Cell Ageing And Cell Death

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Cellular Aging and Cell Death

Author : Nikki J. Holbrook
Publisher : John Wiley & Sons
ISBN 13 : 9780471121237
Total Pages : 344 pages
Book Rating : 4.1/5 (212 download)

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Book Synopsis Cellular Aging and Cell Death by : Nikki J. Holbrook

Download or read book Cellular Aging and Cell Death written by Nikki J. Holbrook and published by John Wiley & Sons. This book was released on 1995-12-20 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular AGING AND CELL DEATH Edited by Nikki J. Holbrook, George R. Martin, and Richard A.Lockshin Cellular Aging and Cell Death provides a thorough understanding ofthe mechanisms responsible for cellular aging, covering the recentresearch on programmed cell death and senescence, and describingtheir role in the control of cell proliferation and the agingprocess. This one-of-a-kind book is the first to combine the twohottest research areas of cell biology into one comprehensivetext. Leading experts contribute to give readers an authoritativeoverview of the distinct fields of cellular aging and programmedcell death, as well as to demonstrate how both fields are criticalto understanding the aging process. They address the large andgrowing interest in apoptosis, especially with regard to themolecular signals that induce and regulate programmed cell death,and the role of apoptosis in a variety of age-associated diseasesand disabilities. Throughout the book, a strong emphasis is placedon the interrelationship of the molecular, cellular, andphysiological aspects of senescence. Individual chapters discuss such topics as the role and regulationof apoptosis in development, the potential impact of cell death onsuch postmitotic tissues as nerve and muscle, and suggest thatprogrammed cell death plays an important role in both pathologicaland nonpathological aspects of aging, including neurodegenerativediseases. One important chapter focuses on the most recent research involvingthe study of telomeres, whose reduction in length with age and celldivision may underlie cellular senescence. The subject of neuronalcell death is also put into the perspective of aging. Cellular Aging and Cell Death bridges the rapidly growing fields ofcellular aging and programmed cell death. This thorough, yetconcise book will be of particular interest to graduate studentsand researchers within the fields of cell and developmentalbiology, neurobiology, immunology, and physiology. Physicians andmedical students involved in the fields of gerontology andpathology will also find this an informative reference.

Cell Ageing and Cell Death

Author : Ioan Davies
Publisher :
ISBN 13 : 9780521261722
Total Pages : 362 pages
Book Rating : 4.2/5 (617 download)

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Book Synopsis Cell Ageing and Cell Death by : Ioan Davies

Download or read book Cell Ageing and Cell Death written by Ioan Davies and published by . This book was released on 1984 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: The phenomenon of cell aging and cell death are of considerable importance in many areas of biology. This joint symposium between the Society for Experimental Biology and the British Society for Research in Ageing considers the topic from an interdisciplinary point of view. The contents range from the initiation of cell senescence and the factors controlling the life span of cells, to the competing theories implicating programmed or accidental sequences of events in the process of cell deterioration. The fundamental nature of the subject will generate interest in the book across a wide range of biological and medical disciplines.

Handbook of Oxidants and Antioxidants in Exercise

Author : C. Sen
Publisher : Elsevier
ISBN 13 : 0080538290
Total Pages : 1219 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Handbook of Oxidants and Antioxidants in Exercise by : C. Sen

Download or read book Handbook of Oxidants and Antioxidants in Exercise written by C. Sen and published by Elsevier. This book was released on 2000-02-16 with total page 1219 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interest in the science of exercise dates back to the time of ancient Greece. Today exercise is viewed not only as a leisurely activity but also as an effective preventive and therapeutic tool in medicine. Further biomedical studies in exercise physiology and biochemistry reports that strenuous physical exercise might cause oxidative lipid damage in various tissues. The generation of reactive oxygen species is elevated to a level that overwhelms the tissue antioxidant defense systems resulting in oxidative stress.The Handbook of Oxidants and Antioxidants in Exercise examines the different aspects of exercise-induced oxidative stress, its management, and how reactive oxygen may affect the functional capacity of various vital organs and tissues. It includes key related issues such as analytical methods, environmental factors, nutrition, aging, organ function and several pathophysiological processes.This timely publication will be of relevance to those in biomedical science and was designed to be readily understood by the general scientific audience.

Cellular and Molecular Aspects of Ageing

Author : Valquiria Bueno
Publisher : Springer Nature
ISBN 13 : 3031550226
Total Pages : 159 pages
Book Rating : 4.0/5 (315 download)

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Book Synopsis Cellular and Molecular Aspects of Ageing by : Valquiria Bueno

Download or read book Cellular and Molecular Aspects of Ageing written by Valquiria Bueno and published by Springer Nature. This book was released on with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Times, Cells, and Aging

Author : Bernard Strihler
Publisher : Academic Press
ISBN 13 :
Total Pages : 510 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Times, Cells, and Aging by : Bernard Strihler

Download or read book Times, Cells, and Aging written by Bernard Strihler and published by Academic Press. This book was released on 1977-01-28 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: Time, Cells, and Aging, 2nd Edition presents the mechanics of cell function and the relevant implications of the molecular-genetic view to the aging phenomena. This book explores the biology of the aging process. Comprised of 11 chapters, this edition starts with an overview of the causes and mechanisms underlying the gradual deterioration of structure and function characteristics of aging. This text then examines the two aspects of the behavior of man, including the reasoned conscious behavior and the greater dependence on reaction patterns predicted on the successful responses of the past. Other chapters explore the relationship between aging and mortality rate in animals, which is a result of an organism's deceasing ability to function optimally in carrying out his vital functions. The final chapter deals with the implementation of a research plan relevant to understanding the primary mechanisms of the aging process. This book is a valuable resource for gerontologists, biologists, and molecular biologists.

Plant Cell Death Processes

Author : Larry D. Nooden
Publisher : Elsevier
ISBN 13 : 0080492088
Total Pages : 419 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Plant Cell Death Processes by : Larry D. Nooden

Download or read book Plant Cell Death Processes written by Larry D. Nooden and published by Elsevier. This book was released on 2003-12-09 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: Programmed cell death is a common pattern of growth and development in both animals and plants. However, programmed cell death and related processes are not as generally recognized as central to plant growth. This is changing fast and is becoming more of a focus of intensive research. This edited work will bring under one cover recent reviews of programmed cell death, apoptosis and senescence.Summaries of the myriad aspects of cell death in plantsDiscussion of the broadest implications of these disparite resultsA unification of fields where there has been no cross talkEnables easy entry into diverse but related lines of research

New Research on Cell Aging and Death

Author : Roman Strakos̆
Publisher :
ISBN 13 : 9781536136272
Total Pages : 181 pages
Book Rating : 4.1/5 (362 download)

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Book Synopsis New Research on Cell Aging and Death by : Roman Strakos̆

Download or read book New Research on Cell Aging and Death written by Roman Strakos̆ and published by . This book was released on 2018 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: New Research on Cell Aging and Death reviews previous literature to describe the main behavioral and biochemical characteristics of the SAMP8 mouse model, discussing its main advantages as well as potential weaknesses to model age-related diseases. The subsequent chapter discusses the effect of the mechanism of cell death of neutrophil granulocytes on the realization of the inflammatory process. Neutrophil granulocytes play a central role in the innate nonspecific defense response of the human organism. In addition, neutrophils infiltrate secondary lymphoid organs where they regulate the development of adaptive immunity. Later, the authors suggest that in C. albicans, apoptotic mechanisms are valuable as major strategies with several characteristics such as phosphatidylserine exposure, DNA fragmentation, and activation of metacaspase. Studying antifungal agents with varying mechanisms of action can be effective in appropriately treating potentially fatal candidiasis. In one study, the authors evaluated the effects of natural and chemical compounds on promoter activities of several human DNA repair-associated genes in HeLa S3 cells. . The results indicated that naturally occurring compounds, for example, trans-resveratrol, upregulate TP53 promoter activity. Sustaining an appropriate level of genes encoding DNA repair factors is thought to be necessary for cell survival by preventing the accumulation of DNA mismatches and epigenetic alterations. The concluding review focuses on the effects of aging on adult neurogenesis, a process of producing new neurons from neural stem cells and neural progenitor cells in the neocortex, comparing the dentate gyrus and subventricular zone.

Studies of Aging

Author : Hal Sternberg
Publisher : Springer Science & Business Media
ISBN 13 : 3642599168
Total Pages : 214 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Studies of Aging by : Hal Sternberg

Download or read book Studies of Aging written by Hal Sternberg and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: This laboratory manual provides the researcher with a specific group of techniques, emphasising throughout hands-on information. A variety of protocols using molecular, cellular and physiological techniques are presented in detail and appropriate animal models have been selected for the study of ageing and ageing-related diseases. Non-invasive in vivo techniques are described for the study of Alzheimers dementia and cardiovascular diseases, while techniques for detection of oxidative processes are presented to explore the role of free radicals in causing cell damage and mutations as well as techniques to study apoptosis for its role in cell ageing. XXXXXXXXX Neuer Text This lab manual provides hands-on protocols using molecular, cellular, and physiological techniques and the appropriate animal models for the study of aging and aging-related diseases. Non-invasive in vivo techniques are described for the study of Alzheimers dementia and cardiovascular diseases. Techniques for detection of oxidative processes are presented to explore the role of free radicals in causing cell damage, as well as techniques to study apoptosis for its role in cell aging. A Springer Lab Manual

New Research on Cell Aging

Author : Reginald B. Garvey
Publisher : Nova Publishers
ISBN 13 : 9781600214011
Total Pages : 202 pages
Book Rating : 4.2/5 (14 download)

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Book Synopsis New Research on Cell Aging by : Reginald B. Garvey

Download or read book New Research on Cell Aging written by Reginald B. Garvey and published by Nova Publishers. This book was released on 2007 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents research on cell growth and the ageing process. Emphasis is given to implications for cancer therapy, abnormal mitosis and aberrant nuclear morphology, neoplastic transformations, negative charges on various malignant cell types.

Cell Aging: Molecular Mechanisms and Implications for Disease

Author : Christian Behl
Publisher : Springer Science & Business Media
ISBN 13 : 3642451799
Total Pages : 113 pages
Book Rating : 4.6/5 (424 download)

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Book Synopsis Cell Aging: Molecular Mechanisms and Implications for Disease by : Christian Behl

Download or read book Cell Aging: Molecular Mechanisms and Implications for Disease written by Christian Behl and published by Springer Science & Business Media. This book was released on 2013-12-18 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aging represents a physiological and per se non-pathological and multifactorial process involving a set of key genes and mechanisms being triggered by different endogenous and exogenous factors. Since aging is a major risk factor in connection with a variety of human disorders, it is increasingly becoming a central topic in biochemical and medical research. The plethora of theories on aging – some of which have been discussed for decades – are neither isolated nor contradictory but instead can be connected in a network of pathways and processes at the cellular and molecular levels. This book summarizes the most prominent and important approaches, focusing on telomeres, DNA damage and oxidative stress as well as on the possible role of nutrition, the interplay between genes and environment (epigenetics) and intracellular protein homeostasis and introduces some genes that have actually extended life spans in animal models. Linking these different determinants of aging with disease, this volume aims to reveal their multiple interdependencies. We see that there is no single “perfect” theory of aging and that instead it is possible to define what the authors call the molecular aging matrix of the cell. A better knowledge of its key mechanisms and the mutual connections between its components will lead to a better understanding of age-associated disorders such as Alzheimer’s disease.

Cellular Ageing and Replicative Senescence

Author : Suresh I.S. Rattan
Publisher : Springer
ISBN 13 : 3319262394
Total Pages : 358 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Cellular Ageing and Replicative Senescence by : Suresh I.S. Rattan

Download or read book Cellular Ageing and Replicative Senescence written by Suresh I.S. Rattan and published by Springer. This book was released on 2016-05-09 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the origins and subsequent history of research results in which attempts have been made to clarify issues related to cellular ageing, senescence, and age-related pathologies including cancer. Cellular Ageing and Replicative Senescence revisits more than fifty-five years of research based on the discovery that cultured normal cells are mortal and the interpretation that this phenomenon is associated with the origins of ageing. The mortality of normal cells and the immortality of cancer cells were also reported to have in vivo counterparts. Thus began the field of cytogerontology. Cellular Ageing and Replicative Senescence is organized into five sections: history and origins; serial passaging and progressive ageing; cell cycle arrest and senescence; system modulation; and recapitulation and future expectations. These issues are discussed by leading thinkers and researchers in biogerontology and cytogerontology. This collection of articles provides state-of-the-art information, and will encourage students, teachers, health care professionals and others interested in the biology of ageing to explore the fascinating and challenging question of why and how our cells age, and what can and cannot be done about it.

Mechanisms of Cell Death

Author : Zahra Zakeri
Publisher :
ISBN 13 :
Total Pages : 236 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Mechanisms of Cell Death by : Zahra Zakeri

Download or read book Mechanisms of Cell Death written by Zahra Zakeri and published by . This book was released on 1999 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contains papers from a July 1998 conference held at the Queens College Campus of the City University of New York. Papers are arranged in sections on mechanisms and general considerations, programmed (developmental) cell death, and cell death and pathological and clinical situations. Specific topics

The Role of DNA Damage and Repair in Cell Aging

Author : B.A. Gilchrest
Publisher : Elsevier
ISBN 13 : 9780444504944
Total Pages : 270 pages
Book Rating : 4.5/5 (49 download)

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Book Synopsis The Role of DNA Damage and Repair in Cell Aging by : B.A. Gilchrest

Download or read book The Role of DNA Damage and Repair in Cell Aging written by B.A. Gilchrest and published by Elsevier. This book was released on 2001-03-09 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aging occurs at the level of individual cells, a complex interplay between intrinsic "programming" and exogenous "wear and tear", with genetically-determined cellular capacity to repair environmentally-induced DNA damage playing a central role in the rate of aging and its specific manifestations. In 12 chapters, "The Role of DNA Damage and Repair in Cell Aging" provides an intellectual framework for aging of mitotic and post-mitotic cells, describes a variety of model systems for further studies, and reviews current concepts of DNA responses and their relationship to the phenomenon of aging. As part of a series entitled "Advances in Cell Aging and Gerontology," this volume also summarizes seminal recent discoveries such as the molecular basis for Werner syndrome (a mutant DNA helicase), the complementary roles of telomere shortening and telomerase activity in cell senescence versus immortalization, the role of apoptosis in the homeostasis of aging tissue, and the existence of an inducible SOS-like response in mammalian cells that minimizes DNA damage from repeatedly encountered injurious environmental agents. Insights into the relationship between cellular aging and age-associated diseases, particularly malignancies, are also provided in several chapters. This book is an excellent single source of information for anyone interested in DNA repair, mechanisms of aging, or certainly their intersection. Students will gain a general appreciation of these fields, but even the most senior investigators will benefit from the detailed coverage of rapidly advancing areas.

Programmed Cell Death, Volume I

Author : S. Estus
Publisher : Elsevier Science
ISBN 13 : 9780444504937
Total Pages : 368 pages
Book Rating : 4.5/5 (49 download)

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Book Synopsis Programmed Cell Death, Volume I by : S. Estus

Download or read book Programmed Cell Death, Volume I written by S. Estus and published by Elsevier Science. This book was released on 2001-05-02 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Apoptosis, or programmed cell death, is an adaptive form of cell death that plays a critical role in turnover of mitotic cells and various tissues in the adult, including epithelial cells, fibroblasts and various endocrine cells. Programmed cell death also plays a major role in development in organizing the body plan and molding intricate cellular structures such as nerve cell circuits in the brain. Rapidly progressing research into the molecular and biochemical underpinnings of the programmed cell death process are revealing novel genetic programs and molecular interactions that coordinate a process that results in death and removal of cells without an immune response and in the absence of the adverse effects on neighboring cells. Programmed Cell Death, Volume I, critically details the molecular, biochemical and cellular mechanisms of apoptosis. This volume covers programmed cell death in a variety of tissues and organ systems highlighting the interesting families of proteins involved in promoting or preventing apoptosis. These include the caspase and calpain families of proteases, Bcl-2 family members, and inhibitors of apoptosis proteins. Each chapter is written by an internationally recognized expert in a particular aspect of programmed cell death. This book will provide the reader with a comprehensive understanding of the cascade of events leading from an apoptotic signal, such as trophic factor withdrawal or increased oxidative stress, to cell death. Importantly, this volume also covers signaling mechanisms designed to prevent apoptosis. Such anti-apoptotic signaling cascades involve neurotrophic factors and stress response pathways. Programmed Cell Death, Volume I, provides the molecular and cellular foundation for http://www.elsevier.com/locate/isbn/0444507302Programmed Cell Death, Volume II in which the roles of aberrant regulation of apoptosis in human diseases ranging from cancer to Alzheimer's disease are considered.

Molecular Mechanisms of Aging

Author : Konrad Beyreuther
Publisher : Springer Science & Business Media
ISBN 13 : 3642842240
Total Pages : 327 pages
Book Rating : 4.6/5 (428 download)

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Book Synopsis Molecular Mechanisms of Aging by : Konrad Beyreuther

Download or read book Molecular Mechanisms of Aging written by Konrad Beyreuther and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Encyclopedia of Aging and Public Health

Author : Sana Loue
Publisher : Springer Science & Business Media
ISBN 13 : 0387337539
Total Pages : 852 pages
Book Rating : 4.3/5 (873 download)

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Book Synopsis Encyclopedia of Aging and Public Health by : Sana Loue

Download or read book Encyclopedia of Aging and Public Health written by Sana Loue and published by Springer Science & Business Media. This book was released on 2008-01-16 with total page 852 pages. Available in PDF, EPUB and Kindle. Book excerpt: Americans are living longer, and the elder population is growing larger. To meet the ongoing need for quality information on elder health, the Encyclopedia of Aging and Public Health combines multiple perspectives to offer readers a more accurate and complete picture of the aging process. The book takes a biopsychosocial approach to the complexities of its subject. In-depth introductory chapters include coverage on a historical and demographic overview of aging in America, a guide to biological changes accompanying aging, an analysis of the diversity of the U.S. elder population, legal issues commonly affecting older adults, and the ethics of using cognitively impaired elders in research. From there, over 425 entries cover the gamut of topics, trends, diseases, and phenomena: -Specific populations, including ethnic minorities, custodial grandparents, and centenarians -Core medical conditions associated with aging, from cardiac and pulmonary diseases to Parkinson’s and Alzheimer’s -Mental and emotional disorders -Drugs/vitamins/alternative medicine -Disorders of the eyes, feet, and skin -Insomnia and sleep disorders; malnutrition and eating disorders -Sexual and gender-related concerns -And a broad array of social and political issues, including access to care, abuse/neglect, veterans’ affairs, and assisted suicide Entries on not-quite-elders’ concerns (e.g., midlife crisis, menopause) are featured as well. And all chapters and entries include references and resource lists. The Encyclopedia has been developed for maximum utility to clinicians, social workers, researchers, and public health professionals working with older adults. Its multidisciplinary coverage and scope of topics make this volume an invaluable reference for academic and public libraries.

A Means to an End

Author : William R. Clark
Publisher : Oxford University Press, USA
ISBN 13 : 0195153758
Total Pages : 252 pages
Book Rating : 4.1/5 (951 download)

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Book Synopsis A Means to an End by : William R. Clark

Download or read book A Means to an End written by William R. Clark and published by Oxford University Press, USA. This book was released on 2002 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Why do we age? Is aging inevitable? Will advances in medical knowledge allow us to extend the human lifespan beyond its present limits? Recent discoveries in the fields of cell biology and molecular genetics are seriously challenging the assumption that human lifespans are beyond our control.