Chromosome Conformation Capture On Chip 4c

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Capturing Chromosome Conformation

Author : Beatrice Bodega
Publisher : Humana
ISBN 13 : 9781071606636
Total Pages : 322 pages
Book Rating : 4.6/5 (66 download)

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Book Synopsis Capturing Chromosome Conformation by : Beatrice Bodega

Download or read book Capturing Chromosome Conformation written by Beatrice Bodega and published by Humana. This book was released on 2020-10-29 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed book collects methods based on the evolution of the chromosome conformation capture (3C) technique and other complementary approaches to dissect chromatin conformation with an emphasis on dissection of nuclear compartmentalization and visualization in imaging. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Capturing Chromosome Conformation: Methods and Protocols serves as an ideal guide for researchers working to further understand 3D genome organization.

Chromatin Immunoprecipitation Assays

Author : Philippe Collas
Publisher : Methods in Molecular Biology
ISBN 13 :
Total Pages : 290 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Chromatin Immunoprecipitation Assays by : Philippe Collas

Download or read book Chromatin Immunoprecipitation Assays written by Philippe Collas and published by Methods in Molecular Biology. This book was released on 2009-08-25 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, researchers deeply involved in the development and improvement of chromatin immunoprecipitation assays (ChIP) provide cutting-edge protocols devoted to the most recent progress in ChIP and related subjects.

Hi-C Data Analysis

Author : Silvio Bicciato
Publisher : Humana
ISBN 13 : 9781071613924
Total Pages : 0 pages
Book Rating : 4.6/5 (139 download)

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Book Synopsis Hi-C Data Analysis by : Silvio Bicciato

Download or read book Hi-C Data Analysis written by Silvio Bicciato and published by Humana. This book was released on 2022-09-04 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume details a comprehensive set of methods and tools for Hi-C data processing, analysis, and interpretation. Chapters cover applications of Hi-C to address a variety of biological problems, with a specific focus on state-of-the-art computational procedures adopted for the data analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Hi-C Data Analysis: Methods and Protocols aims to help computational and molecular biologists working in the field of chromatin 3D architecture and transcription regulation.

Modeling the 3D Conformation of Genomes

Author : Guido Tiana
Publisher : CRC Press
ISBN 13 : 1351386999
Total Pages : 306 pages
Book Rating : 4.3/5 (513 download)

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Book Synopsis Modeling the 3D Conformation of Genomes by : Guido Tiana

Download or read book Modeling the 3D Conformation of Genomes written by Guido Tiana and published by CRC Press. This book was released on 2019-01-15 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a timely summary of physical modeling approaches applied to biological datasets that describe conformational properties of chromosomes in the cell nucleus. Chapters explain how to convert raw experimental data into 3D conformations, and how to use models to better understand biophysical mechanisms that control chromosome conformation. The coverage ranges from introductory chapters to modeling aspects related to polymer physics, and data-driven models for genomic domains, the entire human genome, epigenome folding, chromosome structure and dynamics, and predicting 3D genome structure.

Eukaryotic Transcriptional and Post-Transcriptional Gene Expression Regulation

Author : Narendra Wajapeyee
Publisher :
ISBN 13 : 9781493965182
Total Pages : 278 pages
Book Rating : 4.9/5 (651 download)

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Book Synopsis Eukaryotic Transcriptional and Post-Transcriptional Gene Expression Regulation by : Narendra Wajapeyee

Download or read book Eukaryotic Transcriptional and Post-Transcriptional Gene Expression Regulation written by Narendra Wajapeyee and published by . This book was released on 2016 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume describes a variety of protocols that will allow the readers to study different aspects of transcriptional and posttranscriptional gene expression regulation in eukaryotic cells. Chapters focus on the latest use of CRISPRi and RNAi technologies for studying various aspects of transcriptional and posttranscriptional regulation and tools to navigate protocols on key bioinformatics. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls Authoritative and cutting-edge, Eukaryotic Transcription and Post-Transcription Gene Expression Regulation aims to ensure successful results in the further study of this vital field.

Chemical Biology of the Genome

Author : Siddhartha Roy
Publisher : Academic Press
ISBN 13 : 0128176458
Total Pages : 352 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Chemical Biology of the Genome by : Siddhartha Roy

Download or read book Chemical Biology of the Genome written by Siddhartha Roy and published by Academic Press. This book was released on 2021-05-14 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical Biology of the Genome provides a comprehensive overview of essential concepts and principles of genomic and epigenomics dynamics as explored through the lens of chemical biology. Key examples and case studies illustrate chemical biology methods for study and analysis of the genome and epigenome, with an emphasis on relevance to physiological and pathophysiological processes and drug discovery. Authors and international leaders in biochemical studies of the genome, Drs. Siddhartha Roy and Tapas Kundu, adopt an integrated, interdisciplinary approach throughout, demonstrating how fast evolving chemical and mass-scale sequencing tools are increasingly used to interpret biochemical processes of the genome. Later sections discuss chemical modifications of the genome, DNA sequence recognition by proteins and gene regulation, GWAS and EpiGWAS studies, 3D architecture of the genome, and functional genome architecture. In-depth, discovery focused chapters examine intervention in gene networks using SiRNA/ShRNA, miRNA, and anti-miR, small molecule modulation of iPS, drug resistance pathways altered DNA methylation as drug targets, anti-miR as therapeutics, and nanodelivery of drugs. - Offers an interdisciplinary discussion of the chemical biology of the genome and epigenome, employing illustrative case studies in both physiological and pathophysiological contexts - Supports researchers in employing chemical and mass-scale sequencing approaches to interpret genomic and epigenomic dynamics - Highlights innovative pathways and molecular targets for new disease study and drug discovery

Chromatin

Author : Randall H. Morse
Publisher : Academic Press
ISBN 13 : 0128148101
Total Pages : 586 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Chromatin by : Randall H. Morse

Download or read book Chromatin written by Randall H. Morse and published by Academic Press. This book was released on 2024-06-15 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chromatin: Structure, Function, and History covers the basics of chromatin biology, beginning with the discoveries that culminated in the recognition of the nucleosome as the basic subunit of chromatin. Chromatin folding, nucleosome positioning, and histone variants are discussed, as well as research on chromatin modifications and remodeling, which exploded in the early to mid-1990s and led to widespread interest in epigenetics. Considerable attention is given to methods and experiments that led to key insights and recent developments such as the use of genome-wide approaches and innovations in imaging approaches are also emphasized. By providing historical background together with detailed discussion of contemporary studies, the book aims to instill in the reader an appreciation not only of our current knowledge of chromatin structure and function, but also of the remarkable path that has taken chromatin to the forefront of modern research. - Provides a current, expansive, and well-documented resource on chromatin and epigenetics - Addresses the role of chromatin in transcription regulation and chromatin abnormalities in disease - Reviews the historical background of specific areas of chromatin research, enabling readers to understand how the field was born and to appreciate the discoveries and technical advances that have propelled it forward

HiC-Pro: an Optimized and Flexible Pipeline for Hi-C Data Processing

Author : Oldenburg Oldenburg Press
Publisher :
ISBN 13 : 9781523764426
Total Pages : 40 pages
Book Rating : 4.7/5 (644 download)

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Book Synopsis HiC-Pro: an Optimized and Flexible Pipeline for Hi-C Data Processing by : Oldenburg Oldenburg Press

Download or read book HiC-Pro: an Optimized and Flexible Pipeline for Hi-C Data Processing written by Oldenburg Oldenburg Press and published by . This book was released on 2016-01-29 with total page 40 pages. Available in PDF, EPUB and Kindle. Book excerpt: HiC-Pro is an optimized and flexible pipeline for processing Hi-C data from raw reads to normalized contact maps. HiC-Pro maps reads, detects valid ligation products, performs quality controls and generates intra- and inter-chromosomal contact maps. It includes a fast implementation of the iterative correction method and is based on a memory-efficient data format for Hi-C contact maps. In addition, HiC-Pro can use phased genotype data to build allele-specific contact maps. We applied HiC-Pro to different Hi-C datasets, demonstrating its ability to easily process large data in a reasonable time. Source code and documentation are available at http://github.com/nservant/HiC-Pro.

Plant Chromatin Dynamics

Author : Marian Bemer
Publisher : Humana
ISBN 13 : 9781493984510
Total Pages : 0 pages
Book Rating : 4.9/5 (845 download)

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Book Synopsis Plant Chromatin Dynamics by : Marian Bemer

Download or read book Plant Chromatin Dynamics written by Marian Bemer and published by Humana. This book was released on 2018-08-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a comprehensive collection of protocols that can be used to study plant chromatin structure and composition. Chapters divided into three sections detail the profiling of chromatin features in relation to epigenetic regulation, investigate the interaction between chromatin modifications and gene regulation, and explore the 3D spatial organization of the chromatin inside the nucleus. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Plant Chromatin Dynamics: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Genetics and Genomics of Eye Disease

Author : Xiaoyi Raymond Gao
Publisher : Academic Press
ISBN 13 : 0128167270
Total Pages : 386 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Genetics and Genomics of Eye Disease by : Xiaoyi Raymond Gao

Download or read book Genetics and Genomics of Eye Disease written by Xiaoyi Raymond Gao and published by Academic Press. This book was released on 2019-09-12 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetics and Genomics of Eye Disease: Advancing to Precision Medicine thoroughly examines the latest genomics methods for studying eye disease, including complex eye disorders associated with multiple genes. GWAS, WES, WGS, RNA-sequencing, and transcriptome analysis as employed in ocular genomics are discussed in-depth, as are genomics findings tied to early-onset glaucoma, strabismus, age-related macular degeneration, adult-onset glaucoma, diabetic retinopathy, keratoconus, and leber congenital amaurosis, among other diseases. Research and clinical specialists offer guidance on conducting preventative screenings and counseling patients, as well as the promise of machine learning, computational statistics and artificial intelligence in advancing ocular genomics research. - Offers thorough guidance on conducting genetic and genomic studies of eye disease - Examines the genetic basis of a wide range of complex eye diseases and single-gene and Mendelian disorders - Discusses the application of genetic testing and genetic risk prediction in eye disease diagnosis and patient counseling

The Dictionary of Genomics, Transcriptomics and Proteomics, 4 Volume Set

Author : Guenter Kahl
Publisher : John Wiley & Sons
ISBN 13 : 3527328521
Total Pages : 2744 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis The Dictionary of Genomics, Transcriptomics and Proteomics, 4 Volume Set by : Guenter Kahl

Download or read book The Dictionary of Genomics, Transcriptomics and Proteomics, 4 Volume Set written by Guenter Kahl and published by John Wiley & Sons. This book was released on 2015-06-08 with total page 2744 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its fifth edition and for the first time available as an electronic product with all entries cross-linked. This very successful long-seller has once again been thoroughly updated and greatly expanded. It now contains over 13,000 entries, and comprehensively covering genomics, transcriptomics, and proteomics. Each entry contains an extensive explanation, including a comprehensive listing of synonyms and acronyms, and all formulas have been redrawn to create a uniform style, while most of the figures are custom designed for this dictionary. The ultimate reference for all terms in the -omics fields.

Stem Cell Epigenetics

Author :
Publisher : Academic Press
ISBN 13 : 0128140860
Total Pages : 320 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Stem Cell Epigenetics by :

Download or read book Stem Cell Epigenetics written by and published by Academic Press. This book was released on 2020-08-07 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Growing evidence suggests that epigenetic mechanisms play a central role in stem cell biology and are vital for determining gene expression during cellular differentiation and governing mammalian development. In Stem Cell Epigenetics, leading international researchers examine how chromatin regulation and bona fide epigenetic mechanisms underlie stem cell renewal and differentiation. Authors also explore how the diversity of cell types, including the extent revealed by single cell omic approaches, is achieved, and how such processes may be reversed or managed via epigenetic reprogramming.Topics discussed include chromatin in pluripotency, stem cells and DNA methylation, histone modifications in stem cells and differentiation, higher-order chromatin conformation in pluripotent cells, stem cells and cancer, epigenetics and disease modeling, brain organoids from pluripotent cells, transcriptional regulation in stem cells and differentiation, non-coding RNAs in pluripotency and early differentiation, and diseases caused by epigenetic alterations in stem cells. Additionally, the book discusses the potential implementation of stem cell epigenetics in drug discovery, regenerative medicine, and disease treatment. Stem Cell Epigenetics will provide researchers and physicians with a state-of-the-art map to orient across the frontiers of this fast-evolving field. - Analyzes the role of epigenetics in embryonic stem cell regulation - Indicates the epigenetic mechanisms involved in stem cell differentiation and highlights modifications and misregulations that may result in disease pathogenesis - Examines the potential applications of stem cell epigenetics in therapeutic disease interventions and regenerative medicine, providing a foundation for researchers and physicians to bring this exciting and fast-evolving field into a clinical setting - Features chapter contributions by leading international experts

Perinatal and Developmental Epigenetics

Author : Garima Singh
Publisher : Academic Press
ISBN 13 : 0128217863
Total Pages : 406 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Perinatal and Developmental Epigenetics by : Garima Singh

Download or read book Perinatal and Developmental Epigenetics written by Garima Singh and published by Academic Press. This book was released on 2022-12-02 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: Perinatal and Developmental Epigenetics, Volume 32, a new volume in the Translational Epigenetics series, provides a thorough overview of epigenetics in the early developmental and perinatal stages, illuminating pathways for drug discovery and clinical advances. Here, over 25 international researchers examine recent steps forward in our understanding of epigenetic programming during perinatal and early development. The book opens with an in-depth introduction to known and newly discovered epigenetic marks and how they regulate various cellular processes. Later sections examine various prenatal and perinatal environmental experiences and their ability to derail the normal developmental trajectory via epigenetic reprogramming. Insights and suggestions for future research illuminate approaches for identifying individual disease susceptibility. Concluding chapters highlight preventative and targeted therapeutic pathways to improve quality of life into adulthood. - Examines disease onset stemming from epigenetic changes during the perinatal periods - Features contributions from international experts in the field, including basic biology, disease research and drug discovery - Offers intervention strategies to mitigate adverse developmental programming to improve health outcomes

Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine

Author : Malgorzata Kloc
Publisher : Springer Nature
ISBN 13 : 3031065735
Total Pages : 657 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine by : Malgorzata Kloc

Download or read book Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine written by Malgorzata Kloc and published by Springer Nature. This book was released on 2022-11-08 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume reviews the latest research on the functional implications of nuclear, chromosomal and genomic organization and architecture on cell and organismal biology, and development and progression of diseases. The architecture of the cell nucleus and non-random arrangement of chromosomes, genes, and the non-membranous nuclear bodies in the three-dimensional (3D) space alters in response to the environmental, mechanical, chemical, and temporal cues. The changes in the nuclear, chromosomal, or genomic compaction and configuration modify the gene expression program and induce or inhibit epigenetic modifications. The intrinsically programmed rearrangements of the nuclear architecture are necessary for cell differentiation, the establishment of cell fate during development and maturation of tissues and organs including the immune, muscle, and nervous systems. The non-programmed changes in the nuclear architecture can lead to fragmentation of the nucleus and instability of the genome and thus cause cancer. Microbial and viral infections can lead to a clustering of centromeres, telomeres and ribosomal DNA and alter the properties of the nuclear membrane, allowing large immobile macromolecules to enter the nucleus. Recent advances in next-generation sequencing technologies combined with nucleus/chromosome conformation capture, super-resolution imaging, chromosomal contact maps methods, integrative modeling, and genetic approaches, are uncovering novel features and importance of nuclear, chromosomal and genomic architecture. This book is an interesting read for cell biologists, researchers studying the structure and function of chromosomes, and anyone else who wants to get an overview of the field of nuclear, chromosomal and genomic architecture.

Next-Generation Genome Sequencing

Author : Michal Janitz
Publisher : John Wiley & Sons
ISBN 13 : 3527644733
Total Pages : 281 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Next-Generation Genome Sequencing by : Michal Janitz

Download or read book Next-Generation Genome Sequencing written by Michal Janitz and published by John Wiley & Sons. This book was released on 2011-08-24 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by leading experts from industry and academia, this first single comprehensive resource addresses recent developments in next generation DNA sequencing technology and their impact on genome research, drug discovery and health care. As such, it presents a detailed comparative analysis of commercially available platforms as well as insights into alternative, emerging sequencing techniques. In addition, the book not only covers the principles of DNA sequencing techniques but also social, ethical and commercial aspects, the concept of personalized medicine and a five-year perspective of DNA sequencing.

RNA Biology in Cardiovascular Disease

Author : Maarten M. G. van den Hoogenhof
Publisher : Frontiers Media SA
ISBN 13 : 2889718085
Total Pages : 151 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis RNA Biology in Cardiovascular Disease by : Maarten M. G. van den Hoogenhof

Download or read book RNA Biology in Cardiovascular Disease written by Maarten M. G. van den Hoogenhof and published by Frontiers Media SA. This book was released on 2021-12-06 with total page 151 pages. Available in PDF, EPUB and Kindle. Book excerpt:

A Handbook of Transcription Factors

Author : Timothy R. Hughes
Publisher : Springer Science & Business Media
ISBN 13 : 904819069X
Total Pages : 310 pages
Book Rating : 4.0/5 (481 download)

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Book Synopsis A Handbook of Transcription Factors by : Timothy R. Hughes

Download or read book A Handbook of Transcription Factors written by Timothy R. Hughes and published by Springer Science & Business Media. This book was released on 2011-05-10 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transcription factors are the molecules that the cell uses to interpret the genome: they possess sequence-specific DNA-binding activity, and either directly or indirectly influence the transcription of genes. In aggregate, transcription factors control gene expression and genome organization, and play a pivotal role in many aspects of physiology and evolution. This book provides a reference for major aspects of transcription factor function, encompassing a general catalogue of known transcription factor classes, origins and evolution of specific transcription factor types, methods for studying transcription factor binding sites in vitro, in vivo, and in silico, and mechanisms of interaction with chromatin and RNA polymerase.