Canine Lymphoma Pathogenesis Diagnosis Prognosis And Treatment Current And Future Perspectives

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Canine lymphoma pathogenesis, diagnosis, prognosis and treatment: current and future perspectives

Author : Vittoria Castiglioni
Publisher : Frontiers Media SA
ISBN 13 : 2832552269
Total Pages : 110 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Canine lymphoma pathogenesis, diagnosis, prognosis and treatment: current and future perspectives by : Vittoria Castiglioni

Download or read book Canine lymphoma pathogenesis, diagnosis, prognosis and treatment: current and future perspectives written by Vittoria Castiglioni and published by Frontiers Media SA. This book was released on 2024-08-28 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt: Canine lymphoma is the most common hematopoietic neoplasm in dogs, arising from monoclonal expansion of B lymphocytes, T lymphocytes, or null cells (non-B and non-T, natural killer cells - NK). It might originate in any area of the body and its most striking feature is its heterogeneity, accounting for more than 30 different subtypes. Novel entities have recently been described and characterized in canine medicine, such as diffuse small B-cell lymphoma and small cell T cell intestinal lymphoma, to list a few. Despite extensive studies, recent progression in therapeutical approaches and improved outcomes, relapse or recurrence remain a common problem with conventional therapy for intermediate/high grade lymphomas, in contrast with indolent ones that are generally characterized by a fairer outcome. In light of the aforementioned considerations, differentiation among different subtypes is essential for predicting behavior and determining adequate treatment and this still largely relies on immunophenotyping through immunohistochemistry (IHC), flow cytometry, and polymerase chain reaction (PCR) for antigen receptor rearrangements (PARR). Paralleling these techniques, molecular biomarkers MicroRNAs (miRNAs) for accurate and rapid diagnosis are developing, together with blood-based liquid biopsies detecting circulating tumor DNA. We aim to showcase new insights into canine lymphoma pathogenesis, biology, early diagnosis, prognosis, clinical-pathological features and therapeutic approaches. To do this we strongly encourage contributions from veterinary oncologists, radiologists, pathologists, immunologists and geneticists to get a comprehensive approach to this entity. The aim of this Research Topic is to provide an overview on tools currently available in pathogenesis, diagnosis, prognosis and treatment and give insights of new advances in canine lymphoma with a comparative oncology perspective. Submissions that focus on the following are highly encouraged: - Novel canine lymphoma diagnostic tools (e.g. enabling early tumor detection); - The treatment of canine lymphoma with novel therapeutic approaches exploiting immune- or targeted therapy; - The molecular and biological pathways driving tumor development and multicentric dissemination of canine lymphoma; - Novel insights on the epidemiology and risk factors of canine lymphoma; - Comparative studies on the similarities and differences between canine and lymphoma in humans or other species; - Advances in canine lymphoma staging (including evaluation of prognostic factors); - Study of paraneoplastic syndromes associated with canine lymphoma. With regards to methodological approaches, we will welcome articles that include: - Cytology and immunocytochemistry; - Histopathology and immunohistochemistry; - Clonality testing (PARR); - Flow cytometry; - Molecular landscape and gene analysis; - Animal model characterization; - Biomarker discovery and validation; - Diagnostic imaging; - Surgical approaches. Vittoria Castiglioni is an employee for IDEXX Laboratories (Germany) and Sabina Soldati is an Associate in Pathology Experts GmbH.

Withrow and MacEwen's Small Animal Clinical Oncology

Author : Stephen J. Withrow
Publisher : Elsevier Health Sciences
ISBN 13 : 1437723624
Total Pages : 775 pages
Book Rating : 4.4/5 (377 download)

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Book Synopsis Withrow and MacEwen's Small Animal Clinical Oncology by : Stephen J. Withrow

Download or read book Withrow and MacEwen's Small Animal Clinical Oncology written by Stephen J. Withrow and published by Elsevier Health Sciences. This book was released on 2012-11-13 with total page 775 pages. Available in PDF, EPUB and Kindle. Book excerpt: With a unique focus on the most effective interventional techniques, Withrow & MacEwen's Small Animal Clinical Oncology, 5th Edition tells the full story of cancer in dogs and cats - what it is, how to diagnose it, and how to treat many of the most common cancers encountered in clinical practice. Nearly 500 color photographs, diagrams, x-rays, and gross views depict the clinical manifestations of various cancers. This edition covers the latest advances in clinical oncology, including chemotherapy, surgical oncology, and diagnostic techniques. With contributions from 65 veterinary oncology experts, this authoritative reference is a must-have for current, evidence-based therapeutic strategies on canine and feline oncology. "I really love this book. If you are interested in veterinary oncology, have a flick through this book online or at a conference when you get the chance. I hope that you agree with me that this is the definitive oncology reference source for the early 21st century and that you feel compelled to buy it. Your patients will thank you for it." Reviewed by: Gerry Polton MA VetMB MSc(Clin Onc) DipECVIM-CA(Onc) MRCVS, UK Date: July 2014 Cutting-edge information on the complications of cancer, pain management, and the latest treatment modalities prepares you to diagnose and treat pets with cancer rather than refer cases to a specialist. A consistent format for chapters on body system tumors includes coverage of incidence and risk factors, pathology, natural behavior of tumors, history and clinical signs, diagnostic techniques and workup, treatment options, and prognosis for specific malignancies. A systems approach to the diagnosis and management of cancer facilitates access to information about the many malignancies affecting small animal patients. Nearly 500 color images provide accurate depictions of specific diseases and procedures. Helpful drug formularies provide quick access to information on indications, toxicities, and recommended dosages for chemotherapeutic and analgesic drugs used in cancer treatment. Expert contributors provide in-depth coverage of the most current information in his or her respective specialty in veterinary oncology. Chemotherapy protocols are included when case studies prove clinical efficacy. Discussion of compassion and supportive care for the management of pain, nutritional needs, and grief includes methods for handling the pet's pain and nutritional complications as well as the pet owner's grief when treatment is not successful. Thoroughly UPDATED chapters cover the most recent changes in the clinical management of melanoma, mast cell tumors, tumors of the skeletal system, tumors of the endocrine system, tumors of the mammary gland, urinary cancers, nervous system cancers, lymphoma, and histiocytic diseases. NEW Clinical Trials and Developmental Therapeutics chapter discusses the various phases of clinical trials as well as current challenges and opportunities in oncology drug development. NEW! A focus on the best recommended treatment options highlights therapeutic strategies that have been vetted by veterinary oncology experts. NEW co-author Dr. Rodney L. Page adds his valuable perspective, expertise, and research experience.

Cowell and Tyler's Diagnostic Cytology and Hematology of the Dog and Cat - E-Book

Author : Amy C. Valenciano
Publisher : Elsevier Health Sciences
ISBN 13 : 0323243029
Total Pages : 603 pages
Book Rating : 4.3/5 (232 download)

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Book Synopsis Cowell and Tyler's Diagnostic Cytology and Hematology of the Dog and Cat - E-Book by : Amy C. Valenciano

Download or read book Cowell and Tyler's Diagnostic Cytology and Hematology of the Dog and Cat - E-Book written by Amy C. Valenciano and published by Elsevier Health Sciences. This book was released on 2013-07-02 with total page 603 pages. Available in PDF, EPUB and Kindle. Book excerpt: - NEW! Four new chapters — The Adrenal Gland, Immunocytochemistry, Flow Cytometry, and Molecular Methods in Lymphoid Malignancies — provide you with detailed information on how these topics relate to clinical disease diagnosis. - NEW! Revised chapters throughout the text give you the most complete and up-to-date coverage of recently recognized conditions, new terminology, and new procedures. - NEW! Callouts highlighting Tips and Pitfalls facilitate quick access and detailed instructions for in-house laboratory evaluation, including specimen preparation and diagnosis, as well as submission and transport of samples for commercial laboratory interpretation.

Cutaneous T-Cell Lymphoma

Author : Herschel S. Zackheim
Publisher : CRC Press
ISBN 13 : 9780849321016
Total Pages : 152 pages
Book Rating : 4.3/5 (21 download)

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Book Synopsis Cutaneous T-Cell Lymphoma by : Herschel S. Zackheim

Download or read book Cutaneous T-Cell Lymphoma written by Herschel S. Zackheim and published by CRC Press. This book was released on 2004-10-28 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cutaneous T-cell lymphoma (CTCL) is a general term for many lymphomas of the skin including mycosis Fungoides and Sezary syndrome. This book presents the state of the art in CTCL epidemiology, clinical features, pathology, immunochemistry, diagnostic molecular techniques, staging and prognosis, and treatment. Edited by one of the leading experts in the disease, Cutaneous T-Cell Lymphoma: Mycosis Fungoides and Sezary Syndrome provides comprehensive coverage of the disease and presents techniques for diagnosis and state-of-the-art treatment modalities, such as ultraviolet light, steroids, and topical chemotherapeutics.

Comparative Oncology

Author : Alecsandru Ioan Baba
Publisher :
ISBN 13 : 9789732714577
Total Pages : 787 pages
Book Rating : 4.7/5 (145 download)

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Book Synopsis Comparative Oncology by : Alecsandru Ioan Baba

Download or read book Comparative Oncology written by Alecsandru Ioan Baba and published by . This book was released on 2007 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Veterinary Clinical Pathology

Author :
Publisher :
ISBN 13 :
Total Pages : 1076 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis Veterinary Clinical Pathology by :

Download or read book Veterinary Clinical Pathology written by and published by . This book was released on 2008 with total page 1076 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Jak-Stat Signaling : From Basics to Disease

Author : Thomas Decker
Publisher : Springer Science & Business Media
ISBN 13 : 3709108918
Total Pages : 451 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Jak-Stat Signaling : From Basics to Disease by : Thomas Decker

Download or read book Jak-Stat Signaling : From Basics to Disease written by Thomas Decker and published by Springer Science & Business Media. This book was released on 2012-06-06 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: JAK tyrosine kinases and STAT transcription factors constitute a signaling pathway, which is activated by cytokines. By activating gene transcription it regulates essential biological responses to environmental cues. The Jak-Stat pathway is involved in the regulation of cell development, differentiation, proliferation and apoptosis. Improper function may contribute to hematopoietic malignancies and cancer. This book provides comprehensive insights into the latest basic and clinical developments in the field. The first part reviews recent findings and new technologies pertaining to basics of Jak-Stat function. The second part describes the evolution of Jak-Stat signaling and the role of the pathway in invertebrate organisms. The third part focuses on Jak-Stat signaling in hematopoietic cells under both physiological and pathophysiological conditions. Finally, chapters in the fourth section describe the relationship of Jak-Stat signaling to various states of disease, particularly infection, leukemias and solid cancers. The book is intended for all scientists in molecular biology, biochemistry and cell biology dealing with biomedical issues.

Thoracic Lymphadenopathy

Author : Vikas Pathak
Publisher :
ISBN 13 : 9781536167009
Total Pages : 113 pages
Book Rating : 4.1/5 (67 download)

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Book Synopsis Thoracic Lymphadenopathy by : Vikas Pathak

Download or read book Thoracic Lymphadenopathy written by Vikas Pathak and published by . This book was released on 2020-03-09 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thoracic lymphadenopathy consists of mediastinal and/or hilar lymphadenopathy. Thoracic lymph nodes are anatomically one of the most complex groups of the lymphatic network in the body and describing them could be nerve wracking if there is no proper understanding of the locations, its systemic divisions and its significance in diseased states. Thoracic lymphadenopathy is one of the most common radiological findings seen on the CT scan of thorax. The incidence of these findings have particularly increased in the era of lung cancer screening with low dose CT scan of the chest. The differential diagnosis for mediastinal and hilar lymphadenopathy is broad and spans from being reactive to benign disease to lung cancer or metastatic cancer. In this book, we have tried to simplify the lymph node stations based on the latest IASLC guidelines, done a very comprehensive review about mediastinal and hilar lymphadenopathy in different disease states and provided the pathway to diagnosis. This book also gives a detailed account of noninvasive testing including CT chest and PET CTs. This book also discusses in detail the advanced endoscopic and non-endoscopic procedures like EBUS-TBNA, EUS and Mediastinoscopy that we have at our disposal for the diagnosis of thoracic lymphadenopathy. The indications, contraindications, sensitivity and specificity of each procedure is discussed in detail.

Learning from Disease in Pets

Author : Rebecca A. Krimins
Publisher : CRC Press
ISBN 13 : 0429509111
Total Pages : 215 pages
Book Rating : 4.4/5 (295 download)

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Book Synopsis Learning from Disease in Pets by : Rebecca A. Krimins

Download or read book Learning from Disease in Pets written by Rebecca A. Krimins and published by CRC Press. This book was released on 2020-11-25 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learning from Disease in Pets: A ‘One Health’ Model for Discovery is the first encompassing reference guide for veterinarians, researchers and physicians on conducting studies using spontaneous models of disease in animals. The study of naturally occurring disease in (pet) animals can help model our understanding of the biology, prevention and therapy of human and animal diseases. Studies of pet dogs, for instance, can aid treatment of complex medical problems such as cancer, orthopedic, cardiopulmonary, and neuro-inflammatory diseases, and zoonotic infections. Each chapter within this novel cross-species approach is contributed by a leader, or leaders, in their field of research. Using clinical trials to learn how pets with real diseases respond to therapy can lead to breakthroughs in human medicine, as well as benefiting pets suffering from otherwise debilitating illness. Despite similarities of diseases across species, there are very few spontaneous models of disease used in research compared with models where disease is induced in healthy laboratory animals. Many medical researchers and veterinarians have a multitude of questions regarding how to use naturally occurring diseases in pets for the discovery of treatments and diagnostics: this book will demonstrate how to safely make this happen. This book encourages veterinarians to build on and disseminate existing findings for the wider benefit of pets and humans. Many pets suffering from incurable illnesses may benefit from clinical trials; the book includes a section on the imperative communication styles necessary within the research environment and with clients, a compelling discussion on the ethics of using pets in veterinary clinical research, comprehensive tables of diseases that spontaneously occur in animals and humans, the regulatory requirements necessary to move therapy from benchside research to patient bedside, as well as intricate details on how to design a robust clinical study.

Canine Genetics, Health and Medicine

Author :
Publisher : BoD – Books on Demand
ISBN 13 : 1839626542
Total Pages : 190 pages
Book Rating : 4.8/5 (396 download)

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Book Synopsis Canine Genetics, Health and Medicine by :

Download or read book Canine Genetics, Health and Medicine written by and published by BoD – Books on Demand. This book was released on 2021-06-02 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: The advances being made in veterinary medicine in the modern era are continuously pushing the boundaries of what is presently possible and available. From unraveling canine genetics and gene therapies to understanding the microbiome and the effects parasites have on canine health. Whilst many advances are being made with clinical diagnosis, surgeries, prosthetics, pharmaceuticals, and imaging techniques, preventative medicine is also at the forefront of technology. Our understanding of the medical issues, critical care, pharmaceutics, anatomy, pathology, genetics, and disease are all imperative in making advances in canine medicine. This book covers a diverse range of topics in canine health by highlighting recent and forthcoming canine medicine and health innovations and improvements.

Cumulated Index Medicus

Author :
Publisher :
ISBN 13 :
Total Pages : 1364 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Cumulated Index Medicus by :

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1994 with total page 1364 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Polymyositis and Dermatomyositis

Author : Marinos C. Dalakas
Publisher : Butterworth-Heinemann
ISBN 13 : 1483163040
Total Pages : 362 pages
Book Rating : 4.4/5 (831 download)

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Book Synopsis Polymyositis and Dermatomyositis by : Marinos C. Dalakas

Download or read book Polymyositis and Dermatomyositis written by Marinos C. Dalakas and published by Butterworth-Heinemann. This book was released on 2013-10-22 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymyositis and Dermatomyositis provides extensive information regarding Polymyositis and Dermatomyositis (PM/DM), which is described as a heterogeneous disease complex. This book is divided into four sections: Part I (Clinical Features) covers the classification of PM/DM, details of the clinical presentation, and the disease's association with the other connective tissue disorders and malignancies. Part II (Etiology and Mechanisms) covers advances in the immunopathology and viral etiology of PM/DM along with a frequently recognized entity: inclusion body myositis. Part III (Diagnosis and Treatment) covers the histologic, muscle enzyme histochemical, electron microscopic, and resin histology features of PM/DM along with those electromyographic features that could help make a more accurate diagnosis. Part IV (Overview) summarizes the issues that may not have been clear and highlights differing and unsettled views or present available data. This text is directed to clinicians in private practice or in academic institutions concerned with PM/DM patients, including neurologists, rheumatologists, pediatricians, dermatologists, physiatrists, and neuromuscular investigators. This book is intended as well for neuromuscular pathologists who interpret muscle biopsy specimens and electromyographers who perform EMG studies to help determine the clinical diagnosis. Researchers in immunology and immunopathology of neuromuscular diseases will find discussions in this book invaluable.

Pediatric Lymphomas

Author : Howard J. Weinstein
Publisher : Springer Science & Business Media
ISBN 13 : 354068753X
Total Pages : 296 pages
Book Rating : 4.5/5 (46 download)

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Book Synopsis Pediatric Lymphomas by : Howard J. Weinstein

Download or read book Pediatric Lymphomas written by Howard J. Weinstein and published by Springer Science & Business Media. This book was released on 2007-01-20 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a comprehensive textbook of Hodgkin's and non-Hodgkin's lymphomas written by leaders in the field of childhood lymphomas. It includes clinical, pathologic and molecular biology of each subtype of lymphoma. The pathology chapters are comprehensive and include excellent photographs. The book is at the level of subspecialists in pediatric hematology and oncology, radiation oncology, pediatric surgery and hematopathology.

Journal of the American Veterinary Medical Association

Author : American Veterinary Medical Association
Publisher :
ISBN 13 :
Total Pages : 1042 pages
Book Rating : 4.3/5 (117 download)

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Book Synopsis Journal of the American Veterinary Medical Association by : American Veterinary Medical Association

Download or read book Journal of the American Veterinary Medical Association written by American Veterinary Medical Association and published by . This book was released on 2008 with total page 1042 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1915-49 and 1956- include the Proceedings of the annual meeting of the association.

Immune Checkpoint Inhibitors in Cancer

Author : Fumito Ito
Publisher : Elsevier Health Sciences
ISBN 13 : 0323549500
Total Pages : 271 pages
Book Rating : 4.3/5 (235 download)

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Book Synopsis Immune Checkpoint Inhibitors in Cancer by : Fumito Ito

Download or read book Immune Checkpoint Inhibitors in Cancer written by Fumito Ito and published by Elsevier Health Sciences. This book was released on 2018-09-03 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: Get a quick, expert overview of the latest clinical information and guidelines for cancer checkpoint inhibitors and their implications for specific types of cancers. This practical title by Drs. Fumito Ito and Marc Ernstoff synthesizes the most up-to-date research and clinical guidance available on immune checkpoint inhibitors and presents this information in a compact, easy-to-digest resource. It's an ideal concise reference for trainee and practicing medical oncologists, as well as those in research. - Discusses the current understanding of how to best harness the immune system against different types of cancer at various stages. - Helps you translate current research and literature into practical information for daily practice. - Presents information logically organized by disease site. - Covers tumor immunology and biology; toxicities associated with immune checkpoint inhibitors; and future outlooks. - Consolidates today's available information on this timely topic into one convenient resource.

Essentials of Surgical Pediatric Pathology

Author : Marta C. Cohen
Publisher : Cambridge University Press
ISBN 13 : 1316124150
Total Pages : 1225 pages
Book Rating : 4.3/5 (161 download)

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Book Synopsis Essentials of Surgical Pediatric Pathology by : Marta C. Cohen

Download or read book Essentials of Surgical Pediatric Pathology written by Marta C. Cohen and published by Cambridge University Press. This book was released on 2015-02-05 with total page 1225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essentials of Surgical Pediatric Pathology is a clear and practical yet comprehensive guide for trainee pediatric pathologists and non-pediatric pathologists. Each chapter corresponds to one of the main subspecialties, such as dermatopathology, head and neck pathology, and system pathology. Practical guidance is given on handling pediatric specimens and the authors highlight the ways in which common conditions present differently in adults and children. Other chapters cover conditions typical of childhood, including soft tissue tumors and blue round cell tumors. The chapters begin with a brief clinical presentation, followed by a clear macroscopical and histological description of the principal pathologies seen in children. Up-to-date genetic and immunohistochemical information is provided, and the book includes hundreds of high-quality color images. Written and edited by leading international experts in the field, this is an essential resource for trainee pediatric pathologists, as well as general pathologists who may encounter pediatric cases.

Veterinary Comparative Hematopathology

Author : Victor E. Valli
Publisher : John Wiley & Sons
ISBN 13 : 0470344164
Total Pages : 572 pages
Book Rating : 4.4/5 (73 download)

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Book Synopsis Veterinary Comparative Hematopathology by : Victor E. Valli

Download or read book Veterinary Comparative Hematopathology written by Victor E. Valli and published by John Wiley & Sons. This book was released on 2008-02-28 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hematopoietic neoplasms are the most common animal tumors for which chemo- or radiation therapy are now given. New research, information, and images unavailable in any previous publication now make it possible to examine these diseases, categorize for treatment, and in some cases ascertain the impact on survival. A ground-breaking book in veterinary medicine, Veterinary Comparative Hematopathology is a heavily illustrated comprehensive reference on hematopoietic neoplasms in domestic and laboratory animals. The book enables veterinary pathologists and oncologists to provide more specificity in both diagnosis and therapy, and will serve as a seminal reference for future work in the field. The book offers a unique comparative approach based on the WHO classification of these tumors in humans. Known animal tumors are described and compared to their counterparts in humans. Those tumors now defined in humans but without a recognized animal counterpart are described in the human context, thus better facilitating future identification in animals. Ground-breaking book in veterinary medicine Over 1400 color images Comprehensive reference for veterinary pathologists and oncologists Unique comparative approach makes this a seminal text on animal tumors