Breast Cancer Cells Cooperate During Invasion And Metastasis

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Breast Cancer Cells Cooperate During Invasion and Metastasis

Author : Louisiane Perrin
Publisher :
ISBN 13 :
Total Pages : 104 pages
Book Rating : 4.:/5 (128 download)

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Book Synopsis Breast Cancer Cells Cooperate During Invasion and Metastasis by : Louisiane Perrin

Download or read book Breast Cancer Cells Cooperate During Invasion and Metastasis written by Louisiane Perrin and published by . This book was released on 2021 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metastasis continues to be the leading cause of breast cancer-related deaths. Metastasis is a multistep process during which cancer cells leave the primary tumor, invade and seed inside secondary tissues, leading to lethal organ failure. Currently, no efficient method exists for the elimination of invasive cancer cells, which poses a major clinical challenge. Indeed, while localized cancers are clinically manageable, invasive breast cancer is largely an uncurable disease. Understanding how cancer cells sustain an invasive behavior may lead to the development of novel potent therapies.A vast genetic and phenotypic heterogeneity exists among invasive cancer cells. This heterogeneity is important to investigate as, in breast cancer patients, most metastatic nodules are polyclonal and consist of cancer cells that invaded and disseminated collectively. While recent studies demonstrated that collective invasion can be cooperative, where leader cells enable the invasion of otherwise non-invasive follower cells, the mechanisms regulating their cooperativity have been poorly investigated. Additionally, it is not known whether cooperative invasion can lead to metastasis, where metastatic cells enable the dissemination of non-metastatic cells. Our laboratory previously showed that breast cancer cells can locally degrade the extracellular matrix using invadopodia, which are membrane protrusions enriched in matrix metalloproteinases. Importantly, invadopodia are required for metastasis of single cancer cells. However, whether invadopodia enable the collective invasion and metastasis of cancer cell clusters remains unknown. Further, the role of invadopodia-mediated matrix degradation in leader vs. follower cells is unclear. In this dissertation, we aim to understand how cancer clones with and without invadopodia may cooperate during invasion and metastasis. Our results suggest that a few cells with invadopodia can drive the metastasis of cell clusters from multiclonal tumors. From this work, we believe that a more detailed understanding of how cancer cells cooperate may help in identifying new targets for preventing metastasis.

Defining the Pro-metastatic Functions of LPP in Breast Cancer

Author : Yi Ling Elaine Ngan
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (964 download)

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Book Synopsis Defining the Pro-metastatic Functions of LPP in Breast Cancer by : Yi Ling Elaine Ngan

Download or read book Defining the Pro-metastatic Functions of LPP in Breast Cancer written by Yi Ling Elaine Ngan and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Metastatic breast cancer remains the biggest challenge to the successful treatment of this disease. Overexpression of the HER2/ErbB2 receptor tyrosine kinase is associated with metastatic disease and correlates with reduced patient survival. TGF[beta] can activate signaling pathways that cooperate with ErbB2 to enhance the migratory, invasive and metastatic behavior of breast cancer cells. Furthermore, TGF[beta] is a strong inducer of an epithelial-to-mesenchymal transition (EMT), and breast cancers with EMT features are associated with poor clinical outcomes.Using a panel of ErbB2-overexpressing breast cancer cells that undergo TGF[beta]-induced EMT, I identified Lipoma Preferred Partner (LPP) as an indispensable mediator of breast cancer cell migration and invasion in vitro. I show that LPP is recruited to focal adhesion (FA) complexes through its LIM1 domain and subsequently recruits [alpha]-actinin, an actin cross-linking protein, as a mechanism to facilitate FA dynamics, enhance cell migration, and increase cell invasion of breast cancer cells that can undergo an EMT. In addition, I have discovered a novel role for LPP in invadopodia formation, ECM degradation and breast cancer metastasis. Live-cell time-lapse intravital imaging in a chick chorioallantoic membrane (CAM) system reveals that LPP localizes to invadopodia during breast cancer extravasation. In mouse xenograft models, loss of LPP leads to a significant impairment in spontaneous lung metastasis formation, while primary mammary tumor growth is unaffected. Moreover, I demonstrate that LPP is necessary for the efficient dissemination of breast cancer cells from the primary tumor, as diminished LPP expression significantly reduces the number of detectable circulating tumor cells, and impairs the extravasation of breast cancer cells to establish pulmonary metastasis. Together, these data demonstrate that LPP promotes breast cancer metastasis through its role in mediating invadopodia formation to drive tumor cell invasion and colonization of secondary sites. Finally, I have identified LPP as a novel substrate of the c-Src tyrosine kinase in response to TGF[beta]-stimulation. In multiple murine and human breast cancer cell lines, LPP is tyrosine-phosphorylated following TGF[beta] treatment, and this phosphorylation can be blocked using pharmacological inhibitors against Src family kinases. ErbB2-expressing breast cancer cells specifically lacking Src also revealed impaired LPP phosphorylation in response to TGF[beta]. To elucidate the potential consequences of LPP phosphorylation, I constructed a panel of LPP phospho-mutants and demonstrated that phosphorylation of Y245, Y301 and Y302 within LPP is required for cellular invasion, invadopodia formation, ECM degradation and breast cancer metastasis.Collectively, the work described in this thesis is the first to define LPP as a novel pro-metastatic mediator that integrates TGF[beta] and ErbB2 signaling to promote the migration, invasion and metastasis of breast cancer cells." --

Metastasis of Breast Cancer

Author : R.E. Mansel
Publisher : Springer Science & Business Media
ISBN 13 : 1402058667
Total Pages : 439 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Metastasis of Breast Cancer by : R.E. Mansel

Download or read book Metastasis of Breast Cancer written by R.E. Mansel and published by Springer Science & Business Media. This book was released on 2007-06-14 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by experts in the subject area, the book covers a broad range of topics in the metastasis of breast cancer, from genetics, biology to clinical management. Main topics include genetic control, biology, growth factors, cell adhesion, cell motility and invasion, natures of bone metastasis, sentinel node therapies, hormonal links, new biomarkers and detection of micrometastasis and diagnosis. This timely book also covers the current treatment options.

Systems Biology of Cancer

Author : Sam Thiagalingam
Publisher : Cambridge University Press
ISBN 13 : 0521493390
Total Pages : 597 pages
Book Rating : 4.5/5 (214 download)

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Book Synopsis Systems Biology of Cancer by : Sam Thiagalingam

Download or read book Systems Biology of Cancer written by Sam Thiagalingam and published by Cambridge University Press. This book was released on 2015-04-09 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.

Breast Cancer Biology

Author : Dil Afroze
Publisher : BoD – Books on Demand
ISBN 13 : 1789239613
Total Pages : 127 pages
Book Rating : 4.7/5 (892 download)

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Book Synopsis Breast Cancer Biology by : Dil Afroze

Download or read book Breast Cancer Biology written by Dil Afroze and published by BoD – Books on Demand. This book was released on 2020-07-08 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a comprehensive overview of recent developments in the field of breast cancer biology. It is a complete and descriptive reference on motioning pathways and new treatment options for the future transnational scientists and clinicians working on cancer research and treatment. We greatly appreciate the work of all the contributors to this book. They have brought with them tremendous diversity of perspectives and fields, which is truly reflective of the complexity of the topic, and they have come together in this project to serve as the node of multidisciplinary collaboration in this field. Finally, we must acknowledge the thousands of cancer patients who have participated in the studies, and who have inspired us to gather information to significantly progress knowledge in the field in recent years.

Breast Cancer

Author : Mehmet Gunduz
Publisher : BoD – Books on Demand
ISBN 13 : 9533077662
Total Pages : 598 pages
Book Rating : 4.5/5 (33 download)

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Book Synopsis Breast Cancer by : Mehmet Gunduz

Download or read book Breast Cancer written by Mehmet Gunduz and published by BoD – Books on Demand. This book was released on 2011-12-14 with total page 598 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is the leading cause of death in most countries and its consequences result in huge economic, social and psychological burden. Breast cancer is the most frequently diagnosed cancer type and the leading cause of cancer death among females. In this book, we discussed characteristics of breast cancer cell, role of microenvironment, stem cells and metastasis for this deadly cancer. We hope that this book will contribute to the development of novel diagnostic as well as therapeutic approaches.

Epithelial-Mesenchymal Plasticity in Cancer Metastasis

Author : Mohit Kumar Jolly
Publisher : MDPI
ISBN 13 : 3039367242
Total Pages : 512 pages
Book Rating : 4.0/5 (393 download)

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Book Synopsis Epithelial-Mesenchymal Plasticity in Cancer Metastasis by : Mohit Kumar Jolly

Download or read book Epithelial-Mesenchymal Plasticity in Cancer Metastasis written by Mohit Kumar Jolly and published by MDPI. This book was released on 2020-12-29 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent studies have highlighted that epithelial-mesenchymal transition (EMT) is not only about cell migration and invasion, but it can also govern many other important elements such as immunosuppression, metabolic reprogramming, senescence-associated secretory phenotype (SASP), stem cell properties, therapy resistance, and tumor microenvironment interactions. With the on-going debate about the requirement of EMT for cancer metastasis, an emerging focus on intermediate states of EMT and its reverse process mesenchymal-epithelial transition (MET) offer new ideas for metastatic requirements and the dynamics of EMT/MET during the entire metastatic cascade. Therefore, we would like to initiate discussions on viewing EMT and its downstream signaling networks as a fulcrum of cellular plasticity, and a facilitator of the adaptive responses of cancer cells to distant organ microenvironments and various therapeutic assaults. We hereby invite scientists who have prominently contributed to this field, and whose valuable insights have led to the appreciation of epithelial-mesenchymal plasticity as a more comprehensive mediator of the adaptive response of cancer cells, with huge implications in metastasis, drug resistance, tumor relapse, and patient survival.

Essentials of Glycobiology

Author : Ajit Varki
Publisher : CSHL Press
ISBN 13 : 9780879696818
Total Pages : 694 pages
Book Rating : 4.6/5 (968 download)

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Book Synopsis Essentials of Glycobiology by : Ajit Varki

Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

The Heterogeneity of Cancer Metabolism

Author : Anne Le
Publisher : Springer
ISBN 13 : 331977736X
Total Pages : 186 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis The Heterogeneity of Cancer Metabolism by : Anne Le

Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Metastatic Cancer: Clinical and Biological Perspectives

Author : Rahul Jandial
Publisher : CRC Press
ISBN 13 : 9781587066597
Total Pages : 312 pages
Book Rating : 4.0/5 (665 download)

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Book Synopsis Metastatic Cancer: Clinical and Biological Perspectives by : Rahul Jandial

Download or read book Metastatic Cancer: Clinical and Biological Perspectives written by Rahul Jandial and published by CRC Press. This book was released on 2013-08-08 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most cancer deaths are a result of metastasis. The spread of a primary tumor to colonize neighboring and distant organs is the relentless endgame that defines the neoplastic process. Patients who have been diagnosed with cancer are treated to prevent both the recurrence of the tumor at the site of origin and metastasis that would re-stage them as advanced stage IV cancer. Historically and still with some types of cancer, stage IV is perceived by patients as “terminal.” Fortunately, recent molecular therapies have extended the lives of patients with advanced cancer and reassuringly people living with metastatic disease increasingly visit our clinics. What is the path forward? Given that the consilience of science and medicine is a dynamic art from which therapies arise, it would be misguided to consider any single work adequate at capturing the horizon for research. So with humility we constructed this text as primer for scientists. It begins with a broad introduction to the clinical management of common cancers. This is intended to serve as a foundation for investigators to consider when developing basic science hypotheses. Unquestionably, medical and surgical care of cancer patients reveals biology and dictates how novel therapeutics will ultimately be evaluated in clinical trials. The second section of this text offers provocative and evolving insights that underscore the breadth of science involved in the elucidation of cancer metastasis biology. The text concludes with information that integrates scientific and clinical foundations to highlight translational research. This book serves as a framework for scientists to conceptualize clinical and translational knowledge on the complexity of disease that is metastatic cancer.

Translational Research in Breast Cancer

Author : Dong-Young Noh
Publisher : Springer Nature
ISBN 13 : 9813296208
Total Pages : 630 pages
Book Rating : 4.8/5 (132 download)

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Book Synopsis Translational Research in Breast Cancer by : Dong-Young Noh

Download or read book Translational Research in Breast Cancer written by Dong-Young Noh and published by Springer Nature. This book was released on 2021-05-13 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes recent advances in translational research in breast cancer and presents emerging applications of this research that promise to have meaningful impacts on diagnosis and treatment. It introduces ideas and materials derived from the clinic that have been brought to "the bench" for basic research, as well as findings that have been applied back to "the bedside". Detailed attention is devoted to breast cancer biology and cell signaling pathways and to cancer stem cell and tumor heterogeneity in breast cancer. Various patient-derived research models are discussed, and a further focus is the role of biomarkers in precision medicine for breast cancer patients. Next-generation clinical research receives detailed attention, addressing the increasingly important role of big data in breast cancer research and a wide range of other emerging developments. An entire section is also devoted to the management of women with high-risk breast cancer. Translational Research in Breast Cancer will help clinicians and scientists to optimize their collaboration in order to achieve the common goal of conquering breast cancer.

Comparative Oncology

Author : Alecsandru Ioan Baba
Publisher :
ISBN 13 : 9789732714577
Total Pages : 787 pages
Book Rating : 4.7/5 (145 download)

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Book Synopsis Comparative Oncology by : Alecsandru Ioan Baba

Download or read book Comparative Oncology written by Alecsandru Ioan Baba and published by . This book was released on 2007 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mammary Tumor Cell Cycle, Differentiation, and Metastasis

Author : Robert B. Dickson
Publisher : Springer
ISBN 13 :
Total Pages : 456 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Mammary Tumor Cell Cycle, Differentiation, and Metastasis by : Robert B. Dickson

Download or read book Mammary Tumor Cell Cycle, Differentiation, and Metastasis written by Robert B. Dickson and published by Springer. This book was released on 1996-07-31 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mammary Tumor Cell Cycle, Differentiation and Metastasis is the fifth volume since 1988 in a series designed to broadly examine current advances in the cellular and molecular biology of breast cancer. As in previous volumes, the editors have invited recognized experts in cutting-edge topics to provide a chapter focused on their area of research. The editors have turned to the researchers who study rodent models of the disease and to those who study the cellular and molecular basis of human breast cancer. The first section of the book is devoted to new mouse models of mammary development and tumorigenesis. The second section moves to studies of human breast cancer and focuses on receptors, signalling, and the cell cycle. The final section deals with defective tissue interactions in human breast cancer. We are now in a period of extremely rapid accumulation of data on the molecular and cellular biology of breast cancer. These findings are highlighted in chapters from Mammary Tumor Cell Cycle, Differentiation and Metastasis: Advances in Cellular and Molecular Biology of Breast Cancer.

Epithelial—Mesenchymal Interactions in Cancer

Author : Itzhak D. Goldberg
Publisher : Birkhäuser
ISBN 13 : 3034890702
Total Pages : 304 pages
Book Rating : 4.0/5 (348 download)

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Book Synopsis Epithelial—Mesenchymal Interactions in Cancer by : Itzhak D. Goldberg

Download or read book Epithelial—Mesenchymal Interactions in Cancer written by Itzhak D. Goldberg and published by Birkhäuser. This book was released on 2013-03-07 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The contribution of epithelia-mesenchyme interaction to normal development (eg., tissue formation) and to neoplasia has become a subject of increasing interest to scientists because of recent progress in deciphering the molecular signals that mediate this interaction. Clearly, some of the same types of molecules (eg., growth factors and their receptors, proteolytic enzymes, cell adhesion molecules, and structural proteins of the extracellular matrix) mediate exchange of information between epithelia and mesenchyme during normal development and malignant growth. However, defects in the regulation of this exchange appear to contribute to malignancy by allowing growth promoting, invasogenic, and angiogenic factors to accumulate within the microenvironment of the tumor. For example, recent studies suggest that abnormal interactions between tumor epithelial cells and stromal mesenchymal cells contribute to the overproduction and accumulation of scatter factor (hepatocyte growth factor), an invasogenic and angiogenic cytokine, in certain types of tumor. The production and and activation of type IV collagenase, a matrix-degrading enzyme required for tumor cell invasion, appears to require intimate cooperation between tumor and stromal cells. The material contained in this volume highlights the state-of-the-art of knowledge of the molecular mechanisms by which epithelia and mesenchyme collaborate, and the abnormalities in these mechanisms that may lead to the development of cancer.

A Role for the Tumor Microenvironment in Regulating Cytoskeletal Dynamics in the Setting of Breast Cancer Migration and Invasion

Author : Kaitlyn M. Dvorak
Publisher :
ISBN 13 :
Total Pages : 143 pages
Book Rating : 4.:/5 (111 download)

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Book Synopsis A Role for the Tumor Microenvironment in Regulating Cytoskeletal Dynamics in the Setting of Breast Cancer Migration and Invasion by : Kaitlyn M. Dvorak

Download or read book A Role for the Tumor Microenvironment in Regulating Cytoskeletal Dynamics in the Setting of Breast Cancer Migration and Invasion written by Kaitlyn M. Dvorak and published by . This book was released on 2018 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt: The tumor microenvironment (TME) is a heterogeneous region that is comprised of tumor cells, stromal cells, and secreted factors and creates an environment favorable for tumor cell invasion and metastasis. An important step in the shift to a pro-cancerous microenvironment is the transformation of normal stromal fibroblasts to carcinoma-associated fibroblasts (CAFs). CAFs are present in a majority of solid tumors and can directly promote tumor cell motility via cytokine, chemokine and growth factor secretion into the TME, making them a critical TME component to understand. The exact effects that the TME has upon cytoskeletal regulation in motile tumor cells remain enigmatic. The conserved formin family of cytoskeleton regulating proteins plays essential roles in the assembly and/or bundling of unbranched actin filaments. Mammalian Diaphanous-related formin-2 (mDia2/DIAPH3/Drf3/Dia) assembles a dynamic F-actin cytoskeleton that underlies tumor cell migration and invasion. We previously showed that the chemokine CXCL12 can influence breast tumor cell migration and invasion through modification of the mDia2-directed actin cytoskeleton. The endogenous source of CXCL12 was unexplored. Therefore, the objective of this study was to understand whether CAF-derived chemokines from the TME impact breast tumor cell motility through modification of the formin-assembled F-actin cytoskeleton. In this study, we used CAF-derived conditioned media (CM) from WS19T fibroblasts, a transformed patient-derived tumor-adjacent breast CAF cell line, and studied its cell-autonomous impact upon tumor-cell motility. In triple-negative MDA-MB-231 human breast cancer cells, WS19T CAF-CM significantly and robustly increased wound closure and invasion relative to normal human mammary fibroblast (HMF)-CM. Unexpectedly, western blot analysis of WS19T-CM-treated MDA-MB-231 cells revealed a significant loss of mDia2 protein expression. WS19T-CM also promoted proteasome-mediated mDia2 degradation in MDA-MB-231s relative to control HMF-CM and WS21T CAF-CM, a breast CAF cell line that failed to reduced mDia2 expression, but significantly increased MDA-MB-231 migration. Cytokine array analysis of CM identified upregulated secreted factors in WS19T-CM relative to control WS21T CM, including the chemokine CXCL12 (SDF1a). As CXCL12 was identified as a factor secreted by fibroblasts and heavily involved in cancer cell migration and invasion, we hypothesized that CXCL12 is a CM factor influencing mDia2 protein loss, while increasing MDA-MB-231 cell invasion and migration. Exogenous CXCL12 treatment resulted in increased wound closure and loss of mDia2 protein expression. Blocking CXCL12 signaling with AMD3100, a specific inhibitor of CXCR4, augmented motility and rescued mDia2 protein expression in the presence of WS19T-CM. Our data suggest a mechanism whereby CAFs promote tumor cell migration and invasion through CXCL12 secretion to regulate the mDia2-directed cytoskeleton in breast tumor cells, and highlights a novel therapeutic approach of treating highly invasive primary lesions through targeting the TME.

Tumor Vascularization

Author : Domenico Ribatti
Publisher : Academic Press
ISBN 13 : 0128194944
Total Pages : 198 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Tumor Vascularization by : Domenico Ribatti

Download or read book Tumor Vascularization written by Domenico Ribatti and published by Academic Press. This book was released on 2020-01-21 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tumor Vascularization discusses the different types of growth of tumor blood vessels and their implications on research and healthcare. The book is divided into three parts: the first one, General Mechanisms, discusses different vessel growth mechanisms, such as sprouting angiogenesis, non-angiogenesis dependent growth, intussusceptive microvascular growth, vascular co-option and vasculogenic mimicry. The second and third parts, entitled Clinical Implications and Therapeutic Implications are dedicated to translating recent findings in this field to patient treatment and healthcare. This book is a valuable source for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in tumor progression and blood vessels. Explains new, non-orthodox concepts recently developed and related to the modality of growth of tumor blood vessels Provides information on the types of angiogenesis, non-angiogenesis dependent growth and vascular co-option, discussing both their similarities and differences Encompasses a discussion on clinical implications of tumor vascularization to translate research findings into treatment

The Cheating Cell

Author : Athena Aktipis
Publisher : Princeton University Press
ISBN 13 : 0691163847
Total Pages : 256 pages
Book Rating : 4.6/5 (911 download)

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Book Synopsis The Cheating Cell by : Athena Aktipis

Download or read book The Cheating Cell written by Athena Aktipis and published by Princeton University Press. This book was released on 2020-03-24 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: A fundamental and groundbreaking reassessment of how we view and manage cancer When we think of the forces driving cancer, we don’t necessarily think of evolution. But evolution and cancer are closely linked because the historical processes that created life also created cancer. The Cheating Cell delves into this extraordinary relationship, and shows that by understanding cancer’s evolutionary origins, researchers can come up with more effective, revolutionary treatments. Athena Aktipis goes back billions of years to explore when unicellular forms became multicellular organisms. Within these bodies of cooperating cells, cheating ones arose, overusing resources and replicating out of control, giving rise to cancer. Aktipis illustrates how evolution has paved the way for cancer’s ubiquity, and why it will exist as long as multicellular life does. Even so, she argues, this doesn’t mean we should give up on treating cancer—in fact, evolutionary approaches offer new and promising options for the disease’s prevention and treatments that aim at long-term management rather than simple eradication. Looking across species—from sponges and cacti to dogs and elephants—we are discovering new mechanisms of tumor suppression and the many ways that multicellular life-forms have evolved to keep cancer under control. By accepting that cancer is a part of our biological past, present, and future—and that we cannot win a war against evolution—treatments can become smarter, more strategic, and more humane. Unifying the latest research from biology, ecology, medicine, and social science, The Cheating Cell challenges us to rethink cancer’s fundamental nature and our relationship to it.