Chemosensitivity

Download Chemosensitivity PDF Online Free

Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1592598692
Total Pages : 234 pages
Book Rating : 4.5/5 (925 download)

DOWNLOAD NOW!


Book Synopsis Chemosensitivity by : Rosalyn D. Blumenthal

Download or read book Chemosensitivity written by Rosalyn D. Blumenthal and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: A state-of-the art collection of readily reproducible laboratory methods for assessing chemosensitivity in vitro and in vivo, and for assessing the parameters that modulate chemosensitivity in individual tumors. Chemosensitivity, Volume 1: In Vitro Assays provides a panel of 16 in vitro measures of chemosensitivity in adherent and non-adherent cells for single agents and combinations of agents. In addition to immunohistochemical and imaging approaches, these assays include clonogenic, colorimetric, fluorometric, and physiological assays. Highlights include image analysis to assess drug sensitivity, high throughput approaches using green fluorescent protein, DIMSCAN (a microcomputer fluorescence-based assay), and the ChemoFx assay used in biotechnology. A companion volume, Volume 2: In Vivo Models, Imaging, and Molecular Regulators, provides protocols for classifying tumors into response categories and customizing chemotherapy regimens to individual patients.

Chemosensitivity Testing in Oncology

Download Chemosensitivity Testing in Oncology PDF Online Free

Author :
Publisher : Springer Science & Business Media
ISBN 13 : 3642190227
Total Pages : 262 pages
Book Rating : 4.6/5 (421 download)

DOWNLOAD NOW!


Book Synopsis Chemosensitivity Testing in Oncology by : Uwe Reinhold

Download or read book Chemosensitivity Testing in Oncology written by Uwe Reinhold and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past 50 years many in vitro and in vivo drug response assay systems have been developed to determine the potential - tivity of chemotherapy agents. The idea was to eliminate ineffective agents and unnecessary toxic treatment while selecting drugs active in vitro or in the mouse model that might increase the probability of response in the patient. None of these test models, however, achieved routine clinical application in the past. This might be at least in part - lated to large discrepancies that were described between the s- cess rate of the assay systems and the clinical benefit in cancer - tients. The heterogeneity of chemosensitivity that exists between different tumors as well as between individual tumor lesions may be one explanation for these findings. Furthermore, different assay end points such as proliferation, metabolism, and vitality were - veloped to evaluate the effects of cytostatic drugs on tumor cells, and these might be related to the differing results. However, knowledge about procedures for assay-assisted treatment selection has increased rapidly within the past few years, and several studies suggest that test-directed chemotherapy selection now may - prove response rates and survival in various types of tumors. The International Society for Chemosensitivity Testing in - cology (ISCO) was founded to promote, coordinate, and improve clinical and laboratory research in the field of predictive drug te- ing in human tumor cells.

Breast Cancer Chemosensitivity

Download Breast Cancer Chemosensitivity PDF Online Free

Author :
Publisher : Springer Science & Business Media
ISBN 13 : 0387740392
Total Pages : 175 pages
Book Rating : 4.3/5 (877 download)

DOWNLOAD NOW!


Book Synopsis Breast Cancer Chemosensitivity by : Dihua Yu

Download or read book Breast Cancer Chemosensitivity written by Dihua Yu and published by Springer Science & Business Media. This book was released on 2009-12-30 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Breast Cancer Chemosensitivity, a group of world leading experts review critical aspects of resistance to systemic therapy in breast cancer patients. Beginning with a clinical overview of the problem, the book then focuses on the latest findings of molecular mechanisms of drug resistance. Coverage provides an example of using novel approaches for chemosensitization of breast cancer cells that gives readers an idea about the future direction in breast cancer treatment. It allows those who are interested in breast cancer therapy to get a jump-start on critical issues in breast cancer therapeutic resistance.

Augmentation of Peripheral Chemosensitivity During Hypermetabolism

Download Augmentation of Peripheral Chemosensitivity During Hypermetabolism PDF Online Free

Author :
Publisher : Universal-Publishers
ISBN 13 : 1581123272
Total Pages : 361 pages
Book Rating : 4.5/5 (811 download)

DOWNLOAD NOW!


Book Synopsis Augmentation of Peripheral Chemosensitivity During Hypermetabolism by : Ismaeel Bin-Jaliah

Download or read book Augmentation of Peripheral Chemosensitivity During Hypermetabolism written by Ismaeel Bin-Jaliah and published by Universal-Publishers. This book was released on 2006 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: The carotid body initiates reflexes aimed principally at the homeostatic maintenance of blood gas tensions. This thesis tested the hypothesis that the carotid body is also a physiological glucosensor, with a role in mediating exercise hyperpnoea. In anaesthetised rats, insulin-induced hypoglycaemia (from ca. 6.5 to 2.8 mmol L-1) caused an ca. two-fold increase of oxygen consumption that was associated with a significant, carotid body-dependent increase in ventilation (from ca. 420 to 640 ml min-1 kg-1) without change in blood gas tensions. This hypoglycaemic hyperpnoea was associated with hypokalaemia and no alterations of ventilation or metabolism were observed in euglycaemic, control studies, thus excluding any role for [K+] or insulin. During hypermetabolism, a proportional augmentation of peripheral CO2 gain, measured from the phrenic electroneurogram during artificial ventilation, was shown to maintain the arterial blood gas status. In vitro, measurements of single-fibre chemoafferent discharge showed that low [glucose], over a physiological range and during normoxia, increased neither the carotid baseline discharge nor the CO2 sensitivity. Taken together, these results demonstrate that the carotid body is not a physiological sensor of glucose but augmentation of the carotid body chemosensitivity via an undetermined yet, hypermetabolism-related factor(s) is most likely to be involved in exercise hyperpnoea.

Holland-Frei Cancer Medicine

Download Holland-Frei Cancer Medicine PDF Online Free

Author :
Publisher : John Wiley & Sons
ISBN 13 : 111900084X
Total Pages : 2004 pages
Book Rating : 4.1/5 (19 download)

DOWNLOAD NOW!


Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.

Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Chemosensitivity Testing in Gynecologic Malignancies and Breast Cancer

Download Chemosensitivity Testing in Gynecologic Malignancies and Breast Cancer PDF Online Free

Author :
Publisher : S. Karger AG (Switzerland)
ISBN 13 :
Total Pages : 218 pages
Book Rating : 4.4/5 (194 download)

DOWNLOAD NOW!


Book Synopsis Chemosensitivity Testing in Gynecologic Malignancies and Breast Cancer by : Ossi R. Köchli

Download or read book Chemosensitivity Testing in Gynecologic Malignancies and Breast Cancer written by Ossi R. Köchli and published by S. Karger AG (Switzerland). This book was released on 1994 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'It will form an important addition to a scientific library and a useful addition to the (contributions series) which should be part of any obstetrics and gynaecology library.' New Zealand Journal of Obstetrics and Gynaecology

Self-Eating on Demand: Autophagy in Cancer and Cancer Therapy

Download Self-Eating on Demand: Autophagy in Cancer and Cancer Therapy PDF Online Free

Author :
Publisher : Frontiers Media SA
ISBN 13 : 2889454223
Total Pages : 111 pages
Book Rating : 4.8/5 (894 download)

DOWNLOAD NOW!


Book Synopsis Self-Eating on Demand: Autophagy in Cancer and Cancer Therapy by : Patrizia Agostinis

Download or read book Self-Eating on Demand: Autophagy in Cancer and Cancer Therapy written by Patrizia Agostinis and published by Frontiers Media SA. This book was released on 2018-02-19 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: Macroautophagy, the major lysosomal pathway for recycling intracellular components including whole organelles, has emerged as a key process modulating tumorigenesis, tumor–stroma interactions, and cancer therapy. An impressive number of studies over the past decade have unraveled the plastic role of autophagy during tumor development and dissemination. The discoveries that autophagy may either support or repress neoplastic growth and contextually favor or weaken resistance and impact antitumor immunity have spurred efforts from many laboratories trying to conceptualize the complex role of autophagy in cancer using cellular and preclinical models. This complexity is further accentuated by recent findings highlighting that various autophagy-related genes have roles beyond this catabolic mechanism and interface with oncogenic pathways, other trafficking and degradation mechanisms and the cell death machinery. From a therapeutic perspective, knowledge of how autophagy modulates the tumor microenvironment is crucial to devise autophagy-targeting strategies using smart combination of drugs or anticancer modalities. This eBook contains a collection of reviews by autophagy researchers and provides a background to the state-of-the-art in the field of autophagy in cancer, focusing on various aspects of autophagy regulation ranging from its molecular components to its cell autonomous role, e.g. in cell division and oncogenesis, miRNAs regulation, cross-talk with cell death pathways as well as cell non-autonomous role, e.g. in secretion, interface with tumor stroma and clinical prospects of autophagy-based biomarkers and autophagy modulators in anticancer therapy. This eBook is part of the TransAutophagy initiative to better understand the clinical implications of autophagy in cancer.

Respiratory Control

Download Respiratory Control PDF Online Free

Author :
Publisher : University Press of Kentucky
ISBN 13 : 9780813130743
Total Pages : 266 pages
Book Rating : 4.1/5 (37 download)

DOWNLOAD NOW!


Book Synopsis Respiratory Control by : Dexter F. Speck, Michael S. Dekin, W. Robert Revelette, Donald A. Frazier

Download or read book Respiratory Control written by Dexter F. Speck, Michael S. Dekin, W. Robert Revelette, Donald A. Frazier and published by University Press of Kentucky. This book was released on with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Chemosensitivity

Download Chemosensitivity PDF Online Free

Author :
Publisher : Humana Press
ISBN 13 : 9781588295866
Total Pages : 442 pages
Book Rating : 4.2/5 (958 download)

DOWNLOAD NOW!


Book Synopsis Chemosensitivity by : Rosalyn D. Blumenthal

Download or read book Chemosensitivity written by Rosalyn D. Blumenthal and published by Humana Press. This book was released on 2005-02-14 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: A state-of-the art collection of readily reproducible laboratory methods for assessing chemosensitivity in vitro and in vivo, and for assessing the parameters that modulate chemosensitivity in individual tumors. Chemosensitivity,Volume 2: In Vivo Models, Imaging, and Molecular Regulators contains cutting-edge protocols for classifying tumors into response categories and for customizing therapy to individuals. These readily reproducible techniques allow measurements of DNA damage, apoptotic cell death, and the molecular and cellular regulators of cytotoxicity, as well as in vivo animal modeling of chemosensitivity. A companion volume, Volume 1: In Vitro Assays contains in vitro and in vivo techniques to identify which new agents or combination of agents are effective for each type of tumor.

Journal of the National Cancer Institute

Download Journal of the National Cancer Institute PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : 576 pages
Book Rating : 4.:/5 (319 download)

DOWNLOAD NOW!


Book Synopsis Journal of the National Cancer Institute by :

Download or read book Journal of the National Cancer Institute written by and published by . This book was released on 2012 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cancer Treatment Reports

Download Cancer Treatment Reports PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : 670 pages
Book Rating : 4.E/5 ( download)

DOWNLOAD NOW!


Book Synopsis Cancer Treatment Reports by :

Download or read book Cancer Treatment Reports written by and published by . This book was released on 1986 with total page 670 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Peritoneal Surface Malignancies

Download Peritoneal Surface Malignancies PDF Online Free

Author :
Publisher : Springer
ISBN 13 : 3319129376
Total Pages : 127 pages
Book Rating : 4.3/5 (191 download)

DOWNLOAD NOW!


Book Synopsis Peritoneal Surface Malignancies by : Emel Canbay

Download or read book Peritoneal Surface Malignancies written by Emel Canbay and published by Springer. This book was released on 2015-07-09 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book has been designed to provide the full description of the comprehensive management of peritoneal surface malignancies as a new emerging specialty. Combined treatment of cytoreductive surgery (CRS) and hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) introduced by our leader Paul H. Sugarbaker are performed to treat peritoneal metastases by surgeons all around the world. Therefore this book is focused on detailed surgical anatomy of the peritoneum, preoperative clinical assessment of the peritoneal surface malignancy, patient preparation and operation room equipments, different surgical procedures for CRS and reconstruction, intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC) and neoadjuvant intraperitoneal chemotherapy, early postoperative intraperitoneal chemotherapy (EPIC) and molecular basis of peritoneal surface malignancies. The chapter on molecular mechanisms of the formation of peritoneal carcinomatosis provides insight into a rapidly expanding knowledge within this speciality. This book should be valuable for surgical oncologists who deal with multimodal treatment for peritoneal surface malignancies, as well as for the trained peritonectomy surgeons. For the senior surgeons, it will also introduce new techniques and approaches in this field such as dealing with the omental cakes and massive organ involvement that requires multi-organ resection.

Chemosensitivity Testing in Oncology

Download Chemosensitivity Testing in Oncology PDF Online Free

Author :
Publisher : Springer Science & Business Media
ISBN 13 : 9783540434689
Total Pages : 264 pages
Book Rating : 4.4/5 (346 download)

DOWNLOAD NOW!


Book Synopsis Chemosensitivity Testing in Oncology by : Uwe Reinhold

Download or read book Chemosensitivity Testing in Oncology written by Uwe Reinhold and published by Springer Science & Business Media. This book was released on 2002-10-31 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past 50 years many in vitro and in vivo drug response assay systems have been developed to determine the potential - tivity of chemotherapy agents. The idea was to eliminate ineffective agents and unnecessary toxic treatment while selecting drugs active in vitro or in the mouse model that might increase the probability of response in the patient. None of these test models, however, achieved routine clinical application in the past. This might be at least in part - lated to large discrepancies that were described between the s- cess rate of the assay systems and the clinical benefit in cancer - tients. The heterogeneity of chemosensitivity that exists between different tumors as well as between individual tumor lesions may be one explanation for these findings. Furthermore, different assay end points such as proliferation, metabolism, and vitality were - veloped to evaluate the effects of cytostatic drugs on tumor cells, and these might be related to the differing results. However, knowledge about procedures for assay-assisted treatment selection has increased rapidly within the past few years, and several studies suggest that test-directed chemotherapy selection now may - prove response rates and survival in various types of tumors. The International Society for Chemosensitivity Testing in - cology (ISCO) was founded to promote, coordinate, and improve clinical and laboratory research in the field of predictive drug te- ing in human tumor cells.

Respiratory Control

Download Respiratory Control PDF Online Free

Author :
Publisher : University Press of Kentucky
ISBN 13 : 0813181771
Total Pages : 714 pages
Book Rating : 4.8/5 (131 download)

DOWNLOAD NOW!


Book Synopsis Respiratory Control by : Dexter F. Speck

Download or read book Respiratory Control written by Dexter F. Speck and published by University Press of Kentucky. This book was released on 2021-12-15 with total page 714 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding of the respiratory control system has been greatly improved by technological and methodological advances. This volume integrates results from many perspectives, brings together diverse approaches to the investigations, and represents important additions to the field of neural control of breathing. Topics include membrane properties of respiratory neurons, in vitro studies of respiratory control, chemical neuroanatomy, central integration of respiratory afferents, modulation of respiratory pattern by peripheral afferents, respiratory chemoreception, development of respiratory control, behavioral control of breathing, and human ventilatory control. Forty-seven experts in the field report research and discuss novel issues facing future investigations in this collection of papers from an international conference of nearly two hundred leading scientists held in October 1990. This research is of vital importance to respiratory physiologists and those in neurosciences and neurobiology who work with integrative sensory and motor systems and is pertinent to both basic and clinical investigations. Respiratory Control is destined to be widely cited because of the strength of the contributors and the dearth of similar works.

Apoptosis and Cancer Chemotherapy

Download Apoptosis and Cancer Chemotherapy PDF Online Free

Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1592597203
Total Pages : 347 pages
Book Rating : 4.5/5 (925 download)

DOWNLOAD NOW!


Book Synopsis Apoptosis and Cancer Chemotherapy by : John A. Hickman

Download or read book Apoptosis and Cancer Chemotherapy written by John A. Hickman and published by Springer Science & Business Media. This book was released on 1999-04-08 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past few years have witnessed an astonishing international effort that established the role of some 20 new molecules in apoptosis and added activation or suppression of apoptosis to the accepted biological functions of a great many others already familiar in cancer biology. Some of these molecules are receptors, transducing cytokine-mediated signals; others appear to intensify or diminish the risk that a compro mised cell will fire its apoptosis effector mechanism. All are of interest as potential targets for tumor therapy, and some may prove to be control points influenced in the pathogenesis of cancer and other diseases as diverse as viral infection, neurodegenerative disorders, and stroke. Sometimes, in the midst of these developments, a kind of euphoria ap pears to have gripped the research community, with the expectation that apoptosis will afford explanations to many unsolved questions in cellu lar regulation. This book, in a series of thoughtful and provocative ar ticles--some from established leaders in the field, and others from younger scientists--seeks to redress the balance.

Drug Resistance in Leukemia &

Download Drug Resistance in Leukemia & PDF Online Free

Author :
Publisher : CRC Press
ISBN 13 : 9783718653874
Total Pages : 458 pages
Book Rating : 4.6/5 (538 download)

DOWNLOAD NOW!


Book Synopsis Drug Resistance in Leukemia & by : Gert-Jan L. Kaspers

Download or read book Drug Resistance in Leukemia & written by Gert-Jan L. Kaspers and published by CRC Press. This book was released on 1993-01-01 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last ten years have seen the publication of a vast amount of data regarding cellular resistance to drugs in cancer cells. Recent studies have demonstrated that drug resistance assays appear to be predictive of clinical response and suggest that clinicians should now be considering the potential applications of these assays in the treatment of patients with hematological neoplasms. This collection of papers from the International Symposium on the Clinical Value of Drug Resistance Assays in Leukemia and Lymphoma, Amsterdam, 1992, provides a state-of-the-art discussion on drug resistance assays and their role in the design and individualization of treatment protocols.

Gastric Cancer: New Insights for the Healthcare Professional: 2011 Edition

Download Gastric Cancer: New Insights for the Healthcare Professional: 2011 Edition PDF Online Free

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464900213
Total Pages : 664 pages
Book Rating : 4.4/5 (649 download)

DOWNLOAD NOW!


Book Synopsis Gastric Cancer: New Insights for the Healthcare Professional: 2011 Edition by :

Download or read book Gastric Cancer: New Insights for the Healthcare Professional: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gastric Cancer: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Gastric Cancer. The editors have built Gastric Cancer: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Gastric Cancer in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Gastric Cancer: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.