Cancer Immunotherapy Mechanisms Of Cancer Immunity Engineering Immune Based Therapies And Developing Clinical Trials

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Cancer Immunotherapy: Mechanisms of Cancer Immunity, Engineering Immune- Based Therapies and Developing Clinical Trials

Author : Jianxun Song
Publisher : Bentham Science Publishers
ISBN 13 : 1681080486
Total Pages : 283 pages
Book Rating : 4.6/5 (81 download)

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Book Synopsis Cancer Immunotherapy: Mechanisms of Cancer Immunity, Engineering Immune- Based Therapies and Developing Clinical Trials by : Jianxun Song

Download or read book Cancer Immunotherapy: Mechanisms of Cancer Immunity, Engineering Immune- Based Therapies and Developing Clinical Trials written by Jianxun Song and published by Bentham Science Publishers. This book was released on 2015-04-16 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinicians, patients and scientists, alike, have been battling cancer for over several decades; however, patient outcomes have not significantly improved over the years with conventional therapies. In recent years, this has caused researchers to look for a change in the status quo, and, the awareness of the human immune system, which has an intrinsic mechanism to control microbial pathogens and dysfunctional self-tissues, has triggered scientists to look for new modes of cancer therapy. Cancer Immunotherapy has become a major research field as a result of these efforts, gaining some recognition for notable breakthroughs in cancer patient prognosis. Frontiers in Cancer Immunology collectively presents the methods which have been studied and used in cancer immunotherapy based on the different components of human immune system. The series will give clinicians and immunologists a roadmap of current trends in all branches of cancer immunology. This volume lists the major immune system components (such as T cells and NK cells and associated antigens/antibodies) which have been demonstrated to limit the growth of or kill tumor cells. Relevant applications in cancer therapy are also included in addition to a general introduction to engineered as well as targeted cancer immunotherapies (cancer vaccines).

Cancer Immunotherapy

Author : Jianxun Song
Publisher :
ISBN 13 :
Total Pages : 274 pages
Book Rating : 4.:/5 (927 download)

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Book Synopsis Cancer Immunotherapy by : Jianxun Song

Download or read book Cancer Immunotherapy written by Jianxun Song and published by . This book was released on 2015 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Frontiers in Cancer Immunology - Cancer Immunotherapy: Mechanisms of Cancer Immunity, Engineering Immune-Based Therapies and Developing Clinical Trials

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Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (972 download)

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Book Synopsis Frontiers in Cancer Immunology - Cancer Immunotherapy: Mechanisms of Cancer Immunity, Engineering Immune-Based Therapies and Developing Clinical Trials by :

Download or read book Frontiers in Cancer Immunology - Cancer Immunotherapy: Mechanisms of Cancer Immunity, Engineering Immune-Based Therapies and Developing Clinical Trials written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cancer Immunology and Immunotherapy

Author : Mansoor M. Amiji
Publisher : Academic Press
ISBN 13 : 012823637X
Total Pages : 550 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Cancer Immunology and Immunotherapy by : Mansoor M. Amiji

Download or read book Cancer Immunology and Immunotherapy written by Mansoor M. Amiji and published by Academic Press. This book was released on 2021-08-18 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy examines the challenges of delivering immuno-oncology therapies. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. Nanotechnology-based targeted delivery strategies could improve the delivery efficiency of IO agents as well as provide additional avenues for novel therapeutic and vaccination strategies. Additionally, a number of locally-administered immunogenic scaffolds and therapeutic strategies, such as the use of STING agonist, could benefit from rationally designed biomaterials and delivery approaches. Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side. - Comprehensive treaty covering all aspects of immuno-oncology (IO) - Novel strategies for delivery of IO therapeutics and vaccines - Forecasting on the future of nanotechnology and drug delivery for IO

Tumor Immunology and Immunotherapy

Author : Robert C. Rees
Publisher : OUP Oxford
ISBN 13 : 0191664553
Total Pages : 496 pages
Book Rating : 4.1/5 (916 download)

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Book Synopsis Tumor Immunology and Immunotherapy by : Robert C. Rees

Download or read book Tumor Immunology and Immunotherapy written by Robert C. Rees and published by OUP Oxford. This book was released on 2014-05-29 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Patients are beginning to benefit from antibody based, cellular and vaccine approaches that are effective against genetically diverse and therapy-resistance cancers. BCG immunotherapy is now being used as a first line treatment for human bladder cancer and the introduction of prophylactic vaccination against Hepatitis B and HPV cancers is starting to show positive results. Following recent FDA approval for a vaccination against prostate cancer, and optimistic results in clinical trials for a vaccine targeting cancer antigens in lung cancer, cancer immunotherapy is now significantly impacting patient clinical management. Tumor Immunology and Immunotherapy provides an up-to-date and comprehensive account of cancer immunity and immunotherapy. It discusses our adaptive and innate immunity to cancer, the mechanisms underpinning our immune response, current approaches to cancer immunotherapy, and how tumour and host responses can circumvent effective anti-cancer immunity. The book examines recent results, publications and current areas of interest including 'immune editing' and the specific issues that are affecting the research and development of vaccines, providing insight into how these problems may be overcome, as viewed by world leaders in the field. Tumor Immunology and Immunotherapy will appeal to clinicians working in oncology and cancer immunotherapy, and research scientists including PhD and masters students, post-doctoral researchers and senior investigators.

Advancing Progress in the Development of Combination Cancer Therapies with Immune Checkpoint Inhibitors

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309490898
Total Pages : 89 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Advancing Progress in the Development of Combination Cancer Therapies with Immune Checkpoint Inhibitors by : National Academies of Sciences, Engineering, and Medicine

Download or read book Advancing Progress in the Development of Combination Cancer Therapies with Immune Checkpoint Inhibitors written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2019-09-05 with total page 89 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, significant progress has been made in the clinical development and use of various types of cancer immunotherapy, all of which rely on the immune system to fight cancer. The majority of new cancer drug applications submitted to the Food and Drug Administration (FDA) are for immunotherapies or combinations involving immunotherapies. One type of immunotherapy is an immune checkpoint inhibitor. Cells in the human body have proteins that regulate the immune system response to foreign invaders (e.g., cancer cells, microorganisms). However, cancer cells can coopt these "checkpoint" proteins and thwart the immune system's ability to recognize and attack cancer cells. To help promote an immune response to cancer, researchers have developed immune checkpoint inhibitors that enable T-cells to recognize cancer cells as foreign and to prevent deactivation of an immune system response. To examine the challenges and opportunities to develop combination cancer therapies that include immune checkpoint inhibitors, the National Cancer Policy Forum held a workshop on July 16â€"17, 2018, in Washington, DC. This workshop convened stakeholders with a broad range of expertise, including cancer researchers, clinicians, patient advocates, and representatives from industry, academia, and government. This publication summarizes the presentations and discussions from the workshop.

Immunotherapy of Cancer

Author : Mary L. Disis
Publisher : Springer Science & Business Media
ISBN 13 : 1597450111
Total Pages : 517 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Immunotherapy of Cancer by : Mary L. Disis

Download or read book Immunotherapy of Cancer written by Mary L. Disis and published by Springer Science & Business Media. This book was released on 2007-10-28 with total page 517 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expert bench and clinical scientists join forces to concurrently review both the state-of-the-art in tumor immunology and its clinical translation into promising practical treatments. The authors explain in each chapter the scientific basis behind such therapeutic agents as monoclonal antibodies, cytokines, vaccines, and T-cells, and illustrate their clinical manipulation to combat cancer. Additional chapters address statistical analysis-both of clinical trials and assay evaluations-methods for the discovery of antigens, adoptive T cell therapy, and adaptive and innate immunity. The challenges in clinical trial design, the need for biomarkers of response-such as novel imaging techniques and immunologic monitoring-and the new advances and directions in cancer immunotherapy are also fully examined.

Cancer Immunology and Immunotherapy

Author : Glenn Dranoff
Publisher : Springer Science & Business Media
ISBN 13 : 3642141366
Total Pages : 313 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Cancer Immunology and Immunotherapy by : Glenn Dranoff

Download or read book Cancer Immunology and Immunotherapy written by Glenn Dranoff and published by Springer Science & Business Media. This book was released on 2011-04-11 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interplay between tumors and their immunologic microenvironment is complex, difficult to decipher, but its understanding is of seminal importance for the development of novel prognostic markers and therapeutic strategies. The present review discusses tumor-immune interactions in several human cancers that illustrate various aspects of this complexity and proposes an integrated scheme of the impact of local immune reactions on clinical outcome. Current active immunotherapy trials have shown durable tumor regressions in a fraction of patients. However, clinical efficacy of current vaccines is limited, possibly because tumors skew the immune system by means of myeloid-derived suppressor cells, inflammatory type 2 T cells and regulatory T cells (Tregs), all of which prevent the generation of effector cells. To improve the clinical efficacy of cancer vaccines in patients with metastatic disease, we need to design novel and improved strategies that can boost adaptive immunity to cancer, help overcome Tregs and allow the breakdown of the immunosuppressive tumor microenvironment.

Novel Immunotherapeutic Approaches to the Treatment of Cancer

Author : Paul D. Rennert
Publisher : Springer
ISBN 13 : 3319298275
Total Pages : 285 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Novel Immunotherapeutic Approaches to the Treatment of Cancer by : Paul D. Rennert

Download or read book Novel Immunotherapeutic Approaches to the Treatment of Cancer written by Paul D. Rennert and published by Springer. This book was released on 2016-05-30 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer care is undergoing a radical transformation as novel technologies are directed toward new treatments and personalized medicine. The most dramatic advances in the treatment of cancer have come from therapeutics that augment the immune response to tumors. The immune checkpoint inhibitors are the best-known and most highly advanced examples of Immune Therapeutics targeting tumor cells and include approved antibody drugs directed at the cell surface proteins CTLA4 and PD-1. These are now considered foundational treatments for several solid tumor indications, and that list of indications is growing quickly. More broadly, antibodies have become workhorse molecules across the entire immunotherapy landscape. Antibodies to novel targets modulate the activity of diverse immune cell regulatory proteins. Engineered antibodies can induce tumor cell death or expose tumor cells to poisonous toxins (ADCC and ADC, respectively). Bi-specific antibodies can engage multiple tumor targets simultaneously, or can redirect lymphocytes to attack tumor cells. The antigen-binding domains within antibodies can be spliced onto cell stimulatory domains and transduced into T cells or NK cells, creating remarkable tumor-specific cellular therapeutics (CAR-T, CAR-NK). Beyond antibody-based therapies there are highly diverse and differentiated technology tool kits being applied to immunotherapy. Small molecule drugs are being developed to attack the tumor microenvironment, novel tumor vaccine approaches are showing great promise, patient lymphocytes are being isolated, expanded and reintroduced to patients, gene-editing techniques are becoming widely deployed, and a vast number of new tumor targets, and mutated tumor proteins (neoantigens), are being discovered. The past decade has seen unprecedented success in the treatment of diverse cancers. The authors of this volume have been asked to not only review progress to date, but importantly, to look ahead, and anticipate the evolution of cancer treatment across diverse Immune Therapeutic approaches. Our hypothesis is that the advances we are seeing across the immunotherapy landscape will further evolve and synergize, leading us finally to outright cures for many cancers.

Immunotherapy in Translational Cancer Research

Author : Laurence J. N. Cooper
Publisher : John Wiley & Sons
ISBN 13 : 1118123220
Total Pages : 306 pages
Book Rating : 4.1/5 (181 download)

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Book Synopsis Immunotherapy in Translational Cancer Research by : Laurence J. N. Cooper

Download or read book Immunotherapy in Translational Cancer Research written by Laurence J. N. Cooper and published by John Wiley & Sons. This book was released on 2018-05-01 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide to state-of-the-art cancer immunotherapy in translational cancer research A volume in the Translational Oncology series, Immunotherapy in Translational Cancer Research explores the recent developments in the role that immunotherapy plays in the treatment of a wide range of cancers. The editors present key concepts, illustrative examples, and suggest alternative strategies in order to achieve individualized targeted therapy. Comprehensive in scope, Immunotherapy in Translational Cancer Research reviews the relevant history, current state, and the future of burgeoning cancer-fighting therapies. The book also includes critical information on drug development, clinical trials, and governmental resources and regulatory issues. Each chapter is created to feature: development of the immunotherapy; challenges that have been overcome in order to scale up and undertake clinical trials; and clinical experience and application of research. This authoritative volume is edited by a team of noted experts from MD Anderson Cancer Center, the world’s foremost cancer research and care center and: Offers a comprehensive presentation of state-of-the-art cancer immunotherapy research that accelerates the pace of clinical cancer care Filled with the concepts, examples, and approaches for developing individualized therapy Explores the breath of treatments that reflect the complexity of the immune system itself Includes contributions from a panel international experts in the field of immunotherapy Designed for physicians, medical students, scientists, pharmaceutical executives, public health and public policy government leaders and community oncologists, this essential resource offers a guide to the bidirectional interaction between laboratory and clinic immunotherapy cancer research.

Advances in Tumor Immunology and Immunotherapy

Author : Joseph D. Rosenblatt
Publisher : Springer Science & Business Media
ISBN 13 : 1461488095
Total Pages : 369 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Advances in Tumor Immunology and Immunotherapy by : Joseph D. Rosenblatt

Download or read book Advances in Tumor Immunology and Immunotherapy written by Joseph D. Rosenblatt and published by Springer Science & Business Media. This book was released on 2013-10-25 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in understanding of fundamental immunology have created new insights into the dynamic interactions between tumors and the immune system. This includes new understanding of T- and B-cell interaction, immune inhibitory mechanisms including the biology of T regulatory cells, myeloid suppressor cells, and dendritic cell subsets. Enhanced understanding of mechanisms underlying T-cell anergy such as arginine deprivation, immunosuppressive cytokines, defective innate and interferon response pathways, and NKG2D downregulation have all provided new insight into suppression of anti-tumor immunity and tumor evasion. In addition to emerging understanding of tumor evasion, new immune targets such as CTLA4 blockade, NK stimulatory receptors, manipulation of the antigen processing and presentation, cytokine and costimulatory responses all provide new possibilities for enhancing anti-tumor immunity even in tumors previously felt to be resistant to immune attack. Several of these strategies have already been realized in the clinic. The volume will explore evolving paradigms in antigen presentation, dendritic cell biology, the innate response and immunosuppressive mechanisms, and emerging strategies for manipulation of the immune system for therapeutic benefit that have realized success in neuroblastoma, leukemia, melanoma, lung cancer, and allogeneic transplantation. Early successes as well as failures will be highlighted to provide a snapshot of the state of clinical immunotherapy with an eye to future possibilities such as combination therapies, adoptive T-cell transfer, and the retargeting of immune cells via T-cell receptor engineering.

Cancer Immunotherapy Principles and Practice, Second Edition

Author : Lisa H. Butterfield, PhD
Publisher : Springer Publishing Company
ISBN 13 : 0826137431
Total Pages : 1339 pages
Book Rating : 4.8/5 (261 download)

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Book Synopsis Cancer Immunotherapy Principles and Practice, Second Edition by : Lisa H. Butterfield, PhD

Download or read book Cancer Immunotherapy Principles and Practice, Second Edition written by Lisa H. Butterfield, PhD and published by Springer Publishing Company. This book was released on 2021-08-25 with total page 1339 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thoroughly updated to reflect major advances in the field of immuno-oncology, this second edition of Cancer Immunotherapy Principles and Practice, from the Society for Immunotherapy of Cancer (SITC), remains the definitive resource for information on tumor immunology and cancer immunotherapy treatments. An essential reference for both novice and experienced cancer researchers, oncologists, and related practitioners alike, the book not only guides readers through the fundamental scientific principles of the field all the way to translational and practical clinical applications for treating and managing oncologic disease, but also provides a comprehensive understanding of the regulatory processes that support the safe and effective delivery of immunotherapy to patients with cancer. The expanded and updated second edition now spans 68 chapters, including 12 new chapters, covering major topics and innovations that have shaped the rapid development of immunotherapy and its ascension into the standard of care as first-line treatment for a growing number of disease settings. New to this edition are chapters with deeper insight into our understanding of cancer genomics and determinants of response, immunogenic cell death, cancer and stromal cell-intrinsic pathways of immune resistance, cancer immune exclusion, adoptive cell therapy, metabolomics, tumor mutation burden, immunotherapy in combination with radiation therapy, synthetic biology, and more. Complete with detailed illustrations, tables, and key points for targeted reference, Cancer Immunotherapy Principles and Practice, Second Edition is the most comprehensive and authoritative resource for scientists and clinicians looking to expand their knowledge base of this dynamic field. Key Features: Offers key insights and perspectives on cancer immunology and immunotherapy treatments from renowned experts in the field Covers the basic principles and science behind cancer immunotherapy and tumor immunology Includes treatment strategies for a vast array of available immunotherapy classes and agents, such as cytokine therapies, oncolytic viruses, cancer vaccines, CAR T therapies, and combination immunotherapies Provides essential information on FDA-approved immunotherapies, including clinical management and outcome data related to response rates, risks, and toxicities Discusses special considerations for immunotherapy in the context of specific disease settings, including skin cancers, genitourinary cancers, gastrointestinal cancers, hepatocellular carcinomas, gynecologic malignancies, breast cancers, lung cancers, head and neck cancers, brain tumors, sarcomas, pediatric cancers, and treatments combined with radiation therapy Clarifies the complex regulatory aspects behind the development and approval of immunotherapy drugs

Cancer Immunotherapy Principles and Practice

Author : Lisa H. Butterfield, PhD
Publisher : Springer Publishing Company
ISBN 13 : 1617052736
Total Pages : 921 pages
Book Rating : 4.6/5 (17 download)

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Book Synopsis Cancer Immunotherapy Principles and Practice by : Lisa H. Butterfield, PhD

Download or read book Cancer Immunotherapy Principles and Practice written by Lisa H. Butterfield, PhD and published by Springer Publishing Company. This book was released on 2017-06-28 with total page 921 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Drs. Butterfield, Kaufman and Marincola on behalf of the SITC have created a comprehensive must-have resource covering the basic and translational science behind approved and investigational immune therapies, and disease-by-disease clinical application of the therapies, written by leaders in the field. The textbook will be highly valuable reading for those just entering the field and for experienced scientists and clinicians looking to expand their knowledge base.” —Mario Sznol, MD, Professor of Medicine (Medical Oncology), Yale School of Medicine, New Haven, Connecticut “Given the important and exciting advances in cancer immunotherapy, it is not surprising that there is no dearth of books on the subject. Despite the competition, however, this book is a unique masterpiece and a must-have comprehensive resource for anyone interested in this area and for every medical library.” Score: 100, 5 Stars, Doody’s Medical Reviews Cancer Immunotherapy Principles and Practice, from the Society for Immunotherapy of Cancer (SITC), is the authoritative reference on cancer immunobiology and the immunotherapy treatments that harness the immune system to combat malignant disease. Featuring five sections and over 50 chapters covering the Basic Principles of Tumor Immunology, Cancer Immunotherapy Targets and Classes, Immune Function in Cancer Patients, Disease-Specific Treatments and Outcomes, and Regulatory Aspects of Cancer Immunotherapy, this book covers all major topics that have shaped the development of immunotherapy and propelled it to its current place at the forefront of cancer treatment innovation. This volume is a comprehensive resource for oncologists and fellows, immunologists, cancer researchers, and related practitioners seeking understanding of the basic science and clinical applications of cancer immunotherapy. As well as presenting the evidence for immune-based cancer treatment, it positions immunotherapy in the context of other available cancer treatments and provides data on response rates, risks, and toxicities across a variety of diseases. Filled with detailed tables, and instructive illustrations, as well as key points for quick reference, Cancer Immunotherapy Principles and Practice simplifies a challenging and dynamic subject. KEY FEATURES Clearly summarizes the basic principles and research supporting cancer immunotherapy clinical translation Contains expert guidance and treatment strategies for all immunotherapy classes and agents, including cell-based therapies, monoclonal antibodies, cytokine therapies, checkpoint inhibitors, oncolytic viruses, adjuvant approaches, and treatment combinations Includes expert perspectives from leading authorities in the field Provides information on all FDA-approved immunotherapies, including clinical management and outcome data Discusses clinical aspects of immunotherapy for individual cancer types, including melanoma and other skin cancers, lung cancers, gynecologic cancers, gastrointestinal cancers, hematologic cancers, genitourinary cancers, head and neck cancers, sarcomas, brain and other CNS cancers, breast cancer, and pediatric malignancies. Explains regulatory aspects behind the development and approval of immunotherapy drugs

Cancer Immunotherapy

Author : David B. Teplow
Publisher : Academic Press
ISBN 13 : 0128165766
Total Pages : 354 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Cancer Immunotherapy by : David B. Teplow

Download or read book Cancer Immunotherapy written by David B. Teplow and published by Academic Press. This book was released on 2019-08-03 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Immunotherapy, Volume 165 in the Progress in Molecular Biology and Translational Science series, provides informative monographs on a variety of research topics related to different approaches to cancer immunotherapy, with this release focusing on TNFR2 in cancer immunology and immunotherapy, From the Hellstrom paradox towards cancer cure, CAR T-cell treatment of T-cell malignancy , Immunotherapy of pancreatic cancer, Cancer stem cell immunology/immunotherapy, Cytokine release syndrome, Tumor cell-based mechanisms of resistance to immune attack, and Mushroom compounds in cancer immunotherapy. Includes comprehensive coverage of molecular biology Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided Contains contributions from renowned experts in the field

Immunotherapy in Resistant Cancer: From the Lab Bench Work to Its Clinical Perspectives

Author : Jorge Morales-Montor
Publisher : Academic Press
ISBN 13 : 0128220295
Total Pages : 288 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Immunotherapy in Resistant Cancer: From the Lab Bench Work to Its Clinical Perspectives by : Jorge Morales-Montor

Download or read book Immunotherapy in Resistant Cancer: From the Lab Bench Work to Its Clinical Perspectives written by Jorge Morales-Montor and published by Academic Press. This book was released on 2020-10-01 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunotherapy in Resistant Cancer: From the Lab Bench Work to Its Clinical Perspectives provides high level knowledge on detailed mechanisms of actions and biological interactions of different immune drugs, with an aim of offering researchers and clinicians cutting-edge therapies to overcome drug resistance. The book explains the latest immunotherapies for different types of cancer, helping users carry out research projects or create alternatives for drug development in the pharmaceutical industry. Topics discussed include the relationship between immunotherapy and macrophages, immune checkpoints in different types of cancer, immune cocktails in solid tumors, and immune-phenotyping. Additionally, the book presents basic and clinical data on immunoresistance and glycosylation. This book is a valuable source for cancer researchers, medical doctors, clinicians and members of the biomedical field who must understand certain mechanisms to fight cancer that is resistant to immunotherapy. - Provides basic and clinical evidence based on molecular interactions and clinical studies to address the risks and benefits of cancer immunotherapy - Presents the results of new immunotherapy trials, discussing the state-of-the-art in different types of cancer - Discusses targeted therapies approved by the FDA, along with therapies with clinical potential used in basic studies

Developments in T Cell Based Cancer Immunotherapies

Author : Paolo A. Ascierto
Publisher : Humana Press
ISBN 13 : 3319211676
Total Pages : 315 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Developments in T Cell Based Cancer Immunotherapies by : Paolo A. Ascierto

Download or read book Developments in T Cell Based Cancer Immunotherapies written by Paolo A. Ascierto and published by Humana Press. This book was released on 2015-11-26 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume illustrates the salient aspects of cancer biology relevant to the successful implementation of immunotherapy. Topics include enhancement of antigen-specific immune responses by anti-cancer vaccines, modulation of the function of T cells within the tumor microenvironment, and the effects of genetic, epigenetic, developmental, and environmental determinants on T cell function. Other topics covered include the ex vivo expansion of T or other immune cells and their genetic modification or reprogramming to increase their ability to survive and expand when adoptively transferred back to the patients. Specific attention is devoted to the genetic manipulation of T cells through the introduction of re-directed T cell receptors, chimeric antibody receptors, and other genetic manipulation aimed at improving their effectiveness as anti-cancer agents. Furthermore, the revolutionary role of checkpoint inhibitors and their potential in combination with other immunotherapeutic approaches or with standard chemo and radiation therapy are extensively discussed.

Regulation of Cancer Immune Checkpoints

Author : Jie Xu
Publisher : Springer Nature
ISBN 13 : 9811532664
Total Pages : 657 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Regulation of Cancer Immune Checkpoints by : Jie Xu

Download or read book Regulation of Cancer Immune Checkpoints written by Jie Xu and published by Springer Nature. This book was released on 2020-03-17 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book systematically reviews the most important findings on cancer immune checkpoints, sharing essential insights into this rapidly evolving yet largely unexplored research topic. The past decade has seen major advances in cancer immune checkpoint therapy, which has demonstrated impressive clinical benefits. The family of checkpoints for mediating cancer immune evasion now includes CTLA-4, PD-1/PD-L1, CD27/CD70, FGL-1/LAG-3, Siglec-15, VISTA (PD-1L)/VSIG3, CD47/SIRPA, APOE/LILRB4, TIGIT, and many others. Despite these strides, most patients do not show lasting remission, and some cancers have been completely resistant to the therapy. The potentially lethal adverse effects of checkpoint blockade represent another major challenge, the mechanisms of which remain poorly understood. Compared to the cancer signaling pathways, such as p53 and Ras, mechanistic studies on immune checkpoint pathways are still in their infancy. To improve the responses to checkpoint blockade therapy and limit the adverse effects, it is essential to understand the molecular regulation of checkpoint molecules in both malignant and healthy cells/tissues. This book begins with an introduction to immune checkpoint therapy and its challenges, and subsequently describes the regulation of checkpoints at different levels. In closing, it discusses recent therapeutic developments based on mechanistic findings, and outlines goals for future translational studies. The book offers a valuable resource for researchers in the cancer immunotherapy field, helping to form a roadmap for checkpoint regulation and develop safer and more effective immunotherapies.