Chemokine Receptors

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The Chemokine Factsbook

Author : Krishna Vaddi
Publisher : Elsevier
ISBN 13 : 0080529089
Total Pages : 219 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis The Chemokine Factsbook by : Krishna Vaddi

Download or read book The Chemokine Factsbook written by Krishna Vaddi and published by Elsevier. This book was released on 1997-04-01 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: How do you keep track of basic information on the proteins you work with? Where do you find details of their physicochemical properties, amino acid sequences, gene organization? Are you tired of scanning review articles, primary papers and databases to locate that elusive fact? The Academic Press FactsBook series will satisfy scientists and clinical researchers suffering from information overload. Each volume provides a catalog of the essential properties of families of molecules. Gene organization, amino acid sequences, physicochemical properties, and biological activity are presented using a common, easy-to-follow format. Taken together they compile everything you want to know about proteins but are too busy to look for. The Chemokine FactsBook contains more than 40 entries on chemokines, and chemokine receptors from human or other origin, including IL-8, MCP-1, C5-a, RANTES, Lymphotactin, and CC CKR-1. The text provides information on tissue sources, target cells, physicochemical properties, transcription factors, regulation of expression in disease, receptor-binding characteristics, gene structure and location, amino acid sequences, and accession numbers and references. Contains over 40 entries on chemokines and chemokine receptors from human or other origin, including: IL-8 MCP-1 C5-a RANTES Lymphotactin CC CKR-1 Entries provide information on: Tissue sources Target cells Physicochemical properties Transcription factors Regulation of expression Expression in disease Receptor-binding characteristics Gene structure and location Amino acid sequences Database accession numbers References

The Chemokine Receptors

Author : Jeffrey K. Harrison
Publisher : Springer Science & Business Media
ISBN 13 : 1597450200
Total Pages : 412 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis The Chemokine Receptors by : Jeffrey K. Harrison

Download or read book The Chemokine Receptors written by Jeffrey K. Harrison and published by Springer Science & Business Media. This book was released on 2007-11-17 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume, new to The Receptors series, focuses on several areas, including the birth, maturation, and structure of Chemokines; Neutrophil, Dendritic, and Lymphocyte trafficking; and Chemokine Receptors in diseases such as AIDs and lung cancer. In particular the book contains cutting-edge information ranging from basic molecular and cellular mechanisms to physiological and pathological roles of chemokines.

Chemokine Receptors in Cancer

Author : Amy M. Fulton
Publisher : Springer Science & Business Media
ISBN 13 : 1603272674
Total Pages : 181 pages
Book Rating : 4.6/5 (32 download)

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Book Synopsis Chemokine Receptors in Cancer by : Amy M. Fulton

Download or read book Chemokine Receptors in Cancer written by Amy M. Fulton and published by Springer Science & Business Media. This book was released on 2009-06-12 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemokines are a superfamily of low molecular weight cytokines that were initially described based on their ability to induce the directed migration of leukocytes to sites of inflammation or injury. In humans, there are approximately 45 chemokines that bind to 19 G-protein-coupled receptors. In addition to mediating cellular migration, chemokines have now been shown to affect many cellular functions including survival, adhesion, invasion, proliferation, and to regulate circulating chemokine levels. Although chemokine receptors were first described on leukocytes, it is now appreciated that chemokine receptors are also expressed by many other cells including endothelial and epithelial cells. Since the first description of chemokine receptors on malignant cells in 2001, an extensive literature has developed describing the expression and function of chemokine receptors in many malignancies. These studies support the initial hypothesis that malignant cells use chemokine receptors to migrate to distant sites of ligand expression and that expression of certain receptors is associated with a poor prognosis. It has also become apparent that malignancies of different tissues may use a diverse profile of chemokine receptors and that the same receptor may mediate metastasis to different sites in tumors of different histological origins. Receptor function may also maintain survival and expansion of the primary tumor.

Chemokines, Chemokine Receptors and Disease

Author : Lisa M. Schwiebert
Publisher : Gulf Professional Publishing
ISBN 13 : 9780121533557
Total Pages : 418 pages
Book Rating : 4.5/5 (335 download)

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Book Synopsis Chemokines, Chemokine Receptors and Disease by : Lisa M. Schwiebert

Download or read book Chemokines, Chemokine Receptors and Disease written by Lisa M. Schwiebert and published by Gulf Professional Publishing. This book was released on 2005-09-02 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume in the Current Topics in Membranes series discusses the biology of chemokines and their binding partners, chemokine receptors, in normal and disease-related states. Chemokines are small proteins that are important in normal immune responses. Recent research demonstrates a role for these proteins in a variety of diseases such as heart disease, allergy, asthma, and cancer. As a result of the discovery of this link to disease, the topic of chemokines and drugs that block their actions has become an intense are of study. This book presents the topics of chemokines, chemokine receptors, and related pathologies in an integrated manner that provides the reader with a comprehensive and up-to-date knowledge of these topics. Provides a comprehensive overview of the history, molecular biology, cell biology, pharmacology, physiology, and pathophysiology of chemokines and their receptors Each chapter discusses "future directions and unanswered questions" of chemokine biology Serves as a road map for future research

Regulation of Chemokine- Receptor Interactions and Functions

Author : Martin J. Stone
Publisher : MDPI
ISBN 13 : 3038427284
Total Pages : 229 pages
Book Rating : 4.0/5 (384 download)

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Book Synopsis Regulation of Chemokine- Receptor Interactions and Functions by : Martin J. Stone

Download or read book Regulation of Chemokine- Receptor Interactions and Functions written by Martin J. Stone and published by MDPI. This book was released on 2018-03-19 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Regulation of Chemokine-Receptor Interactions and Functions" that was published in IJMS

Chemokine Receptors and NeuroAIDS

Author : Olimpia Meucci
Publisher : Springer Science & Business Media
ISBN 13 : 1441907939
Total Pages : 446 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Chemokine Receptors and NeuroAIDS by : Olimpia Meucci

Download or read book Chemokine Receptors and NeuroAIDS written by Olimpia Meucci and published by Springer Science & Business Media. This book was released on 2009-12-02 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemokine Receptors and NeuroAIDS: Beyond the Co-receptor Function and Links to Other Neuropathologies focuses on unresolved or emerging issues concerning the role of chemokine receptors in neuronal injury and HIV neuropathology, including their ability to regulate fundamental neuronal and glial functions and their role in neurovirulence and neurotoxicity. Although the importance of these molecules in the CNS physiology and pathology is now apparent, these issues are still matter of debate, and further research is required to design effective pharmacological agents that specifically target the brain chemokine system without major side effects. To this end, specific topics have been selected and are reviewed by international experts within the basic science/medical community. This book encourages investigation in the most controversial areas and fosters interaction between clinicians and basic scientists. The book also increases awareness about differences in disease progression among different parts of the world as well as selected patient populations, which may also help identifying novel therapeutic strategies.

Progress and challenges with therapeutic targeting of chemokine receptors

Author : Vadim Gaponenko
Publisher : Frontiers Media SA
ISBN 13 : 2832536050
Total Pages : 141 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Progress and challenges with therapeutic targeting of chemokine receptors by : Vadim Gaponenko

Download or read book Progress and challenges with therapeutic targeting of chemokine receptors written by Vadim Gaponenko and published by Frontiers Media SA. This book was released on 2023-10-18 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Chemokine Receptors as Drug Targets

Author : Martine J. Smit
Publisher : John Wiley & Sons
ISBN 13 : 3527632344
Total Pages : 598 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Chemokine Receptors as Drug Targets by : Martine J. Smit

Download or read book Chemokine Receptors as Drug Targets written by Martine J. Smit and published by John Wiley & Sons. This book was released on 2010-12-07 with total page 598 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemokines are hormone-like signaling molecules secreted by cells to signal infection and guide the immune response. Following a decade of basic chemokine research, the pharmaceutical industry has now begun to exploit this crucial signaling pathway for the development of innovative drugs against AIDS, cancer, neural and autoimmune diseases. Here is the first reference focusing on these novel drug development opportunities. Opening with a general introduction on chemokine function and chemokine receptor biology, the second part covers the known implications of these signaling molecules in human diseases, such as cancer, neural disorders, and viral infection, including AIDS. The third part systematically surveys current drug development efforts at targeting individual chemokine receptors, as well as other chemokine interaction partners, including up-to-date reports from the pharmaceutical industry.

Chemokine Receptors in Health and Disease

Author :
Publisher : Elsevier
ISBN 13 : 0443221731
Total Pages : 220 pages
Book Rating : 4.4/5 (432 download)

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Book Synopsis Chemokine Receptors in Health and Disease by :

Download or read book Chemokine Receptors in Health and Disease written by and published by Elsevier. This book was released on 2024-09-10 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume reviews the current research in Chemokine Receptors and their role in physiological processes in the body, as well as their role in different pathological conditions. Chemokine Receptors are important for the migration of different types of cells, including immune cells to lymphoid organs and non-lymphoid organs thanks to the interaction with chemokines. The presence of different chemokine receptors on the cells’ surface was studied in normal states and diseases, some of them correlating with migration of subsets that play pro-disease roles or other help controlling the condition. Currently, state-of-the-art technology is helping researchers to better identify gene and protein expression of chemokine receptors at the single cell level. This large new data reveals the complexity of co-expression of various markers in the same cells and as well among different types of cells. Moreover, chemokine receptors are also helpful to identify different stages among subsets, and their correlation with better or worst responses in disease. Finally, treatments designed to inhibit or to block chemokine receptors are designed and tested at the preclinical and clinical level with different results. Here, we focus on the main chemokine receptors described in the current literature that play a role in health and diseases such as infections, autoimmune disorders, and cancer. Chemokine receptors in the era of single cell gene and protein analysis Chemokine receptor’s role in COVID-19 Update in the role of chemokine receptors in health and disease

Chemokines and Chemokine Receptors in Brain Homeostasis

Author : Flavia Trettel
Publisher : Frontiers Media SA
ISBN 13 : 288919616X
Total Pages : 126 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Chemokines and Chemokine Receptors in Brain Homeostasis by : Flavia Trettel

Download or read book Chemokines and Chemokine Receptors in Brain Homeostasis written by Flavia Trettel and published by Frontiers Media SA. This book was released on 2015-08-17 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: Virtually involved in all pathologies that present an inflammatory component, it is now evident that, in the central nervous system, chemokines and chemokine receptors possess pleiotropic properties beyond chemotaxis: costitutive brain expression of chemokines and their receptors on endothelial cells, but also on neurons and glia, suggests a role for such molecules in mediating homeostatic cross-talk between cells of the brain perenchyma. Cross-talk between neurons and glia is determinant to the establishment and maintenance of a brain enviroment that ensure normal function, and in particular glial cells are active players that respond to enviromental changes and act for the survival, growth, differentiation and repair of the nervous tissue: in this regard brain endogenous chemokines represent key molecules that play a role in brain development, neurogenesis, neurotransmission and neuroprotection. As important regulators of peripheral immune response, chemokines are molecules of the immune system that play a central role in coordinating communication between the nervous and the immune systems, in the context of infections and brain injury. Indeed, in phatological processes resulting from infections, brain trauma, ischemia and chronic neurodegenerative diseases, chemokines represent important neuroinflammatory mediators that drive leucocytes trafficking into the central nervous system, facilitating an immune response by targeting cells of the innate and adaptive immune system. The third edition of the international conference "Chemokines and Chemokine Receptors in the Nervous System", hold in Rome in October 2013, represented an exciting platform to promote discussion among researchers in different disciplines to understand the role of chemokines in brain homoestasis. This Frontiers Research Topic arises from this conference, and wants to be an opportunity to further discuss and highlight the importance of brain chemokines as key molecules that, not only grant the interplay between the immune and the nervous systems, but in addition drive modulatory functions on brain homeoastasis orchestrating neurons, microglia, and astrocytes communication.

Chemokine Receptors and AIDS

Author : Thomas R. O'Brien
Publisher : CRC Press
ISBN 13 : 042952482X
Total Pages : 224 pages
Book Rating : 4.4/5 (295 download)

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Book Synopsis Chemokine Receptors and AIDS by : Thomas R. O'Brien

Download or read book Chemokine Receptors and AIDS written by Thomas R. O'Brien and published by CRC Press. This book was released on 2019-04-23 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative reference presents the latest research on the role of chemokines, chemokine receptors, and genetic variability in the susceptibility, prevention, and treatment of HIV-1-exploring new therapeutic strategies for improved treatment of HIV-1 infected patients by blocking chemokine receptor expression. With contributions from s

Chemokine Biology - Basic Research and Clinical Application

Author : Bernhard Moser
Publisher : Springer Science & Business Media
ISBN 13 : 3764374233
Total Pages : 214 pages
Book Rating : 4.7/5 (643 download)

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Book Synopsis Chemokine Biology - Basic Research and Clinical Application by : Bernhard Moser

Download or read book Chemokine Biology - Basic Research and Clinical Application written by Bernhard Moser and published by Springer Science & Business Media. This book was released on 2006-03-16 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemokines play an important role in recruiting inflammatory cells into tissues in response to infection and inflammation. They also play an important role in coordinating the movement of T-cells, B-cells and dentritic cells, necessary to generate an immune response (response to injury, allergens, antigens, invading microorganisms). They selectively attract leukocytes to inflammatory foci, inducing both cell migration and activation. They are involved in various diseases, like atherosclerosis, lung and skin inflammation, multiple sclerosis, or HIV. Volume 1 of this two-volume set discusses the immunobiology of chemokines. It is divided into two parts: a) cellular targets in innate and adaptive immunity, and b) effector cell traffic-unrelated functions. Together with volume 2, which discusses the pathophysiology of chemokines, both volumes give a comprehensive overview of chemokine biology.

Chemoattractant Ligands and Their Receptors

Author : Richard Horuk
Publisher : CRC Press
ISBN 13 : 9780849385483
Total Pages : 404 pages
Book Rating : 4.3/5 (854 download)

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Book Synopsis Chemoattractant Ligands and Their Receptors by : Richard Horuk

Download or read book Chemoattractant Ligands and Their Receptors written by Richard Horuk and published by CRC Press. This book was released on 1996-08-14 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemoattractant Ligands and Their Receptors succinctly summarizes cutting-edge research in the important area of chemoattraction in immunology. It explains how chemoattractant molecules mobilize immune cells to ward off attack by invading pathogens, both at a molecular and at a cellular level. Written by acknowledged experts in the field, it contains detailed molecular and structural information on each of the major chemoattractants and their receptors. Its unique multidisciplinary approach encompasses biology, immunology, protein chemistry, and molecular biology. A time-saving reference for both researchers and students.

Chemokines and Chemokine Receptors

Author : John Michael Galasso
Publisher :
ISBN 13 :
Total Pages : 356 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Chemokines and Chemokine Receptors by : John Michael Galasso

Download or read book Chemokines and Chemokine Receptors written by John Michael Galasso and published by . This book was released on 1998 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Chemokine Receptors

Author : Richard Horuk
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (113 download)

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Book Synopsis Chemokine Receptors by : Richard Horuk

Download or read book Chemokine Receptors written by Richard Horuk and published by . This book was released on 1997 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Chemokines

Author : Nuska Tschammer
Publisher : Springer
ISBN 13 : 3319140604
Total Pages : 248 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Chemokines by : Nuska Tschammer

Download or read book Chemokines written by Nuska Tschammer and published by Springer. This book was released on 2015-03-02 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Obesity, Fatty Liver and Liver Cancer

Author : Jun Yu
Publisher : Springer
ISBN 13 : 9811086842
Total Pages : 165 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Obesity, Fatty Liver and Liver Cancer by : Jun Yu

Download or read book Obesity, Fatty Liver and Liver Cancer written by Jun Yu and published by Springer. This book was released on 2018-06-28 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers a state-of-the-art illustration of recent discoveries concerning obesity-related fatty liver diseases and liver cancer. The contents are extensive and comprehensive. It brings important topics in the field all together under one umbrella, from epidemiology and etiology, molecular pathogenesis, cellular biology, epigenetics, immunology, microbiology, animal models to therapeutic approaches and treatments. All the book contributors are leading experts in the field. It will appeal to researchers, clinicians and graduate students in obesity, fatty liver diseases, GI/Liver cancer field. It may also yield benefits for pharmaceutical companies with regard to drug discovery.