Cancer Cell Structures Carcinogens And Genomic Instability

Download Cancer Cell Structures Carcinogens And Genomic Instability full books in PDF, epub, and Kindle. Read online Cancer Cell Structures Carcinogens And Genomic Instability ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

Cancer: Cell Structures, Carcinogens and Genomic Instability

Author : Leon P. Bignold
Publisher : Springer Science & Business Media
ISBN 13 : 9783764371562
Total Pages : 398 pages
Book Rating : 4.3/5 (715 download)

DOWNLOAD NOW!

Book Synopsis Cancer: Cell Structures, Carcinogens and Genomic Instability by : Leon P. Bignold

Download or read book Cancer: Cell Structures, Carcinogens and Genomic Instability written by Leon P. Bignold and published by Springer Science & Business Media. This book was released on 2006 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tumors can be induced by a variety of physical and chemical carcinogens. The resulting tumor cells are usually abnormal in their morphology and behavior and transmit their abnormalities to their daughter tumor cells. Most theories of the pathogenesis of tumors suggest that carcinogens in some way cause alterations either of the genomes or of inheritable patterns of gene expression in normal cells, which then cause morphological and behavioral changes. This volume presents a collection of articles aimed at the question by what genetic or epigenetic mechanisms carcinogens can cause morphological abnormalities of tumor cells. It includes reviews of cellular targets of known carcinogens, and presents varying viewpoints of how morphological abnormalities and the actions of carcinogens might be related. The volume will be of interest to all those who are involved in cancer research or in the prevention, diagnosis or management of tumors in humans or animals.

Comparative Oncology

Author : Alecsandru Ioan Baba
Publisher :
ISBN 13 : 9789732714577
Total Pages : 787 pages
Book Rating : 4.7/5 (145 download)

DOWNLOAD NOW!

Book Synopsis Comparative Oncology by : Alecsandru Ioan Baba

Download or read book Comparative Oncology written by Alecsandru Ioan Baba and published by . This book was released on 2007 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Molecular Biology of the Cell

Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

DOWNLOAD NOW!

Book Synopsis Molecular Biology of the Cell by :

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Genome Stability

Author : Igor Kovalchuk
Publisher : Academic Press
ISBN 13 : 0323856802
Total Pages : 762 pages
Book Rating : 4.3/5 (238 download)

DOWNLOAD NOW!

Book Synopsis Genome Stability by : Igor Kovalchuk

Download or read book Genome Stability written by Igor Kovalchuk and published by Academic Press. This book was released on 2021-07-17 with total page 762 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genome stability and genome diversification in response to environmental factors. Here, across thirty-eight chapters, leading researchers provide a deep analysis of genome stability in DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, examining how epigenetic factors contribute to genome stability and how these species pass memories of encounters to progeny. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, and genome stability in response to aging. This second edition has been fully revised to address evolving research trends, including CRISPRs/Cas9 genome editing; conventional versus transgenic genome instability; breeding and genetic diseases associated with abnormal DNA repair; RNA and extrachromosomal DNA; cloning, stem cells, and embryo development; programmed genome instability; and conserved and divergent features of repair. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability. - A deep analysis of genome stability research from various kingdoms, including epigenetics and transgenerational effects - Provides comprehensive coverage of mechanisms utilized by different organisms to maintain genomic stability - Contains applications of genome instability research and outcomes for human disease - Features all-new chapters on evolving areas of genome stability research, including CRISPRs/Cas9 genome editing, RNA and extrachromosomal DNA, programmed genome instability, and conserved and divergent features of repair

Mechanisms of Carcinogenesis

Author : Elizabeth K. Weisburger
Publisher : Springer Science & Business Media
ISBN 13 : 9400925263
Total Pages : 210 pages
Book Rating : 4.4/5 (9 download)

DOWNLOAD NOW!

Book Synopsis Mechanisms of Carcinogenesis by : Elizabeth K. Weisburger

Download or read book Mechanisms of Carcinogenesis written by Elizabeth K. Weisburger and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: but also the possibility of intervention in specific stages. In Human behavior, including stress and other factors, plays an important role in neoplasia, although too little is known addition, variables which affect cancer development as well on the reasons for such development. Carcinogens, which as some endogenous factors can be better delineated help initiate the neoplastic process, may be either synthetic through such investigations. The topics of this volume encompass premalignant non or naturally-occurring. Cancer causation may be ascribed to invasive lesions, species-specific aspects of carcinogenicity, certain chemicals, physical agents, radioactive materials, viruses, parasites, the genetic make-up of the organism, and radiation, viruses, a quantum theory of carinogenesis, onco bacteria. Humans, eumetazoan animals and vascular plants genes, and selected environmental carcinogens. are susceptible to the first six groups of cancer causes, whe reas the last group, bacteria, seems to affect only vascular plants. Neoplastic development may begin with impairment ofJmdy defenses by a toxic material (carcinogen) which acts as an initiator, followed by promotion and progression to an overt neoplastic state. Investigation of these processes Series Editor Volume Editor allows not only a better insight into the mechanism of action Hans E. Kaiser Elizabeth K. Weisburger vii ACKNOWLEDGEMENT Inspiration and encouragement for this wide ranging project on cancer distribution and dissemination from a comparative biological and clinical point of view, was given by my late friend E. H. Krokowski.

Cancer as a Metabolic Disease

Author : Thomas Seyfried
Publisher : John Wiley & Sons
ISBN 13 : 1118310306
Total Pages : 482 pages
Book Rating : 4.1/5 (183 download)

DOWNLOAD NOW!

Book Synopsis Cancer as a Metabolic Disease by : Thomas Seyfried

Download or read book Cancer as a Metabolic Disease written by Thomas Seyfried and published by John Wiley & Sons. This book was released on 2012-05-18 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.

Telomeres and Telomerase in Cancer

Author : Keiko Hiyama
Publisher : Springer Science & Business Media
ISBN 13 : 1603278796
Total Pages : 375 pages
Book Rating : 4.6/5 (32 download)

DOWNLOAD NOW!

Book Synopsis Telomeres and Telomerase in Cancer by : Keiko Hiyama

Download or read book Telomeres and Telomerase in Cancer written by Keiko Hiyama and published by Springer Science & Business Media. This book was released on 2009-03-18 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: Telomerase, an enzyme that maintains telomeres and endows eukaryotic cells with immortality, was first discovered in tetrahymena in 1985. In 1990s, it was proven that this enzyme also plays a key role in the infinite proliferation of human cancer cells. Now telomere and telomerase are widely accepted as important factors involved in cancer biology, and as promising diagnostic tools and therapeutic targets. Recently, role of telomerase in “cancer stem cells” has become another attractive story. Until now, there are several good books on telomere and telomerase focusing on biology in ciliates, yeasts, and mouse or basic sciences in human, providing basic scientists or students with updated knowledge.

Genetic Instability in Cancer

Author : Tomas Lindahl
Publisher :
ISBN 13 : 9780879694852
Total Pages : 353 pages
Book Rating : 4.6/5 (948 download)

DOWNLOAD NOW!

Book Synopsis Genetic Instability in Cancer by : Tomas Lindahl

Download or read book Genetic Instability in Cancer written by Tomas Lindahl and published by . This book was released on 1996-01-01 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Oxford Textbook of Oncology

Author : David J. Kerr
Publisher : Oxford University Press
ISBN 13 : 0191065110
Total Pages : 2837 pages
Book Rating : 4.1/5 (91 download)

DOWNLOAD NOW!

Book Synopsis Oxford Textbook of Oncology by : David J. Kerr

Download or read book Oxford Textbook of Oncology written by David J. Kerr and published by Oxford University Press. This book was released on 2016-01-28 with total page 2837 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written and edited by internationally recognised leaders in the field, the new edition of the Oxford Textbook of Oncology has been fully revised and updated, taking into consideration the advancements in each of the major therapeutic areas, and representing the multidisciplinary management of cancer. Structured in six sections, the book provides an accessible scientific basis to the key topics of oncology, examining how cancer cells grow and function, as well as discussing the aetiology of cancer, and the general principles governing modern approaches to oncology treatment. The book examines the challenges presented by the treatment of cancer on a larger scale within population groups, and the importance of recognising and supporting the needs of individual patients, both during and after treatment. A series of disease-oriented, case-based chapters, ranging from acute leukaemia to colon cancer, highlight the various approaches available for managing the cancer patient, including the translational application of cancer science in order to personalise treatment. The advice imparted in these cases has relevance worldwide, and reflects a modern approach to cancer care. The Oxford Textbook of Oncology provides a comprehensive account of the multiple aspects of best practice in the discipline, making it an indispensable resource for oncologists of all grades and subspecialty interests.

Radiation Carcinogenesis

Author : Arthur C. Upton
Publisher : Elsevier Publishing Company
ISBN 13 :
Total Pages : 498 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!

Book Synopsis Radiation Carcinogenesis by : Arthur C. Upton

Download or read book Radiation Carcinogenesis written by Arthur C. Upton and published by Elsevier Publishing Company. This book was released on 1986 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the first comprehensive and systematic survey of present knowledge about radiation carcinogenesis. World experts review in detail current information on such topics as the incidence of various forms of cancer in irradiated populations, the carcinogenic effects of ionizing radiation in laboratory animals, theoretical mechanisms of radiation carcinogenesis, and the implications of the data for assessing the risks of human cancer. In view of recent controversy about the carcinogenic hazards of low-level exposure to radiation and other carcinogens, this book is a timely contribution toward our understanding of the carcinogenic risks of low-level radiation.

Health Risks from Exposure to Low Levels of Ionizing Radiation

Author : Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation
Publisher : National Academies Press
ISBN 13 : 0309133343
Total Pages : 422 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!

Book Synopsis Health Risks from Exposure to Low Levels of Ionizing Radiation by : Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation

Download or read book Health Risks from Exposure to Low Levels of Ionizing Radiation written by Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation and published by National Academies Press. This book was released on 2006-03-23 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the seventh in a series of titles from the National Research Council that addresses the effects of exposure to low dose LET (Linear Energy Transfer) ionizing radiation and human health. Updating information previously presented in the 1990 publication, Health Effects of Exposure to Low Levels of Ionizing Radiation: BEIR V, this book draws upon new data in both epidemiologic and experimental research. Ionizing radiation arises from both natural and man-made sources and at very high doses can produce damaging effects in human tissue that can be evident within days after exposure. However, it is the low-dose exposures that are the focus of this book. So-called “late” effects, such as cancer, are produced many years after the initial exposure. This book is among the first of its kind to include detailed risk estimates for cancer incidence in addition to cancer mortality. BEIR VII offers a full review of the available biological, biophysical, and epidemiological literature since the last BEIR report on the subject and develops the most up-to-date and comprehensive risk estimates for cancer and other health effects from exposure to low-level ionizing radiation.

Cancer Evolution

Author : Charles Swanton
Publisher : Perspectives Cshl
ISBN 13 : 9781621821434
Total Pages : 350 pages
Book Rating : 4.8/5 (214 download)

DOWNLOAD NOW!

Book Synopsis Cancer Evolution by : Charles Swanton

Download or read book Cancer Evolution written by Charles Swanton and published by Perspectives Cshl. This book was released on 2017 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tumor progression is driven by mutations that confer growth advantages to different subpopulations of cancer cells. As a tumor grows, these subpopulations expand, accumulate new mutations, and are subjected to selective pressures from the environment, including anticancer interventions. This process, termed clonal evolution, can lead to the emergence of therapy-resistant tumors and poses a major challenge for cancer eradication efforts. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines cancer progression as an evolutionary process and explores how this way of looking at cancer may lead to more effective strategies for managing and treating it. The contributors review efforts to characterize the subclonal architecture and dynamics of tumors, understand the roles of chromosomal instability, driver mutations, and mutation order, and determine how cancer cells respond to selective pressures imposed by anticancer agents, immune cells, and other components of the tumor microenvironment. They compare cancer evolution to organismal evolution and describe how ecological theories and mathematical models are being used to understand the complex dynamics between a tumor and its microenvironment during cancer progression. The authors also discuss improved methods to monitor tumor evolution (e.g., liquid biopsies) and the development of more effective strategies for managing and treating cancers (e.g., immunotherapies). This volume will therefore serve as a vital reference for all cancer biologists as well as anyone seeking to improve clinical outcomes for patients with cancer.

Signal Transduction in Cancer

Author : David A. Frank
Publisher : Springer Science & Business Media
ISBN 13 : 1402073402
Total Pages : 358 pages
Book Rating : 4.4/5 (2 download)

DOWNLOAD NOW!

Book Synopsis Signal Transduction in Cancer by : David A. Frank

Download or read book Signal Transduction in Cancer written by David A. Frank and published by Springer Science & Business Media. This book was released on 2002-12-31 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."

Carcinogens, Dna Damage And Cancer Risk: Mechanisms Of Chemical Carcinogenesis

Author : Miriam Christine Poirier
Publisher : World Scientific
ISBN 13 : 981323721X
Total Pages : 391 pages
Book Rating : 4.8/5 (132 download)

DOWNLOAD NOW!

Book Synopsis Carcinogens, Dna Damage And Cancer Risk: Mechanisms Of Chemical Carcinogenesis by : Miriam Christine Poirier

Download or read book Carcinogens, Dna Damage And Cancer Risk: Mechanisms Of Chemical Carcinogenesis written by Miriam Christine Poirier and published by World Scientific. This book was released on 2018-09-28 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: As chemical exposures and cancer rates increase worldwide, there is a need for students, researchers, public health professionals, and physicians to understand the mechanisms connecting exposure with human cancer risk. This new book is an essential reference, as well as introduction to the field of chemical carcinogenesis, with particular focus on DNA damage as a critical link between exposure and disease, and emphasis on biomarkers associated with cancer risk in humans. In addition to DNA damage, related topics covered include metabolism of selected chemical carcinogens, exposure-induced epigenetic changes, cancer-associated mutations and reduction of DNA damage and cancer risk by chemoprevention. The book is designed to be a comprehensive guide to basic principles, a teaching tool for academics, and a map for the development of protective mechanisms to reduce human cancer risk.

Handbook of Cancer Models with Applications

Author : W. Y. Tan
Publisher : World Scientific
ISBN 13 : 9812779485
Total Pages : 592 pages
Book Rating : 4.8/5 (127 download)

DOWNLOAD NOW!

Book Synopsis Handbook of Cancer Models with Applications by : W. Y. Tan

Download or read book Handbook of Cancer Models with Applications written by W. Y. Tan and published by World Scientific. This book was released on 2008 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: Composed of contributions from an international team of leading researchers, this book pulls together the most recent research results in the field of cancer modeling to provide readers with the most advanced mathematical models of cancer and their applications.Topics included in the book cover oncogenetic trees, stochastic multistage models of carcinogenesis, effects of ionizing radiation on cell cycle and genomic instability, induction of DNA damage by ionizing radiation and its repair, epigenetic cancer models, bystander effects of radiation, multiple pathway models of human colon cancer, and stochastic models of metastasis. The book also provides some important applications of cancer models to the assessment of cancer risk associated with various hazardous environmental agents, to cancer screening by MRI, and to drug resistance in cancer chemotherapy. An updated statistical design and analysis of xenograft experiments as well as a statistical analysis of cancer occult clinical data are also provided.The book will serve as a useful source of reference for researchers in biomathematics, biostatistics and bioinformatics; for clinical investigators and medical doctors employing quantitative methods to develop procedures for cancer diagnosis, prevention, control and treatment; and for graduate students.

Theories of Carcinogenesis

Author : Olav Hilmar Iversen
Publisher : CRC Press
ISBN 13 : 9780891165798
Total Pages : 364 pages
Book Rating : 4.1/5 (657 download)

DOWNLOAD NOW!

Book Synopsis Theories of Carcinogenesis by : Olav Hilmar Iversen

Download or read book Theories of Carcinogenesis written by Olav Hilmar Iversen and published by CRC Press. This book was released on 1988-01-01 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of an international conference held in Oslo, Aug. 1986. Topics include: philosophy of science; oncogenes; two-stage theory; aging; phenotypic cellular changes; and growth control, cell proliferation, hormonal carcinogenesis, clonality. Acidic paper. Annotation copyright Book News, Inc. Portland, Or.

Sunlight, Vitamin D and Skin Cancer

Author : Jörg Reichrath
Publisher : Springer Nature
ISBN 13 : 3030462277
Total Pages : 422 pages
Book Rating : 4.0/5 (34 download)

DOWNLOAD NOW!

Book Synopsis Sunlight, Vitamin D and Skin Cancer by : Jörg Reichrath

Download or read book Sunlight, Vitamin D and Skin Cancer written by Jörg Reichrath and published by Springer Nature. This book was released on 2020-09-11 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third edition is a comprehensive and updated overview of positive and negative effects of UV-exposure, with a focus on Vitamin D and skin cancer. Researchers, oncologists,and students will be provided with the most significant and timely information related to topics such as the epidemiology of skin cancer, the immune system and skin cancer, ultraviolet damage, DNA repair and Vitamin D in Nonmelanoma skin cancer and malignant melanoma. There have been a number of new, scientific findings in this fast moving field that necessitated a thoroughly updated and revised edition including new Vitamin D metabolites and skin cancer, new findings on the beneficial effects of UV and solar UV and skin cancer, adverse effects of sun protection and sunscreens, sun exposure and mortality, and more. The book will summarize essential, up-to-date information for every clinician or scientist interested in how to balance the positive and negative effects of UV‐exposure to minimize the risks of developing vitamin D deficiency and skin cancer.