Chemical Mutagenesis In Mammals And Man

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Biologic Markers in Reproductive Toxicology

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 9780309039796
Total Pages : 424 pages
Book Rating : 4.0/5 (397 download)

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Book Synopsis Biologic Markers in Reproductive Toxicology by : National Research Council

Download or read book Biologic Markers in Reproductive Toxicology written by National Research Council and published by National Academies Press. This book was released on 1989-02-01 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Does exposure to environmental toxicants inhibit our ability to have healthy children who develop normally? Biologic markersâ€"indicators that can tell us when environmental factors have caused a change at the cellular or biochemical level that might affect reproductive abilityâ€"are a promising tool for research aimed at answering that important question. Biologic Markers in Reproductive Toxicology examines the potential of these markers in environmental health studies; clarifies definitions, underlying concepts, and possible applications; and shows the benefits to be gained from their use in reproductive and neurodevelopmental research.

Diet Nutrition And Cancer

Author : National Research Council
Publisher : Legare Street Press
ISBN 13 : 9781015691629
Total Pages : 0 pages
Book Rating : 4.6/5 (916 download)

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Book Synopsis Diet Nutrition And Cancer by : National Research Council

Download or read book Diet Nutrition And Cancer written by National Research Council and published by Legare Street Press. This book was released on 2022-10-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.

Chemical Mutagens

Author : Alexander Hollaender
Publisher : Springer Science & Business Media
ISBN 13 : 146158972X
Total Pages : 256 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Chemical Mutagens by : Alexander Hollaender

Download or read book Chemical Mutagens written by Alexander Hollaender and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ready acceptance and wide demand for copies of the first two volumes of Chemical Mutagens: Principles and Methods Jar Their Detection have demon strated the need for wider dissemination of information on this timely and urgent subject. Therefore, it was imperative that a third volume be prepared to include more detailed discussions on techniques of some of the methods that were presented from a theoretical point of view in the first two volumes, and to update this rapidly expanding field with current findings and the new developments that have taken place in the past three years. Also included is a special chapter by Dr. Charlotte Auerbach giving the historical background of the discovery of chemical mutagenesis. Methods for recognizing mutagenic compounds in vitro are a necessary preliminary step toward arriving at satisfactory solutions for recognizing significant mutation rates in man, which must be done before our test tube methods of detection can be considered reliable. Two chapters in this volume make important contributions to this problem. Due to the increasing activity in efforts to perfect techniques for detecting chemical mutagens and their effects on man, it is planned to continue this series of volumes as necessary to keep abreast of current findings.

Chemical Mutagens

Author : Frederick J. De Serr
Publisher : Springer Science & Business Media
ISBN 13 : 1461336945
Total Pages : 394 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Chemical Mutagens by : Frederick J. De Serr

Download or read book Chemical Mutagens written by Frederick J. De Serr and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 8 of Chemical Mutagens covers a wide range of topics in this continuously changing field. This volume includes chapters on the detection of genetic damage in mammalian sperm both at specific loci and over the entire genome. The discussion of in vitro techniques for working with mammalian cells covers not only specific locus assays but also cellular activation systems. Another chapter extensively discusses the need for a revised protocol for the micronucleus assay. Structure activity relationships are investigated in a chapter dealing with hair dye constituents. One of the most comprehensive chapters deals with problems associated with the detection of mutagenic effects in defined human populations. Finally, there is a detailed presentation of a comprehensive study tabulating the genetic bioassay data on some known or suspected human carcinogens. In keeping with our policy of publishing important legislation in the area of chemical mutagens, we have also included the Council of the European Communities Directive of 18 September 1979. Frederick J. de Serres Research Triangle Park, North Carolina vii Contents Chapter 1 Detection of Effects of Mutagens in Human Populations George R. Hoffmann 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. Monitoring Progeny for Evidence of Germ-Cell Mutations. . . . . 3 2. 1. The Classical Approach: Phenotypic Monitoring . . . . . . . 3 2. 2. Monitoring for Changes in Gene Products . . . . . . . . . . . 7 3. Detection of Gene Mutations in Somatic Cells. . . . . . . . . . . . . 9 3. 1. Drug-Resistant Lymphocytes . . . . . . . . . . . . . . . . . . . . . . 9 3. 2. Hemoglobin Variants . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 4. Nongenetic Indicators of Mutagen Exposure . . . . . . . . . . . . . 21 4. 1. Alkylation of Proteins . . . . . . . . . . . . . . . . . . . . . . . . . . . 21 4. 2. DNA Damage . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Mutagenesis in Sub-Mammalian Systems

Author : G.E. Paget
Publisher : Springer Science & Business Media
ISBN 13 : 9401166390
Total Pages : 234 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Mutagenesis in Sub-Mammalian Systems by : G.E. Paget

Download or read book Mutagenesis in Sub-Mammalian Systems written by G.E. Paget and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topics in Toxicology Toxicology is a science that stands at the intersection of several interests and disciplines. These intersecting forces are by no means all scientific since some are legal and some are commercial. All have valid things to say about the conduct and interpretation of toxicity experiments. The practising toxicologist must bear all these sometimes conflicting forces in mind as he carries out his duties. This is especially true, of course, of the toxicologist in industry. Toxicology is also a field in which contract research particularly flourishes and a number of major contract research companies have established over the years a reputation for contributing usefully to the practice of this skill. These contract research organisations are particu larly favoured to develop an appreciation of the problems of the industrial toxicologist, since it is very common for such a company to service the toxicological needs of companies in several sectors of industry producing new chemical compounds, and the contract research company, therefore, is aware of a wider diversity of problems than probably affects a single toxicologist in one industry.

Chemical Mutagens

Author : Frederick J. de Serres
Publisher : Springer Science & Business Media
ISBN 13 : 1461566258
Total Pages : 517 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Chemical Mutagens by : Frederick J. de Serres

Download or read book Chemical Mutagens written by Frederick J. de Serres and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 517 pages. Available in PDF, EPUB and Kindle. Book excerpt: New developments in the study of environmental mutagens continue to evolve in this rapidly emerging field. In Volume 7 of Chemical Mutagens, we have focused on various new techniques for the detection of genetic damage in somatic cells and germ cells of mammals and the use of lower eukaryotic microorganisms to detect aneuploidy as well as other types of genetic damage. Attention has also been given to the role of in vitro metabolic activation as a mechanism for modifying the genetic effects of different environmental chemicals. In a chapter on compar ative mutagenesis, reaction kinetics and their relationship to the mu tagenic action of monofunctional alkylating agents in higher eukaryotic organisms are examined. In another chapter, the pharmacology and toxicology of nitrites and nitrates, which are in widespread distribution in the environment, are discussed in detail. The books in this series have provided a mechanism for the publication of many important new developments in the study of the genetic effects of environmental chemicals. This series was launched by Dr. Alexander Hollaender who, beginning in 1971, edited Volumes 1-4 and then coedited Volumes 5-7. The success of his lO-year effort with these volumes is another testimony to Dr. Hollaender's many contri butions to the field of environmental mutagenesis. As Dr.

Safety of Genetically Engineered Foods

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309166152
Total Pages : 254 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Safety of Genetically Engineered Foods by : National Research Council

Download or read book Safety of Genetically Engineered Foods written by National Research Council and published by National Academies Press. This book was released on 2004-07-08 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assists policymakers in evaluating the appropriate scientific methods for detecting unintended changes in food and assessing the potential for adverse health effects from genetically modified products. In this book, the committee recommended that greater scrutiny should be given to foods containing new compounds or unusual amounts of naturally occurring substances, regardless of the method used to create them. The book offers a framework to guide federal agencies in selecting the route of safety assessment. It identifies and recommends several pre- and post-market approaches to guide the assessment of unintended compositional changes that could result from genetically modified foods and research avenues to fill the knowledge gaps.

Chemical Mutagenesis in Laboratory Mammals

Author :
Publisher :
ISBN 13 :
Total Pages : 164 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis Chemical Mutagenesis in Laboratory Mammals by :

Download or read book Chemical Mutagenesis in Laboratory Mammals written by and published by . This book was released on 1973 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over 350 references to books and journal articles published during 1928-1973. Also covers foreign-language literature. Arranged under citation index, Agent index, Chemical abstracts registry number index, Organism index, KWIC index, Author index, First author index, and Addendum. Entries in Citation index and First author index provide essential bibliographical information.

Health Effects of Exposure to Low Levels of Ionizing Radiation

Author : National Research Council
Publisher : National Academies
ISBN 13 : 0309039959
Total Pages : 436 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Health Effects of Exposure to Low Levels of Ionizing Radiation by : National Research Council

Download or read book Health Effects of Exposure to Low Levels of Ionizing Radiation written by National Research Council and published by National Academies. This book was released on 1990-02-01 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reevaluates the health risks of ionizing radiation in light of data that have become available since the 1980 report on this subject was published. The data include new, much more reliable dose estimates for the A-bomb survivors, the results of an additional 14 years of follow-up of the survivors for cancer mortality, recent results of follow-up studies of persons irradiated for medical purposes, and results of relevant experiments with laboratory animals and cultured cells. It analyzes the data in terms of risk estimates for specific organs in relation to dose and time after exposure, and compares radiation effects between Japanese and Western populations.

The Children of Atomic Bomb Survivors

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309045371
Total Pages : 524 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis The Children of Atomic Bomb Survivors by : National Research Council

Download or read book The Children of Atomic Bomb Survivors written by National Research Council and published by National Academies Press. This book was released on 1991-02-01 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: Do persons exposed to radiation suffer genetic effects that threaten their yet-to-be-born children? Researchers are concluding that the genetic risks of radiation are less than previously thought. This finding is explored in this volume about the children of atomic bomb survivors in Hiroshima and Nagasakiâ€"the population that can provide the greatest insight into this critical issue. Assembled here for the first time are papers representing more than 40 years of research. These documents reveal key results related to radiation's effects on pregnancy termination, sex ratio, congenital defects, and early mortality of children. Edited by two of the principal architects of the studies, J. V. Neel and W. J. Schull, the volume also offers an important comparison with studies of the genetic effects of radiation on mice. The wealth of technical details will be immediately useful to geneticists and other specialists. Policymakers will be interested in the overall conclusions and discussion of future studies.

Chemical Mutagens

Author : Alexander Hollaender
Publisher : Springer Science & Business Media
ISBN 13 : 146158969X
Total Pages : 287 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Chemical Mutagens by : Alexander Hollaender

Download or read book Chemical Mutagens written by Alexander Hollaender and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: The best protection against environmental mutagens is to identify them before they ever come into general use. But it is always possible that some substance will escape detection and affect a large number of persons without this being realized until later generations. This article considers ways in which such a genetic emergency might be promptly detected. A mutation-detecting system should be relevant in that it tests for effects that are as closely related as possible to those that are feared. It should be sensitive enough to detect a moderate increase in mutation rate, able to discover the increase promptly before more damage is done, responsive to various kinds of mutational events, and designed in such a way as to maxi mize the probability that the Gause of an increase can be found. Methods based on germinal mutation necessarily involve enormous numbers of persons and tests. On the other hand, with somatic mutations the individual cell becomes the unit of measurement rather than the in dividual person. For this reason, I think that somatic tests are preferable to germinal tests, despite the fact that it is germinal mutations which are feared.

Biomarkers in Marine Organisms

Author : Ph. Garrigues
Publisher : Elsevier
ISBN 13 : 008052804X
Total Pages : 573 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Biomarkers in Marine Organisms by : Ph. Garrigues

Download or read book Biomarkers in Marine Organisms written by Ph. Garrigues and published by Elsevier. This book was released on 2001-11-07 with total page 573 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many previous studies and books have been dedicated to fundamental and developmental aspects of biomarkers. The purpose of this book is to provide, through various case studies, an overview of the practical use of biological markers in marine animals to evaluate the health effects of environmental contamination in marine ecosystems. More precisely, the book presents the results obtained during the development and application of biological markers as indicators of exposure/effect to toxic chemicals in marine environments, using diverse sentinel species such as fish, bivalves and crustaceans. An important aspect is also the publication of technical annexes that describe in detail the experimental procedures developed for both chemical and biochemical measurement.

Chemicals and the Future of Man

Author : United States. Congress. Senate. Government Operations
Publisher :
ISBN 13 :
Total Pages : 320 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Chemicals and the Future of Man by : United States. Congress. Senate. Government Operations

Download or read book Chemicals and the Future of Man written by United States. Congress. Senate. Government Operations and published by . This book was released on 1971 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Chemicals and the Future of Man

Author : United States. Congress. Senate. Committee on Government Operations. Subcommittee on Executive Reorganization and Government Research
Publisher :
ISBN 13 :
Total Pages : 312 pages
Book Rating : 4.:/5 (31 download)

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Book Synopsis Chemicals and the Future of Man by : United States. Congress. Senate. Committee on Government Operations. Subcommittee on Executive Reorganization and Government Research

Download or read book Chemicals and the Future of Man written by United States. Congress. Senate. Committee on Government Operations. Subcommittee on Executive Reorganization and Government Research and published by . This book was released on 1971 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Environmental and Pollution Science

Author : Mark L. Brusseau
Publisher : Academic Press
ISBN 13 : 0128147202
Total Pages : 658 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Environmental and Pollution Science by : Mark L. Brusseau

Download or read book Environmental and Pollution Science written by Mark L. Brusseau and published by Academic Press. This book was released on 2019-02-22 with total page 658 pages. Available in PDF, EPUB and Kindle. Book excerpt: Environmental and Pollution Science, Third Edition, continues its tradition on providing readers with the scientific basis to understand, manage, mitigate, and prevent pollution across the environment, be it air, land, or water. Pollution originates from a wide variety of sources, both natural and man-made, and occurs in a wide variety of forms including, biological, chemical, particulate or even energy, making a multivariate approach to assessment and mitigation essential for success. This third edition has been updated and revised to include topics that are critical to addressing pollution issues, from human-health impacts to environmental justice to developing sustainable solutions. Environmental and Pollution Science, Third Edition is designed to give readers the tools to be able to understand and implement multi-disciplinary approaches to help solve current and future environmental pollution problems. - Emphasizes conceptual understanding of environmental systems and can be used by students and professionals from a diversity of backgrounds focusing on the environment - Covers many aspects critical to assessing and managing environmental pollution including characterization, risk assessment, regulation, transport and fate, and remediation or restoration - New topics to this edition include Ecosystems and Ecosystem Services, Pollution in the Global System, Human Health Impacts, the interrelation between Soil and Human Health, Environmental Justice and Community Engagement, and Sustainability and Sustainable Solutions - Includes color photos and diagrams, chapter questions and problems, and highlighted key words

Exploring the Biological Contributions to Human Health

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309132975
Total Pages : 287 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Exploring the Biological Contributions to Human Health by : Institute of Medicine

Download or read book Exploring the Biological Contributions to Human Health written by Institute of Medicine and published by National Academies Press. This book was released on 2001-07-02 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: It's obvious why only men develop prostate cancer and why only women get ovarian cancer. But it is not obvious why women are more likely to recover language ability after a stroke than men or why women are more apt to develop autoimmune diseases such as lupus. Sex differences in health throughout the lifespan have been documented. Exploring the Biological Contributions to Human Health begins to snap the pieces of the puzzle into place so that this knowledge can be used to improve health for both sexes. From behavior and cognition to metabolism and response to chemicals and infectious organisms, this book explores the health impact of sex (being male or female, according to reproductive organs and chromosomes) and gender (one's sense of self as male or female in society). Exploring the Biological Contributions to Human Health discusses basic biochemical differences in the cells of males and females and health variability between the sexes from conception throughout life. The book identifies key research needs and opportunities and addresses barriers to research. Exploring the Biological Contributions to Human Health will be important to health policy makers, basic, applied, and clinical researchers, educators, providers, and journalists-while being very accessible to interested lay readers.

Plant Mutation Breeding and Biotechnology

Author : Q. Y. Shu
Publisher : CABI
ISBN 13 : 1780640854
Total Pages : 612 pages
Book Rating : 4.7/5 (86 download)

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Book Synopsis Plant Mutation Breeding and Biotechnology by : Q. Y. Shu

Download or read book Plant Mutation Breeding and Biotechnology written by Q. Y. Shu and published by CABI. This book was released on 2012 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: This book presents contemporary information on mutagenesis in plants and its applications in plant breeding and research. The topics are classified into sections focusing on the concepts, historical development and genetic basis of plant mutation breeding (chapters 1-6); mutagens and induced mutagenesis (chapters 7-13); mutation induction and mutant development (chapters 14-23); mutation breeding (chapters 24-34); or mutations in functional genomics (chapters 35-41). This book is an essential reference for those who are conducting research on mutagenesis as an approach to improving or modifying a trait, or achieving basic understanding of a pathway for a trait --.