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Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Robert J. Alpern
Publisher : Elsevier
ISBN 13 : 0080559506
Total Pages : 2922 pages
Book Rating : 4.0/5 (85 download)
Download or read book Seldin and Giebisch's The Kidney written by Robert J. Alpern and published by Elsevier. This book was released on 2007-10-10 with total page 2922 pages. Available in PDF, EPUB and Kindle. Book excerpt: A classic nephrology reference for over 20 years, Seldin & Giebisch's The Kidney, is the acknowledged authority on renal physiology and pathophysiology. The fourth edition follows the changed focus of nephrology research to the study of how individual molecules work together to affect cellular and organ function, emphasizing the mechanisms of disease. With over 40 new chapters and over 1000 illustrations, this edition offers the most in-depth discussion anywhere of the physiologic and pathophysiologic processes of renal disease. Comprehensive, authoritative coverage progresses from molecular biology and cell physiology to clinical issues regarding renal function and dysfunction. If you research the development of normal renal function or the mechanisms underlying renal disease, Seldin & Giebisch's The Kidney is your number one source for information.* Offers the most comprehensive coverage of fluid and electrolyte regulation and dysregulation in 51 completely revised chapters unlike Brenner & Rector's The Kidney which devotes only 7 chapters to this topic.* Includes 3 sections, 31 chapters, devoted to regulation and disorders of acid-base homeostasis, and epithelial and nonepithelial transport regulation. Brenner & Rector's only devotes 5 chapters to these topics.* Previous three editions edited by Donald Seldin and Gerhard Giebisch, world renowned names in nephrology. The title for the fourth edition has been changed to reflect their considerable work on previous editions and they have also written the forward for this edition. * Over 20 million adults over age 20 have chronic kidney disease with the number of people diagnosed doubling each decade making it America's ninth leading cause of death.
Author : Hikaru Koide
Publisher :
ISBN 13 :
Total Pages : 244 pages
Book Rating : 4.3/5 (91 download)
Download or read book Extracellular Matrix in the Kidney written by Hikaru Koide and published by . This book was released on 1994 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jong Hoon Park
Publisher : Springer
ISBN 13 : 9811020418
Total Pages : 128 pages
Book Rating : 4.8/5 (11 download)
Download or read book Cystogenesis written by Jong Hoon Park and published by Springer. This book was released on 2016-10-12 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.
Author : Rachel K. Miller
Publisher : Springer
ISBN 13 : 3319514369
Total Pages : 373 pages
Book Rating : 4.3/5 (195 download)
Download or read book Kidney Development and Disease written by Rachel K. Miller and published by Springer. This book was released on 2017-04-13 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kidney Development and Disease brings together established and young investigators who are leading authorities in nephrology to describe recent advances in three primary areas of research. The first section describes the use of animal models as powerful tools for the discovery of numerous molecular mechanisms regulating kidney development. The second section focuses on nephric cell renewal and differentiation, which lead to diverse cell fates within the developing kidney, and discusses diseases resulting from the aberrant regulation of the balance between cell fate decisions. The final section concentrates on morphogenesis of the developing kidney and its maintenance after formation as well as the diseases resulting from failures in these processes. Kidney form and function have been extensively studied for centuries, leading to discoveries related to their development and disease. Recent scientific advances in molecular and imaging techniques have broadened our understanding of nephron development and maintenance as well as the diseases related to these processes.
Author : Lauri Saxen
Publisher : Cambridge University Press
ISBN 13 : 0521301521
Total Pages : 185 pages
Book Rating : 4.5/5 (213 download)
Download or read book Organogenesis of the Kidney written by Lauri Saxen and published by Cambridge University Press. This book was released on 1987-04-16 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although this description of a model system for cell differentation and organogenesis emphasizes the mammalian kidney, detailed coverage is also given to the development of the transient excretory organs.
Author : Melissa Helen Little
Publisher : Academic Press
ISBN 13 : 012800438X
Total Pages : 615 pages
Book Rating : 4.1/5 (28 download)
Download or read book Kidney Development, Disease, Repair and Regeneration written by Melissa Helen Little and published by Academic Press. This book was released on 2015-08-06 with total page 615 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kidney Development, Disease, Repair and Regeneration focuses on the molecular and cellular basis of kidney development, exploring the origins of kidney lineages, the development of kidney tissue subcompartments, as well as the genetic and environmental regulation of kidney development. Special coverage is given to kidney stem cells and possible steps towards kidney repair and regeneration. Emphasis is placed on the fetal origins of postnatal renal disease and our current understanding of the molecular basis of damage and repair. Biomedical researchers across experimental nephrology and developmental biology will find this a key reference for learning how the underlying developmental mechanisms of the kidney will lead to greater advances in regenerative medicine within nephrology. - Offers researchers a single comprehensive resource written by leaders from both the developmental biology and the experimental nephrology communities - Focuses on understanding the molecular basis of organogenesis in the kidney as well as how this can be affected both genetically and environmentally - Explains the underlying developmental mechanisms which influence the kidney's inherent repair capacity - Demonstrates how a deeper understanding of mechanisms will lead to greater advances in regenerative medicine
Author : Seppo Vainio
Publisher : Humana Press
ISBN 13 : 9781493990207
Total Pages : 248 pages
Book Rating : 4.9/5 (92 download)
Download or read book Kidney Organogenesis written by Seppo Vainio and published by Humana Press. This book was released on 2019-02-13 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book details protocols on classical methods and very modern ex vivo mammalian developmental kidney model systems. Chapters focus on generation of mosaic embryonic kidneys, culture of the kidney tissues ex vivo, embryonic kidney progenitor cell, 3Dkidney model cell line based cultures, programming the kidney cell fates in human pluripotent cells, protocols to target the functional players in kidney ontogenesis, 4D and 3D ex vivo imaging, drosphila, and computational approaches to kidney ontogenesis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Kidney Organogenesis: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Author : Bi-Cheng Liu
Publisher : Springer
ISBN 13 : 9811388717
Total Pages : 707 pages
Book Rating : 4.8/5 (113 download)
Download or read book Renal Fibrosis: Mechanisms and Therapies written by Bi-Cheng Liu and published by Springer. This book was released on 2019-08-09 with total page 707 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book systemically presents the latest research on renal fibrosis, covering all the major topics in the field, including the possible mechanisms, biomarkers, and strategies for prevention and treatment of chronic kidney disease (CKD). Due to its high prevalence, CKD represents a huge global economic and social burden. Irrespective of the initial causes, CKD progresses to end stage kidney disease (ESKD) due to renal fibrosis, which is characterized by glomerulosclerosis, tubule atrophy and atresia, and the excessive accumulation of extracellular matrix (ECM) in the kidney. Unfortunately, an estimated 1%-2% of the adult population living with CKD will need renal replacement therapy at some point as a result of ESKD. As such, strategies for preventing or slowing CKD progression to ESKD are of utmost importance, and studies aiming to understand the mechanisms of renal fibrosis have been the focus of intensive research. Recently, novel insights into the pathophysiological processes have furthered our understanding of the pathogenesis of renal fibrosis, and more importantly, promoted studies on the early diagnosis and treatment of CKD. This book draws lessons from the extensive, state-of-the-art research in this field, elaborating the new theories and new techniques to offer readers a detailed and comprehensive understanding of renal fibrosis and as well as inspiration for future research directions.
Author : International Agency for Research on Cancer
Publisher :
ISBN 13 : 9789283224372
Total Pages : 400 pages
Book Rating : 4.2/5 (243 download)
Download or read book WHO Classification of Tumours of the Urinary System and Male Genital Organs written by International Agency for Research on Cancer and published by . This book was released on 2016-02-02 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: WHO Classification of Tumours of the Urinary System and Male Genital Organs is the eighth volume in the 4th Edition of the WHO series on histological and genetic typing of human tumours. This authoritative, concise reference book provides an international standard for oncologists and pathologists and will serve as an indispensable guide for use in the design of studies monitoring response to therapy and clinical outcome. Diagnostic criteria, pathological features, and associated genetic alterations are described in a strictly disease-oriented manner. Sections on all recognized neoplasms and their variants include new ICD-O codes, epidemiology, clinical features, macroscopy, pathology, genetics, and prognosis and predictive factors. It contains numerous color photographs, MRIs, ultrasound images, CT scans, charts and references.
Author :
Publisher : Academic Press
ISBN 13 : 0080859453
Total Pages : 643 pages
Book Rating : 4.0/5 (88 download)
Download or read book Cilia and Flagella written by and published by Academic Press. This book was released on 1995-08-31 with total page 643 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cilia and Flagella presents protocols accessible to all individuals working with eukaryotic cilia and flagella. These recipes delineate laboratory methods and reagents, as well as critical steps and pitfalls of the procedures. The volume covers the roles of cilia and flagella in cell assembly and motility, the cell cycle, cell-cell recognition and other sensory functions, as well as human diseases and disorders. Students, researchers, professors, and clinicians should find the book's combination of "classic" and innovative techniques essential to the study of cilia and flagella.Key Features* A complete guide containing more than 80 concise technical chapters friendly to both the novice and experienced researcher* Covers protocols for cilia and flagella across systems and species from Chlamydomonas and Euglena to mammals* Both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time, including microscopy, electrophoresis, and PCR* Relevant to clinicians interested in respiratory disease, male infertility, and other syndromes, who need to learn biochemical, molecular, and genetic approaches to studying cilia, flagella, and related structures
Author : Primo N. Lara
Publisher : Springer
ISBN 13 : 3319179039
Total Pages : 400 pages
Book Rating : 4.3/5 (191 download)
Download or read book Kidney Cancer written by Primo N. Lara and published by Springer. This book was released on 2015-06-10 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kidney Cancer: Principles and Practice is a comprehensive and interdisciplinary textbook that encompasses all clinically relevant aspects of the disease. This new edition has been extensively updated and includes brand new material covering the most recent developments in kidney cancer diagnosis and therapy. The user-friendly and clinically oriented content of the book guarantees that it will be of great interest to a wide range of medical professionals, and every effort has been made to ensure that contributions are both easy to understand and directly related to patient care. Content presentation departs from the usual dense chapter format featuring a lengthy series of paragraphs. Instead, each chapter contains several boxed sections, including one that summarizes essential "take home points" for the busy clinician and another that presents a patient-oriented case highlighting the clinical application of elements discussed in that chapter. In addition, accessible original images, illustrations, and diagrams (some in full color) are used to simplify particularly complex material. This book will be of value for clinicians, researchers, residents, fellows, students, and knowledgeable lay people. The contributors comprise an international group of authors with expertise in kidney cancer epidemiology, molecular biology, pathology, diagnosis, clinical features, staging, prognostic and predictive factors, surgery, systemic therapy, and emerging investigational approaches, among others.
Author : Edith Louise Potter
Publisher :
ISBN 13 :
Total Pages : 328 pages
Book Rating : 4.3/5 (91 download)
Download or read book Normal and Abnormal Development of the Kidney written by Edith Louise Potter and published by . This book was released on 1972 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Kwang W. Jeon
Publisher : Academic Press
ISBN 13 : 0128003111
Total Pages : 277 pages
Book Rating : 4.1/5 (28 download)
Download or read book International Review of Cell and Molecular Biology written by Kwang W. Jeon and published by Academic Press. This book was released on 2014-11-18 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: International Review of Cell and Molecular Biology presents comprehensive reviews and current advances in cell and molecular biology. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. The series has a world-wide readership, maintaining a high standard by publishing invited articles on important and timely topics authored by prominent cell and molecular biologists. - Authored by some of the foremost scientists in the field - Provides comprehensive reviews and current advances - Wide range of perspectives on specific subjects - Valuable reference material for advanced undergraduates, graduate students and professional scientists
Author : Jinghua Hu
Publisher : CRC Press
ISBN 13 : 0429888945
Total Pages : 360 pages
Book Rating : 4.4/5 (298 download)
Download or read book Polycystic Kidney Disease written by Jinghua Hu and published by CRC Press. This book was released on 2019-10-24 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on the investigatory methods applied to autosomal dominant polycystic kidney disease (ADPKD), one of the most common human genetic diseases. ADPKD is caused by mutations in PKD1 and TRPP2, two integral membrane proteins that function as receptor/ion channels in primary cilia of tubular epithelial cells. Thus, ADPKD belongs to ciliopathies, a group of disorders caused by abnormal cilia formation or function. This proposed book will cover the state-of-the-art methods ranging from molecular biology, biochemistry, electrophysiology, to tools in model animal studies. Key Features Explores the role of cilia in polycystic kidney disease Focuses on myriad state-of-the-art methods and techniques Reviews specific mutations integral to this autosomal genetic disease Includes discussions of model systems
Author : Cheryl D. Helgason
Publisher : Humana Press
ISBN 13 : 9781627031271
Total Pages : 550 pages
Book Rating : 4.0/5 (312 download)
Download or read book Basic Cell Culture Protocols written by Cheryl D. Helgason and published by Humana Press. This book was released on 2012-11-20 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: At some point in their careers, virtually every scientist and technician, as well as many medical professionals, regardless of their area of specialization have a need to utilize cell culture systems. Updating and significantly expanding upon the previous editions, Basic Cell Culture Protocols, Fourth Edition provides the novice cell culturist with sufficient information to perform the basic techniques, to ensure the health and identity of their cell lines, and to be able to isolate and culture specialized primary cell types. The intent of this extensive volume is to generate a valuable resource containing clear methodologies pertinent to current areas of investigation, rather than attempting to educate cell culturists on specific cell types or organ systems. Written in the highly successful Methods in Molecular BiologyTM, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and up-to-date, Basic Cell Culture Protocols, Fourth Edition compiles the essential techniques needed to approach this vital laboratory activity with full success.
Author : Marlies Elger
Publisher : Springer
ISBN 13 :
Total Pages : 116 pages
Book Rating : 4.:/5 (321 download)
Download or read book The Vascular Pole of the Renal Glomerulus of Rat written by Marlies Elger and published by Springer. This book was released on 1997-10-10 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: Knowledge of the architecture of the renal glomerulus is a prerequisite for understanding both glomerular function and pathology. Glomerular filtration depends on comparably high intracapillary hydrostatic pressures. These high pressures must be balanced by commensurate counterforces to maintain structural integrity. Elevated pressures can damage the glomerulus. The "window" for pressures high enough for effective filtration and yet tolerable to the glomerulus is narrow. Precise regulation is therefore necessary to keep intraglomerular pressure within an appropriate range. This study provides a comprehensive description of the glomerular arterioles, which are the vessels primarily responsible for the regulation of intraglomerular pressures. It thereby describes the structures which may be presumed to generate counterforces needed to assure structural stability. The arterioles are closely associated with the supporting system comprised of the intra- and extraglomerular mesangium. The extraglomerular mesangium forms a spider-like clamp providing a mechanical interconnection of all components of the vascular pole. At the same time, it may act as a tension receptor, i.e. as a sensor of intraglomerular pressures. Due to its intimate relationship to the macula densa, the extraglomerular mesangium receives information on the distal solute delivery and therefore may act as the integrative center within the juxtaglomerular apparatus. The close spatial association between the afferent and efferent arterioles at the vascular pole suggests a direct regulatory interaction between both arterioles. In addition, the specific wall structure of the efferent arteriole exhibiting the features of a shear stress receptor suggests new pathways for feedback regulation of glomerular hemodynamics.
