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Catalyst Components For Coupling Reactions
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Book Synopsis Catalyst Components for Coupling Reactions by : Gary A. Molander
Download or read book Catalyst Components for Coupling Reactions written by Gary A. Molander and published by John Wiley & Sons. This book was released on 2013-05-30 with total page 1749 pages. Available in PDF, EPUB and Kindle. Book excerpt: The long awaited Handbook for all synthetic chemists working on coupling reactions, compiling all major catalyst components in use in the area. Consists of a compilation of articles taken from the EROS database, with the inclusion of about 20 newly commissioned catalysts/pre-catalysts/ligands that have made an impact in this area of synthetic organic chemistry. Includes catalyst systems used in Heck, Kumada-Tamao-Corriu, Suzuki-Miyaura, Hiyama-Hatanaka, Negishi, Migita-Kosugi-Stille, Buchwald-Hartwig, and Tsuji-Trost coupling reactions.
Book Synopsis Handbook of Reagents for Organic Synthesis: Catalyst components for coupling reactions by :
Download or read book Handbook of Reagents for Organic Synthesis: Catalyst components for coupling reactions written by and published by . This book was released on 1999 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis New Carbon–Carbon Coupling Reactions Based on Decarboxylation and Iron-Catalyzed C–H Activation by : Rui Shang
Download or read book New Carbon–Carbon Coupling Reactions Based on Decarboxylation and Iron-Catalyzed C–H Activation written by Rui Shang and published by Springer. This book was released on 2016-12-09 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis presents the latest developments in new catalytic C–C bond formation methods using easily accessible carboxylate salts through catalytic decarboxylation with good atom economy, and employing the sustainable element iron as the catalyst to directly activate C–H bonds with high step efficiency. In this regard, it explores a mechanistic understanding of the newly discovered decarboxylative couplings and the catalytic reactivity of the iron catalyst with the help of density functional theory calculation. The thesis is divided into two parts, the first of which focuses on the development of a series of previously unexplored, inexpensive carboxylate salts as useful building blocks for the formation of various C–C bonds to access valuable chemicals. In turn, the second part is devoted to several new C–C bond formation methodologies using the most ubiquitous transition metal, iron, as a catalyst, and using the ubiquitous C–H bond as the coupling partner.
Book Synopsis Copper Catalysis in Organic Synthesis by : Gopinathan Anilkumar
Download or read book Copper Catalysis in Organic Synthesis written by Gopinathan Anilkumar and published by John Wiley & Sons. This book was released on 2020-06-24 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most current information on growing field of copper catalysis Copper Catalysis in Organic Synthesis contains an up-to-date overview of the most important reactions in the presence of copper catalysts. The contributors—noted experts on the topic—provide an introduction to the field of copper catalysis, reviewing its development, scope, and limitations, as well as providing descriptions of various homo- and cross-coupling reactions. In addition, information is presented on copper-catalyzed C–H activation, amination, carbonylation, trifluoromethylation, cyanation, and click reactions. Comprehensive in scope, the book also describes microwave-assisted and multi-component transformations as well as copper-catalyzed reactions in green solvents and continuous flow reactors. The authors highlight the application of copper catalysis in asymmetric synthesis and total synthesis of natural products and heterocycles as well as nanocatalysis. This important book: Examines copper and its use in organic synthesis as a more cost-effective and sustainable for researchers in academia and industry Offers the first up-to-date book to explore copper as a first line catalyst for many organic reactions Presents the most significant developments in the area, including cross-coupling reactions, C–H activation, asymmetric synthesis, and total synthesis of natural products and heterocycles Contains over 20 contributions from leaders in the field Written for catalytic chemists, organic chemists, natural products chemists, pharmaceutical chemists, and chemists in industry, Copper Catalysis in Organic Synthesis offers a book on the growing field of copper catalysis, covering cross-coupling reactions, C–H activation, and applications in the total synthesis of natural products.
Book Synopsis Computer-Aided Design of Catalysts by : Robert Becker
Download or read book Computer-Aided Design of Catalysts written by Robert Becker and published by CRC Press. This book was released on 1993-06-29 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides an update on recent developments in computer-aided design and modeling of catalysts for a variety of important industrial applications. Key hurdles in catalyst design are different for each application: the modeling frontiers for methane partial oxidation, automotive catalysis,
Book Synopsis Synthesis of Chiral Catalysts and Their Application to Asymmetric Cross-coupling Reactions and Selective Hydrogenation by : Hussein Mohamed Galal El-Din Ali
Download or read book Synthesis of Chiral Catalysts and Their Application to Asymmetric Cross-coupling Reactions and Selective Hydrogenation written by Hussein Mohamed Galal El-Din Ali and published by . This book was released on 1990 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Nickel- and Palladium-Catalyzed Cross Coupling Reactions by : Rebecca Green
Download or read book Nickel- and Palladium-Catalyzed Cross Coupling Reactions written by Rebecca Green and published by . This book was released on 2016 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: The following dissertation discusses the development of a nickel catalyst for the synthesis of Csp2-Csp bonds in addition to the development and mechanistic studies of nickel and palladium catalysts for the synthesis of Csp2-N bonds. The first chapter is a review of the cross-coupling reactions discussed in this dissertation. Nickel and palladium will be compared with respect to physical properties and reactivity differences. The challenges associated with nickel-catalyzed cross coupling will be illustrated, while drawing analogies to analogous palladium-catalyzed reactions. The literature background for the synthesis of Csp2-Csp bonds, catalyzed by palladium and palladium/copper catalytic systems, will be reviewed, while highlighting the challenges and limitations of the field. The field of Csp2-N bond-forming reactions will be examined, as the differences in reactivity between nickel and palladium will be emphasized. Chapter 2 discusses our efforts towards the development of a nickel catalyst for the development of a Csp2-Csp bond forming reaction, performed in the absence of a copper co-catalyst. Chapter 3 describes the development of a single-component nickel complex that catalyzes the coupling of aryl chlorides with primary alkylamines. A series of mechanistic experiments, including synthesis of catalytic intermediates and kinetic experiments, were performed to elucidate the mechanism of the reaction. Chapter 4 discusses our report the palladium-catalyzed coupling of aryl halides withammonia and gaseous amines as their ammonium salts. A difference in selectivity between reactions of aryl chlorides and aryl bromides was discovered and investigated. Chapter 5 describes the development of a single-component nickel catalyst for the coupling of aryl chlorides with ammonia and ammonium sulfate to form the corresponding primary arylamines. The application of ammonium salts was extended to the coupling of gaseous amines, such as methylamine and ethylamine, which were subjected to the reaction conditions as their hydrochloride salt.
Book Synopsis Development and Applications of Pd Catalysts for C-N Cross-Coupling Reactions by : Brett P. Fors
Download or read book Development and Applications of Pd Catalysts for C-N Cross-Coupling Reactions written by Brett P. Fors and published by . This book was released on 2011 with total page 605 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chapter 1 A procedure for forming a highly active Pd(0) catalyst from Pd(OAc) 2, water, and biarylphosphine ligands has been developed. This protocol generates a catalyst system, which exhibits excellent reactivity and efficiency in the coupling of a variety of amides and anilines with aryl chlorides. Chapter 2 A new class of one-component Pd precatalysts bearing biarylphosphine ligands is described. These precatalysts are air- and thermally-stable, are easily-activated under normal reaction conditions at or below room temperature, and ensure the formation of the highly-active mono-ligated Pd(0) complex necessary for oxidative addition. The use of these precatalysts as a convenient source of LPd(0) in C-N cross-coupling reactions is explored. The reactivity that is demonstrated in this study is unprecedented in palladium chemistry. Chapter 3 A catalyst system based on a new biarylphosphine ligand that shows excellent reactivity for C-N cross-coupling reactions is reported. This catalyst system enables the use of aryl mesylates as a coupling partner in C-N bond-forming reactions. Additionally, the use of this ligand permits the highly selective monoarylation of an array of primary aliphatic amines and anilines at low catalyst loadings and with fast reaction times, including the first monoarylation of methylamine. Lastly, oxidative addition complexes based on the new ligand are included, which provide insight into the origin of reactivity for this system. Chapter 4 An investigation into the Pd-catalyzed C-N cross-coupling reactions of aryl iodides is described. Neal is shown to have a significant inhibitory effect on these processes. By switching to a solvent system in which the iodide byproduct was insoluble, reactions of aryl iodides were accomplished with the same efficiencies as aryl chlorides and bromides. Using catalyst systems based on certain biarylphosphine ligands, aryl iodides were successfully reacted with an array of primary and secondary amines in high yields. Lastly, reactions of heteroarylamines and heteroaryliodides were also conducted in high yields. Chapter 5 A catalyst based on a new biarylphosphine ligand for the Pd-catalyzed cross-coupling reactions of amides and aryl chlorides is described. This system shows the highest turnover frequencies reported to date for these reactions, especially for aryl chloride substrates bearing an ortho substituent. An array of amides and aryl chlorides were successfully reacted in good to excellent yields. Chapter 6. An efficient Pd-catalyst for the transformation of aryl chlorides, triflates and nonaflates to nitroaromatics has been developed. This reaction proceeds under weekly basic conditions and displays a broad scope and excellent functional group compatibility. Moreover, this method allows for the synthesis of aromatic nitro compounds that cannot be accessed efficiently via other nitration protocols. Mechanistic insight into the trasmetallation step of the catalytic process is also reported. Chapter 7. An alternative approach to catalyst development, which led to a Pd catalyst based on two biarylphosphine ligands for C-N cross-coupling reactions, is reported. By effectively being able to take the form of multiple catalysts this system manifests the best properties that catalysts based on either of the two ligands exhibit separately and displays the highest reactivity and substrate scope of any system that has been reported to date for these reactions.
Book Synopsis Catalyst Components for Coupling Reactions by : Gary A. Molander
Download or read book Catalyst Components for Coupling Reactions written by Gary A. Molander and published by Wiley. This book was released on 2008-09-02 with total page 696 pages. Available in PDF, EPUB and Kindle. Book excerpt: The long awaited Handbook for all synthetic chemists working on coupling reactions, compiling all major catalyst components in use in the area. Consists of a compilation of articles taken from the EROS database, with the inclusion of about 20 newly commissioned catalysts/pre-catalysts/ligands that have made an impact in this area of synthetic organic chemistry. Includes catalyst systems used in Heck, Kumada-Tamao-Corriu, Suzuki-Miyaura, Hiyama-Hatanaka, Negishi, Migita-Kosugi-Stille, Buchwald-Hartwig, and Tsuji-Trost coupling reactions.
Book Synopsis Screening and Deconvoluting Complex Mixtures of Catalyst Components in Reaction Development by : Eléna Wolf
Download or read book Screening and Deconvoluting Complex Mixtures of Catalyst Components in Reaction Development written by Eléna Wolf and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reaction development is a complex multidimensional problem that, in a representative scenario, requires often the unique convergence of multiple parameters for a desired reactivity. The incorrect choice of a single parameter, such as the pre-catalyst, the ligand, the solvent or the acid/base, can completely eliminate the reactivity of the system. Thus, the process often requires extensive manipulations to obtain a lead hit. To avoid this time consuming process, many creative screening approaches have been developed but the large number of reactions necessary to explore the intersection of just three or four parameters is still a challenge for chemists who do not have access to high throughput experimentation. A reaction-economic combinatorial strategy is described for lead hit identification in catalyst discovery directed towards a specific transformation. Complex mixtures of rationally chosen pre-catalysts and ligands are screened against various reaction parameters to identify lead conditions in a small number of reactions. Iterative deconvolution of the resulting hits identifies which components contribute to the lead in situ generated catalyst. The application of this screening approach is described in the dehydrative Friedel-Crafts reaction, in the ortho-C-H arylation of benzamides, in the C3-indole alkylation and in the asymmetric hetero Diels-Alder cycloaddition.
Book Synopsis Expanding the Scope of Coupling Partners in Catalytic Cross-Coupling Reactions by : Xi Ye Hua
Download or read book Expanding the Scope of Coupling Partners in Catalytic Cross-Coupling Reactions written by Xi Ye Hua and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbon-carbon (C-C) bond formation is among the most important processes in organic chemistry. Transition metal catalyzed C-C bond formation is an active research area that shows great potential due to high selectivity and relatively mild conditions. In Chapter 1, a new reaction for direct acylation of aryl halides is discussed. Specifically, the catalytic reaction between aryl halides/pseudohalides and aldehydes is explored. The choice of ligand, base, solvent, temperature, catalyst and substrates are important factors for optimizing this catalytic reaction. The various combinations of all these factors have, therefore, been examined by high-throughput screening (HTS) in order to develop the new C-C coupling reaction. In Chapter 2, a new methodology is reported in order to expand the scope of the Kumada-Corriu cross-coupling reaction. The strategy to achieve this goal is mechanistically based, matching oxidative addition rates with the rate of syringe pump addition of the Grignard to minimize the exposure of sensitive groups to the aggressive nucleophile. Aryl chlorides containing esters, amides, nitriles, pyrazines, carbamates, ketones, and other sensitive functionalities are all demonstrated to undergo chemoselective cross-coupling with this technique. The mechanistic reason for the effectiveness of this strategy is uncovered by continuous-infusion ESI-MS studies.
Book Synopsis Nickel Catalyzed Regioselective Reductive Coupling Reactions by : Sanjeewa K. Rodrigo
Download or read book Nickel Catalyzed Regioselective Reductive Coupling Reactions written by Sanjeewa K. Rodrigo and published by . This book was released on 2014 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Coupling or cycloaddition of two different p-components for the construction of more complex structural motifs is commonly used in organic synthesis. Most of these systems involve a transition metal based catalyst and for reductive coupling reactions, various reducing agents are also employed. This dissertation is focused on the development and mechanistic investigation of nickel-catalyzed reductive coupling processes for useful organic transformations, specifically the coupling of aldehydes and alkynes and the cyclotrimerization of alkynes.
Book Synopsis Multicomponent Reactions by : Jieping Zhu
Download or read book Multicomponent Reactions written by Jieping Zhu and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the very first book on this hot topic, the expert editors andauthors present a comprehensive overview of these elegantreactions. From the contents: Organoboron compounds Free-radical mediated multicomponent coupling reactions Applications in drug discovery Metal catalyzed reactions Total synthesis of natural products Asymmetric isocyanide-based reactions The Biginelli reaction Asymmetric isocyanide-based reactions The Domino-Knoevenagel-Hetero-Diels-Alder Reaction and relatedtransformations Catalytic asymmetric reactions Algorithm based methods for discovering novel reactions Post-condensation modifications of the Passerini and Ugireactions An essential reference for organic and catalytic chemists, andthose working in organometallics both in academia and industry.
Book Synopsis Catalyst materials & properties by : Femina Patel
Download or read book Catalyst materials & properties written by Femina Patel and published by GRIN Verlag. This book was released on 2014-07-01 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt: Document from the year 2014 in the subject Engineering - Chemical Engineering, Nirma University (Institute of Technology, Nirma University, Ahmedabad, Gujarat), course: Chemical Engineering, language: English, abstract: Catalysis has made a rapid progress and there can be observed many new applications of catalysts. Heterogeneous and homogeneous catalysts used commercially are chemically and physically complex, sophisticated materials and because of the chemical and physical complexity of catalysts, catalyst research and development is highly multidisciplinary field which require knowledge of chemistry, chemical engineering, material science and physics. In order to design, develop and prepare new catalysts, a process which requires detailed knowledge of catalyst material, catalyst properties and art/science of catalyst preparation. The main objective of this book is to present an overview on catalyst materials and properties so that both the student and the experienced practitioner can understand the concept of catalyst materials and properties.
Book Synopsis Metal-catalyzed Cross-coupling Reactions by : A. de Meijere
Download or read book Metal-catalyzed Cross-coupling Reactions written by A. de Meijere and published by . This book was released on 2004 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Catalytic Carbon-hydrogen Bond Cross Coupling Reactions for Carbon-carbon Bond Formations by : Wai Wing Chan
Download or read book Catalytic Carbon-hydrogen Bond Cross Coupling Reactions for Carbon-carbon Bond Formations written by Wai Wing Chan and published by . This book was released on 2014 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Spectroscopy in Heterogeneous Catalysis by : W Delgass
Download or read book Spectroscopy in Heterogeneous Catalysis written by W Delgass and published by Elsevier. This book was released on 2012-12-02 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Spectroscopy in Heterogeneous Catalysis deals with the applications of spectroscopy in heterogeneous catalysis. The concepts and capabilities of a particular technique, experimental procedures, and examples of all proven or potentially important applications are discussed. The use of spectroscopic measurements in guiding empirical approaches to applied problems and to fundamental studies of the chemical identity of catalytic surfaces is also described. This book is comprised of eight chapters and begins with a discussion on the scope of spectroscopy in catalysis and applications of spectroscopy to zeolite catalysts. The following chapters focus on infrared spectroscopy, with emphasis on the theory and interpretation of infrared spectra; Raman spectroscopy and the theory of the Raman effect; diffuse reflectance and photoacoustic spectroscopies; and Mössbauer spectroscopy. Electron spin resonance spectroscopy and nuclear magnetic resonance spectroscopy are also considered. The final chapter is devoted to X-ray photoelectron spectroscopy (XPS) and its application to core electrons, along with the experimental equipment and procedures used. The applications of XPS to studies of surface behavior and catalyst composition and chemistry are outlined. This monograph will be a useful resource for physicists, researchers, and potential researchers in heterogeneous catalysis.
