Brain Networks In Aging Reorganization And Modulation By Interventions

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Brain Networks in Aging: Reorganization and Modulation by Interventions

Author : Junfeng Sun
Publisher : Frontiers Media SA
ISBN 13 : 2889454169
Total Pages : 170 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Brain Networks in Aging: Reorganization and Modulation by Interventions by : Junfeng Sun

Download or read book Brain Networks in Aging: Reorganization and Modulation by Interventions written by Junfeng Sun and published by Frontiers Media SA. This book was released on 2018-02-22 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: Old adults undertake multiple reduced cognitive abilities in aging, which are accompanied with specific brain reorganization in forms of regional brain activity and brain tissues, inter-region connectivity, and topology of whole brain networks in both function and structure. The plasticity changes of brain activities in old adults are explained by the mechanisms of compensation and dedifferentiation. For example, older adults have been observed to have greater, usually bilateral, prefrontal activities during memory tasks compared to the typical unilateral prefrontal activities in younger adults, which was explained as a compensation for the reduced brain activities in visual processing cortices. Dedifferentiation is another mechanism to explain that old adults are with much less selective and less distinct activity in task-relevant brain regions compared with younger adults. A larger number of studies have examined the plasticity changes of brain from the perspective of regional brain activities. However, studies on only regional brain activities cannot fully elucidate the neural mechanisms of reduced cognitive abilities in aging, as multiple regions are integrated together to achieve advanced cognitive function in human brain. In recent years, brain connectivity/network, which targets how brain regions are integrated, have drawn increasing attention in neuroscience with the development of neuroimaging techniques and graph theoretical analysis. Connectivity quantifies functional association or neural fibers between two regions that may be spatially far separated, and graph theoretical analysis of brain network examines the complex interactions among multiple regions from the perspective of topology. Studies showed that compared to younger adults, older adults had altered strength of task-relevant functional connectivity between specific brain regions in cognitive tasks, and the alternation of connectivity are correlated to behavior performance. For example, older adults had weaker functional connectivity between the premotor cortex and a region in the left dorsolateral prefrontal cortex in a working memory task. Interventions like cognitive training and neuro-modulation (e.g., transcranial magnetic stimulation) have been shown to be promising in regaining or retaining the decreasing cognitive abilities in aging. However, only few neuroimaging studies have examined the influence of interventions to old adult’s brain activity, connectivity, and cognitive performance. This Research Topic calls for contributions on brain network of subjects in normal aging or with age-related diseases like mild cognitive impairment and Alzheimer’s disease. The studies are expected to be based on neuroimaging techniques including but not limited to functional magnetic resonance imaging, Electroencephalography, and diffusion tensor imaging, and contributions on the influence of interventions to brain networks in aging are highly encouraged. All these studies would enrich our understanding of neural mechanisms underlying aging, and offer new insights for developing possible interventions to retain cognitive abilities in aging subjects.

Brain Networks in Aging: Reorganization and Modulation by Interventions

Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (136 download)

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Book Synopsis Brain Networks in Aging: Reorganization and Modulation by Interventions by :

Download or read book Brain Networks in Aging: Reorganization and Modulation by Interventions written by and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Old adults undertake multiple reduced cognitive abilities in aging, which are accompanied with specific brain reorganization in forms of regional brain activity and brain tissues, inter-region connectivity, and topology of whole brain networks in both function and structure. The plasticity changes of brain activities in old adults are explained by the mechanisms of compensation and dedifferentiation. For example, older adults have been observed to have greater, usually bilateral, prefrontal activities during memory tasks compared to the typical unilateral prefrontal activities in younger adults, which was explained as a compensation for the reduced brain activities in visual processing cortices. Dedifferentiation is another mechanism to explain that old adults are with much less selective and less distinct activity in task-relevant brain regions compared with younger adults. A larger number of studies have examined the plasticity changes of brain from the perspective of regional brain activities. However, studies on only regional brain activities cannot fully elucidate the neural mechanisms of reduced cognitive abilities in aging, as multiple regions are integrated together to achieve advanced cognitive function in human brain. In recent years, brain connectivity/network, which targets how brain regions are integrated, have drawn increasing attention in neuroscience with the development of neuroimaging techniques and graph theoretical analysis. Connectivity quantifies functional association or neural fibers between two regions that may be spatially far separated, and graph theoretical analysis of brain network examines the complex interactions among multiple regions from the perspective of topology. Studies showed that compared to younger adults, older adults had altered strength of task-relevant functional connectivity between specific brain regions in cognitive tasks, and the alternation of connectivity are correlated to behavior performance. For example, older adults had weaker functional connectivity between the premotor cortex and a region in the left dorsolateral prefrontal cortex in a working memory task. Interventions like cognitive training and neuro-modulation (e.g., transcranial magnetic stimulation) have been shown to be promising in regaining or retaining the decreasing cognitive abilities in aging. However, only few neuroimaging studies have examined the influence of interventions to old adult's brain activity, connectivity, and cognitive performance. This Research Topic calls for contributions on brain network of subjects in normal aging or with age-related diseases like mild cognitive impairment and Alzheimer's disease. The studies are expected to be based on neuroimaging techniques including but not limited to functional magnetic resonance imaging, Electroencephalography, and diffusion tensor imaging, and contributions on the influence of interventions to brain networks in aging are highly encouraged. All these studies would enrich our understanding of neural mechanisms underlying aging, and offer new insights for developing possible interventions to retain cognitive abilities in aging subjects.

Cognitive and Brain Aging: Interventions to Promote Well-Being in Old Age. Roadmap for Interventions Preventing Cognitive Aging

Author : Pamela M. Greenwood
Publisher : Frontiers Media SA
ISBN 13 : 2889634892
Total Pages : 326 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Cognitive and Brain Aging: Interventions to Promote Well-Being in Old Age. Roadmap for Interventions Preventing Cognitive Aging by : Pamela M. Greenwood

Download or read book Cognitive and Brain Aging: Interventions to Promote Well-Being in Old Age. Roadmap for Interventions Preventing Cognitive Aging written by Pamela M. Greenwood and published by Frontiers Media SA. This book was released on 2020-03-03 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Brain Networks Reorganization During Maturation and Healthy Aging-emphases for Resilience

Author : Gabriel Gonzalez-Escamilla
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (118 download)

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Book Synopsis Brain Networks Reorganization During Maturation and Healthy Aging-emphases for Resilience by : Gabriel Gonzalez-Escamilla

Download or read book Brain Networks Reorganization During Maturation and Healthy Aging-emphases for Resilience written by Gabriel Gonzalez-Escamilla and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Translational Research in Traumatic Brain Injury

Author : Daniel Laskowitz
Publisher : CRC Press
ISBN 13 : 1498766579
Total Pages : 412 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Translational Research in Traumatic Brain Injury by : Daniel Laskowitz

Download or read book Translational Research in Traumatic Brain Injury written by Daniel Laskowitz and published by CRC Press. This book was released on 2015-12-01 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas: Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.

The Cambridge Handbook of Successful Aging

Author : Rocío Fernández-Ballesteros
Publisher : Cambridge University Press
ISBN 13 : 1108641431
Total Pages : 969 pages
Book Rating : 4.1/5 (86 download)

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Book Synopsis The Cambridge Handbook of Successful Aging by : Rocío Fernández-Ballesteros

Download or read book The Cambridge Handbook of Successful Aging written by Rocío Fernández-Ballesteros and published by Cambridge University Press. This book was released on 2019-01-24 with total page 969 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent studies show that more people than ever before are reaching old age in better health and enjoying that health for a longer time. This Handbook outlines the latest discoveries in the study of aging from bio-medicine, psychology, and socio-demography. It treats the study of aging as a multidisciplinary scientific subject, since it requires the interplay of broad disciplines, while offering high motivation, positive attitudes, and behaviors for aging well, and lifestyle changes that will help people to stay healthier across life span and in old age. Written by leading scholars from various academic disciplines, the chapters delve into the most topical aspects of aging today - including biological mechanisms of aging, aging with health, active and productive aging, aging with satisfaction, aging with respect, and aging with dignity. Aimed at health professionals as well as general readers, this Cambridge Handbook offers a new, positive approach to later life.

From Neurons to Neighborhoods

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309069882
Total Pages : 610 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis From Neurons to Neighborhoods by : National Research Council

Download or read book From Neurons to Neighborhoods written by National Research Council and published by National Academies Press. This book was released on 2000-11-13 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: How we raise young children is one of today's most highly personalized and sharply politicized issues, in part because each of us can claim some level of "expertise." The debate has intensified as discoveries about our development-in the womb and in the first months and years-have reached the popular media. How can we use our burgeoning knowledge to assure the well-being of all young children, for their own sake as well as for the sake of our nation? Drawing from new findings, this book presents important conclusions about nature-versus-nurture, the impact of being born into a working family, the effect of politics on programs for children, the costs and benefits of intervention, and other issues. The committee issues a series of challenges to decision makers regarding the quality of child care, issues of racial and ethnic diversity, the integration of children's cognitive and emotional development, and more. Authoritative yet accessible, From Neurons to Neighborhoods presents the evidence about "brain wiring" and how kids learn to speak, think, and regulate their behavior. It examines the effect of the climate-family, child care, community-within which the child grows.

The Cambridge Handbook of Cognitive Aging

Author : Ayanna K. Thomas
Publisher : Cambridge University Press
ISBN 13 : 1108690742
Total Pages : 1019 pages
Book Rating : 4.1/5 (86 download)

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Book Synopsis The Cambridge Handbook of Cognitive Aging by : Ayanna K. Thomas

Download or read book The Cambridge Handbook of Cognitive Aging written by Ayanna K. Thomas and published by Cambridge University Press. This book was released on 2020-05-28 with total page 1019 pages. Available in PDF, EPUB and Kindle. Book excerpt: Decades of research have demonstrated that normal aging is accompanied by cognitive change. Much of this change has been conceptualized as a decline in function. However, age-related changes are not universal, and decrements in older adult performance may be moderated by experience, genetics, and environmental factors. Cognitive aging research to date has also largely emphasized biological changes in the brain, with less evaluation of the range of external contributors to behavioral manifestations of age-related decrements in performance. This handbook provides a comprehensive overview of cutting-edge cognitive aging research through the lens of a life course perspective that takes into account both behavioral and neural changes. Focusing on the fundamental principles that characterize a life course approach - genetics, early life experiences, motivation, emotion, social contexts, and lifestyle interventions - this handbook is an essential resource for researchers in cognition, aging, and gerontology.

The Wiley Handbook of Cognitive Control

Author : Tobias Egner
Publisher : John Wiley & Sons
ISBN 13 : 1118920546
Total Pages : 629 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis The Wiley Handbook of Cognitive Control by : Tobias Egner

Download or read book The Wiley Handbook of Cognitive Control written by Tobias Egner and published by John Wiley & Sons. This book was released on 2017-03-20 with total page 629 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering basic theory, new research, and intersections with adjacent fields, this is the first comprehensive reference work on cognitive control – our ability to use internal goals to guide thought and behavior. Draws together expert perspectives from a range of disciplines, including cognitive psychology, neuropsychology, neuroscience, cognitive science, and neurology Covers behavioral phenomena of cognitive control, neuroanatomical and computational models of frontal lobe function, and the interface between cognitive control and other mental processes Explores the ways in which cognitive control research can inform and enhance our understanding of brain development and neurological and psychiatric conditions

Cognitive Changes and the Aging Brain

Author : Kenneth M. Heilman
Publisher : Cambridge University Press
ISBN 13 : 1108688497
Total Pages : pages
Book Rating : 4.1/5 (86 download)

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Book Synopsis Cognitive Changes and the Aging Brain by : Kenneth M. Heilman

Download or read book Cognitive Changes and the Aging Brain written by Kenneth M. Heilman and published by Cambridge University Press. This book was released on 2019-12-05 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the changes in the brain and in cognitive functions that occur with aging in the absence of a neurological, psychiatric, or medical disease. It discusses aging-related changes in many brain functions, including memory, language, sensory perception, motor function, creativity, attention, executive functions, emotions and mood. The neural mechanisms that may account for specific aging-related changes in cognition, perception and behavior are explored, as well as the means by which aging-related cognitive decrements can be managed and possibly ameliorated. Consequently, this book will be of value to clinicians, including neurologists, psychiatrists, geriatricians, primary care physicians, psychologists and speech-language pathologists. In addition, researchers and graduate students who want to learn about the aging brain will find this an indispensable guide.

Brain Networks for Studying Healthy and Pathological Aging Mechanisms and Intervention Efficacy

Author : Christos Frantzidis
Publisher : Frontiers Media SA
ISBN 13 : 2889661229
Total Pages : 577 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Brain Networks for Studying Healthy and Pathological Aging Mechanisms and Intervention Efficacy by : Christos Frantzidis

Download or read book Brain Networks for Studying Healthy and Pathological Aging Mechanisms and Intervention Efficacy written by Christos Frantzidis and published by Frontiers Media SA. This book was released on 2020-11-18 with total page 577 pages. Available in PDF, EPUB and Kindle. Book excerpt: Previous studies showed that both healthy and pathological aging are associated with changes in brain structure and function of the mature human brain. The most prominent anatomical alteration are changes in prefrontal cortex morphology, volume loss and reduced white-matter integrity and hippocampal atrophy. Cognitive decline affects mainly the performance of episodic memory, speed of sensory information processing, working memory, inhibitory function and long-term memory. It has been also proposed that due to the aforementioned changes the aging brain engages in compensatory brain mechanism such as a broader activation of cortical regions (mainly frontal) rather than specialized activation. Evidence suggests that similar changes occur with pathological aging but to a greater extent. In this case information flow is disrupted due to neurodegeneration, functional activation of posterior (occipito-temporal) regions is decreased and as a consequence the brain fails to process sensorial input in the ventral pathway and cognitive deficits appear. In the last years, functional alterations associated with aging have been studied using the mathematical notion of graph theory that offers an integrative approach since it examines different properties of the brain network: 1) Organization level 2) amount of local information processing, 3) information flow 4) cortical community structure and 5) identification of functional / anatomical hubs. So, graph theory offers an attractive way to model brain networks organization and to quantify their pathological deviations. Previous studies have already employed this mathematical notion and demonstrated that age-related neurodegeneration is often accompanied by loss of optimal network organization either due to diminished local information processing or due to progressive isolation of distant brain regions. They have also found that changes in network properties may be present even in the preclinical phase, which could be taken as a biological marker of disease.

Fundamentals of Brain Network Analysis

Author : Alex Fornito
Publisher : Academic Press
ISBN 13 : 0124081185
Total Pages : 496 pages
Book Rating : 4.1/5 (24 download)

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Book Synopsis Fundamentals of Brain Network Analysis by : Alex Fornito

Download or read book Fundamentals of Brain Network Analysis written by Alex Fornito and published by Academic Press. This book was released on 2016-03-04 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamentals of Brain Network Analysis is a comprehensive and accessible introduction to methods for unraveling the extraordinary complexity of neuronal connectivity. From the perspective of graph theory and network science, this book introduces, motivates and explains techniques for modeling brain networks as graphs of nodes connected by edges, and covers a diverse array of measures for quantifying their topological and spatial organization. It builds intuition for key concepts and methods by illustrating how they can be practically applied in diverse areas of neuroscience, ranging from the analysis of synaptic networks in the nematode worm to the characterization of large-scale human brain networks constructed with magnetic resonance imaging. This text is ideally suited to neuroscientists wanting to develop expertise in the rapidly developing field of neural connectomics, and to physical and computational scientists wanting to understand how these quantitative methods can be used to understand brain organization. Winner of the 2017 PROSE Award in Biomedicine & Neuroscience and the 2017 British Medical Association (BMA) Award in Neurology Extensively illustrated throughout by graphical representations of key mathematical concepts and their practical applications to analyses of nervous systems Comprehensively covers graph theoretical analyses of structural and functional brain networks, from microscopic to macroscopic scales, using examples based on a wide variety of experimental methods in neuroscience Designed to inform and empower scientists at all levels of experience, and from any specialist background, wanting to use modern methods of network science to understand the organization of the brain

Brain Repair After Stroke

Author : Steven C. Cramer
Publisher : Cambridge University Press
ISBN 13 : 1139490656
Total Pages : 307 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Brain Repair After Stroke by : Steven C. Cramer

Download or read book Brain Repair After Stroke written by Steven C. Cramer and published by Cambridge University Press. This book was released on 2010-10-28 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Increasing evidence identifies the possibility of restoring function to the damaged brain via exogenous therapies. One major target for these advances is stroke, where most patients can be left with significant disability. Treatments have the potential to improve the victim's quality of life significantly and reduce the time and expense of rehabilitation. Brain Repair After Stroke reviews the biology of spontaneous brain repair after stroke in animal models and in humans. Detailed chapters cover the many forms of therapy being explored to promote brain repair and consider clinical trial issues in this context. This book provides a summary of the neurobiology of innate and treatment-induced repair mechanisms after hypoxia and reviews the state of the art for human therapeutics in relation to promoting behavioral recovery after stroke. Essential reading for stroke physicians, neurologists, rehabilitation physicians and neuropsychologists.

Music and the Aging Brain

Author : Lola Cuddy
Publisher : Academic Press
ISBN 13 : 0128174234
Total Pages : 476 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Music and the Aging Brain by : Lola Cuddy

Download or read book Music and the Aging Brain written by Lola Cuddy and published by Academic Press. This book was released on 2020-05-28 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Music and the Aging Brain describes brain functioning in aging and addresses the power of music to protect the brain from loss of function and how to cope with the ravages of brain diseases that accompany aging. By studying the power of music in aging through the lens of neuroscience, behavioral, and clinical science, the book explains brain organization and function. Written for those researching the brain and aging, the book provides solid examples of research fundamentals, including rigorous standards for sample selection, control groups, description of intervention activities, measures of health outcomes, statistical methods, and logically stated conclusions. Summarizes brain structures supporting music perception and cognition Examines and explains music as neuroprotective in normal aging Addresses the association of hearing loss to dementia Promotes a neurological approach for research in music as therapy Proposes questions for future research in music and aging

Cognitive Neuroscience of Aging

Author : Roberto Cabeza
Publisher : Oxford University Press
ISBN 13 : 0199372934
Total Pages : 633 pages
Book Rating : 4.1/5 (993 download)

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Book Synopsis Cognitive Neuroscience of Aging by : Roberto Cabeza

Download or read book Cognitive Neuroscience of Aging written by Roberto Cabeza and published by Oxford University Press. This book was released on 2017 with total page 633 pages. Available in PDF, EPUB and Kindle. Book excerpt: A rapidly growing body of research has consituted a new discipline that may be called cognitive neuroscience of aging. This book offers an introduction to the topic, useful to both professionals & students in cognitive neuroscience, cognitive psychology, neuroscience, neuropsychology & neurology.

Cognitive Aging

Author : Denise Park
Publisher : Psychology Press
ISBN 13 : 1135887519
Total Pages : 294 pages
Book Rating : 4.1/5 (358 download)

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Book Synopsis Cognitive Aging by : Denise Park

Download or read book Cognitive Aging written by Denise Park and published by Psychology Press. This book was released on 2012-12-06 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: As our society ages, the topic of cognitive aging is becoming increasingly important. This volume provides an accessible overview of how the cognitive system changes as a function of normal aging. Building on the successful first edition, this volume provide an even more comprehensive coverage of the major issues affecting memory, attention, language, speech and other aspects of cognitive functioning. The essential chapters from the first edition have been thoroughly revised and updated and new chapters have been introduced which draw in neuroscience studies and more applied topics. In addition, contributors were encouraged to ensure their chapters are accessible to students studying the topic for the first time. This therefore makes the volume appealing as a textbook on senior undergraduate and graduate courses.

Nurturing the Older Brain and Mind

Author : Pamela M. Greenwood
Publisher : MIT Press
ISBN 13 : 0262300559
Total Pages : 351 pages
Book Rating : 4.2/5 (623 download)

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Book Synopsis Nurturing the Older Brain and Mind by : Pamela M. Greenwood

Download or read book Nurturing the Older Brain and Mind written by Pamela M. Greenwood and published by MIT Press. This book was released on 2012-01-27 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: Two noted researchers explain scientific evidence that shows why certain experiential and lifestyle factors may promote and maintain cognitive vitality in older adults. Although our physical abilities clearly decline as we age, cognitive decline in healthy old age is neither universal nor inevitable. In Nurturing the Older Brain, Pamela Greenwood and Raja Parasuraman show that scientific research does not support the popular notion of the inexorable and progressive effects of cognitive aging in all older adults. They report that many adults maintain a high level of cognitive function into old age and that certain experiential and lifestyle factors—including education, exercise, diet, and opportunities for new learning—contribute to the preservation of cognitive abilities. Many popular accounts draw similar conclusions and give similar lifestyle advice but lack supporting scientific evidence. Greenwood and Parasuraman offer a comprehensive review of research on cognitive and brain aging. They show that even the aged brain remains capable of plasticity—the ability to adapt to and benefit from experience—and they summarize evidence that brain plasticity is heightened by certain types of cognitive training, by aerobic exercise, and by certain diets. They also report on the somewhat controversial use of estrogen and cognition-enhancing drugs, on environmental adaptations (including "virtual assistants") that help older adults "age in place," and on genetic factors in cognitive aging. The past twenty years of research points to ways that older adults can lead rich and cognitively vital lives. As millions of baby boomers head toward old age, Greenwood and Parasuraman's accessible book could not be more timely.