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Cancer RNome: Nature & Evolution

Author : Mansi Arora
Publisher : Springer
ISBN 13 : 981131568X
Total Pages : 323 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Cancer RNome: Nature & Evolution by : Mansi Arora

Download or read book Cancer RNome: Nature & Evolution written by Mansi Arora and published by Springer. This book was released on 2018-11-02 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last decade, researchers working in the field of cancer biology have shifted their focus from genetic defects to epigenetic dysregulation, especially that of non-coding RNAs (ncRNAs). This book encompasses a comprehensive review of the transcriptional landscape of the cell and its involvement in the cancer pathophysiology. The first two chapters elucidate the basics of biosynthesis, mechanism of action and modulation of the epigenetic regulation of gene expression by coding as well as non-coding RNAs. The third chapter discusses the aberrant expression of the cellular RNome in the cancer cells and highlights its role in the orchestration of processes involved in evolution as well as the sustenance of cancer cells. The fourth chapter describes the recent advances in the field of translating the transcriptome into diagnostic/prognostic biomarkers and as targets for novel anti-cancer therapies. The final chapter then reviews the emerging experimental approaches to screen, identify and explore the functions of ncRNAs. Providing valuable insights into the field of RNome in the context of cancer, this book is helpful to students, researchers and clinicians..

Cancer through the Lens of Evolution and Ecology

Author : Jason A. Somarelli
Publisher : CRC Press
ISBN 13 : 1040027687
Total Pages : 306 pages
Book Rating : 4.0/5 (4 download)

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Book Synopsis Cancer through the Lens of Evolution and Ecology by : Jason A. Somarelli

Download or read book Cancer through the Lens of Evolution and Ecology written by Jason A. Somarelli and published by CRC Press. This book was released on 2024-05-29 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer cells exist in an ever-changing “ecology” and are subject to evolutionary pressures just like any species in nature. This edited book explores the following themes: 1) how the dynamics of mutation, epigenetics, and gene expression noise are sources of genetic diversity; 2) how scarce resources influence cancer therapy resistance; 3) how predator-prey dynamics are mirrored in immune-cancer cross-talk; 4) how cancer cells parallel niche construction theory; 5) how changing fitness landscapes enable cancer growth; and 6) how cancer cells interact within the body. The book is a resource for understanding cancer as a disease of multicellularity grounded in evolutionary principles. By using this knowledge, researchers are starting to exploit these behaviors for treatment paradigms. Key Features Bridges disciplines exemplifying the ways disparate fields create new perspectives when integrated. Offers insights from leading scholars in cancer biology, ecology and evolutionary biology. Provides a timely recognition by oncologists that evolutionary paradigms are crucial for breakthroughs in cancer treatment. Integrates basic and applied sciences of oncology and evolutionary biology.

Ecology and Evolution of Cancer

Author : Beata Ujvari
Publisher : Academic Press
ISBN 13 : 0128043806
Total Pages : 292 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Ecology and Evolution of Cancer by : Beata Ujvari

Download or read book Ecology and Evolution of Cancer written by Beata Ujvari and published by Academic Press. This book was released on 2017-02-08 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ecology and Evolution of Cancer is a timely work outlining ideas that not only represent a substantial and original contribution to the fields of evolution, ecology, and cancer, but also goes beyond by connecting the interfaces of these disciplines. This work engages the expertise of a multidisciplinary research team to collate and review the latest knowledge and developments in this exciting research field. The evolutionary perspective of cancer has gained significant international recognition and interest, which is fully understandable given that somatic cellular selection and evolution are elegant explanations for carcinogenesis. Cancer is now generally accepted to be an evolutionary and ecological process with complex interactions between tumor cells and their environment sharing many similarities with organismal evolution. As a critical contribution to this field of research the book is important and relevant for the applications of evolutionary biology to understand the origin of cancers, to control neoplastic progression, and to prevent therapeutic failures. - Covers all aspects of the evolution of cancer, appealing to researchers seeking to understand its origins and effects of treatments on its progression, as well as to lecturers in evolutionary medicine - Functions as both an introduction to cancer and evolution and a review of the current research on this burgeoning, exciting field, presented by an international group of leading editors and contributors - Improves understanding of the origin and the evolution of cancer, aiding efforts to determine how this disease interferes with biotic interactions that govern ecosystems - Highlights research that intends to apply evolutionary principles to help predict emergence and metastatic progression with the aim of improving therapies

Rebel Cell

Author : Kat Arney
Publisher : BenBella Books
ISBN 13 : 1950665518
Total Pages : 256 pages
Book Rating : 4.9/5 (56 download)

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Book Synopsis Rebel Cell by : Kat Arney

Download or read book Rebel Cell written by Kat Arney and published by BenBella Books. This book was released on 2020-10-20 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Why do we get cancer? Is it our modern diets and unhealthy habits? Chemicals in the environment? An unwelcome genetic inheritance? Or is it just bad luck? The answer is all of these and none of them. We get cancer because we can't avoid it—it's a bug in the system of life itself. Cancer exists in nearly every animal and has afflicted humans as long as our species has walked the earth. In Rebel Cell: Cancer, Evolution, and the New Science of Life's Oldest Betrayal, Kat Arney reveals the secrets of our most formidable medical enemy, most notably the fact that it isn't so much a foreign invader as a double agent: cancer is hardwired into the fundamental processes of life. New evidence shows that this disease is the result of the same evolutionary changes that allowed us to thrive. Evolution helped us outsmart our environment, and it helps cancer outsmart its environment as well—alas, that environment is us. Explaining why "everything we know about cancer is wrong," Arney, a geneticist and award-winning science writer, guides readers with her trademark wit and clarity through the latest research into the cellular mavericks that rebel against the rigid biological "society" of the body and make a leap towards anarchy. We need to be a lot smarter to defeat such a wily foe—smarter even than Darwin himself. In this new world, where we know that every cancer is unique and can evolve its way out of trouble, the old models of treatment have reached their limits. But we are starting to decipher cancer's secret evolutionary playbook, mapping the landscapes in which these rogue cells survive, thrive, or die, and using this knowledge to predict and confound cancer's next move. Rebel Cell is a story about life and death, hope and hubris, nature and nurture. It's about a new way of thinking about what this disease really is and the role it plays in human life. Above all, it's a story about where cancer came from, where it's going, and how we can stop it.

Cancer selection

Author : James Graham
Publisher : Aculeus Pr
ISBN 13 : 9780963024206
Total Pages : 213 pages
Book Rating : 4.0/5 (242 download)

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Book Synopsis Cancer selection by : James Graham

Download or read book Cancer selection written by James Graham and published by Aculeus Pr. This book was released on 1992 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conventional evolutionary theory cannot explain the existence of humans & other complex animals; another mechanism is needed, says James Graham, & it is none other than cancer. This radical theory, already published in a science journal, is aimed at amateurs & professionals. "I think I agree with him... a good idea," John W. Galloway, Nature. "Intriguing...resolves many outstanding problems," SciTech Book News. Literary reviewers like it too: "absorbing...provocative." The Small Press Book Review. "fascinating...sheer intellectual virtuosity." West Coast Review of Books. "distinguished." The Book Reader. Order from: James Graham, PO Box 142, Lexington Virginia 24450 telephone 540 464 4554. Also available from Amazon.com, Barnes & Noble and other retailers.

Malignancy and Evolution

Author : Morley Roberts
Publisher :
ISBN 13 :
Total Pages : 319 pages
Book Rating : 4.:/5 (636 download)

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Book Synopsis Malignancy and Evolution by : Morley Roberts

Download or read book Malignancy and Evolution written by Morley Roberts and published by . This book was released on 1934 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt:

From Ecology to Cancer Biology and Back Again

Author : Frederick R. Adler
Publisher : Frontiers Media SA
ISBN 13 : 2889746151
Total Pages : 259 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis From Ecology to Cancer Biology and Back Again by : Frederick R. Adler

Download or read book From Ecology to Cancer Biology and Back Again written by Frederick R. Adler and published by Frontiers Media SA. This book was released on 2022-03-08 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cancer Evolution

Author : Charles Swanton
Publisher : Perspectives Cshl
ISBN 13 : 9781621821434
Total Pages : 350 pages
Book Rating : 4.8/5 (214 download)

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Book Synopsis Cancer Evolution by : Charles Swanton

Download or read book Cancer Evolution written by Charles Swanton and published by Perspectives Cshl. This book was released on 2017 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tumor progression is driven by mutations that confer growth advantages to different subpopulations of cancer cells. As a tumor grows, these subpopulations expand, accumulate new mutations, and are subjected to selective pressures from the environment, including anticancer interventions. This process, termed clonal evolution, can lead to the emergence of therapy-resistant tumors and poses a major challenge for cancer eradication efforts. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines cancer progression as an evolutionary process and explores how this way of looking at cancer may lead to more effective strategies for managing and treating it. The contributors review efforts to characterize the subclonal architecture and dynamics of tumors, understand the roles of chromosomal instability, driver mutations, and mutation order, and determine how cancer cells respond to selective pressures imposed by anticancer agents, immune cells, and other components of the tumor microenvironment. They compare cancer evolution to organismal evolution and describe how ecological theories and mathematical models are being used to understand the complex dynamics between a tumor and its microenvironment during cancer progression. The authors also discuss improved methods to monitor tumor evolution (e.g., liquid biopsies) and the development of more effective strategies for managing and treating cancers (e.g., immunotherapies). This volume will therefore serve as a vital reference for all cancer biologists as well as anyone seeking to improve clinical outcomes for patients with cancer.

Cancer Evolution

Author :
Publisher :
ISBN 13 :
Total Pages : 44 pages
Book Rating : 4.:/5 (999 download)

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Book Synopsis Cancer Evolution by :

Download or read book Cancer Evolution written by and published by . This book was released on 2017 with total page 44 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cancer

Author : Melvyn F. Greaves
Publisher : Oxford University Press, USA
ISBN 13 :
Total Pages : 298 pages
Book Rating : 4.4/5 (91 download)

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Book Synopsis Cancer by : Melvyn F. Greaves

Download or read book Cancer written by Melvyn F. Greaves and published by Oxford University Press, USA. This book was released on 2000 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is everywhere. Around one in three of us will at some time in our lives have an unwelcome diagnosis of cancer; every day 1500 Americans and vastly more non-Americans die of the disease. For Western societies relishing health, wealth, and longevity, its continued prominence is one of thegreatest challenges to our scientists. And the illness we call cancer is extraordinarily diverse in its causation, symptoms, likelihood of effective treatment - in some sense, every patient's cancer is unique, and that is part of the problem. In this important new book, Mel Greaves explains why theold paradigms of infectious diseases or genetic disorders have proved fruitless when trying to account for the complex and elusive puzzle that is cancer. Rather, he claims that looking at cancer in its evolutionary context, we can begin to answer some of the big questions in cancer that concern usall. Drawing on both ancient and more modern evolutionary legacies, he shows how human development has changed the rules of evolutionary games, trapping us in a nature-nurture mismatch. Compelling examples, from the King of Naples intestinal tumour in the 15th Century, through the epidemic ofscrotal skin cancer in 18th century chimney sweeps, to the current surge of cases of prostate cancer illustrate his thesis. And finally, he looks at the implications for research, prevention, and treatment of cancer that an evolutionary perspective provides. Drawing on all the most recentresearch, this is the first book to put cancer in its evolutionary framework. At a time when Darwinian perspectives on everything from language acquisition to economics are gaining ground, medicine seems to have much to gain from the insights provided by evolutionary biology. Written in anexceptionally lucid and entertaining style, this book will be of broad interest to all those who wish to understand the big C, the biggest killer of them all.

Rethinking Cancer

Author : Bernhard Strauss
Publisher : MIT Press
ISBN 13 : 0262045214
Total Pages : 433 pages
Book Rating : 4.2/5 (62 download)

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Book Synopsis Rethinking Cancer by : Bernhard Strauss

Download or read book Rethinking Cancer written by Bernhard Strauss and published by MIT Press. This book was released on 2021-04-27 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading scientists argue for a new paradigm for cancer research, proposing a complex systems view of cancer supported by empirical evidence. Current consensus in cancer research explains cancer as a disease caused by specific mutations in certain genes. After dramatic advances in genome sequencing, never before have we known so much about the individual cancer cell--and yet never before has it been so unclear what to do with this knowledge. In this volume, leading researchers argue for a new theory framework for understanding and treating cancer. The contributors propose a complex systems view of cancer, presenting conceptual building blocks for a new research paradigm supported by empirical evidence. The contributors first discuss the new research framework in terms of theoretical foundations and then take up the relevance of a systems approach, reviewing such topics as nonlinearity, recurrence after treatment, the cellular attractor concept, network theory, and non-coding DNA--the "dark matter" of our genome. They address the temporality of cancer progression, drawing on evolutionary theory and clinical experience. Finally, they cover the dominant role of the tissue microenvironment in cancer, analyzing topics including altered metabolic pathways, the disease-defining influence on metastasis, and the interconnectedness of different environmental niches across levels of organization.

Philosophy of Cancer

Author : Marta Bertolaso
Publisher : Springer
ISBN 13 : 9402408657
Total Pages : 200 pages
Book Rating : 4.4/5 (24 download)

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Book Synopsis Philosophy of Cancer by : Marta Bertolaso

Download or read book Philosophy of Cancer written by Marta Bertolaso and published by Springer. This book was released on 2016-08-24 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the 1970s, the origin of cancer is being explored from the point of view of the Somatic Mutation Theory (SMT), focusing on genetic mutations and clonal expansion of somatic cells. As cancer research expanded in several directions, the dominant focus on cells remained steady, but the classes of genes and the kinds of extra-genetic factors that were shown to have causal relevance in the onset of cancer multiplied. The wild heterogeneity of cancer-related mutations and phenotypes, along with the increasing complication of models, led to an oscillation between the hectic search of ‘the’ few key factors that cause cancer and the discouragement in face of a seeming ‘endless complexity’. To tame this complexity, cancer research started to avail itself of the tools that were being developed by Systems Biology. At the same time, anti-reductionist voices began claiming that cancer research was stuck in a sterile research paradigm. This alternative discourse even gave birth to an alternative theory: the Tissue Organization Field Theory (TOFT). A deeper philosophical analysis shows limits and possibilities of reductionist and anti-reductionist positions and of their polarization. This book demonstrates that a radical philosophical reflection is necessary to drive cancer research out of its impasses. At the very least, this will be a reflection on the assumptions of different kinds of cancer research, on the implications of what cancer research has been discovering over 40 years and more, on a view of scientific practice that is most able to make sense of the cognitive and social conflicts that are seen in the scientific community (and in its results), and, finally, on the nature of living entities with which we entertain this fascinating epistemological dance that we call scientific research. The proposed Dynamic and Relational View of carcinogenesis is a starting point in all these directions.

Explaining Cancer

Author : Anya Plutynski
Publisher : Oxford University Press
ISBN 13 : 0199967466
Total Pages : 281 pages
Book Rating : 4.1/5 (999 download)

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Book Synopsis Explaining Cancer by : Anya Plutynski

Download or read book Explaining Cancer written by Anya Plutynski and published by Oxford University Press. This book was released on 2018-07-18 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Explaining Cancer, Anya Plutynski addresses a variety of philosophical questions that arise in the context of cancer science and medicine. She begins with the following concerns: · How do scientists classify cancer? Do these classifications reflect nature's "joints"? · How do cancer scientists identify and classify early stage cancers? · What does it mean to say that cancer is a "genetic" disease? What role do genes play in "mechanisms for" cancer? · What are the most important environmental causes of cancer, and how do epidemiologists investigate these causes? · How exactly has our evolutionary history made us vulnerable to cancer? Explaining Cancer uses these questions as an entrée into a family of philosophical debates. It uses case studies of scientific practice to reframe philosophical debates about natural classification in science and medicine, the problem of drawing the line between disease and health, mechanistic reasoning in science, pragmatics and evidence, the roles of models and modeling in science, and the nature of scientific explanation.

Single-stranded RNA phages

Author : Paul Pumpens
Publisher : CRC Press
ISBN 13 : 042967290X
Total Pages : 616 pages
Book Rating : 4.4/5 (296 download)

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Book Synopsis Single-stranded RNA phages by : Paul Pumpens

Download or read book Single-stranded RNA phages written by Paul Pumpens and published by CRC Press. This book was released on 2020-02-03 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a comprehensive guide to single-stranded RNA phages (family Leviviridae), first discovered in 1961. These phages played a unique role in early studies of molecular biology, the genetic code, translation, replication, suppression of mutations. Special attention is devoted to modern applications of the RNA phages and their products in nanotechnology, vaccinology, gene discovery, evolutionary and environmental studies. Included is an overview of the generation of novel vaccines, gene therapy vectors, drug delivery, and diagnostic tools exploring the role of RNA phage-derived products in the revolutionary progress of the protein tethering and bioimaging protocols. Key Features Presents the first full guide to single-stranded RNA phages Reviews the history of molecular biology summarizing the role RNA phages in the development of the life sciences Demonstrates how RNA phage-derived products have resulted in nanotechnological applications Presents an up-to-date account of the role played by RNA phages in evolutionary and environmental studies

Ecological Genomics

Author : Christian R. Landry
Publisher : Springer Science & Business Media
ISBN 13 : 9400773471
Total Pages : 358 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Ecological Genomics by : Christian R. Landry

Download or read book Ecological Genomics written by Christian R. Landry and published by Springer Science & Business Media. This book was released on 2013-11-25 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Researchers in the field of ecological genomics aim to determine how a genome or a population of genomes interacts with its environment across ecological and evolutionary timescales. Ecological genomics is trans-disciplinary by nature. Ecologists have turned to genomics to be able to elucidate the mechanistic bases of the biodiversity their research tries to understand. Genomicists have turned to ecology in order to better explain the functional cellular and molecular variation they observed in their model organisms. We provide an advanced-level book that covers this recent research and proposes future development for this field. A synthesis of the field of ecological genomics emerges from this volume. Ecological Genomics covers a wide array of organisms (microbes, plants and animals) in order to be able to identify central concepts that motivate and derive from recent investigations in different branches of the tree of life. Ecological Genomics covers 3 fields of research that have most benefited from the recent technological and conceptual developments in the field of ecological genomics: the study of life-history evolution and its impact of genome architectures; the study of the genomic bases of phenotypic plasticity and the study of the genomic bases of adaptation and speciation.

Applied Bioinformatics

Author : Paul Maria Selzer
Publisher : Springer Science & Business Media
ISBN 13 : 3540728007
Total Pages : 297 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis Applied Bioinformatics by : Paul Maria Selzer

Download or read book Applied Bioinformatics written by Paul Maria Selzer and published by Springer Science & Business Media. This book was released on 2008-01-18 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: At last, here is a baseline book for anyone who is confused by cryptic computer programs, algorithms and formulae, but wants to learn about applied bioinformatics. Now, anyone who can operate a PC, standard software and the internet can also learn to understand the biological basis of bioinformatics, of the existence as well as the source and availability of bioinformatics software, and how to apply these tools and interpret results with confidence. This process is aided by chapters that introduce important aspects of bioinformatics, detailed bioinformatics exercises (including solutions), and to cap it all, a glossary of definitions and terminology relating to bioinformatics.

Nature and Psychology

Author : Anne R. Schutte
Publisher : Springer Nature
ISBN 13 : 3030690202
Total Pages : 287 pages
Book Rating : 4.0/5 (36 download)

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Book Synopsis Nature and Psychology by : Anne R. Schutte

Download or read book Nature and Psychology written by Anne R. Schutte and published by Springer Nature. This book was released on 2021-08-23 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is comprised of contributions to the 67th Nebraska Symposium on Motivation, which brought together various research disciplines such as psychology, education, health sciences, natural resources, environmental studies to investigate the ways in which nature influences cognition, health, human behavior, and well-being. The symposium is positioned to explore two proposed mechanisms in the most depth: 1) the psycho-evolutionary theory of stress recovery and 2) Attention Restoration Theory. The contributions in the volume represent research guided by both of these posited mechanisms, rigorously examine these theories and processes, and share methodological innovations that can be utilized across programs of research. This volume will be of great interest to researchers on natural environments, practitioners and clinicians working with an environmental lens at the intersection of psychology, social work, education and the health sciences, as well as researchers and students in environmental and conservation psychology. Chapter 5 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.