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Cancer And Other Human Diseases
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Author :United States. Congress. House. Committee on Science and Technology. Subcommittee on Natural Resources, Agriculture Research, and Environment Publisher : ISBN 13 : Total Pages :288 pages Book Rating :4.3/5 (121 download)
Book Synopsis Cancer and Other Human Diseases by : United States. Congress. House. Committee on Science and Technology. Subcommittee on Natural Resources, Agriculture Research, and Environment
Download or read book Cancer and Other Human Diseases written by United States. Congress. House. Committee on Science and Technology. Subcommittee on Natural Resources, Agriculture Research, and Environment and published by . This book was released on 1984 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Tumor Suppressor Par-4 by : Vivek M. Rangnekar
Download or read book Tumor Suppressor Par-4 written by Vivek M. Rangnekar and published by Springer Nature. This book was released on 2022-01-01 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: Par-4 is a naturally occurring tumor suppressor. Studies have indicated that overexpression of Par-4 selectively induces apoptosis in cancer cells while leaving normal, health, cells unaffected. Mechanisms contributing to this cancer-selective action of Par-4 have been associated with PKA activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. On the other hand, endogenous Par-4 sensitizes cells to the action of a broad range of apoptotic inducers acting via the extrinsic and intrinsic pathways. A number of binding partners of Par-4 have been identified and shown to regulate Par-4 function in cancer and other diseases, such as Alzheimer’s and major depression. Recent studies have recognized a number of natural products, dietary supplements, synthetic molecules and FDA-approved drugs that induce the secretion of Par-4 protein to cause apoptosis in primary or metastatic tumors, one of which is in clinical trials. More than 50 different laboratories worldwide are involved in Par-4 based research of this unique protein that has progressed from the bench to clinical trials. This second, companion volume will provide a comprehensive overview of Par-4’s role in cancer and other diseases. Chapters are written by leading researchers, and will be useful for a broad audience across the scientific community, particularly students and trainees, who are the next generation of scientists and clinicians to participate in new studies and discoveries on Par-4.
Book Synopsis The Genetics of Cancer by : B.A. Ponder
Download or read book The Genetics of Cancer written by B.A. Ponder and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has been recognized for almost 200 years that certain families seem to inherit cancer. It is only in the past decade, however, that molecular genetics and epidemiology have combined to define the role of inheritance in cancer more clearly, and to identify some of the genes involved. The causative genes can be tracked through cancer-prone families via genetic linkage and positional cloning. Several of the genes discovered have subsequently been proved to play critical roles in normal growth and development. There are also implications for the families themselves in terms of genetic testing with its attendant dilemmas, if it is not clear that useful action will result. The chapters in The Genetics of Cancer illustrate what has already been achieved and take a critical look at the future directions of this research and its potential clinical applications.
Book Synopsis Infections Causing Human Cancer by : Harald zur Hausen
Download or read book Infections Causing Human Cancer written by Harald zur Hausen and published by John Wiley & Sons. This book was released on 2007-09-24 with total page 531 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infections must be thought as one of the most important, if not the most important, risk factors for cancer development in humans. Approximately 15-20% of all cases of cancer around the world are caused by viruses. The establishment of a causal relationship between the presence of specific infective agents and certain types of human cancer represents a key step in the development of novel therapeutic and preventive strategies. In this book, Professor zur Hausen (Nobel Prize in Physiology/Medicine 2008) provides a thorough and comprehensive overview on carcinogenic infective agents -- viruses, bacteria, parasites and protozoons -- as well as their corresponding transforming capacities and mechanisms. The result is an invaluable and instructive reference for all oncologists, microbiologists and molecular biologists working in the area of infections and cancer. The author was among the first scientists to reveal the cervical cancer-inducing mechanisms of human papilloma viruses and isolated HPV16 and HPV18, and, as early as 1976, published the hypothesis that wart viruses play a role in the development of this type of cancer.
Download or read book The pH Miracle written by Robert O. Young and published by Grand Central Life & Style. This book was released on 2008-11-16 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: Forget counting calories, fat grams, and cholesterol. Forget blood pressure, blood sugar, and hormone levels. The single most important health measurement is the pH level in your blood. Now, The pH Miracle unlocks the surprisingly crucial role pH balance plays in weight loss. How acidic or alkaline your blood is (pH levels) directly affects your health and is controlled by diet. For example, if the blood becomes overly acidic from eating too much of the wrong kinds of food -- wheat, bananas, meats, and cheese -- it can lead to weight gain, diabetes, heart disease, cancer, and more. The Youngs' program includes over 50 recipes and explains which foods to eat, which to avoid, and which supplements can help on the way towards optimal health and weight loss. In just weeks, readers will find they have more energy and a stronger immune system, and will have shed pounds and inches.
Book Synopsis The Immortal Life of Henrietta Lacks by : Rebecca Skloot
Download or read book The Immortal Life of Henrietta Lacks written by Rebecca Skloot and published by Crown. This book was released on 2010-02-02 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: #1 NEW YORK TIMES BESTSELLER • “The story of modern medicine and bioethics—and, indeed, race relations—is refracted beautifully, and movingly.”—Entertainment Weekly NOW A MAJOR MOTION PICTURE FROM HBO® STARRING OPRAH WINFREY AND ROSE BYRNE • ONE OF THE “MOST INFLUENTIAL” (CNN), “DEFINING” (LITHUB), AND “BEST” (THE PHILADELPHIA INQUIRER) BOOKS OF THE DECADE • ONE OF ESSENCE’S 50 MOST IMPACTFUL BLACK BOOKS OF THE PAST 50 YEARS • WINNER OF THE CHICAGO TRIBUNE HEARTLAND PRIZE FOR NONFICTION NAMED ONE OF THE BEST BOOKS OF THE YEAR BY The New York Times Book Review • Entertainment Weekly • O: The Oprah Magazine • NPR • Financial Times • New York • Independent (U.K.) • Times (U.K.) • Publishers Weekly • Library Journal • Kirkus Reviews • Booklist • Globe and Mail Her name was Henrietta Lacks, but scientists know her as HeLa. She was a poor Southern tobacco farmer who worked the same land as her slave ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine: The first “immortal” human cells grown in culture, which are still alive today, though she has been dead for more than sixty years. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions. Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave. Henrietta’s family did not learn of her “immortality” until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family—past and present—is inextricably connected to the dark history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of. Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family—especially Henrietta’s daughter Deborah. Deborah was consumed with questions: Had scientists cloned her mother? Had they killed her to harvest her cells? And if her mother was so important to medicine, why couldn’t her children afford health insurance? Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences.
Book Synopsis Multiple Myeloma and Other Plasma Cell Neoplasms by : Meletios A. Dimopoulos
Download or read book Multiple Myeloma and Other Plasma Cell Neoplasms written by Meletios A. Dimopoulos and published by Springer. This book was released on 2018-02-16 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive source of up-to-date information on plasma cell neoplasms. Key features include the provision of new criteria for the diagnosis of symptomatic multiple myeloma requiring treatment and the description of novel therapies for myeloma and other plasma cell neoplasms that have only very recently been licensed by the U.S. Food and Drug Administration. Examples include lenalidomide as first-line therapy, panobinostat in combination with bortezomib plus dexamethasone for relapsed/refractory myeloma, ibrutinib for Waldenström’s macroglobulinemia, and new therapeutic regimens for systemic amyloidosis and POEMS syndrome. Information is also provided on drug combinations that have shown encouraging results and are very near to approval. Other important aspects covered in the book are the role of different imaging modalities in workup and the significance of newly acquired data relating to prognosis and minimal residual disease. Readers will find Multiple Myeloma and Other Plasma Cell Neoplasms to be a rich source of knowledge that will be invaluable in improving patient management.
Download or read book The Cancer Atlas written by Ahmedin Jemal and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This atlas illustrates the latest available data on the cancer epidemic, showing causes, stages of development, and prevalence rates of different types of cancers by gender, income group, and region. It also examines the cost of the disease, both in terms of health care and commercial interests, and the steps being taken to curb the epidemic, from research and screening to cancer management programs and health education.
Book Synopsis How Tobacco Smoke Causes Disease by :
Download or read book How Tobacco Smoke Causes Disease written by and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Book Synopsis Targeting Lysine Demethylases in Cancer and Other Human Diseases by : Qin Yan
Download or read book Targeting Lysine Demethylases in Cancer and Other Human Diseases written by Qin Yan and published by Springer Nature. This book was released on 2023-10-28 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive summary of our current knowledge on lysine demethylases, a class of epigenetic regulators. It takes the reader on an exciting journey spanning the past two decades, starting from the initial discovery and characterization of these enzymes and leading up to the development of their small molecule modulators. These modulators have shown promise in clinical trials and hold great potential to improve patient outcomes. The book captures the progress made in this field and highlights the significant advancements that have paved the way for potential therapeutic applications. The book covers a wide range of topics, spanning both basic biology and clinical implications associated with lysine demethylases. It offers a comprehensive historical and conceptual framework for the discovery and characterization of similar epigenetic enzymes or modulators. Chapter one serves as an introductory overview, providing insights into the general characteristics and functions of lysine demethylases. In subsequent chapters, specifically chapters two to eight, each major family of lysine demethylases is individually explored in depth. By providing in-depth insights into the functional aspects of these enzymes, the book allows readers to grasp their significance in regulating cellular processes and influencing pathogenesis. Moreover, the book goes beyond fundamental knowledge and also explores the development of diagnostic and therapeutic strategies related to lysine demethylases. It highlights the potential for utilizing these enzymes as therapeutic targets for the treatment of various diseases, including cancer and infectious diseases. Additionally, the book highlights future directions aimed at further unraveling the roles of lysine demethylases and translating these findings into the clinic.
Book Synopsis Cancer and Noncoding RNAs by : Jayprokas Chakrabarti
Download or read book Cancer and Noncoding RNAs written by Jayprokas Chakrabarti and published by Academic Press. This book was released on 2017-10-13 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer and Noncoding RNAs offers an in-depth exploration of noncoding RNAs and their role in epigenetic regulation of complex human disease, most notably cancer. In addition to examining microRNAs, this volume provides a unique evaluation of more recently profiled noncoding RNAs now implicated in carcinogenesis, including lncRNAs, piRNAs, circRNAs, and tRNAs, identifying differences in function between these noncoding RNAs and how they interact with the rest of the epigenome. A broad range of chapters from experts in the field detail epigenetic regulation of various cancer types, along with recent next generation sequencing technologies, genome-wide association studies (GWAS) and bioinformatics approaches. This book will help researchers in genomic medicine and cancer biology better understand the role of noncoding RNAs in epigenetics, aiding in the development of useful biomarkers for diagnosis, prognosis and new RNA-based disease therapies. Provides a comprehensive analysis of noncoding RNAs implicated in epigenetic regulation of gene expression and chromatin dynamics Educates researchers and graduate students by highlighting, in addition to miRNAs, a range of noncoding RNAs newly associated with carcinogenesis Applies current knowledge of noncoding RNAs and epigenomics towards developing cancer and RNA-based disease therapies Features contributions by leading experts in the field
Book Synopsis The Alchemy of Disease by : John Whysner
Download or read book The Alchemy of Disease written by John Whysner and published by Columbia University Press. This book was released on 2020-06-02 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the dawn of the industrial age, we have unleashed a bewildering number of potentially harmful chemicals. But out of this vast array, how do we identify the actual threats? What does it take to prove that a certain chemical causes cancer? How do we translate academic knowledge of the toxic effects of particular substances into understanding real-world health consequences? The science that answers these questions is toxicology. In The Alchemy of Disease, John Whysner offers an accessible and compelling history of toxicology and its key findings. He details the experiments and discoveries that revealed the causal connections between chemical exposures and diseases. Balancing clear accounts of groundbreaking science with human drama and public-policy relevance, Whysner describes key moments in the development of toxicology and their thorny social and political implications. The book features discussions of toxicological problems past and present, including DDT, cigarettes and other carcinogens, lead poisoning, fossil fuels, chemical warfare, pharmaceuticals—including opioids—and the efficacy of animal testing. Offering valuable insight into the science and politics of crucial public-health concerns, The Alchemy of Disease shows that toxicology’s task—pinpointing the chemical cause of an illness—is as compelling as any detective story.
Book Synopsis mTOR in Human Diseases by : Olivier Dormond
Download or read book mTOR in Human Diseases written by Olivier Dormond and published by MDPI. This book was released on 2019-06-18 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mechanistic target of rapamycin (mTOR) is a major signaling intermediary that coordinates favorable environmental conditions with cell growth. Indeed, as part of two functionally distinct protein complexes, named mTORC1 and mTORC2, mTOR regulates a variety of cellular processes, including protein, lipid, and nucleotide synthesis, as well as autophagy. Over the last two decades, major molecular advances have been made in mTOR signaling and have revealed the complexity of the events implicated in mTOR function and regulation. In parallel, the role of mTOR in diverse pathological conditions has also been identified, including in cancer, hamartoma, neurological, and metabolic diseases. Through a series of articles, this book focuses on the role played by mTOR in cellular processes, metabolism in particular, and highlights a panel of human diseases for which mTOR inhibition provides or might provide benefits. It also addresses future studies needed to further characterize the role of mTOR in selected disorders, which will help design novel therapeutic approaches. It is therefore intended for everyone who has an interest in mTOR biology and its application in human pathologies.
Book Synopsis The American Cancer Society's Principles of Oncology by : The American Cancer Society
Download or read book The American Cancer Society's Principles of Oncology written by The American Cancer Society and published by John Wiley & Sons. This book was released on 2018-03-20 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developed by the American Cancer Society this new textbook designed for a wide range of learners and practitioners is a comprehensive reference covering the diagnosis of cancer, and a range of related issues that are key to a multidisciplinary approach to cancer and critical to cancer control and may be used in conjunction with the book, The American Cancer Society's Oncology in Practice: Clinical Management. Edited by leading clinicians in the field and a stellar contributor list from the US and Europe, this book is written in an easy to understand style by multidisciplinary teams of medical oncologists, radiation oncologists and other specialists, reflecting day-to-day decision-making and clinical practice. Input from pathologists, surgeons, radiologists, and other specialists is included wherever relevant and comprehensive treatment guidelines are provided by expert contributors where there is no standard recognized treatment. This book is an ideal resource for anyone seeking a deeper understanding of cancer prevention, screening, and follow-up, which are central to the ACS's worldwide mission on cancer control.
Book Synopsis Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging by : M. A. Hayat
Download or read book Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging written by M. A. Hayat and published by Academic Press. This book was released on 2016-12-28 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections. Presents the most advanced information regarding the role of the autophagic system in life and death Examines whether autophagy acts fundamentally as a cell survivor or cell death pathway or both Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation Features recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, including atherosclerosis and CNS tumors, and their development and treatment Includes chapters authored by leaders in the field around the globe—the broadest, most expert coverage available
Book Synopsis Molecular Epidemiology by : Timothy R. Rebbeck
Download or read book Molecular Epidemiology written by Timothy R. Rebbeck and published by CRC Press. This book was released on 2008-05-21 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume comprises the investigation of factors that may predict the response to treatment, outcome, and survival by exploring: • design considerations in molecular epidemiology, including: case-only family-based approaches for evaluation of genetic susceptibility to exposure and addiction pharmacogenetics incorporation of biomarkers in clinical trials • measurement issues in molecular epidemiology, including DNA biosampling methods principles for high-quality genotyping haplotypes biomarkers of exposure and effect exposure assessment • methods of statistical inference used in molecular epidemiology, including gene-gene and gene-environment interaction analysis novel high-dimensional analysis approaches pathway-based analysis methods haplotype methods, dealing with race and ethnicity risk models a discussion of reporting and interpreting results • A specific discussion and synopsis of these methods provides concrete examples drawn from primary research in cancer Covering design considerations, measurement issues, and methods of statistical inference, and filled with scientific tables, equations, and pictures, Molecular Epidemiology: Applications in Cancer and Other Human Diseases presents a solid, single-source foundation for conducting and interpreting molecular epidemiological studies.
Book Synopsis Reducing Environmental Cancer Risk by : Suzanne H. Reuben
Download or read book Reducing Environmental Cancer Risk written by Suzanne H. Reuben and published by DIANE Publishing. This book was released on 2010-10 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Though overall cancer incidence and mortality have continued to decline in recent years, cancer continues to devastate the lives of far too many Americans. In 2009 alone, 1.5 million American men, women, and children were diagnosed with cancer, and 562,000 died from the disease. There is a growing body of evidence linking environmental exposures to cancer. The Pres. Cancer Panel dedicated its 2008¿2009 activities to examining the impact of environmental factors on cancer risk. The Panel considered industrial, occupational, and agricultural exposures as well as exposures related to medical practice, military activities, modern lifestyles, and natural sources. This report presents the Panel¿s recommend. to mitigate or eliminate these barriers. Illus.
