Characterization Of The Interactions Between Molecular Chaperones And The Amyloid Protein Huntingtin Throughout Its Aggregation Pathway

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Characterization of the Interactions Between Molecular Chaperones and the Amyloid Protein Huntingtin Throughout Its Aggregation Pathway

Author : Merve Özel
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (145 download)

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Book Synopsis Characterization of the Interactions Between Molecular Chaperones and the Amyloid Protein Huntingtin Throughout Its Aggregation Pathway by : Merve Özel

Download or read book Characterization of the Interactions Between Molecular Chaperones and the Amyloid Protein Huntingtin Throughout Its Aggregation Pathway written by Merve Özel and published by . This book was released on 2024 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein misfolding and subsequent aggregation characterize most neurodegenerative diseases and are associated with impaired protein homeostasis (proteostasis). As prominent components of the proteostasis network, molecular chaperones have been identified as modulators of protein aggregation. Understanding their mechanisms of action paves the way for their use as a therapeutic strategy against neurodegenerative diseases. Huntington's disease (HD) is an inherited neurodegenerative disease caused by the abnormal expansion of CAG repeats in the first exon of the Huntingtin protein. Aggregation of the pathogenic HTTExon1 is suggested as the primary cause of neuronal deterioration. Previously, it was shown that a trimeric chaperone complex composed of Hsc70, DNAJB1, and Apg2 can inhibit pathogenic HTTExon1 aggregation and disaggregate preformed HTTExon1 fibrils. As a member of the J-domain protein (JDP) family, and a co-chaperone of Hsc70, DNAJB1 is known to recognize protein substrates, to transfer them to Hsc70, and stimulate the ATPase activity of Hsc70. Recently, a binding interface between DNAJB1 and HTTExon1 has been identified and this work has contributed to the analysis of the effect of this binding site in HTTExon1 suppression and disaggregation activities by the trimeric chaperone complex. In vitro analyses showed that this binding site and unique features of DNAJB1 conferred specificity and functionality, distinguishing it from other JDPs. Furthermore, association between the trimeric chaperones and HTTExon1 along its aggregation pathway was investigated. The data revealed that DNAJB1 and Hsc70 associate with aggregating HTTExon1 only in the presence of each other and an intact ATPase cycle, suggesting a cooperative association of these chaperones with HTTExon1 during aggregation. This association was found to be stable to detergent, suggesting that irreversible sequestration of chaperones in HTTExon1 aggregates is associated with the eventual failure of the trimeric chaperone complex in suppressing HTTExon1 aggregation.

Autophagosome and Phagosome

Author : Vojo Deretic
Publisher : Humana Press
ISBN 13 : 9781588298539
Total Pages : 455 pages
Book Rating : 4.2/5 (985 download)

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Book Synopsis Autophagosome and Phagosome by : Vojo Deretic

Download or read book Autophagosome and Phagosome written by Vojo Deretic and published by Humana Press. This book was released on 2008-04-24 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autophagy and phagocytosis are distinct yet partially morphologically similar processes. Understanding them is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. This book presents autophagosome and phagosome methods for novices and advanced researchers alike. Comprehensive and forward-thinking, the book offers a valuable guide to both cellular processes while inciting researchers to explore their potentially important connections.

The Ubiquitin System

Author : Milton J. Schlesinger
Publisher : Cold Spring Harbor Laboratory Press
ISBN 13 :
Total Pages : 218 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis The Ubiquitin System by : Milton J. Schlesinger

Download or read book The Ubiquitin System written by Milton J. Schlesinger and published by Cold Spring Harbor Laboratory Press. This book was released on 1988 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Molecular Chaperones and Neurodegeneration

Author : Cintia Roodveldt
Publisher : Frontiers Media SA
ISBN 13 : 2889453421
Total Pages : 182 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Molecular Chaperones and Neurodegeneration by : Cintia Roodveldt

Download or read book Molecular Chaperones and Neurodegeneration written by Cintia Roodveldt and published by Frontiers Media SA. This book was released on 2017-12-06 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular chaperones or heat-shock proteins (HSPs) play essential roles in safeguarding structural stability and preventing misfolding and aggregation of proteins, and maintaining the proteome functionality in the cell. For over two decades until the present time, new functions have been discovered and several molecular mechanisms have been elucidated for many chaperones, while the field is being continuously challenged by new open questions. Probably as a consequence of the increasing research on the molecular bases of neurodegenerative diseases, and the realisation that many such disorders are linked to protein misfolding processes, unleashing the roles and mechanisms of chaperones in the context of neurodegeneration has become a prime scientific goal. This e-book contains a diversity of reviews, perspective and original research articles highlighting the importance and potential of this emerging subject.

Molecular Chaperones in Health and Disease

Author : Matthias Gaestel
Publisher : Springer Science & Business Media
ISBN 13 : 9783540258759
Total Pages : 464 pages
Book Rating : 4.2/5 (587 download)

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Book Synopsis Molecular Chaperones in Health and Disease by : Matthias Gaestel

Download or read book Molecular Chaperones in Health and Disease written by Matthias Gaestel and published by Springer Science & Business Media. This book was released on 2005-09-27 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular chaperones are involved in a wide variety of essential cellular processes in living cells. A subset of molecular chaperones have been initially described as heat shock proteins protecting cells from stress damage by keeping cellular proteins in a folding competent state and preventing them from irreversible aggregation. Later it became obvious that molecular chaperones are also expressed constitutively in the cell and are involved in complex processes such as protein synthesis, intracellular protein transport, post-translational modification and secretion of proteins as well as receptor signalling. Hence, it is not surprising that molecular chaperones are implicated in the pathogenesis of many relevant diseases and could be regarded as potential pharmacological targets. Starting with the analysis of the mode of action of chaperones at the molecular, cellular and organismic level, this book will then describe specific aspects where modulation of chaperone action could be of pharmacological and therapeutic interest.

Protein Homeostasis

Author : Richard I. Morimoto
Publisher :
ISBN 13 : 9781936113064
Total Pages : 0 pages
Book Rating : 4.1/5 (13 download)

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Book Synopsis Protein Homeostasis by : Richard I. Morimoto

Download or read book Protein Homeostasis written by Richard I. Morimoto and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proper folding of proteins is crucial for cell function. Chaperones and enzymes that post-translationally modify newly synthesized proteins help ensure that proteins fold correctly, and the unfolded protein response functions as a homeostatic mechanism that removes misfolded proteins when cells are stressed. This book covers the entire spectrum of proteostasis in healthy cells and the diseases that result when control of protein production, protein folding, and protein degradation goes awry.

Protein Misfolding, Aggregation and Conformational Diseases

Author : Vladimir N. Uversky
Publisher : Springer Science & Business Media
ISBN 13 : 0387259198
Total Pages : 450 pages
Book Rating : 4.3/5 (872 download)

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Book Synopsis Protein Misfolding, Aggregation and Conformational Diseases by : Vladimir N. Uversky

Download or read book Protein Misfolding, Aggregation and Conformational Diseases written by Vladimir N. Uversky and published by Springer Science & Business Media. This book was released on 2007-11-24 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research indicates that most neurodegenerative diseases, systemic amyloidoses and many others, arise from the misfolding and aggregation of an underlying protein. This is the first book to discuss significant achievements in protein structure-function relationships in biochemistry, molecular biology and molecular medicine. The authors summarize recent progress in the understanding of the relationships between protein misfolding, aggregation and development of protein deposition disorders.

Peptide-Lipid Interactions

Author : Sidney A. Simon
Publisher : Academic Press
ISBN 13 : 0080925855
Total Pages : 606 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Peptide-Lipid Interactions by : Sidney A. Simon

Download or read book Peptide-Lipid Interactions written by Sidney A. Simon and published by Academic Press. This book was released on 2002-11-13 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains a comprehensive overview of peptide-lipid interactions by leading researchers. The first part covers theoretical concepts, experimental considerations, and thermodynamics. The second part presents new results obtained through site-directed EPR, electron microscopy, NMR, isothermal calorimetry, and fluorescence quenching. The final part covers problems of biological interest, including signal transduction, membrane transport, fusion, and adhesion. Key Features * world-renowned experts * state-of-the-art experimental methods * monolayers, bilayers, biological membranes * theoretical aspects and computer simulations * rafts * synaptic transmission * membrane fusion * signal transduction

Molecular Biology of the Cell

Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of the Cell by :

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Genetic Instabilities and Neurological Diseases

Author : Robert D. Wells
Publisher : Elsevier
ISBN 13 : 0080463770
Total Pages : 783 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Genetic Instabilities and Neurological Diseases by : Robert D. Wells

Download or read book Genetic Instabilities and Neurological Diseases written by Robert D. Wells and published by Elsevier. This book was released on 2011-10-13 with total page 783 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic Instabilities and Neurological Diseases covers DNA repeat instability and neurological disorders, covering molecular mechanisms of repeat expansion, pathogenic mechanisms, clinical phenotype, parental gender effects, genotype-phenotype correlation, and diagnostic applications of the molecular data. This updated edition provides updates of these repeat expansion mutations, including the addition of many new chapters, and old chapters rewritten as extensions of the previous edition. This book is an invaluable reference source for neuroscientists, geneticists, neurologists, molecular biologists, genetic counsellors and students. - Contributions by most of the principal research teams in the area, edited by world-renowned leaders - Lays the background for future investigations on related diseases

HSF1 and Molecular Chaperones in Biology and Cancer

Author : Marc Laurence Mendillo
Publisher : Springer Nature
ISBN 13 : 3030402045
Total Pages : 185 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis HSF1 and Molecular Chaperones in Biology and Cancer by : Marc Laurence Mendillo

Download or read book HSF1 and Molecular Chaperones in Biology and Cancer written by Marc Laurence Mendillo and published by Springer Nature. This book was released on 2020-04-15 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein homeostasis, or “Proteostasis”, lies at the heart of human health and disease. From the folding of single polypeptide chains into functional proteins, to the regulation of intracellular signaling pathways, to the secreted signals that coordinate cells in tissues and throughout the body, the proteostasis network operates to support cell health and physiological fitness. However, cancer cells also hijack the proteostasis network and many of these same processes to sustain the growth and spread of tumors. The chapters in this book are written by world experts in the many facets of the proteostasis network. They describe cutting-edge insights into the structure and function of the major chaperone and degradation systems in healthy cells and how these systems are co-opted in cancer cells and the cells of the tumor microenvironment. The chapters also cover therapeutic interventions such as the FDA-approved proteasome inhibitors Velcade and Krypolis as well as other therapies currently under clinical investigation to disarm the ability of the proteostasis network to support malignancy. This compendium is the first of its kind and aims to serve as a reference manual for active investigators and a primer for newcomers to the field. This book is dedicated to the memory of Susan Lindquist, a pioneer of the proteostasis field and a champion of the power of basic scientific inquiry to unlock the mechanisms of human disease. The chapter “Reflections and Outlook on Targeting HSP90, HSP70 and HSF1 in Cancer: A Personal Perspective” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Handbook of the Neuroscience of Aging

Author : Patrick R. Hof
Publisher : Academic Press
ISBN 13 : 0080954057
Total Pages : 712 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Handbook of the Neuroscience of Aging by : Patrick R. Hof

Download or read book Handbook of the Neuroscience of Aging written by Patrick R. Hof and published by Academic Press. This book was released on 2010-05-22 with total page 712 pages. Available in PDF, EPUB and Kindle. Book excerpt: A single volume of 85 articles, the Handbook of the Neurobiology of Aging is an authoritative selection of relevant chapters from the Encyclopedia of Neuroscience, the most comprehensive source of neuroscience information assembled to date (AP Oct 2008). The study of neural aging is a central topic in neuroscience, neuropsychology and gerontology. Some well-known age-related neurological diseases include Parkinson's and Alzheimer's, but even more common are problems of aging which are not due to disease but to more subtle impairments in neurobiological systems, including impairments in vision, memory loss, muscle weakening, and loss of reproductive functions, changes in body weight, and sleeplessness. As the average age of our society increases, diseases of aging become more common and conditions associated with aging need more attention by doctors and researchers. This book offers an overview of topics related to neurobiological impairments which are related to the aging brain and nervous system. Coverage ranges from animal models to human imaging, fundamentals of age-related neural changes and pathological neurodegeneration, and offers an overview of structural and functional changes at the molecular, systems, and cognitive levels. Key pathologies such as memory disorders, Alzheimer's, dementia, Down syndrome, Parkinson's, and stroke are discussed, as are cutting edge interventions such as cell replacement therapy and deep brain stimulation. There is no other current single-volume reference with such a comprehensive coverage and depth. Authors selected are the internationally renowned experts for the particular topics on which they write, and the volume is richly illustrated with over 100 color figures. A collection of articles reviewing our fundamental knowledge of neural aging, the book provides an essential, affordable reference for scientists in all areas of Neuroscience, Neuropsychology and Gerontology. - The most comprehensive source of up-to-date data on the neurobiology of aging, review articles cover: normal, sensory and cognitive aging; neuroendocrine, structural and molecular factors; and fully address both patholgy and intervention - Chapters represent an authoritative selection of relevant material from the most comprehensive source of information about neuroscience ever assembled, (Encyclopedia of Neuroscience), synthesizing information otherwise dispersed across a number of journal articles and book chapters, and saving researchers the time consuming process of finding and integrating this information themselves - Offering outstanding scholarship, each chapter is written by an expert in the topic area and over 20% of chapters feature international contributors, (representing 11 countries) - Provides more fully vetted expert knowledge than any existing work with broad appeal for the US, UK and Europe, accurately crediting the contributions to research in those regions - Fully explores various pathologies associated with the aging brain (Alzheimer's, dementia, Parkinson's, memory disorders, stroke, Down's syndrome, etc.) - Coverage of disorders and key interventions makes the volume relevant to clinicians as well as researchers - Heavily illustrated with over 100 color figures

Evolution and Disease

Author : James Thomas Charles Nash
Publisher :
ISBN 13 :
Total Pages : 90 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Evolution and Disease by : James Thomas Charles Nash

Download or read book Evolution and Disease written by James Thomas Charles Nash and published by . This book was released on 1915 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt:

In-cell NMR Spectroscopy

Author : Yutaka Ito
Publisher : Royal Society of Chemistry
ISBN 13 : 1839160934
Total Pages : 322 pages
Book Rating : 4.8/5 (391 download)

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Book Synopsis In-cell NMR Spectroscopy by : Yutaka Ito

Download or read book In-cell NMR Spectroscopy written by Yutaka Ito and published by Royal Society of Chemistry. This book was released on 2019-12-09 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: In-cell NMR spectroscopy is a relatively new field. Despite its short history, recent in-cell NMR-related publications in major journals indicate that this method is receiving significant general attention. This book provides the first informative work specifically focused on in-cell NMR. It details the historical background of in-cell NMR, host cells for in-cell NMR studies, methods for in-cell biological techniques and NMR spectroscopy, applications, and future perspectives. Researchers in biochemistry, biophysics, molecular biology, cell biology, structural biology as well as NMR analysts interested in biological applications will all find this book valuable reading.

Encyclopedia of Signaling Molecules

Author : Sangdun Choi
Publisher : Springer
ISBN 13 : 9781441904607
Total Pages : 0 pages
Book Rating : 4.9/5 (46 download)

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Book Synopsis Encyclopedia of Signaling Molecules by : Sangdun Choi

Download or read book Encyclopedia of Signaling Molecules written by Sangdun Choi and published by Springer. This book was released on 2012-07-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological processes are driven by complex systems of functionally interacting signaling molecules. Thus, understanding signaling molecules is essential to explain normal or pathological biological phenomena. A large body of clinical and experimental data has been accumulated over these years, albeit in fragmented state. Hence, systems biological approaches concomitant with the understanding of each molecule are ideal to delineate signaling networks/pathways involved in the biologically important processes. The control of these signaling pathways will enrich our healthier life. Currently, there are more than 30,000 genes in human genome. However, not all the proteins encoded by these genes work equally in order to maintain homeostasis. Understanding the important signaling molecules as completely as possible will significantly improve our research-based teaching and scientific capabilities. This encyclopedia presents 350 biologically important signaling molecules and the content is built on the core concepts of their functions along with early findings written by some of the world’s foremost experts. The molecules are described by recognized leaders in each molecule. The interactions of these single molecules in signal transduction networks will also be explored. This encyclopedia marks a new era in overview of current cellular signaling molecules for the specialist and the interested non-specialist alike During past years, there were multiple databases to gather this information briefly and very partially. Amidst the excitement of these findings, one of the great scientific tasks of the coming century is to bring all the useful information into a place. Such an approach is arduous but at the end will infuse the lacunas and considerably be a streamline in the understanding of vibrant signaling networks. Based on this easy-approach, we can build up more complicated biological systems.

Protein Self-Assembly

Author : Jennifer J. McManus
Publisher : Humana
ISBN 13 : 9781493996803
Total Pages : 266 pages
Book Rating : 4.9/5 (968 download)

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Book Synopsis Protein Self-Assembly by : Jennifer J. McManus

Download or read book Protein Self-Assembly written by Jennifer J. McManus and published by Humana. This book was released on 2020-08-08 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores experimental and computational approaches to measuring the most widely studied protein assemblies, including condensed liquid phases, aggregates, and crystals. The chapters in this book are organized into three parts: Part One looks at the techniques used to measure protein-protein interactions and equilibrium protein phases in dilute and concentrated protein solutions; Part Two describes methods to measure kinetics of aggregation and to characterize the assembled state; and Part Three details several different computational approaches that are currently used to help researchers understand protein self-assembly. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, Protein Self-Assembly: Methods and Protocols is a valuable resource for researchers who are interested in learning more about this developing field.

Amyloid Proteins

Author : Einar M. Sigurdsson
Publisher : Springer Science & Business Media
ISBN 13 : 1592598749
Total Pages : 390 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Amyloid Proteins by : Einar M. Sigurdsson

Download or read book Amyloid Proteins written by Einar M. Sigurdsson and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: A proven collection of readily reproducible techniques for studying amyloid proteins and their involvement in the etiology, pathogenesis, diagnosis, and therapy of amyloid diseases. The contributors provide methods for the preparation of amyloid and its precursors (oligomers and protofibrils), in vitro assays and analytical techniques for their study, and cell culture models and assays for the production of amyloid proteins. Additional chapters present readily reproducible techniques for amyloid extraction from tissue, its detection in vitro and in vivo, as well as nontransgenic methods for developing amyloid mouse models. The protocols follow the successful Methods in Molecular BiologyTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.