Cancer Diagnostics With Dna Microarrays

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Cancer Diagnostics with DNA Microarrays

Author : Steen Knudsen
Publisher : John Wiley & Sons
ISBN 13 : 0470041099
Total Pages : 272 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Cancer Diagnostics with DNA Microarrays by : Steen Knudsen

Download or read book Cancer Diagnostics with DNA Microarrays written by Steen Knudsen and published by John Wiley & Sons. This book was released on 2006-11-03 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Authored by an international authority in the field,Cancer Diagnostics with DNA Microarrays is a complete reference work on the rapidly growing use of DNA microarray data in the diagnosis of and treatment planning for a large number of human cancers. Uniquely deals with direct clinical application of microarray data to oncology diagnosis, leading to more effective diagnosis of and clearer treatment regimens for a wide range of human cancers Offers clinicians summary presentation of state-of-the-art science of DNA microarrays Each chapter includes bibliographic and further reading suggestions Easily accessible, assuming no special training in statistics or bioinformatics Replete with examples and mini-cases, Cancer Diagnostics with DNA Microarrays offers cancer researchers in private, pharmacologic, and governmental institutions, biomedical statisticians, and practicing oncologists concise, thoughtfully authored guidance on the use of microarray data and analysis as clinical tools. The text carefully addresses the needs of end users – researchers and physicians – using microarrays as a tool to be applied in common clinical situations, and is of interest for students in medicine and biology and professionals in health care as well.

Microarray Technology and Cancer Gene Profiling

Author : Simone Mocellin
Publisher : Springer Science & Business Media
ISBN 13 : 038739978X
Total Pages : 176 pages
Book Rating : 4.3/5 (873 download)

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Book Synopsis Microarray Technology and Cancer Gene Profiling by : Simone Mocellin

Download or read book Microarray Technology and Cancer Gene Profiling written by Simone Mocellin and published by Springer Science & Business Media. This book was released on 2007-08-28 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: Given the revolutionary implications that the use of this technology might have in the clinical management of cancer patients, the principles of DNA array-based tumor gene profiling must be clearly understood for the data to be correctly interpreted and appreciated. This book, written by leading experts, discusses the technical features characterizing the powerful laboratory tool of microarray technology, and reviews applications in the field of oncology.

High-dimensional Microarray Data Analysis

Author : Shuichi Shinmura
Publisher : Springer
ISBN 13 : 9811359989
Total Pages : 419 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis High-dimensional Microarray Data Analysis by : Shuichi Shinmura

Download or read book High-dimensional Microarray Data Analysis written by Shuichi Shinmura and published by Springer. This book was released on 2019-05-14 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book shows how to decompose high-dimensional microarrays into small subspaces (Small Matryoshkas, SMs), statistically analyze them, and perform cancer gene diagnosis. The information is useful for genetic experts, anyone who analyzes genetic data, and students to use as practical textbooks. Discriminant analysis is the best approach for microarray consisting of normal and cancer classes. Microarrays are linearly separable data (LSD, Fact 3). However, because most linear discriminant function (LDF) cannot discriminate LSD theoretically and error rates are high, no one had discovered Fact 3 until now. Hard-margin SVM (H-SVM) and Revised IP-OLDF (RIP) can find Fact3 easily. LSD has the Matryoshka structure and is easily decomposed into many SMs (Fact 4). Because all SMs are small samples and LSD, statistical methods analyze SMs easily. However, useful results cannot be obtained. On the other hand, H-SVM and RIP can discriminate two classes in SM entirely. RatioSV is the ratio of SV distance and discriminant range. The maximum RatioSVs of six microarrays is over 11.67%. This fact shows that SV separates two classes by window width (11.67%). Such easy discrimination has been unresolved since 1970. The reason is revealed by facts presented here, so this book can be read and enjoyed like a mystery novel. Many studies point out that it is difficult to separate signal and noise in a high-dimensional gene space. However, the definition of the signal is not clear. Convincing evidence is presented that LSD is a signal. Statistical analysis of the genes contained in the SM cannot provide useful information, but it shows that the discriminant score (DS) discriminated by RIP or H-SVM is easily LSD. For example, the Alon microarray has 2,000 genes which can be divided into 66 SMs. If 66 DSs are used as variables, the result is a 66-dimensional data. These signal data can be analyzed to find malignancy indicators by principal component analysis and cluster analysis.

Dna Microarray Technology And Data Analysis In Cancer Research

Author : Shaoguang Li
Publisher : World Scientific
ISBN 13 : 981447200X
Total Pages : 131 pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis Dna Microarray Technology And Data Analysis In Cancer Research by : Shaoguang Li

Download or read book Dna Microarray Technology And Data Analysis In Cancer Research written by Shaoguang Li and published by World Scientific. This book was released on 2009-02-04 with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA microarray technology has become a useful technique in gene expression analysis for the development of new diagnostic tools and for the identification of disease genes and therapeutic targets for human cancers. Appropriate control for DNA microarray experiment and reliable analysis of the array data are key to performing the assay and utilizing the data correctly. The most difficult challenge has been the lack of a powerful method to analyze the data for all genes (more than 30,000 genes) simultaneously and to use the microarray data in a decision-making process. In this book, the authors describe DNA microarray technology and data analysis by pointing out current advantages and disadvantages of the technique and available analytical methods. Crucially, new ideas and analytical methods based on the authors' own experience in DNA microarray study and analysis are introduced. It is believed that this new way of interpreting and analyzing microarray data will bring us closer to success in decision-making using the information obtained through the DNA microarray technology.

Microarrays in Diagnostics and Biomarker Development

Author : Bertrand Jordan
Publisher : Springer Science & Business Media
ISBN 13 : 3642282032
Total Pages : 241 pages
Book Rating : 4.6/5 (422 download)

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Book Synopsis Microarrays in Diagnostics and Biomarker Development by : Bertrand Jordan

Download or read book Microarrays in Diagnostics and Biomarker Development written by Bertrand Jordan and published by Springer Science & Business Media. This book was released on 2012-04-23 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microarray technology has made strong progress over the past decade, and there have also been significant changes in application areas, from nucleic acids to proteomics and from research to clinical applications. This book provides a comprehensive overview of microarrays in diagnostics and biomarker development, covering DNA, peptide, protein and tissue arrays. The focus is on entities that are in actual clinical use, or quite close, and on recent developments, such as peptide and aptamer arrays. A further topic is the miniaturisation towards “nanoarrays”, which is expected to have great potential in clinical applications. Relevant issues of bioinformatics and statistical analysis of array data are discussed in detail, as well as the barriers to the commercialisation of array-based tests and the vexing IP issues involved. Thus, the book should be very useful tor active array users as well as to newcomers seeking to make the best choice between different technologies.

The Applications of Bioinformatics in Cancer Detection

Author : Asad Umar
Publisher :
ISBN 13 :
Total Pages : 296 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis The Applications of Bioinformatics in Cancer Detection by : Asad Umar

Download or read book The Applications of Bioinformatics in Cancer Detection written by Asad Umar and published by . This book was released on 2004 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: The state of the science of bioinformatics - that is, application of computer processes to solving biological problems - and its potential for assisting early cancer detection, risk assessment, and risk reduction form the focus of this volume.

DNA Microarrays

Author : Mark Schena
Publisher : Scion Publishing Ltd
ISBN 13 : 1907904395
Total Pages : 289 pages
Book Rating : 4.9/5 (79 download)

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Book Synopsis DNA Microarrays by : Mark Schena

Download or read book DNA Microarrays written by Mark Schena and published by Scion Publishing Ltd. This book was released on 2007-10-01 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA Microarrays: Methods Express covers the very latest in DNA microarray technology, with a clear focus on how these techniques can be used in the lab to gain the very best results. The authors are from some of the leading laboratories in the field and write with real authority on the latest methodology. Every chapter provides detailed step-by-step protocols with valuable hints and tips for success, as well as giving typical experimental results and selected literature citations. This book is a 'must have' manual for researchers in all fields of biology, medicine and agriculture.

High-Throughput Array Instrument for DNA-Based Breast Cancer Diagnostics

Author :
Publisher :
ISBN 13 :
Total Pages : 12 pages
Book Rating : 4.:/5 (946 download)

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Book Synopsis High-Throughput Array Instrument for DNA-Based Breast Cancer Diagnostics by :

Download or read book High-Throughput Array Instrument for DNA-Based Breast Cancer Diagnostics written by and published by . This book was released on 2000 with total page 12 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this project is to develop improved methods for the production, processing, and analysis of microarrays (gene-chips) for breast-cancer diagnostics. These methods are based upon large numbers of discrete DNA spots placed on glass microscope slides typically, and hybridized to a probe derived from a tIssue or blood sample. %or breast- cancer diagnostics, there are two likely predominant modes of use. TIssue samples from suspect lesions, e.g., can be assessed for patterns of gene expression on cDNA arrays, indicative of a specific disease type or state. Additionally, analysis of known mutations can be performed on oligonucleotide-based arrays. We are optimizing cDNA microarray methods, and have achieved excellent limits of detection, although not good enough to detect the rarest transcripts. To improve this situation, we are redesigning our novel imaging (non-scanning) fluorescence microarray reader that currently performs four times better (with respect to limit of detection) than a commercial scanner, and does so about 300 times faster. Our next goal is to implement oligonucleotide arrays by various methods including both padlock probe-based ligation assays and allele-specific hybridization tests for specific known mutations. We are also actively improving direct covalent attachment of oligonucleotides to glass, and methods for printing oligonucleotide arrays much faster and cheaper.

Bioarrays

Author : Krishnarao Appasani
Publisher : Springer Science & Business Media
ISBN 13 : 1597453285
Total Pages : 277 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Bioarrays by : Krishnarao Appasani

Download or read book Bioarrays written by Krishnarao Appasani and published by Springer Science & Business Media. This book was released on 2007-10-04 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an integrated collection of timely articles on the use of bioarray techniques in the fields of biotechnology and molecular medicine. It is the first book to comprehensively integrate molecular diagnostics and molecular pathology. This book serves as an indispensable reference for graduate students, post-docs, and professors as well as an explanatory analysis for executives and scientists in biotechnology and pharmaceutical companies.

Developing Biomarker-Based Tools for Cancer Screening, Diagnosis, and Treatment

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309101344
Total Pages : 112 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Developing Biomarker-Based Tools for Cancer Screening, Diagnosis, and Treatment by : Institute of Medicine

Download or read book Developing Biomarker-Based Tools for Cancer Screening, Diagnosis, and Treatment written by Institute of Medicine and published by National Academies Press. This book was released on 2006-11-18 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research has long sought to identify biomarkers that could detect cancer at an early stage, or predict the optimal cancer therapy for specific patients. Fueling interest in this research are recent technological advances in genomics, proteomics, and metabolomics that can enable researchers to capture the molecular fingerprints of specific cancers and fine-tune their classification according to the molecular defects they harbor. The discovery and development of new markers of cancer could potentially improve cancer screening, diagnosis, and treatment. Given the potential impact cancer biomarkers could have on the cost effectiveness of cancer detection and treatment, they could profoundly alter the economic burden of cancer as well. Despite the promise of cancer biomarkers, few biomarker-based cancer tests have entered the market, and the translation of research findings on cancer biomarkers into clinically useful tests seems to be lagging. This is perhaps not surprising given the technical, financial, regulatory, and social challenges linked to the discovery, development, validation, and incorporation of biomarker tests into clinical practice. To explore those challenges and ways to overcome them, the National Cancer Policy Forum held the conference "Developing Biomarker-Based Tools for Cancer Screening, Diagnosis and Treatment: The State of the Science, Evaluation, Implementation, and Economics" in Washington, D.C., from March 20 to 22, 2006. At this conference, experts gave presentations in one of six sessions. In addition, seven small group discussions explored the policy implications surrounding biomarker development and adoption into clinical practice. Developing Biomarker-based Tools for Developing Cancer Screening, Diagnosis, and Treatment: The State of the Science, Evaluation, Implementation, and Economics-Workshop Summary presents the conference proceedings and will be used by an Institute of Medicine (IOM) committee to develop consensus-based recommendations for moving the field of cancer biomarkers forward.

Expression Profiling of Human Tumors

Author : Marc Ladanyi
Publisher : Springer Science & Business Media
ISBN 13 : 1592593860
Total Pages : 419 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Expression Profiling of Human Tumors by : Marc Ladanyi

Download or read book Expression Profiling of Human Tumors written by Marc Ladanyi and published by Springer Science & Business Media. This book was released on 2003-05-01 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive review of the use of global gene expression profiling to understand human tumors. The authors focus on the analysis of human tissue samples for a variety of cancers, including breast, colorectal, lung, renal, ovarian, bone, and brain tumors, among others. A primer on the technology and its novel analytical methods. Contains over 40 color images. Explains both the theory and practice of comprehensive gene expression profiling. Timely and topical, Expression Profiling of Human Tumors: Diagnostic and Research Applications offers every oncologist, pathologists, and cancer surgeons an essential introduction to the most promising new high-throughput investigative approaches in molecular biology-technology that is already dramatically reshaping the future of cancer research, diagnostic pathology, and clinical oncology.

Molecular Pathology in Cancer Research

Author : Sunil R. Lakhani
Publisher : Springer
ISBN 13 : 149396643X
Total Pages : 369 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Molecular Pathology in Cancer Research by : Sunil R. Lakhani

Download or read book Molecular Pathology in Cancer Research written by Sunil R. Lakhani and published by Springer. This book was released on 2017-01-20 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of the book is to discuss the application of molecular pathology in cancer research, and its contribution in the classification of different tumors and identification of potential molecular targets, as well as how this knowledge may be translated into clinical practice, and the huge impact this field is likely to have in the next 5 to 10 years.

Microarray Technology and Cancer Gene Profiling

Author : Simone Mocellin
Publisher : Springer
ISBN 13 : 9780387516004
Total Pages : 0 pages
Book Rating : 4.5/5 (16 download)

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Book Synopsis Microarray Technology and Cancer Gene Profiling by : Simone Mocellin

Download or read book Microarray Technology and Cancer Gene Profiling written by Simone Mocellin and published by Springer. This book was released on 2008-11-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Given the revolutionary implications that the use of this technology might have in the clinical management of cancer patients, the principles of DNA array-based tumor gene profiling must be clearly understood for the data to be correctly interpreted and appreciated. This book, written by leading experts, discusses the technical features characterizing the powerful laboratory tool of microarray technology, and reviews applications in the field of oncology.

Microarrays in Clinical Diagnostics

Author : Thomas O. Joos
Publisher : Springer Science & Business Media
ISBN 13 : 1592599230
Total Pages : 283 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Microarrays in Clinical Diagnostics by : Thomas O. Joos

Download or read book Microarrays in Clinical Diagnostics written by Thomas O. Joos and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading academic and industrial investigators surveys the world of microarray technology, describing in step-by-step detail diverse DNA and protein assays in clinical laboratories using state-of-the-art technologies. The advanced tools and methods described are designed for mRNA expression analysis, SNP analysis, identification, and quantification of proteins, and for studies of protein-protein interactions. The protocols follow the successful Methods in Molecular BiologyTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.

Cancer Genomics

Author : Ulrich Pfeffer
Publisher : Springer Science & Business Media
ISBN 13 : 9400758421
Total Pages : 591 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Cancer Genomics by : Ulrich Pfeffer

Download or read book Cancer Genomics written by Ulrich Pfeffer and published by Springer Science & Business Media. This book was released on 2013-02-12 with total page 591 pages. Available in PDF, EPUB and Kindle. Book excerpt: The combination of molecular biology, engineering and bioinformatics has revolutionized our understanding of cancer revealing a tight correlation of the molecular characteristics of the primary tumor in terms of gene expression, structural alterations of the genome, epigenetics and mutations with its propensity to metastasize and to respond to therapy. It is not just one or a few genes, it is the complex alteration of the genome that determines cancer development and progression. Future management of cancer patients will therefore rely on thorough molecular analyses of each single case. Through this book, students, researchers and oncologists will obtain a comprehensive picture of what the first ten years of cancer genomics have revealed. Experts in the field describe, cancer by cancer, the progress made and its implications for diagnosis, prognosis and treatment of cancer. The deep impact on the clinics and the challenge for future translational research become evident.

RNA and DNA Diagnostics

Author : Volker A. Erdmann
Publisher : Springer
ISBN 13 : 3319173057
Total Pages : 353 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis RNA and DNA Diagnostics by : Volker A. Erdmann

Download or read book RNA and DNA Diagnostics written by Volker A. Erdmann and published by Springer. This book was released on 2015-06-10 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of molecular diagnostics is preferentially to detect a developing disease before any symptoms appear. There has been a significant increase, fueled by technologies from the human genome project, in the availability of nucleic acid sequence information for all living organisms including bacteria and viruses. When combined with a different type of instrumentation applied, the resulting diagnostics is specific and sensitive. Nucleic acid-based medical diagnosis detects specific DNAs or RNAs from the infecting organism or virus and a specific gene or the expression of a gene associated with a disease. Nucleic acid approaches also stimulate a basic science by opening lines of inquiry that will lead to greater understanding of the molecules at the center of life. One can follow Richard Feynman’s famous statement “What I cannot create, I do not understand.”

Design and Analysis of DNA Microarray Investigations

Author : Richard M. Simon
Publisher : Springer Science & Business Media
ISBN 13 : 0387218661
Total Pages : 205 pages
Book Rating : 4.3/5 (872 download)

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Book Synopsis Design and Analysis of DNA Microarray Investigations by : Richard M. Simon

Download or read book Design and Analysis of DNA Microarray Investigations written by Richard M. Simon and published by Springer Science & Business Media. This book was released on 2006-05-09 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: The analysis of gene expression profile data from DNA micorarray studies are discussed in this book. It provides a review of available methods and presents it in a manner that is intelligible to biologists. It offers an understanding of the design and analysis of experiments utilizing microarrays to benefit scientists. It includes an Appendix tutorial on the use of BRB-ArrayTools and step by step analyses of several major datasets using this software which is available from the National Cancer Institute.