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Cardiovascular Disease And Steroid Hormone Contraception
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Book Synopsis Cardiovascular Disease and Steroid Hormone Contraception by :
Download or read book Cardiovascular Disease and Steroid Hormone Contraception written by and published by World Health Organization. This book was released on 1998 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evaluates the strength and significance of evidence linking use of combined oral contraceptives to an increased risk of cardiovascular disease in women. Recommendations and conclusions reflect the consensus reached by a group of scientists, including researchers directly involved in several recent large-scale investigations of cardiovascular disease and hormone contraception. The experts also considered evidence that other factors, such as smoking, hypertension, diabetes, age, and family history, might influence the risk of cardiovascular disease in users of combined oral contraceptives. In view of major recent changes in the hormonal content of these contraceptives and the prescribing patterns of providers, the assessment concentrates on data collected after 1980. The experts also aimed to determine whether the risk of disease is influenced by the estrogen or progestogen content of different preparations. To facilitate the comparison and interpretation of study results, the report opens with a discussion of the strengths and weaknesses of the different epidemiological approaches used to assess the safety of steroid contraceptives. Also discussed is the important distinction between the use of relative risk to examine epidemiological associations and the use of absolute risk to examine clinical importance. Against this background, the main part of the report examines the strength of evidence linking steroid contraceptives to an increased risk of acute myocardial infarction, ischaemic stroke, haemorrhagic stroke, and venous thromboembolism. Studies of combined oral contraceptives and progestogen-only contraceptives are considered separately for each disease. An effort is also made to determine whether conclusions, based on studies conducted in industrialized countries, are also valid for women living in the developing world. The assessment of findings from epidemiological studies is complemented by a review of possible biological explanations for the effects of combined oral contraceptives on cardiovascular functions. On the basis of all available evidence, the report concludes that mortality rates from cardiovascular disease are extremely low among women of reproductive age and that the added risk of using steroid contraceptives is also very low in users who do not smoke or have other risk factors for cardiovascular disease. A final section places these risks in perspective and offers balanced advice useful to providers of family planning when helping women to make informed choices about the use of hormonal contraceptives.
Book Synopsis Oral Contraceptives and Cardiovascular Disease: An Analysis of the Recent Discussions on the Safety of the Pill by : J. Cohen
Download or read book Oral Contraceptives and Cardiovascular Disease: An Analysis of the Recent Discussions on the Safety of the Pill written by J. Cohen and published by CRC Press. This book was released on 1997-04-15 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a clinical analysis of current concerns about the safety of oral contraceptives in relation to cardiovascular disease. It contains six chapters by experts from the United Kingdom, Germany, Sweden, the United States, and France. Their chapters cover the impact of publicity on use of the pill, the risk of venous thromboembolism, the relationships between the pill and acute myocardial infarction and hemostasis, and the roles of physician education and patient counseling regarding oral contraceptives and venous thromboembolism.
Book Synopsis Sex Steroids and the Cardiovascular System by : Gabor M. Rubanyi
Download or read book Sex Steroids and the Cardiovascular System written by Gabor M. Rubanyi and published by Springer. This book was released on 1992 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evidence accumulated over the past decade show that gonadal steroid hormones participate in an important way in the physiological and pa thophysiological regulation of the cardiovascular system. The hor monal profile appears to put males at a disadvantage biologically in terms of cardiovascular diseases. The incidence of hypertension is higher in men than in pre-monopausal women indicating an influence of gender on the hypertensive disease process. Males and females have equivalent cholesterol levels until puberty but males suffer an ex ponential increase in heart disease in their forties, while the female rise does not start until a decade later, after menopause. Animal and human studies provided ample evidence, that estrogens lower the levels of low density lipoproteins and keep high density lipoproteins elevated. These changes may be advantageous in the prevention of heart diesease. Co ronary artery atherosclerosis has been shown to be more pronounced in ovarectomized female monkeys as in intact females. Androgen, con versely, lowers the high density lipoproteins and elevates low density lipoproteins. Regarding blood pressure, it is well established that hypertension is more severe or develops more rapidly in male than fe male rats in several genetic forms of hypertension, and that gonadal steroid hormones are probably playing an important role in explaining this observation. Risk factors of human hypertension and coronary heart dies ease include menopause and ovarectomy.
Author :Working Group on the Health Consequences of Contraceptive Use and Controlled Fertility Publisher : ISBN 13 : Total Pages :0 pages Book Rating :4.:/5 (143 download)
Book Synopsis Contraception and Reproduction by : Working Group on the Health Consequences of Contraceptive Use and Controlled Fertility
Download or read book Contraception and Reproduction written by Working Group on the Health Consequences of Contraceptive Use and Controlled Fertility and published by . This book was released on 1989 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Se estudian las consecuencias sanitarias de los diferentes patrones reproductivos en la salud de la mujer y de los niños. Tambien se evaluan el riesgo y los beneficios de los diferentes metodos anticonceptivos, aunque algunos de los datos en los que se basa son de paises desarrollados, el nucleo central del informe son los paises en desarrollo.
Author :IARC Working Group on the Evaluation of Carcinogenic Risks to Humans Publisher :World Health Organization ISBN 13 : Total Pages :692 pages Book Rating :4.3/5 (91 download)
Book Synopsis Hormonal Contraception and Post-menopausal Hormonal Therapy by : IARC Working Group on the Evaluation of Carcinogenic Risks to Humans
Download or read book Hormonal Contraception and Post-menopausal Hormonal Therapy written by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans and published by World Health Organization. This book was released on 1999 with total page 692 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evaluates evidence for an increased risk of cancer in women using combined oral contraceptives, progestogen-only hormonal contraceptives, post-menopausal estrogen therapy, and post-menopausal estrogen-progestogen therapy. Although the carcinogenicity of these preparations has been extensively investigated, the book stresses the many complex methodological issues that must be considered when interpreting findings and weighing results. Evidence of an association between use of these preparations and positive effects on health, including a reduced risk of some cancers, is also critically assessed. The first and most extensive monograph evaluates evidence of an association between the use of combined oral contraceptives and cancer at nine sites. Concerning breast cancer, the evaluation concludes that, even if the association is causal, the excess risk for breast cancer associated with patterns of use that are typical today is very small. Studies of predominantly high-dose preparations found an increased risk of hepatocellular carcinoma in the absence of hepatitis viruses. Citing these findings, the evaluation concludes that there is sufficient evidence in humans for the carcinogenicity of combined oral contraceptives. The evaluation also found sufficient evidence for the carcinogenicity of some, but not all, combined preparations in animals. Combined oral contraceptives were classified as carcinogenic to humans. The evaluation also cites conclusive evidence that these agents have a protective effect against cancers of the ovary and endometrium. Progestogen-only contraceptives are evaluated in the second monograph, which considers the association with cancer at six sites. The evaluation found no evidence of an increased risk for breast cancer. Although the evaluation found sufficient evidence in animals for the carcinogenicity of medroxyprogesterone acetate, evidence for the carcinogenicity of progestogen-only contraceptives in humans was judged inadequate. Progestogen-only contraceptives were classified as possibly carcinogenic to humans. The third monograph, on post-menopausal estrogen therapy, considers evidence of an association with cancer at eight sites. Findings from a large number of epidemiological studies indicate a small increase in the risk of breast cancer in women who have used these preparations for five years or more. Studies consistently show an association between use of post-menopausal estrogen therapy and an increased risk for endometrial cancer. Data on the association with other cancers were either inconclusive or suggested no effect on risk. The evaluation concludes that post-menopausal estrogen therapy is carcinogenic to humans. The final monograph evaluates the association between the use of post-menopausal estrogen-progestogen therapy and cancer at four sites. The evaluation of limited data on breast cancer found an increased relative risk observed with long-term use. Data were judged insufficient to assess the effects of past use and of different progestogen compounds, doses, and treatment schedules. For endometrial cancer, the evaluation found an increase in risk relative to non-users when the progestogen was added to the cycle for 10 days or fewer. Post-menopausal estrogen-progestogen therapy was classified as possibly carcinogenic to humans. Concerning post-menopausal therapy in general, the book notes that evidence of carcinogenic risks must be placed in perspective of potential benefits. The prevention of osteoporotic fractures is cited as the best-established benefit. Evidence also suggests that estrogen prevents heart disease and may prevent memory loss and dementia.
Book Synopsis Metabolic Effects of Gonadal Hormones and Contraceptive Steroids by : Hilton A. Salhanick
Download or read book Metabolic Effects of Gonadal Hormones and Contraceptive Steroids written by Hilton A. Salhanick and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 774 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Center for Population Research of the National Institute of Child Health and Human Development began operations in August 1968 and is engaged in research dealing with health-related popula tion problems. We organize and support projects for the develop ment of new contraceptives and in the broad field of population research in the social sciences o The Center also supports a variety of projects dealing with the mechanism of action and medical effects of contraceptives now in use, particularly oral contraceptives and intrauterine devices. These studies were initiated several years ago at the specific direction of Congresso We were pleased, therefore, with the opportunity to help organize and support this important and timely conference on the "Metabolic Effects of Gonadal Hormones and Contraceptive Steroids," the subject of which forms an integral part of the Center's research program. April, 1969 Philip Ao Corfman Director Center for Population Research National Institute of Child Health and Human Development v PREFACE Progress in science is often associated with either a "sixth sense" or an inevitable timeliness. Both factors, perhaps, led the members of the Endocrinology Study Section of the National Institutes of Health to propose, in 1966, that an expanded view of the effects of gonadal hormones, in general, and the contra ceptive steroids, in particular. was needed. There had been ample evaluations of the clinical symptomatology, contraceptive efficacy, and effects on the reproductive system, but there was a dearth of information on their multiple systemic'metabolic effects.
Download or read book Technical Report Series written by and published by . This book was released on 1998 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Hormone Replacement Therapy and Cardiovascular Disease by : A.R. Genazzani
Download or read book Hormone Replacement Therapy and Cardiovascular Disease written by A.R. Genazzani and published by CRC Press. This book was released on 2001-05-15 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a high-level, clinical reference by world-class specialists on the efficacy of hormone replacement therapy for the primary prevention of cardiovascular risk in postmenopausal women. Specific chapters cover pulsed estrogen therapy with Aerodiol and cardiovascular risk assessment in postmenopausal hormone replacement therapies such as Livial (tibolone). This volume is based on the formal presentations and subsequent discussions that took place at the International Menopause Society specially convened Expert Workshop on Hormone Replacement Therapy and Cardiovascular Disease, London, UK, October 13-16, 2000.
Book Synopsis Contraceptive Use and Controlled Fertility by : National Research Council
Download or read book Contraceptive Use and Controlled Fertility written by National Research Council and published by National Academies Press. This book was released on 1989-02-01 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: These four papers supplement the book Contraception and Reproduction: Health Consequences for Women and Children in the Developing World by bringing together data and analyses that would otherwise be difficult to obtain in a single source. The topics addressed are an analysis of the relationship between maternal mortality and changing reproductive patterns; the risks and benefits of contraception; the effects of changing reproductive patterns on infant health; and the psychosocial consequences to women of controlled fertility and contraceptive use.
Book Synopsis Reproductive Choices in 2000 by : Jean Cohen
Download or read book Reproductive Choices in 2000 written by Jean Cohen and published by . This book was released on 2000 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Sex Steroids and the Cardiovascular System: The Proceedings of the 1st Interdisciplinary Workshop, Tuebingen, Germany by : T.H. Lippert
Download or read book Sex Steroids and the Cardiovascular System: The Proceedings of the 1st Interdisciplinary Workshop, Tuebingen, Germany written by T.H. Lippert and published by CRC Press. This book was released on 1997-12-15 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a high-level clinical research text updating current knowledge about the documented effects of sex steroids on the cardiovascular system. It contains nineteen chapters covering the full range of oral contraceptive issues of greatest concern to today's practitioners and researchers in gynecology, obstetrics, reproductive medicine, cardiology, and clinical pharmacology. Key contributions contain the very latest information about the relationship between oral contraceptives and coronary heart disease, hormone replacement therapy (HRT), effects of oral contraceptives on lipid metabolism and carbohydrate metabolism, adverse effects of estrogen treatment, and the relationships between oral contraceptives and hemostasis and breast cancer. Includes detailed bibliographic references and a thorough index.
Author :World Health Organization. Reproductive Health and Research Publisher :World Health Organization ISBN 13 :9241562846 Total Pages :144 pages Book Rating :4.2/5 (415 download)
Book Synopsis Selected Practice Recommendations for Contraceptive Use by : World Health Organization. Reproductive Health and Research
Download or read book Selected Practice Recommendations for Contraceptive Use written by World Health Organization. Reproductive Health and Research and published by World Health Organization. This book was released on 2005 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: This document is one of two evidence-based cornerstones of the World Health Organization's (WHO) new initiative to develop and implement evidence-based guidelines for family planning. The first cornerstone, the Medical eligibility criteria for contraceptive use (third edition) published in 2004, provides guidance for who can use contraceptive methods safely. This document, the Selected practice recommendations for contraceptive use (second edition), provides guidance for how to use contraceptive methods safely and effectively once they are deemed to be medically appropriate. The recommendations contained in this document are the product of a process that culminated in an expert Working Group meeting held at the World Health Organization, Geneva, 13-16 April 2004.
Book Synopsis Contraceptive Steroids by : A. T. Gregoire
Download or read book Contraceptive Steroids written by A. T. Gregoire and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the United States Food and Drug Administration's most difficult tasks is the assessment of risk-benefit ratios for a broad spectrum of therapeutic and prophylactic drugs. Furthermore, it is now widely recog nized that no drug, chemical or even natural substance is completely devoid of risk. Nowhere has this issue been the subject of more controversy than with steroidal contraceptive drugs. Regulated as a special class of products because of their prophylactic use in healthy individuals for prevention of pregnancy rather than for treatment of disease, steroid contraceptives drugs undergo more extensive animal safety tests than any other pharmaceutical agent. This view also contemplates the availability of alternative contraceptive measures posing fewer risks, but the use of less effective methods must take into consideration the hazards associated with pregnancy itself. In April 1983, the Food and Drug Administration and the National Insti tutes of Health in cooperation with the World Health Organization, the Population Council, and the Agency for International Development sponsored a three-day workshop to evaluate current guidelines for preclinical safety studies of contraceptive drugs in light of our extensive knowledge of the side effects of marketed products. The meeting included presenta tions by experts in the fields of comparative metabolism, pharmacokinetics, pharmacology, carcinogenicity, toxicology, coagulation, lipid metabolism, epidemiology and pathology at a meeting of the Fertility and Maternal Health Drugs Advisory Committee of the National Center for Drugs and Biologics, Food and Drug Administration.
Book Synopsis Medical Eligibility Criteria for Contraceptive Use by :
Download or read book Medical Eligibility Criteria for Contraceptive Use written by and published by World Health Organization. This book was released on 2010 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical Eligibility Criteria for Contraceptive Use reviews the medical eligibility criteria for use of contraception, offering guidance on the safety and use of different methods for women and men with specific characteristics or known medical conditions. The recommendations are based on systematic reviews of available clinical and epidemiological research. It is a companion guideline to Selected Practice Recommendations for Contraceptive Use. Together, these documents are intended to be used by policy-makers, program managers, and the scientific community to support national programs in the preparation of service delivery guidelines. The fourth edition of this useful resource supersedes previous editions, and has been fully updated and expanded. It includes over 86 new recommendations and 165 updates to recommendations in the previous edition. Guidance for populations with special needs is now provided, and a new annex details evidence on drug interactions from concomitant use of antiretroviral therapies and hormonal contraceptives. To assist users familiar with the third edition, new and updated recommendations are highlighted. Everyone involved in providing family planning services and contraception should have the fourth edition of Medical Eligibility Criteria for Contraceptive Use at hand.
Book Synopsis Oral Contraception Into the 1990s by : H. W. Halbe
Download or read book Oral Contraception Into the 1990s written by H. W. Halbe and published by Parthenon Publishing. This book was released on 1989 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Consensus Conference on Combination Oral Contraceptives and Cardiovascular Disease. 1998, Göteborg Publisher : ISBN 13 : Total Pages :6 pages Book Rating :4.:/5 (247 download)
Book Synopsis Consensus Conference on Combination Oral Contraceptives and Cardiovascular Disease by : Consensus Conference on Combination Oral Contraceptives and Cardiovascular Disease. 1998, Göteborg
Download or read book Consensus Conference on Combination Oral Contraceptives and Cardiovascular Disease written by Consensus Conference on Combination Oral Contraceptives and Cardiovascular Disease. 1998, Göteborg and published by . This book was released on 1999 with total page 6 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Metabolic Effects of Gonadal Hormones and Contraceptive Steroids by : Hilton A. Salhanick
Download or read book Metabolic Effects of Gonadal Hormones and Contraceptive Steroids written by Hilton A. Salhanick and published by Springer. This book was released on 1995-12-31 with total page 762 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Center for Population Research of the National Institute of Child Health and Human Development began operations in August 1968 and is engaged in research dealing with health-related popula tion problems. We organize and support projects for the develop ment of new contraceptives and in the broad field of population research in the social sciences o The Center also supports a variety of projects dealing with the mechanism of action and medical effects of contraceptives now in use, particularly oral contraceptives and intrauterine devices. These studies were initiated several years ago at the specific direction of Congresso We were pleased, therefore, with the opportunity to help organize and support this important and timely conference on the "Metabolic Effects of Gonadal Hormones and Contraceptive Steroids," the subject of which forms an integral part of the Center's research program. April, 1969 Philip Ao Corfman Director Center for Population Research National Institute of Child Health and Human Development v PREFACE Progress in science is often associated with either a "sixth sense" or an inevitable timeliness. Both factors, perhaps, led the members of the Endocrinology Study Section of the National Institutes of Health to propose, in 1966, that an expanded view of the effects of gonadal hormones, in general, and the contra ceptive steroids, in particular. was needed. There had been ample evaluations of the clinical symptomatology, contraceptive efficacy, and effects on the reproductive system, but there was a dearth of information on their multiple systemic'metabolic effects.
