by : Institute of Medicine
Download or read book Military Strategies for Sustainment of Nutrition and Immune Function in the Field written by Institute of Medicine and published by National Academies Press. This book was released on 1999-05-13 with total page 722 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every aspect of immune function and host defense is dependent upon a proper supply and balance of nutrients. Severe malnutrition can cause significant alteration in immune response, but even subclinical deficits may be associated with an impaired immune response, and an increased risk of infection. Infectious diseases have accounted for more off-duty days during major wars than combat wounds or nonbattle injuries. Combined stressors may reduce the normal ability of soldiers to resist pathogens, increase their susceptibility to biological warfare agents, and reduce the effectiveness of vaccines intended to protect them. There is also a concern with the inappropriate use of dietary supplements. This book, one of a series, examines the impact of various types of stressors and the role of specific dietary nutrients in maintaining immune function of military personnel in the field. It reviews the impact of compromised nutrition status on immune function; the interaction of health, exercise, and stress (both physical and psychological) in immune function; and the role of nutritional supplements and newer biotechnology methods reported to enhance immune function. The first part of the book contains the committee's workshop summary and evaluation of ongoing research by Army scientists on immune status in special forces troops, responses to the Army's questions, conclusions, and recommendations. The rest of the book contains papers contributed by workshop speakers, grouped under such broad topics as an introduction to what is known about immune function, the assessment of immune function, the effect of nutrition, and the relation between the many and varied stresses encountered by military personnel and their effect on health.
Book Synopsis Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays by : Franz J. Hock
Download or read book Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays written by Franz J. Hock and published by Springer Nature. This book was released on 2025-02 with total page 2751 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many aspects of drug safety have become an outstanding and even persistent issue and may occur during the process of both drug discovery and development. Until 15 years ago, drug discovery and evaluation was primarily a sequential process starting with the selection of the most pharmacologically active compound from a series of newly synthesized small molecule chemical series by means of distinctive pharmacological assays. Safety aspects were addressed by evaluation of the selected compound at high doses in a series of specific studies directed at indications other than the intended indication of the new compound. These tests are then followed by pharmacokinetic studies, which are primarily conducted to confirm whether the selected compound possesses a suitable half-life for sufficient exposure and efficacy and, whether it has the desired properties specificity to the intended route of administration. Safety aspects relied predominantly on the conduct of single and repeat toxicologydose studies, which inform changes in organ structure rather than organ function. Both toxicological and pharmacokinetic studies are adapted to the progress of studies in clinical pharmacology and clinical trials. The new edition of this well and broadly accepted reference work contains several innovative and distinguished chapters. This "sequential" strategy has been abandoned with this new version of the book for several reasons: - Of the possible multitude of negative effects that novel drugs may impart on organ function, e.g. ventricular tachy-arrhythmia, many are detected too late in non-clinical studies to inform clinicians. On the other hand, negative findings in chronic toxicity studies in animals may turn out to be irrelevant for human beings. - New scientific approaches, e.g. high-throughput screening, human pluripotent stem cells, transgenic animals, knock-out animals, in silico models, pharmaco-genomics and pharmaco-proteomics, as well as Artificial Intelligence (AI) methods offered new possibilities. - There are several examples, that show that the "druggability" of compounds was considerably underestimated when the probability of success of a new project was assessed. The success rate in the pharmaceutical industry and the introduction of new chemical entities to the market per year dropped dramatically, whereas the development time for a new compound increased, sometimes exceeding the patent protection. Research and development scientists, involving the following changes, therefore adopted a change of strategy: - Parallel instead of sequential involvement of the various disciplines (multidimensional compound optimization). - The term "Safety Pharmacology" was coined. The International Conference on Harmonization (ICH) founded a Safety Pharmacology Working Group and the Safety Pharmacology Society (SPS) was launched. The discipline provided for evaluation, development and validation of a multitude of safety tests outlined in the 'Core Battery of Studies'. - Characterizing the exposure profile of a drug by conducting pharmacokinetic studies that evaluates the absorption, distribution, metabolism and excretion should to be investigated at an early stage of development as results contribute to the selection of a compound for further development. Advancements in Toxicology were achieved by the introduction of new methods, e.g., in silico methods, genetic toxicology, computational toxicology and AI. The book is a landmark in the continuously changing world of drug research and developments. As such, it is essential reading for many groups: not only for all students of pharmacology and toxicology but also for industry scientists and physicians, especially those involved in clinical trials of drugs, and for pharmacists who must know the safety requirements of drugs. The book is essential for scientists and managers in the pharmaceutical industry who are involved in drug discovery, drug development and decision making in the development process. In particular, the book will be of use to government institutions and committees working on official guidelines for drug evaluation worldwide.
Book Synopsis Applied Pharmacokinetics & Pharmacodynamics by : Michael E. Burton
Download or read book Applied Pharmacokinetics & Pharmacodynamics written by Michael E. Burton and published by Lippincott Williams & Wilkins. This book was released on 2006 with total page 924 pages. Available in PDF, EPUB and Kindle. Book excerpt: The definitive advanced-level clinical pharmacokinetics text is now in its Fourth Edition, with new emphasis on the relationship between pharmacokinetics and pharmacodynamics. Written by 70 leading researchers and practitioners, this book is a rigorous yet practical text on the application of pharmacokinetic methods, pharmacodynamic principles, and pharmacotherapeutic data for optimal, individualized drug therapy. This edition includes case studies that apply concepts to actual patient problems. New chapters cover tacrolimus, mycophenolic acid, sirolimus, antipsychotics, and critical evaluation of therapeutic drug monitoring methods. Other new features include more drawings and reference tables and an appendix on outcome studies with therapeutic drug monitoring.
Book Synopsis Rau's Respiratory Care Pharmacology E-Book by : Douglas S. Gardenhire
Download or read book Rau's Respiratory Care Pharmacology E-Book written by Douglas S. Gardenhire and published by Elsevier Health Sciences. This book was released on 2023-05-12 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: **Selected for Doody's Core Titles® 2024 in Respiratory Therapy** You can breathe a little easier knowing there's a proven way to master respiratory pharmacology! For more than 30 years, Rau's Respiratory Care Pharmacology has been the preeminent text on the subject. With easy-to-grasp terminology, relatable explanations, and reader-friendly writing, it simplifies the process of learning pharmacology material like never before. Rau's is organized into three logical sections, covering the basics of respiratory care, frequently used drugs, and critical care medications. New to the 11th edition are recently approved FDA drugs, information on drug approvals, COVID-19 coverage, and new and updated Clinical Connection boxes that focus on important clinical questions, assisting you in connecting the information in the text to the clinical setting and addressing how Respiratory Therapists can help educate patients. - Clinical scenarios with follow-up SOAP assessment help you assess your comprehension of the material. - Self-assessment questions offer you thought-provoking opportunities to test your comprehension of key concepts. - Learning objectives parallel the levels tested by the NBRC® exams to help you identify important information that goes beyond memorization and recall. - Key terms with definitions provide easy access to the pharmacologic vocabulary you should embrace. - Key points boxes in each chapter highlight important concepts in the lesson. - Glossary of all key terms in the text aids you in understanding the terminology associated with respiratory care pharmacology. - Appendices on common Units and Systems of Measurement and Acceptable Mixtures provide references to need-to-know information such as abbreviations, conversion charts for temperatures, liquid metric and solids, and a simple drug compatibility chart for drug mixtures. - Alphabetical drug index provides a direct index to look up information based on drug name. - NEW and UPDATED! Clinical Connection boxes assist you in connecting information in the text to the clinical setting, including providing patients a better understanding of their clinical conditions as related to their drug treatments. - UPDATED! Chapter 1 reflects changes to drug approval. - UPDATED! Chapter 3 reflects changes in aerosol medication devices and addresses aerosol-generating device issues and COVID-19. - UPDATED! The latest FDA-approved medications are referenced in all chapters. - UPDATED! Current asthma (GINA) and COPD (GOLD) guidelines include COVID-19 treatment protocols. - Enhanced readability helps you more easily understand difficult material.
Download or read book The Pineal Gland written by I. Nir and published by . This book was released on 2015-01-07 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists by : Younggil Kwon
Download or read book Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists written by Younggil Kwon and published by Springer Science & Business Media. This book was released on 2001-12-31 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is a handbook primarily designed for scientists andtechnicians without formal pharmacokinetics/pharmacodynamics (PK/PD)training, who work in an industrial setting. The book is a primarydesktop reference and contains easy-to-understand guidance for PK/PDissues, study design, and data interpretation. PK/PD are integralaspects for investigating the disposition and pharmacological efficacyof drugs under various experimental and clinical conditions.
Book Synopsis A Time for Metabolism and Hormones by : Paolo Sassone-Corsi
Download or read book A Time for Metabolism and Hormones written by Paolo Sassone-Corsi and published by Springer. This book was released on 2016-04-04 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the most distinguished investigators in the field gathered together to discuss the present state and the future of the field. The editors trust that this volume will be of use to those colleagues who will be picking up the challenge to unravel how the circadian clock can be targeted for the future development of specific pharmacological strategies toward a number of pathologies.
Book Synopsis Circadian Physiology by : Roberto Refinetti PhD.
Download or read book Circadian Physiology written by Roberto Refinetti PhD. and published by CRC Press. This book was released on 2016-04-19 with total page 689 pages. Available in PDF, EPUB and Kindle. Book excerpt: While the first edition of the critically acclaimed and highly popular Circadian Physiologyoffered a concise but rigorous review of basic and applied research on circadian rhythms, this newest edition provides educators with the primary textbook they need to support a course on this cutting-edge topic. Maintaining the same accessible multidi
Book Synopsis Nonclinical Drug Administration by : Shayne C. Gad
Download or read book Nonclinical Drug Administration written by Shayne C. Gad and published by CRC Press. This book was released on 2017-08-14 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reviews the principles of dosing route selection and calculation of maximum dose of drug that can be administered by route and model species Describes techniques on how to achieve highly selective administration of a drug to a specific therapeutic target Covers techniques on how to calculate necessary systemic exposure for the much higher safety testing requirements—and tricks to achieving such systemic exposure Includes a compendium of useable nonclinical formulation vehicles and excipients, with maximum tolerable levels by route, species, and study duration and how to develop nonclinical formulations that work
