Calcium Regulation By Calcium Binding Proteins In Neurodegenerative Disorders

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Calcium Regulation by Calcium-Binding Proteins in Neurodegenerative Disorders

Author : Claus W. Heizmann
Publisher : Springer Science & Business Media
ISBN 13 : 3662216892
Total Pages : 167 pages
Book Rating : 4.6/5 (622 download)

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Book Synopsis Calcium Regulation by Calcium-Binding Proteins in Neurodegenerative Disorders by : Claus W. Heizmann

Download or read book Calcium Regulation by Calcium-Binding Proteins in Neurodegenerative Disorders written by Claus W. Heizmann and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes the recent advances in the knowledge of the structure and physiological functions of the calcium-binding proteins in the central nervous system, describes their cellular distribution and developmental appearance, and discusses their possible association with neurodegenerative disorders and their use as diagnostic tools. This is the first book describing the structure, localization, and functions of calcium-binding proteins in the central nervous system and their involvement in neurodegenerative disorders. It is of great value to neurobiologists, clinicians, pharmacologists, biochemists and molecular biologists.

Calcium: The molecular basis of calcium action in biology and medicine

Author : R. Pochet
Publisher : Springer Science & Business Media
ISBN 13 : 9401006881
Total Pages : 746 pages
Book Rating : 4.4/5 (1 download)

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Book Synopsis Calcium: The molecular basis of calcium action in biology and medicine by : R. Pochet

Download or read book Calcium: The molecular basis of calcium action in biology and medicine written by R. Pochet and published by Springer Science & Business Media. This book was released on 2011-06-28 with total page 746 pages. Available in PDF, EPUB and Kindle. Book excerpt: The enormous and varied role of calcium in living systems is now widely appreciated by both cell biologists and clinicians. The identification and characterisation of new calcium binding proteins and regulatory pathways is matched by the recognition of the involvement of calcium binding proteins in a growing number of disease states. This book is intended to introduce clinicians to fundamental biological research, whilst at the same time attracting researchers to the clinical world. The publication of the book coincides with the elucidation of the complete Human Genomic Sequence. As a result of this, scientists now have access to an unprecedented array of data, from which new calcium binding proteins and hence new regulatory pathways will undoubtedly be discovered. It is a further aim of this book to provide a `key' to open the door to the new postgenomic era. The book is in three parts. The first section introduces the reader to the role of calcium in cell biology, providing an appreciation of how this small, simple, non-metabolisable agent can move rapidly and silently through the different cellular compartments, thereby influencing and controlling the fate of the cell. This section also illustrates and dissects the often-complex interplay between calcium and numerous agents in muscle and endocrine cells, neurons, hepatocytes, and platelets. In the second section the reader will discover the role of calcium and its partners in common diseases such as migraine and drug dependence. New classes of diseases such as annexinopathies, channelopathies, calcium-sensing disorders, and citrullinemia are discussed, and the authors give many new insights into the molecular mechanisms of the diseases, thereby explaining how and why they occur. Such information is clearly of primary importance for the pharmaceutical industry. New ideas and concepts of neurodegenerative diseases are introduced, which should stimulate new approaches. Clinicians will also have access, in a comprehensive and authoritative yet highly readable chapter, to data from recent large-scale clinical studies on the numerous and widely prescribed calcium antagonists. The final section gives information on new methods and devices for calcium imaging, and illustrates how calcium movement and change can be monitored and ingeniously utilised as a fast, cheap, and accurate drug screening instrument.

Calcium-Binding Proteins in Health and Disease

Author : Anthony Norman
Publisher : Elsevier
ISBN 13 : 0323141420
Total Pages : 650 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Calcium-Binding Proteins in Health and Disease by : Anthony Norman

Download or read book Calcium-Binding Proteins in Health and Disease written by Anthony Norman and published by Elsevier. This book was released on 2012-12-02 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: Calcium-Binding Proteins in Health and Disease includes the papers prepared by the invited speakers as well as many of the free communications. The contributions are grouped according to their general subject matter, based on the classification made by the authors, e.g., Extracellular Metabolism: Calcium Homeostasis; Low-Affinity Calcium-Binding Proteins. There can be little doubt that calcium-binding proteins is a field of scientific endeavor which will continue to produce results of great interest to modern biology. This book is divided into eight sections, the first of which, tackle extracellular calcium metabolism or calcium homeostasis. The next sections focus on topics such as low-affinity calcium-binding proteins; calcium and membranes, channels and transport (pumps); the role of calcium in complex metabolic processes; and gene structure of calcium-binding proteins and their expression. Other chapters cover physical studies on calcium-binding proteins, including X-ray, crystallography, and NMR; structure-function relationships of calcium-binding proteins and their targets; and calcium-binding proteins in health and disease. This book will be of interest to practitioners in the fields of biology and medicine.

Calcium Signaling: From Physiology to Diseases

Author : Senthilkumar Rajagopal
Publisher : Springer
ISBN 13 : 9811051607
Total Pages : 106 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Calcium Signaling: From Physiology to Diseases by : Senthilkumar Rajagopal

Download or read book Calcium Signaling: From Physiology to Diseases written by Senthilkumar Rajagopal and published by Springer. This book was released on 2017-09-28 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on disorders of calcium channels and the use of drugs to treat calcium-related disorders and their associated toxicities. In particular, it discusses the role of various natural products and their attributes in preventing problems associated with calcium imbalances. In addition, the book analyzes trends in the processing of natural products using nanotechnology and their implications in calcium-related disorders. Lastly, it explores some of the most promising aspects of research into calcium signalling disorders – which is especially important, given the wide variety of cellular processes that are controlled by calcium ions – and provides a trustworthy source of up-to-date information in this area of research.

Calcium-binding Proteins in Avian and Mammalian Central Nervous System

Author : Katharina Braun
Publisher : Lubrecht & Cramer, Limited
ISBN 13 :
Total Pages : 82 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis Calcium-binding Proteins in Avian and Mammalian Central Nervous System by : Katharina Braun

Download or read book Calcium-binding Proteins in Avian and Mammalian Central Nervous System written by Katharina Braun and published by Lubrecht & Cramer, Limited. This book was released on 1990 with total page 82 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Calcium Signalling in Alzheimer’s Disease

Author : Mounia Chami
Publisher : MDPI
ISBN 13 : 3036504982
Total Pages : 162 pages
Book Rating : 4.0/5 (365 download)

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Book Synopsis Calcium Signalling in Alzheimer’s Disease by : Mounia Chami

Download or read book Calcium Signalling in Alzheimer’s Disease written by Mounia Chami and published by MDPI. This book was released on 2021-04-22 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer’s disease (AD) is the most well-known neurodegenerative disorder, causing dementia. In recent decades, several studies have reported calcium dysregulation in AD occurring through the intervention of several calcium receptors and channels, and affecting different cellular compartments, such as mitochondria, the endoplasmic reticulum, lysosomes, and microdomains within the plasma membrane. Calcium signalling dysregulation is now considered a common proximal cause of dysfunctional neurons and glial supporting cells. This book gathers the newest results and advances in calcium signaling deregulation mechanisms in AD, how they are linked to other players involved in AD, and the potential therapies targeting calcium alterations to treat AD.

Investigation of the Calcium Binding Protein (calbindin-D28k) Gene

Author : Anthony M. Iacopino
Publisher :
ISBN 13 :
Total Pages : 294 pages
Book Rating : 4.:/5 (229 download)

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Book Synopsis Investigation of the Calcium Binding Protein (calbindin-D28k) Gene by : Anthony M. Iacopino

Download or read book Investigation of the Calcium Binding Protein (calbindin-D28k) Gene written by Anthony M. Iacopino and published by . This book was released on 1990 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Novel Calcium-Binding Proteins

Author : Claus W. Heizmann
Publisher : Springer Science & Business Media
ISBN 13 : 364276150X
Total Pages : 606 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Novel Calcium-Binding Proteins by : Claus W. Heizmann

Download or read book Novel Calcium-Binding Proteins written by Claus W. Heizmann and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt: A wide variety of hormones, neurotransmitters and growth factors exert their cellular effects by reacting first with membrane receptors resulting in an increase of intracellular calcium and the cellular response. The calcium signal in the cell is mediated by the high-affinity calcium binding proteins (characterized by the EF-hand structural element), and by the calcium and phospholipid dependent proteins. Many of these have been discovered most recently. Their purification, distribution, protein and gene structures as well as their physiological roles are discussed. The book is of interest to biochemists and molecular biologists as well as to clinicians and the pharmaceutical industry who can apply the results in this field.

Neuronal Calcium Sensors in Health and Disease

Author : Karl-Wilhelm Koch
Publisher : Frontiers Media SA
ISBN 13 : 288963342X
Total Pages : 313 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Neuronal Calcium Sensors in Health and Disease by : Karl-Wilhelm Koch

Download or read book Neuronal Calcium Sensors in Health and Disease written by Karl-Wilhelm Koch and published by Frontiers Media SA. This book was released on 2020-01-16 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Calcium Binding Proteins in Normal and Transformed Cells

Author : R. Pochet
Publisher : Springer Science & Business Media
ISBN 13 : 1468457543
Total Pages : 212 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Calcium Binding Proteins in Normal and Transformed Cells by : R. Pochet

Download or read book Calcium Binding Proteins in Normal and Transformed Cells written by R. Pochet and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the First European Symposium held in Brussels, Belgium, April 20--22, 1989

The “Calcium Paradox” and its Impact on Neurological and Psychiatric Diseases (Second Edition)

Author : Leandro Bueno Bergantin
Publisher : Cambridge Scholars Publishing
ISBN 13 : 1527518345
Total Pages : 136 pages
Book Rating : 4.5/5 (275 download)

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Book Synopsis The “Calcium Paradox” and its Impact on Neurological and Psychiatric Diseases (Second Edition) by : Leandro Bueno Bergantin

Download or read book The “Calcium Paradox” and its Impact on Neurological and Psychiatric Diseases (Second Edition) written by Leandro Bueno Bergantin and published by Cambridge Scholars Publishing. This book was released on 2018-10-09 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book extends the original concept of the “calcium paradox” discovery, herein compiling more than 300 references in the field of calcium ion (Ca2+/cAMP) signalling pathways, neurotransmission and neurodegeneration, and neurological and psychiatric diseases. In this second edition, novel illustrations and tables (highlighting current medicines for treating these diseases, including their mechanism of action) offer improved insights into the concepts for students and clinicians. The description of other neurodegenerative diseases (Spinal muscular atrophy, Amyotrophic Lateral Sclerosis and Huntington´s disease) also adds further information with regards to treating these diseases. The growing increment in the life expectancy of the world's population has increased concern about age-related neurological diseases (neurodegenerative diseases), such as Alzheimer’s (AD) and Parkinson’s (PD) diseases, among others. It is now well-recognized that an imbalance of intracellular Ca2+ homeostasis contributes to the pathogenesis of neurological diseases like neurodegenerative diseases, including AD and PD, and others. Healthy brain aging can be promoted by regular exercise, moderation in caloric intake and engaging in intellectually challenging activities. These lifestyle factors may stabilize neuronal Ca2+ homeostasis. The discovery of the role of the “calcium paradox” due to the interaction between Ca2+ and cAMP signalling pathways (Ca2+/cAMP interaction) in neurotransmission, and neuroprotection, has subsidized the understanding of pathophysiology, and pharmacology, of the neurological and psychiatric diseases, opening a large pathway for the advancement of new pharmacological strategies for the treatment of these diseases. The proposal outlined in this book involves pharmaceuticals already approved, and may, in combination with improvements in lifestyle factors, allow sustained increments in the life quality of age-related neurological patients. Finally, this book briefly discusses other aspects of Ca2+/cAMP signalling pathways, such as their possible implications on cancer.

Calcium-Binding Proteins and Rage

Author : Claus Heizmann
Publisher : Humana Press
ISBN 13 : 9781493959761
Total Pages : 440 pages
Book Rating : 4.9/5 (597 download)

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Book Synopsis Calcium-Binding Proteins and Rage by : Claus Heizmann

Download or read book Calcium-Binding Proteins and Rage written by Claus Heizmann and published by Humana Press. This book was released on 2016-05-01 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Methods in Molecular Biology book reviews common techniques for studying calcium binding proteins, underlining the diagnostic and clinical importance of this family of proteins. Offers materials lists, protocols, troubleshooting advice and more."

Calcium and Calcium Binding Proteins

Author : Charles Gerday
Publisher : Springer Science & Business Media
ISBN 13 : 3642730426
Total Pages : 265 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Calcium and Calcium Binding Proteins by : Charles Gerday

Download or read book Calcium and Calcium Binding Proteins written by Charles Gerday and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: The idea of Professors Bolis and Gilles to gather together for a 3 days' meeting in the splendid environment of Crans-Montana in Switzerland a limited number of people around the subject of calcium and calcium bind ing proteins seemed at first particularly attractive, and when they asked me to take charge of the scientific organization of the symposium, I accepted with enthusiasm. It rapidly became clear that the major problem would be the selection of the topics, since it was impossible to cover completely and in depth such a broad and dynamic area of research. In our view, one imperative was to associate as intimately as possible the structural and the functional aspects of the areas covered. Apart from one whole day focused on the fascinating roles played by calmodulin in cellular activities, the other sessions were devoted to calmodulin-related calcium binding proteins in muscle and non muscle tissues and to some selected biological systems such as mitochondria, secretory cells or sarcoplasmic reticulum in which calcium also plays a crucial role. The presentations were made by leading investigators in their field. Some of them do not, however, appear in the present volume, for which there are two reasons: first, some of the contributions were somewhat outside the scope of the book; second, three speakers, for valid reasons, simply found no opportunity to write a manuscript in the allotted time.

Calcium Signalling and Disease

Author : Ernesto Carafoli
Publisher : Springer Science & Business Media
ISBN 13 : 1402061919
Total Pages : 591 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Calcium Signalling and Disease by : Ernesto Carafoli

Download or read book Calcium Signalling and Disease written by Ernesto Carafoli and published by Springer Science & Business Media. This book was released on 2007-09-29 with total page 591 pages. Available in PDF, EPUB and Kindle. Book excerpt: Authors highlight several promising discoveries in the field of calcium signaling that provide new information about both genetic and acquired pathologies. Their discussions will give you new insights into the underlying causes of congenital and acquired diseases and point the way to new, even more promising research and therapies.

Biochemistry of Smooth Muscle Contraction

Author : Michael Barany
Publisher : Elsevier
ISBN 13 : 0080527892
Total Pages : 455 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Biochemistry of Smooth Muscle Contraction by : Michael Barany

Download or read book Biochemistry of Smooth Muscle Contraction written by Michael Barany and published by Elsevier. This book was released on 1996-01-04 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: This valuable resource provides a systematic account of the biochemistry of smooth muscle contraction. As a comprehensive guide to this rapidly growing area of research, it covers the structure and characteristic properties of contractile and regulatory proteins, with special emphasis on their predicted function in the live muscle. Also included in this book are intermediate filament proteins, and desmin and vimentin, whose function in smooth muscle is unknown; and several enzymes involved in the phosphorylation-dephosphorylation of contractile and other proteins.

Interrelations between Essential Metal Ions and Human Diseases

Author : Astrid Sigel
Publisher : Springer Science & Business Media
ISBN 13 : 9400775008
Total Pages : 603 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Interrelations between Essential Metal Ions and Human Diseases by : Astrid Sigel

Download or read book Interrelations between Essential Metal Ions and Human Diseases written by Astrid Sigel and published by Springer Science & Business Media. This book was released on 2014-01-27 with total page 603 pages. Available in PDF, EPUB and Kindle. Book excerpt: MILS-13 provides an up-to-date review on the relationships between essential metals and human diseases, covering 13 metals and 3 metalloids: The bulk metals sodium, potassium, magnesium, and calcium, plus the trace elements manganese, iron, cobalt, copper, zinc, molybdenum, and selenium, all of which are essential for life. Also covered are chromium, vanadium, nickel, silicon, and arsenic, which have been proposed as being essential for humans in the 2nd half of the last century. However, if at all, they are needed only in ultra-trace amounts, and because of their prevalence in the environment, it has been difficult to prove whether or not they are required. In any case, all these elements are toxic in higher concentrations and therefore, transport and cellular concentrations of at least the essential ones, are tightly controlled; hence, their homeostasis and role for life, including deficiency or overload, and their links to illnesses, including cancer and neurological disorders, are thoroughly discussed. Indeed, it is an old wisdom that metals are indispensable for life. Therefore, Volume 13 provides in an authoritative and timely manner in 16 stimulating chapters, written by 29 internationally recognized experts from 7 nations, and supported by more than 2750 references, and over 20 tables and 80 illustrations, many in color, a most up-to-date view on the vibrant research area of the Interrelations between Essential Metal Ions and Human Diseases.

Store-Operated Calcium Channels

Author :
Publisher : Academic Press
ISBN 13 : 0124079385
Total Pages : 307 pages
Book Rating : 4.1/5 (24 download)

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Book Synopsis Store-Operated Calcium Channels by :

Download or read book Store-Operated Calcium Channels written by and published by Academic Press. This book was released on 2013-07-24 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Store-operated calcium channels are found in most animal cells and regulate many cellular functions including cell division, growth, differentiation, and cell death. This volume provides a concise and informative overview of the principles of store-operated calcium entry and the key developments in the field from researchers who have led these advances. The overall goal of the volume is to provide interested students and investigators with sufficient information to enable a broad understanding of the progress and current excitement in the field. The volume contains a wealth of information that even experienced investigators in the field will find useful. - The volume provides a comprehensive overview of the mechanisms and functions of store-operated calcium channels - Contributors are authoritative researchers who have produced important advances in the field - The volume is well-illustrated with cartoons and data to facilitate easy comprehension of the subject