Chemistry And Biology Of Beta Lactam Antibiotics

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Synthesis of β-Lactam Antibiotics

Author : Alle Bruggink
Publisher : Springer Science & Business Media
ISBN 13 : 9401008507
Total Pages : 328 pages
Book Rating : 4.4/5 (1 download)

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Book Synopsis Synthesis of β-Lactam Antibiotics by : Alle Bruggink

Download or read book Synthesis of β-Lactam Antibiotics written by Alle Bruggink and published by Springer Science & Business Media. This book was released on 2011-06-27 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Penicillins and cephalosporins have a long history in combating bacterial infections. Despite new infectious diseases and occurring resistance, beta-lactam antibiotics will for many years to come continue to play a prominent role in our therapeutic arsenal. This book covers the industrial development of the chemical and biochemical processes used to manufacture these products, as well as looking ahead to possible future processes. The interplay between synthetic organic chemistry with the understanding and application of enzymes, modeling of fermentation processes and integration through (bio-) chemical process engineering is illustrated. In-depth scientific approaches to biocatalysis and biocatalyst development including enzyme kinetics, enzyme crystal studies and semi-rational enzyme mutations are also presented. Metabolic pathway analysis and modeling of fermentation process are treated as well as molecular precision in synthetic approaches to beta-lactams, their precursors and derivatives. Process technology studies including new reactor concepts, possible short-cut routes and improved down-stream-processing methods complete a broad view on the scope and limitations of the presently developed industrial processes including an intriguing insight into future process possibilities. This book represents an excellent case study on the transformation of traditional, stoïchiometric, organic synthesis and classical fermentations into modern (bio-) catalysis and biosynthesis based on insights in metabolic pathways and enzyme actions.

Rowland and Tozer's Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications

Author : Hartmut Derendorf
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1496385896
Total Pages : 1334 pages
Book Rating : 4.4/5 (963 download)

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Book Synopsis Rowland and Tozer's Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications by : Hartmut Derendorf

Download or read book Rowland and Tozer's Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications written by Hartmut Derendorf and published by Lippincott Williams & Wilkins. This book was released on 2019-07-11 with total page 1334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Updated with the latest clinical advances, Rowland and Tozer’s Clinical Pharmacokinetics and Pharmacodynamics, Fifth Edition , explains the relationship between drug administration and drug response, taking a conceptual approach that emphasizes clinical application rather than science and mathematics. Bringing a real-life perspective to the topic, the book simplifies concepts and gives readers the knowledge they need to better evaluate drug applications.

Cephalosporins and Penicillins

Author : Edwin H. Flynn
Publisher : Elsevier
ISBN 13 : 1483270173
Total Pages : 769 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Cephalosporins and Penicillins by : Edwin H. Flynn

Download or read book Cephalosporins and Penicillins written by Edwin H. Flynn and published by Elsevier. This book was released on 2013-10-22 with total page 769 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cephalosporins and Penicillins: Chemistry and Biology describes the studies made on cephalosporin in relation to the scientific and medicinal benefits that can be derived from cephalosporin C. This collection discusses how cephalosporin C is produced through modern isolation methods. One paper discusses its structure through chemical means, its degradation products, its derivative and other metabolic products such as penicillin N and cephalosporin P. Another paper explains the preparation method for 7-aminocephalosporanic acid and 6-aminopenicillanic acid through biological or chemical means. Another paper explains the alteration of the dihydrothiazine ring of the cephalosporins as the functionalities of these rings are chemically difficult to obtain. One paper also explains the rearrangements of cephalosporins and penicillins; cephalosporin can be synthesized from penicillin through an intermediacy of penicillin sulfoxide. Other papers discuss the pharmacology and toxicology of cephalosporins, as well as the practical tests and methods of assay that can be used in most cephalosporins, and in some cases, in penicillins. This book can prove useful for pharmacologists, microchemists, research workers, and technologists dealing with toxicology.

Antibiotic Drug Resistance

Author : José-Luis Capelo-Martínez
Publisher : John Wiley & Sons
ISBN 13 : 1119282527
Total Pages : 730 pages
Book Rating : 4.1/5 (192 download)

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Book Synopsis Antibiotic Drug Resistance by : José-Luis Capelo-Martínez

Download or read book Antibiotic Drug Resistance written by José-Luis Capelo-Martínez and published by John Wiley & Sons. This book was released on 2019-09-24 with total page 730 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a thorough and authoritative overview of the multifaceted field of antibiotic science – offering guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases. Provides readers with knowledge about the broad field of drug resistance Offers guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases Links strategies to analyze microbes to the development of new drugs, socioeconomic impacts to therapeutic strategies, and public policies to antibiotic-resistance-prevention strategies

Recent Progress in the Chemical Synthesis of Antibiotics

Author : Gabor Lukacs
Publisher : Springer Science & Business Media
ISBN 13 : 3642756174
Total Pages : 808 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Recent Progress in the Chemical Synthesis of Antibiotics by : Gabor Lukacs

Download or read book Recent Progress in the Chemical Synthesis of Antibiotics written by Gabor Lukacs and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 808 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of antibiotics in the treatment by antibacterial and antifungal chemo therapy, has become standard practice since the end of World War Two and has had an enormous impact on healthcare throughout the world. Compounds belonging to this class have also reached an important place in the medical treatment of human cancer. Although, the discovery of most of these agents came from more or less sophisticated screening programs of soil microrganisms, many of the important antibiotics used today in clinical practice are derived from the original biosynthetic products by the application of often novel and generally elaborated chemical synthetic methodologies. In fact the antibiotics have represented (and still represent) for a generation of organic chemists an endless source of molecular structures whose varied assemblage of carbon atom backbones and chemical functions was beyond any possibility of imagination. Perhaps a similar repertoire of chemotypes was formerly offered by the natural products, namely the alkaloids, the terpenes, the vitamins and hormones as well as the pigments of the animal and plant kingdoms, albeit the chemical arrange ments of the antibiotic molecules appeared much more surprising and diverse to the admiring eyes of cultivated organic chemists. The idea of this book, certainly a landmark in the field, came during the Symposium of EUCHEM on Chemical Synthesis of Antibiotics, that was held at Aussois in Savoy, France (May 2-6, 1988), the initiative being taken by Gabor Lukacs to whom Masaji Ohno readily associated as a co-editor.

Antibiotics

Author : Arnold L. Demain
Publisher : Springer
ISBN 13 : 9783642819681
Total Pages : 360 pages
Book Rating : 4.8/5 (196 download)

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Book Synopsis Antibiotics by : Arnold L. Demain

Download or read book Antibiotics written by Arnold L. Demain and published by Springer. This book was released on 2011-12-08 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is quite amazing that the oldest group of medically useful antibiotics, the p-Iactams, are still providing basic microbiologists, biochemists, and clinicians with surprises over 50 years after Fleming's discovery of penicillin production by Penicillium. By the end of the 1950s, the future of the penicillins seemed doubtful as resistant strains of Staphylococcus aureus began to increase in hospital populations. However, the development of semisynthetic penicillins provided new structures with resistance to penicillinase and with broad-spectrum activity. In the 1960s, the discovery of cephalosporin C production by Cephalosporium and its conversion to valuable broad-spectrum antibiotics by semisynthetic means excited the world of chemotherapy. In the early 1970s, the 40-year-old notion that p-lactams were produced only by fungi was destroyed by the discovery of cephamycin production by Streptomyces. Again this basic discovery was exploited by the development of the semisynthetic cefoxitin, which has even broader activity than earlier p-lactams. Later in the 1970 s came the discoveries of nocardicins from Nocardia, clavulanic acid from Streptomyces, and the carbapenems from Streptomyces. Now in the 1980s we learn that p-lactams are produced even by unicellular bacteria and that semisynthetic derivatives of these monobactams may find their way into medicine. Indeed, the future of the prolific p-lactam family seems brighter with each passing decade.

Beta-Lactams

Author : Bimal K. Banik
Publisher : Springer
ISBN 13 : 3319556215
Total Pages : 423 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Beta-Lactams by : Bimal K. Banik

Download or read book Beta-Lactams written by Bimal K. Banik and published by Springer. This book was released on 2017-05-11 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an essential overview of beta-lactams and their medicinal value and use in the preparation of other biologically active compounds. Written by internationally respected authors, the individual chapters explore beta-lactams’ synthesis, their mechanism of formation, biological effects, and function as base materials for other heterocycles of major importance.

Penicillins and Cephalosporins

Author : Robert B. Morin
Publisher : Academic Press
ISBN 13 : 1483277194
Total Pages : 594 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Penicillins and Cephalosporins by : Robert B. Morin

Download or read book Penicillins and Cephalosporins written by Robert B. Morin and published by Academic Press. This book was released on 2014-05-10 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemistry and Biology of ?-Lactam Antibiotics, Volume 1: Penicillins and Cephalosporins provides information pertinent to the study of antibiotics containing the ?-lactam moiety. This book discusses the occurrence of a group of ?-lactam antibiotics structurally related to cephalosporin C. Organized into five chapters, this volume begins with an overview of the mechanism of action of ?-lactam antibiotics that caused many microbiologists to develop screening tools for the detection of the ?-lactam moiety. This text then discusses the discovery of the nocardicins, the thienamycins, and olivanic acids. Other chapters provide a summary of the essential penicillin sulfoxide chemistry that gave rise to many compounds. This book discusses as well the ability of chemists to predict the level of biological activity of a compound from knowledge of its structure through theoretical and physicochemical studies. The final chapter deals with quantitative structure–activity relationships. This book is a valuable resource for microbiologists, chemists, and scientists.

Heterocyclic Scaffolds I

Author : Bimal K. Banik
Publisher : Springer Science & Business Media
ISBN 13 : 3642128440
Total Pages : 386 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Heterocyclic Scaffolds I by : Bimal K. Banik

Download or read book Heterocyclic Scaffolds I written by Bimal K. Banik and published by Springer Science & Business Media. This book was released on 2010-06-08 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contents: B. Alcaide ∙ P. Almendros: Novel Aspects on the Preparation of Spirocyclic and Fused Unsual β-Lactams.- S.S. Bari ∙ A. Bhalla: Spirocyclic β-Lactams: Synthesis and Biological Evaluation of Novel Heterocycles.- L. Troisi ∙ C. Granito ∙ E. Pindinelli: Novel and Recent Synthesis and Applications of β-Lactams.- C. Palomo ∙ M. Oiarbide: β-Lactams Ring Opening: A Useful Entry to Amino Acids and Relevant Nitrogen-Containing Compounds.- B. Mandal ∙ P. Ghosh ∙ B. Basu: Recent Approaches Towards Solid Phase Synthesis of β-Lactams.- A.Arrieta ∙ B. Lecea ∙ F.P. Cossio: Computational Studies on the Synthesis of β-Lactams Via [ 2+2] Thermal Cycloadditions.- B. K. Banik ∙ I. Banik ∙ F. F. Becker: Novel Anticancer β-Lactams

Chemistry and Biology of Beta-Lactams

Author : Bimal Krishna Banik
Publisher : CRC Press
ISBN 13 : 1040146619
Total Pages : 410 pages
Book Rating : 4.0/5 (41 download)

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Book Synopsis Chemistry and Biology of Beta-Lactams by : Bimal Krishna Banik

Download or read book Chemistry and Biology of Beta-Lactams written by Bimal Krishna Banik and published by CRC Press. This book was released on 2024-11-07 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to their medicinal activity and potential use as synthetic starting materials, studies on beta-lactams have increased significantly. This unique volume takes readers on a tour de force from the concept of antibiosis to the serendipity of antibiotics, evolution of beta‐lactam development, and molecular biology of antibiotic resistance. These areas of research have culminated in a deeper understanding of microbiology, particularly in the area of bacterial cell wall synthesis and recycling. Considerable work has been performed by chemists and biologists to continue updating their findings about beta-lactam synthesis. Features: Stereoselective synthesis of monocyclic, bicyclic, and polycyclic beta-lactams Microwave, ultrasound, and solid support-mediated preparation of beta-lactams Diverse medicinal activities including anticancer activities of beta-lactams and products obtained from them Nanoparticles, artificial intelligence, and dipole moments in beta-lactam science Synthesis and mechanism of formation of polyaromatic beta-lactams

Antibacterial Agents

Author : Rosaleen Anderson
Publisher : John Wiley & Sons
ISBN 13 : 1118325443
Total Pages : 379 pages
Book Rating : 4.1/5 (183 download)

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Book Synopsis Antibacterial Agents by : Rosaleen Anderson

Download or read book Antibacterial Agents written by Rosaleen Anderson and published by John Wiley & Sons. This book was released on 2012-05-30 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antibacterial agents act against bacterial infection either by killing the bacterium or by arresting its growth. They do this by targeting bacterial DNA and its associated processes, attacking bacterial metabolic processes including protein synthesis, or interfering with bacterial cell wall synthesis and function. Antibacterial Agents is an essential guide to this important class of chemotherapeutic drugs. Compounds are organised according to their target, which helps the reader understand the mechanism of action of these drugs and how resistance can arise. The book uses an integrated “lab-to-clinic” approach which covers drug discovery, source or synthesis, mode of action, mechanisms of resistance, clinical aspects (including links to current guidelines, significant drug interactions, cautions and contraindications), prodrugs and future improvements. Agents covered include: agents targeting DNA - quinolone, rifamycin, and nitroimidazole antibacterial agents agents targeting metabolic processes - sulfonamide antibacterial agents and trimethoprim agents targeting protein synthesis - aminoglycoside, macrolide and tetracycline antibiotics, chloramphenicol, and oxazolidinones agents targeting cell wall synthesis - β-Lactam and glycopeptide antibiotics, cycloserine, isonaizid, and daptomycin Antibacterial Agents will find a place on the bookshelves of students of pharmacy, pharmacology, pharmaceutical sciences, drug design/discovery, and medicinal chemistry, and as a bench reference for pharmacists and pharmaceutical researchers in academia and industry.

Antibiotic Discovery and Development

Author : Thomas J. Dougherty
Publisher : Springer Science & Business Media
ISBN 13 : 1461414008
Total Pages : 1119 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Antibiotic Discovery and Development by : Thomas J. Dougherty

Download or read book Antibiotic Discovery and Development written by Thomas J. Dougherty and published by Springer Science & Business Media. This book was released on 2011-12-18 with total page 1119 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers all aspects of the antibiotic discovery and development process through Phase II/III. The contributors, a group of highly experienced individuals in both academics and industry, include chapters on the need for new antibiotic compounds, strategies for screening for new antibiotics, sources of novel synthetic and natural antibiotics, discovery phases of lead development and optimization, and candidate compound nominations into development. Beyond discovery , the handbook will cover all of the studies to prepare for IND submission: Phase I (safety and dose ranging), progression to Phase II (efficacy), and Phase III (capturing desired initial indications). This book walks the reader through all aspects of the process, which has never been done before in a single reference. With the rise of antibiotic resistance and the increasing view that a crisis may be looming in infectious diseases, there are strong signs of renewed emphasis in antibiotic research. The purpose of the handbook is to offer a detailed overview of all aspects of the problem posed by antibiotic discovery and development.

Chemistry of Penicillin

Author : Hans T. Clarke
Publisher : Princeton University Press
ISBN 13 : 1400874912
Total Pages : 1116 pages
Book Rating : 4.4/5 (8 download)

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Book Synopsis Chemistry of Penicillin by : Hans T. Clarke

Download or read book Chemistry of Penicillin written by Hans T. Clarke and published by Princeton University Press. This book was released on 2015-12-08 with total page 1116 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book makes available, for interested scientists to procure, absorb, and evaluate, the vast body of information on the research and results of the work on the chemistry of penicillin done in England and the United States during the war. The National Academy of Sciences arranged for the preparation of this summary, Dr. H. T. Clarke and Dr. J. R. Johnson representing the United States on the editorial board, and Sir Robert Robinson representing Britain. The body of the work was prepared by more than 60 outstanding biochemists and biophysicists, who describe the phases of research to which they contributed the most. The work of 23 academic, medical, industrial, and government laboratories is reported. Originally published in 1949. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

Chemistry of Antibiotics and Related Drugs

Author : Mrinal K. Bhattacharjee
Publisher : Springer Nature
ISBN 13 : 303107582X
Total Pages : 276 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Chemistry of Antibiotics and Related Drugs by : Mrinal K. Bhattacharjee

Download or read book Chemistry of Antibiotics and Related Drugs written by Mrinal K. Bhattacharjee and published by Springer Nature. This book was released on 2022-08-23 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook builds on the success of the earlier edition, offering alternative strategies for discovering new antibiotics. It discusses how the various types of antibiotics and related drugs work to cure infections. Then it delves into the very serious matter of how bacteria are becoming resistant to these antibiotics. It also covers the global action plan on antimicrobial resistance from the World Health Organization and discusses several Antibiotic Stewardship Programs adopted by agencies at local levels. Appropriate for a one-semester course at either the graduate or advanced undergraduate level, the book is self-contained and written in accessible language. It includes all necessary background biochemistry material and a discussion of the latest developments in the field of antibiotics. Original research works are frequently cited and experimental procedures and interpretation of results are emphasized.

Comprehensive Natural Products III

Author :
Publisher : Elsevier
ISBN 13 : 0081026919
Total Pages : 4266 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Comprehensive Natural Products III by :

Download or read book Comprehensive Natural Products III written by and published by Elsevier. This book was released on 2020-07-22 with total page 4266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Natural Products III, Third Edition, Seven Volume Set updates and complements the previous two editions, including recent advances in cofactor chemistry, structural diversity of natural products and secondary metabolites, enzymes and enzyme mechanisms and new bioinformatics tools. Natural products research is a dynamic discipline at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids and enzymes. This book reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine and to stimulate new ideas among the established natural products community. Provides readers with an in-depth review of current natural products research and a critical insight into the future direction of the field Bridges the gap in knowledge by covering developments in the field since the second edition published in 2010 Split into 7 sections on key topics to allow students, researchers and professionals to find relevant information quickly and easily Ensures that the knowledge within is easily understood by and applicable to a large audience

The Organic Chemistry of Biological Pathways

Author : John McMurry
Publisher : Roberts and Company Publishers
ISBN 13 : 9780974707716
Total Pages : 524 pages
Book Rating : 4.7/5 (77 download)

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Book Synopsis The Organic Chemistry of Biological Pathways by : John McMurry

Download or read book The Organic Chemistry of Biological Pathways written by John McMurry and published by Roberts and Company Publishers. This book was released on 2005 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intended for advanced undergraduates and graduate students in all areas of biochemistry, The Organic Chemistry of Biological Pathways provides an accurate treatment of the major biochemical pathways from the perspective of mechanistic organic chemistry.

Synthesis of Best-Seller Drugs

Author : Ruben Vardanyan
Publisher : Academic Press
ISBN 13 : 0124115241
Total Pages : 870 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Synthesis of Best-Seller Drugs by : Ruben Vardanyan

Download or read book Synthesis of Best-Seller Drugs written by Ruben Vardanyan and published by Academic Press. This book was released on 2016-01-07 with total page 870 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field. - Describes methods of synthesis, bioactivity and related drugs in key therapeutic areas - Reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and more - Presents a practical layout designed for use as a quick reference tool by those working in drug design, development and implementation