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Cilia
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Book Synopsis Cilia and Nervous System Development and Function by : Kerry L. Tucker
Download or read book Cilia and Nervous System Development and Function written by Kerry L. Tucker and published by Springer Science & Business Media. This book was released on 2013-01-19 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cilia are tiny microtubule-based organelles projecting from the plasma membrane of practically all cells in the body. In the past 10 years a flurry of research has indicated a crucial role of this long-neglected organelle in the development and function of the central nervous system. A common theme of these studies is the critical dependency of signal transduction of the Sonic hedgehog, and more recently, Wnt signaling pathways upon cilia to regulate fate decisions and morphogenesis. Both primary and motile cilia also play crucial roles in the function of the nervous system, including the primary processing of sensory information, the control of body mass, and higher functions such as behavior and cognition, serving as "antennae" for neurons to sense and process their environment. In this book we describe the structure and function of cilia and the various tissues throughout the brain and spinal cord that are dependent upon cilia for their proper development and function.
Download or read book Primary Cilia written by and published by Academic Press. This book was released on 2009-11-30 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the role of cilia in the study of health, development and disease has been increasingly clear, and new discoveries have made this an exciting and important field of research. This comprehensive volume, a complement to the new three-volume treatment of cilia and flagella by King and Pazour, presents easy-to-follow protocols and detailed background information for researchers working with cilia and flagella. *Covers protocols for primary cilia across several systems and species * Both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time * Relevant to clinicians and scientists working in a wide range of fields
Download or read book Cilia written by Paraskevi Goggolidou and published by CRC Press. This book was released on 2018-02-28 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: The scope of the book is to highlight the diverse roles of cilia in human development and disease. Almost all cell types form cilia and although they were first detected about 200 years ago, their significance was unclear. In the past ten years, it has become obvious that cilia have got sensory functions, as well as roles in motility and their mis-formation or the deregulation of the signaling pathways they control has been associated with defective development and human disease. Although research has concentrated on the role of the cilium in each organ, no effort has been made so far to bring all this information together and relate it to the various human diseases. This book aims to gather all the expertise that has been acquired on primary cilia and translate it into a medical and research context that will be of interest to postgraduate students, researchers, medics and scientists.
Download or read book Cilia and Flagella written by and published by Academic Press. This book was released on 1995-08-31 with total page 603 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cilia and Flagella presents protocols accessible to all individuals working with eukaryotic cilia and flagella. These recipes delineate laboratory methods and reagents, as well as critical steps and pitfalls of the procedures. The volume covers the roles of cilia and flagella in cell assembly and motility, the cell cycle, cell-cell recognition and other sensory functions, as well as human diseases and disorders. Students, researchers, professors, and clinicians should find the book's combination of "classic" and innovative techniques essential to the study of cilia and flagella. Key Features * A complete guide containing more than 80 concise technical chapters friendly to both the novice and experienced researcher * Covers protocols for cilia and flagella across systems and species from Chlamydomonas and Euglena to mammals * Both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time, including microscopy, electrophoresis, and PCR * Relevant to clinicians interested in respiratory disease, male infertility, and other syndromes, who need to learn biochemical, molecular, and genetic approaches to studying cilia, flagella, and related structures
Book Synopsis Artificial Cilia by : Jaap MJ den Toonder
Download or read book Artificial Cilia written by Jaap MJ den Toonder and published by Royal Society of Chemistry. This book was released on 2013-05-31 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cilia are tiny hairs covering biological cells to generate and sense fluid flow. Millions of years of evolution have inspired a novel technology which is barely a decade old. Artificial cilia have been developed to control and sense fluid flow in microscopic systems, presenting new and interesting options for flow control in lab-on-a-chip devices. This appealing link between nature and technology has seen rapid development in the last few years, and this book presents a review of the state-of-the-art in the form of a professional reference book. The editors have pioneered the field, having initiated a major European project on this topic soon after its inception. Active researchers in academia and industry will benefit from the comprehensive nature of this book, while postgraduates and those new to the field will gain a clear understanding of the theory, techniques and applications of artificial cilia.
Book Synopsis Cilia: From Mechanisms to Disease–Part A by :
Download or read book Cilia: From Mechanisms to Disease–Part A written by and published by Elsevier. This book was released on 2023-03-24 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cilia: From Mechanisms to Disease, Part A, Volume 175 in the Methods in Cell Biology series, offers a range of techniques and protocols that can be used to study aspects of this interesting cellular organelle both in vitro and in vivo. Sections in this new release include Protocols to induce and study ciliogenesis, Flow Cytometry-Based Approach for the study of primary Cilia, Microscopic observation of human airway ciliary movement using wheat germ agglutinin, Time-lapse imaging of primary cilia behavior with physiological expression of fluorescent ciliary proteins, Evaluation of ciliary-GPCR dynamics using a validated organotypic brain slice culture method, and much more. Other sections cover Studying the morphology, composition and function of the photoreceptor primary cilium in zebrafish, Visualizing Multiciliated Cells in the Zebrafish, Isolation of Ciliary Ectosomes and Analysis of Peptide-mediated Chemotaxis in Chlamydomonas, Using Paramecium as a Model for Ciliopathies, Using organoids to study cilia, Using in vivo cerebellar electroporation to study neuronal cell proliferation and differentiation in a Joubert syndrome mouse model, and more. Offers a detailed overview of the protocols used to study cilia structure and various aspects of ciliary function Provides an approach to the study of some diseases related to ciliary dysfunction, also known as ciliopathies Written in an accessible style by renowned experts in the field
Book Synopsis The Biology of Cilia and Flagella by : M. A. Sleigh
Download or read book The Biology of Cilia and Flagella written by M. A. Sleigh and published by Elsevier. This book was released on 2016-01-11 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Biology of Cilia and Flagella reviews advances in the study of cilia and flagella since 1928. This book focuses on four main topics—structure of cilia, factors that affect ciliary activity, movement of cilia and flagella, and coordination of beat of cilia. In these topics, this compilation specifically discusses the intracellular structures associated with ciliary bases; viscosity of the medium and ciliary activity, and energy relationships of cilia and flagella. The compounding of synchronously beating cilia, variations in shaft structure, and control of ciliary activity by the organism are also elaborated. This text likewise covers the determination of the rate of beat of cilia and root-fiber systems and coordination of ciliary beat. This publication is suitable for biologists and clinicians of other disciplines researching on the structure and physiology of cilia and flagella.
Book Synopsis Artificial Cilia by : Jaap M. J. den Toonder
Download or read book Artificial Cilia written by Jaap M. J. den Toonder and published by Royal Society of Chemistry. This book was released on 2013 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives an overview of the research field of artificial cilia, a novel technology for controlling and sensing fluid flow at microscopic scales. This field is inspired by nature, namely by naturally occurring cilia which are tiny hairs covering biological cells and that are used already for over a billion years by nature to generate and sense fluid flow. The research field started less than a decade ago and has grown fast in recent years, since it offers very interesting options for flow control in lab-on-a-chip devices.
Download or read book Cilia, Part B written by and published by Academic Press. This book was released on 2013-03-16 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers cilia and includes chapters on such topics as methods for studying ciliary polarity in Xenopus, analysis of signaling pathways in mammalian spermatozoa, and biochemical and physiological analysis of axonemal dyneins. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers cilia Contains chapters on such topics as methods for studying ciliary polarity in Xenopus, analysis of signaling pathways in mammalian spermatozoa, and biochemical and physiological analysis of axonemal dyneins
Download or read book Methods in Cilia and Flagella written by and published by Academic Press. This book was released on 2015-03-26 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of this book is to collect methods and protocols for studying cilia in a wide range of different cell types, so that researchers from many fields of biology can start exploring the role of cilia in their own system. Chapters are written by experts in the field Cutting-edge material
Book Synopsis The Cytoskeleton and Cellular Compartmentation: Cilia as Specialized Cellular Domains by : Helena Soares
Download or read book The Cytoskeleton and Cellular Compartmentation: Cilia as Specialized Cellular Domains written by Helena Soares and published by Frontiers Media SA. This book was released on 2021-12-28 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Mechanisms of Cilia Related Diseases by : Joao Goncalves
Download or read book Molecular Mechanisms of Cilia Related Diseases written by Joao Goncalves and published by Frontiers Media SA. This book was released on 2024-05-29 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: Eukaryotic cilia are evolutionarily conserved microtubule-based structures that protrude from the cell surface. In vertebrates, multiple motile and primary (immotile) cilia fulfill sensory and motility functions that are critical for embryonic development and the homeostasis of adult tissues. Cilia malfunction has been shown to cause a growing number of diseases presenting phenotypes such as brain and skeletal developmental problems, intellectual disability, blindness, infertility, obesity, and kidney cysts. Despite their clinical relevance, we are still far from fully understanding the basic biology of these multiple cilia types. For example, we do not know the molecular compositions of all types of cilia nor how cilia structural and functional diversity is generated. Also, we are still identifying the genetic causes of ciliopathies and the impact of mutations on ciliary protein function, cilia biogenesis/maintenance, ciliary functions, and disease development. Understanding all these aspects concerning vertebrate cilia will greatly contribute to the design of innovative therapeutic approaches for cilia-related disorders. Understanding the basic biology of vertebrate cilia is critical for the understanding of cilia-related disorders. However, there are still many open questions about these organelles. For example, we do not know the proteomes and protein-protein interaction networks specific of each cilium type. Also, the function of ciliary proteins is often studied mostly in vitro and in the context of primary cilia. This limits our possibility to answer questions like “why does a certain disease mutation affect only certain types of cilia in specific tissues?”. Therefore, this Research Topic aims to address these issues and focus on the latest findings on the basic biology of vertebrate cilia such as their molecular composition and biogenesis pathways, and also on advances on our understanding of the molecular mechanisms of ciliopathies. The goal of this Research Topic is to cover novel research focused on furthering our understanding on the molecular mechanisms underlying the development of cilia-associated diseases. Areas to be covered in this Research Topic may include, but are not limited to: - Identification of novel cilia-related diseases - Genetic causes of ciliopathies - Molecular mechanisms of disease and development of therapeutic approaches - Molecular composition of vertebrate cilia - Molecular mechanisms of vertebrate cilia biogenesis and multiple functions Original research articles as well as review articles are welcomed.
Book Synopsis Cilia, Mucus, and Mucociliary Interactions by : Nadav Liron
Download or read book Cilia, Mucus, and Mucociliary Interactions written by Nadav Liron and published by CRC Press. This book was released on 1998-02-26 with total page 617 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by nearly 60 of the world's leading investigators in this rapidly expanding field, this state-of-the-art reference furnishes detailed presentations on the basic science and clinical aspects of cilia, mucus, and mucociliary interactions. Providing stimulating coverage of the latest information in a single source, Cilia, Mucus, and Mucoci
Book Synopsis Atlas of Cilia Bioengineering and Biocomputing by : Richard Mayne
Download or read book Atlas of Cilia Bioengineering and Biocomputing written by Richard Mayne and published by CRC Press. This book was released on 2022-09-01 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cilia are microscopic finger-like cell-surface organelles possessed by a great many eukaryotic organisms, including humans, whose purposes include generating local fluid movements via rhythmic whip-like beating and environmental sensing. Despite intense research efforts since their discovery by van Leeuwenhoek in the 1670's, several key questions regarding ciliary functions, experimental manipulation and in silico imitation remain unanswered. Major justifications for cilia research lie in their involvement in various forms of human disease (ciliopathies) and their ability to instantiate decentralised, asynchronous sensorial-actuation of adjacent matter through modulation of beating characteristics. Further elucidation of these characteristics, which is a problem requiring the combined expertise of mathematicians, computer scientists, engineers and life scientists, will lead to novel biomedical therapies, creation of `smart' actuating surfaces for microfluidics/lab-on-chip applications and a greater understanding of fluid mechanics in real-world scenarios. This lavishly-illustrated anthology presents recent advances in the fields of ciliary investigation, manipulation, emulation, mimesis and modelling from key researchers in their fields: its goal is to explain the state-of-the-art in cilia bioengineering and bio-computation in a uniquely creative, accessible manner, towards encouraging further transdisciplinary work in the field as well as educating a broad spectrum of scientists and lay people. The volume is split into three distinct but interwoven themes:Biology: Biological preliminaries for the study of cilia; the state-of-the-art in genetic engineering of ciliated cells for biomedical purposes; reprogramming of cilia dynamics in live cells.Engineering: Creation of macro cilia robots for object sorting applications; pneumatic cilia for the optimization of fluid motion; electrostatic, magnetic and MEMS cilia for microfluidic mixing; reviews in artificial cilia fabrication, actuation and flow induction methods.Numerical and computational modelling. Analyses of thin film cilia for `lab on chip' microfluidic mixing applications; modelling of gel-based artificial cilia towards simulating dynamic behaviors of responsive cilia layers in complex fluids across a wide range of potential applications.
Book Synopsis Cilia: Model Organisms and Intraflagellar Transport by :
Download or read book Cilia: Model Organisms and Intraflagellar Transport written by and published by Academic Press. This book was released on 2009-12-01 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cilia are highly conserved organelles that serve motile functions, sensory functions, or both. These organelles power cell movement, generate fluid flow in various organs, act as sensors of the extracellular environment and have been modified for various specialized tasks such as light reception and smell. Defects in these ubiquitous organelles lead to a broad array of human genetic disorders that range from polycystic kidney disease, retinal degeneration, epilepsy and infertility to developmental defects such as situs inversus and polydactyly. This volume is the third in a three-part series on cilia that focuses on the use of model organisms to gain insight into ciliary function and on the process of intraflagellar transport that is essential for the assembly and maintenance of ciliary structures. Includes both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time Covers forward and reverse genetic analysis of IFT and biochemical methods to define the role of IFT components Methods presented cover molecular, genetic, and biochemical approaches to ciliary function in model organisms
Download or read book Cilia: Structure and Motility written by and published by Academic Press. This book was released on 2009-11-27 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Along with its companion volume on intraflagellar transport, this book provides researchers with a comprehensive and up-to-date source of methods for the analysis cilia and flagella, focusing primarily on approaches that have been devised or significantly extended since the last volume of Methods in Cell Biology on this topic (volume 47, 1995). Edited by Stephen M. King and Gregory J. Pazour, the newest installment of this highly acclaimed serial will serve as an essential addition to the study of cilia and flagella. Covers protocols for cilia and flagella across systems and species Both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time Relevant to clinicians interested in respiratory disease, male infertility, and other syndromes who need to learn biochemical, molecular, and genetic approaches to studying cilia, flagella, and related structures
Book Synopsis Cells Inquiry Card--Cilia in the Airway by :
Download or read book Cells Inquiry Card--Cilia in the Airway written by and published by Teacher Created Materials. This book was released on 2014-01-01 with total page 4 pages. Available in PDF, EPUB and Kindle. Book excerpt: Elaborate on the concept of cells using this science inquiry card and lesson. Using vibrant, engaging images for science exploration allows all students to make connections and relate science concepts to new situations.
