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Author : Beth Ann Kozel
Publisher :
ISBN 13 :
Total Pages : 414 pages
Book Rating : 4.:/5 (563 download)
Download or read book Characterization of Elastic Fiber Assembly written by Beth Ann Kozel and published by . This book was released on 2004 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Léa-Jeanne Ringuette
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (922 download)
Download or read book Analysis of Elastic Fiber Assembly and Ultrastructure with Respect to Dosage Levels of Fibulin-4 written by Léa-Jeanne Ringuette and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Fibulin-4 belongs to the fibulin family of extracellular matrix proteins, consisting of seven known members and characterized by tandem repeats of calcium-binding epidermal growth factor (cbEGF)-like motifs and a C-terminal fibulin module. Fibulin-4 knockout (-/-) mice die perinatally due to aortic rupture. Electron microscopic investigation of the aortic wall shows severe disruption of the formation of the elastic laminae and little association of the elastic fibers with the vascular smooth muscle cell surface. In humans, genetic mutations in the fibulin-4 gene have been identified in two cutis laxa (loose skin) patients, both of which exhibited aortic aneurysms. In this study, the effect of the dosage of fibulin-4 was investigated with available mouse models. Using fibulin-4 heterozygous (+/-) and knockout (-/-) mice, as well as, fibulin-4 knockdown (+/R and R/R) mice, with reduced levels of fibulin-4, electron microscopic analyses of the aortic wall were conducted. Our results indicate that reduced levels of fibulin-4 lead to elastic fiber and collagen fibril abnormalities. Although a significant amount of elastin is produced in mice with low levels of fibulin-4, the elastic laminae that are formed show a lace-like appearance. Both +/R and R/R mice also show large, irregular collagen fibrils in the aorta, suggesting that fibulin-4 plays an important role in the regulation of collagen fibril diameter. This is a novel finding. In addition, a stoichiometric relationship between fibulin-4 and fibulin-5 was investigated using two available mouse models, Fbln4SMKO: Fbln5+/- and Fbln4SMKO: Fbln5-/-; electron microscopy of the aortic wall was conducted. These mice harbor a reduction in fibulin-4 that is specific to the blood vessels. It was demonstrated that the absence of fibulin-5 in the Fbln4SMKO: Fbln5-/- mice, the lace-like appearance of the elastic laminae was improved. Taken together, these results indicate that a stoichiometric relationship between fibulin-4 and fibulin-5 exist during elastic fiber assembly. " --
Author : Peter D. Yurchenco
Publisher : Academic Press
ISBN 13 : 1483289427
Total Pages : 483 pages
Book Rating : 4.4/5 (832 download)
Download or read book Extracellular Matrix Assembly and Structure written by Peter D. Yurchenco and published by Academic Press. This book was released on 2013-10-22 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: The complex and critical process of extracellular matrix (ECM) assembly is described in this book. Assembly may involve molecules interacting with molecules of the same matrix class, such as in collagen, or interactions between different ECM molecules, such as in basement membranes. The text shows how this is driven by structural information within the matrix monomer. This information will be of interest to cell, developmental, and molecular biologists, biochemists, biophysicists, and biomedical researchers involved in macromolecular assembly, biological macromolecules, and extracellular matrix. Addresses assembly of most of the known classes of extracellular matrix macromolecules Discusses higher order structures produced by ECM Gives important concepts in ECM and cell-matrix interactions, Protein structure and protein-protein interactions, Development and tissue remodeling
Author : E.D. Hay
Publisher : Springer Science & Business Media
ISBN 13 : 1461537703
Total Pages : 478 pages
Book Rating : 4.4/5 (615 download)
Download or read book Cell Biology of Extracellular Matrix written by E.D. Hay and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the ten-year interval since the first edition of this volume went to press, our knowledge of extracellular matrix (ECM) function and structure has enor mously increased. Extracellular matrix and cell-matrix interaction are now routine topics in the meetings and annual reviews sponsored by cell biology societies. Research in molecular biology has so advanced the number of known matrix molecules and the topic of gene structure and regulation that we won dered how best to incorporate the new material. For example, we deliberated over the inclusion of chapters on molecular genetics. We decided that with judicious editing we could present the recent findings in molecular biology within the same cell biology framework that was used for the first edition, using three broad headings: what is extracellular matrix, how is it made, and what does it do for cells? Maintaining control over the review of literature on the subject of ECM was not always an easy task, but we felt it was essential to production of a highly readable volume, one compact enough to serve the the student as an introduction and the investigator as a quick update on graduate the important recent discoveries. The first edition of this volume enjoyed con hope the reader finds this edition equally useful. siderable success; we D. Hay Elizabeth vii Contents Introductory Remarks 1 Elizabeth D. Hay PART I. WHAT IS EXTRACELLULAR MATRIX? Chapter 1 Collagen T. F. Linsenmayer 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 2. The Collagen Molecule . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 2. 1. Triple-Helical Domain(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Author : Cinzia Giannini
Publisher : Frontiers Media SA
ISBN 13 : 2889717224
Total Pages : 154 pages
Book Rating : 4.8/5 (897 download)
Download or read book Fibrous Assemblies: From Synthesis and Nanostructure Characterization to Materials Development and Application written by Cinzia Giannini and published by Frontiers Media SA. This book was released on 2021-12-01 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Robert Schleip
Publisher : Elsevier Health Sciences
ISBN 13 : 0702052280
Total Pages : 566 pages
Book Rating : 4.7/5 (2 download)
Download or read book Fascia: The Tensional Network of the Human Body written by Robert Schleip and published by Elsevier Health Sciences. This book was released on 2013-02-26 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the product of an important collaboration between clinicians of the manual therapies and scientists in several disciplines that grew out of the three recent International Fascia Research Congresses (Boston, Amsterdam, and Vancouver). The book editors, Thomas Findley MD PhD, Robert Schleip PhD, Peter Huijing PhD and Leon Chaitow DO, were major organizers of these congresses and used their extensive experience to select chapters and contributors for this book. This volume therefore brings together contributors from diverse backgrounds who share the desire to bridge the gap between theory and practice in our current knowledge of the fascia and goes beyond the 2007, 2009 and 2012 congresses to define the state-of-the-art, from both the clinical and scientific perspective. Prepared by over 100 specialists and researchers from throughout the world, Fascia: The Tensional Network of the Human Body will be ideal for all professionals who have an interest in fascia and human movement - physiotherapists, osteopathic physicians, osteopaths, chiropractors, structural integration practitioners, manual therapists, massage therapists, acupuncturists, yoga or Pilates instructors, exercise scientists and personal trainers - as well as physicians involved with musculoskeletal medicine, pain management and rehabilitation, and basic scientists working in the field. Reflects the efforts of almost 100 scientists and clinicians from throughout the world Offers comprehensive coverage ranging from anatomy and physiology, clinical conditions and associated therapies, to recently developed research techniques Explores the role of fascia as a bodywide communication system Presents the latest information available on myofascial force transmission which helps establish a scientific basis for given clinical experiences Explores the importance of fascia as a sensory organ - for example, its important proprioceptive and nociceptive functions which have implications for the generation of low back pain Describes new imaging methods which confirm the connectivity of organs and tissues Designed to organize relevant information for professionals involved in the therapeutic manipulation of the body’s connective tissue matrix (fascia) as well as for scientists involved in basic science research Reflects the increasing need for information about the properties of fascia, particularly for osteopaths, massage therapists, physiotherapists and other complementary health care professionals Offers new insights on the fascial related foundations of Traditional Chinese Medicine Meridians and the fascial effects of acupuncture
Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Misturu Akashi
Publisher : Springer
ISBN 13 : 4431551395
Total Pages : 271 pages
Book Rating : 4.4/5 (315 download)
Download or read book Engineered Cell Manipulation for Biomedical Application written by Misturu Akashi and published by Springer. This book was released on 2014-10-16 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first to summarize new technologies for engineered cell manipulation. The contents focus on control of cellular functions by nanomaterials and control of three-dimensional cell–cell interactions. Control of cellular functions is important for cell differentiation, maturation, and activation, which generally are controlled by the addition of soluble cytokines or growth factors into cell culture dishes. Target antigen molecules can be efficiently delivered to the cytosol of the dendritic cells using the nanoparticle technique described here, and cellular functions such as dendritic cell maturation can be controlled easily and with precision. This book describes basic preparation of the nanoparticles, activation control of dendritic cells, immune function control, and in vivo application for various vaccination systems. The second type of control,that of cell–cell interaction, is important for tissue engineering in order to develop three-dimensional cellular constructs. To achieve in vitro engineering of three-dimensional human tissue constructs, cell–cell interaction must be controlled in three dimensions, but typical biological cell manipulation technique cannot accomplish this task. An engineered cell manipulation technique is necessary. In this book the authors describe the fabrication of nanofilms onto cell surfaces, development of three-dimensional cellular multilayers, and various applications of the cellular multilayers as three-dimensional human models. This important work will be highly informative for researchers and students in the fields of materials science, polymer science, biomaterials, medicinal science, nanotechnology, biotechnology, and biology.
Author : J. W. S. Hearle
Publisher : Springer
ISBN 13 :
Total Pages : 668 pages
Book Rating : 4.F/5 ( download)
Download or read book Mechanics of Flexible Fibre Assemblies written by J. W. S. Hearle and published by Springer. This book was released on 1980-07-31 with total page 668 pages. Available in PDF, EPUB and Kindle. Book excerpt: Continued and systematic analysis of the mechanics of flexible fibre assemblies dates from about 1945, although the growth of research into textiles after 1920 had included studies of fabric structure and the measurement of mechanical properties. The subject is thus a young one, although this NATO Advanced Study Institute is a sign of developing maturity. However there is an earlier tradition. Relevant, even if somewhat loosely connected, quotations can be found in the works of the engineers of the ancient civilisations, recurring during the llenaissance with Leonardo da Vinci and Galileo. But the glorious libk is with Euler and the Bernoulli family, with their theories of the mechanics of flexible slender rods. While mathematicians have admired the beauty of this work, the invention of elliptic integrals, and the grace of the different classes of planar elastica, it is in the technology of textile materials, composed of flexible fibres and yarns, that the subject has found its more direct application. All this, and much more such as Max Born's doctoral thesis, was brought to our attention in a delightful discourse by Milos Konopasek, who is not only fascinated by the mathematics of Euler and the modern movement of the solutions of bending curves from two dimensions into three by the use of the computer, but also feels a personal link through having lived and studied within sight of the scene of Euler's triumphs in St. Petersburg.
Author : Anand Ramamurthi
Publisher : CRC Press
ISBN 13 : 1315353709
Total Pages : 322 pages
Book Rating : 4.3/5 (153 download)
Download or read book Elastic Fiber Matrices written by Anand Ramamurthi and published by CRC Press. This book was released on 2018-09-03 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Elastic Fiber Matrices: Biomimetic Approaches to Regeneration and Repair provides a comprehensive resource on the intrinsic and pathological aberrations of the complex process of elastic matrix assembly and/or variations thereof in different elastic tissue types, and on strategies to regenerate or restore lost elastin matrix, either in vitro or in vivo, including biomimetic elastin-like-peptides, gene therapy, drug delivery, tissue engineering (biomolecules, scaffolds, and mechanical stimuli), pharmacological approaches, elastin stabilization and preservation, stem cell therapy, allografts/xenografts, and synthetic/biological elastomers. Comprised of individual chapters contributed by leading researchers and scientists in the field, the text details current approaches for elastin matrix regeneration and repair, identifying their various advantages and limitations while offering valuable insight into emerging trends. Thus, this book is a must-have guide for academicians and industry professionals working in the areas of connective tissue biology, tissue engineering, dermal and cardiovascular biomaterials, and drug delivery.
Author : Jinlian Hu
Publisher : John Wiley & Sons
ISBN 13 : 3527342206
Total Pages : 1040 pages
Book Rating : 4.5/5 (273 download)
Download or read book Handbook of Fibrous Materials, 2 Volumes written by Jinlian Hu and published by John Wiley & Sons. This book was released on 2020-06-22 with total page 1040 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by a leading expert in the field with contributions from experienced researchers in fibers and textiles, this handbook reviews the current state of fibrous materials and provides a broad overview of their use in research and development. Volume One focuses on the classes of fibers, their production and characterization, while the second volume concentrates on their applications, including emerging ones in the areas of energy, environmental science and healthcare. Unparalleled knowledge of high relevance to academia and industry.
Author : Feroze N. Ghadially
Publisher : Butterworth-Heinemann
ISBN 13 : 1483192083
Total Pages : 612 pages
Book Rating : 4.4/5 (831 download)
Download or read book Ultrastructural Pathology of the Cell and Matrix written by Feroze N. Ghadially and published by Butterworth-Heinemann. This book was released on 2013-10-22 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ultrastructural Pathology of the Cell and Matrix: Third Edition Volume I present a comprehensive examination of the intracellular lesion. It discusses the analysis of pathological tissues using electron microscope. It addresses the experimental procedures made on the cellular level. Some of the topics covered in the book are the physiological analysis of the nucleus; nuclear matrix, interchromatin, and perichromatin granules; structure and function of centrioles; characteristics of mitochondria; Golgi complex in cell differentiation and neoplasia; and degranulation of rough endoplasmic reticulum. The intracytoplasmic and intranuclear annulate lamellae are fully covered. An in-depth account of the classification, history, and nomenclature of lysosomes are provided. The morphology and normal variations of melanosomes and anchoring fibrils are completely presented. A chapter is devoted to the endocytotic structures and cell processes. Another section focuses on the classification and nomenclature of fibrous components. The book can provide useful information to cytologists, scientists, students, and researchers.
Author : Fred W. Keeley
Publisher : Springer Science & Business Media
ISBN 13 : 3642360025
Total Pages : 297 pages
Book Rating : 4.6/5 (423 download)
Download or read book Evolution of Extracellular Matrix written by Fred W. Keeley and published by Springer Science & Business Media. This book was released on 2013-03-15 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: The evolution of single cells into multicellular organisms was mediated, in large part, by the extracellular matrix. The proteins and glycoconjugates that make up the extracellular matrix provide structural support to cellular complexes, facilitate cell adhesion and migration, and impart mechanical properties that are important for tissue function. Each class of ECM macromolecule has evolved to incorporate distinctive properties that are defined by conserved modules that are mixed together to achieve appropriate function. This volume provides a comprehensive analysis of how the major ECM components evolved over time in order to fill their specific roles found in modern organisms. The major focus is on the structural matrix proteins, matricellular proteins, and more complex ECM structures such as basement membranes. Adhesive proteins and their receptors are also discussed.
Author : Robert Mecham
Publisher : Springer Science & Business Media
ISBN 13 : 3642165559
Total Pages : 429 pages
Book Rating : 4.6/5 (421 download)
Download or read book The Extracellular Matrix: an Overview written by Robert Mecham and published by Springer Science & Business Media. This book was released on 2011-02-16 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment. Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.
Author : Brian K. Hall
Publisher : Academic Press
ISBN 13 : 0124166857
Total Pages : 911 pages
Book Rating : 4.1/5 (241 download)
Download or read book Bones and Cartilage written by Brian K. Hall and published by Academic Press. This book was released on 2014-12-23 with total page 911 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bones and Cartilage provides the most in-depth review and synthesis assembled on the topic, across all vertebrates. It examines the function, development and evolution of bone and cartilage as tissues, organs and skeletal systems. It describes how bone and cartilage develop in embryos and are maintained in adults, how bone is repaired when we break a leg, or regenerates when a newt grows a new limb, or a lizard a new tail. The second edition of Bones and Cartilage includes the most recent knowledge of molecular, cellular, developmental and evolutionary processes, which are integrated to outline a unified discipline of developmental and evolutionary skeletal biology. Additionally, coverage includes how the molecular and cellular aspects of bones and cartilage differ in different skeletal systems and across species, along with the latest studies and hypotheses of relationships between skeletal cells and the most recent information on coupling between osteocytes and osteoclasts All chapters have been revised and updated to include the latest research. Offers complete coverage of every aspect of bone and cartilage, with updated references and extensive illustrations Integrates development and evolution of the skeleton, as well a synthesis of differentiation, growth and patterning Treats all levels from molecular to clinical, embryos to evolution, and covers all vertebrates as well as invertebrate cartilages Includes new chapters on evolutionary skeletal biology that highlight normal variation and variability, and variation outside the norm (neomorphs, atavisms) Updates hypotheses on the origination of cartilage using new phylogenetic, cellular and genetic data Covers stem cells in embryos and adults, including mesenchymal stem cells and their use in genetic engineering of cartilage, and the concept of the stem cell niche
Author : Judith Tamara Cirulis
Publisher :
ISBN 13 : 9780494590607
Total Pages : 412 pages
Book Rating : 4.5/5 (96 download)
Download or read book Self-assembly and Fibre Formation of Elastin-like Polypeptides written by Judith Tamara Cirulis and published by . This book was released on 2009 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Elastin is a polymeric protein of the extracellular matrix that imparts the characteristics of extensibility and elastic recoil to tissues. Recombinant polypeptides based on the domain structures and sequences of human elastin self-assemble into organized fibrous structures, with physical properties similar to those of native polymeric elastin. Elastin self-assembly is initiated by a temperature-induced phase separation, called coacervation. Previous to this work, coacervation temperature had been the only parameter available to measure propensity for self-assembly. A variety of techniques were developed using spectrophotometry, microscopy, and rheometry to differentiate the stages of self-assembly, thereby enabling independent observation and quantitation of each stage, and allowing investigations into properties of polypeptides and solution conditions affecting these stages.Self-assembly in the presence of non-elastin, matrix-associated proteins showed that these proteins maintained the coacervate as small droplets, which sometimes flocculated into fibre-like structures. Rheometry demonstrated a second temperature-induced transition above the coacervation temperature, which resulted in gelation and viscoelastic characteristics similar to microgels.Kinetic analysis of self-assembly yielded two additional parameters: coacervation velocity and maturation velocity. Examining the effects of agitation, salt concentration, temperature, polypeptide concentration, size of a polypeptide, hydrophobic domain sequence, and cross-linking domain structure on the kinetics demonstrated that coacervation and maturation are independent stages of self-assembly involving distinct mechanisms. Microscopic observations showed that protein-rich droplets of coacervate grew by coalescence to a stable droplet size, which correlated to differences in maturation velocities between polypeptides. Coacervate droplet growth appeared limited by the formation of organized polypeptide at the surface of the droplets, decreasing surface fluidity. Many of the general principles of the physical chemistry of colloids and emulsions appeared to apply to the formation, growth and stabilization of coacervates of the elastin-like polypeptides.Together, these observations have resulted in a greater level of understanding of the entire self-assembly process, and provided a comprehensive model of elastin-like polypeptide self-assembly that relates to in vivo assembly of elastic fibres.
Author : Ahmed Barhoum
Publisher : Springer
ISBN 13 : 9783319536545
Total Pages : 1300 pages
Book Rating : 4.5/5 (365 download)
Download or read book Handbook of Nanofibers written by Ahmed Barhoum and published by Springer. This book was released on 2019-09-10 with total page 1300 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Handbook covers all aspects related to Nanofibers, from the experimental set-up for their fabrication to their potential industrial applications. It describes several kinds of nanostructured fibers such as metal oxides, natural polymers, synthetic polymers and hybrid inorganic-polymers or carbon-based materials. The first part of the Handbook covers the fundamental aspects, experimental setup, synthesis, properties and physico-chemical characterization of nanofibers. Specifically, this part details the history of nanofibers, different techniques to design nanofibers, self-assembly in nanofibers, critical parameters of synthesis, fiber alignment, modeling and simulation, types and classifications of nanofibers, and signature physical and chemical properties (i.e. mechanical, electrical, optical and magnetic), toxicity and regulations, bulk and surface functionalization and other treatments to allow them to a practical use. Characterization methods are also deeply discussed here. The second part of the Handbook deals with global markets and technologies and emerging applications of nanofibers, such as in energy production and storage, aerospace, automotive, sensors, smart textile design, energy conversion, tissue engineering, medical implants, pharmacy and cosmetics. Attention is given to the future of research in these areas in order to improve and spread the applications of nanofibers and their commercialization.
