Brain Hypoxia And Ischemia New Insights Into Neurodegeneration And Neuroprotection

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Brain Hypoxia and Ischemia: New Insights Into Neurodegeneration and Neuroprotection

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Author : Natalia N Nalivaeva
Publisher : Frontiers Media SA
ISBN 13 : 2889631176
Total Pages : 162 pages
Book Rating : 4.8/5 (896 download)

Book Synopsis Brain Hypoxia and Ischemia: New Insights Into Neurodegeneration and Neuroprotection by : Natalia N Nalivaeva

Download or read book Brain Hypoxia and Ischemia: New Insights Into Neurodegeneration and Neuroprotection written by Natalia N Nalivaeva and published by Frontiers Media SA. This book was released on 2019-11-15 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

The Newborn Brain

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Author : Hugo Lagercrantz
Publisher : Cambridge University Press
ISBN 13 : 113948558X
Total Pages : 427 pages
Book Rating : 4.1/5 (394 download)

Book Synopsis The Newborn Brain by : Hugo Lagercrantz

Download or read book The Newborn Brain written by Hugo Lagercrantz and published by Cambridge University Press. This book was released on 2010-01-07 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Development of the brain and the emergence of the mind constitute some of the most important concerns of contemporary biology. Disturbances during fetal life may have profound implications for a child's future neurological and psychological development, which can in turn impact society. The new edition of this highly respected work presents a comprehensive review of the basic mechanisms of brain development and the pathophysiology of disorders of the infant brain, written by a team of distinguished neuroscientists, neonatologists, and neuropediatricians. The book follows the main milestones of brain development, from formation of the neural tube and wiring of the neurons in the brain. Neurotrophic factors, neurotransmitters, glial cell biology, cerebral circulation development of sensory functions are all described in detail. Furthermore, there are more philosophical chapters on the evolution of the brain and the emergence of consciousness. Clinical considerations are highlighted where relevant.

Endogenous Neuroprotection

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Author : Bernhard Schaller
Publisher : Nova Publishers
ISBN 13 : 9781604562286
Total Pages : 116 pages
Book Rating : 4.5/5 (622 download)

Book Synopsis Endogenous Neuroprotection by : Bernhard Schaller

Download or read book Endogenous Neuroprotection written by Bernhard Schaller and published by Nova Publishers. This book was released on 2008 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endogenous neuoprotection is a phenomenon where a brief episode of ischemia renders the brain resistant against a subsequent longer-asting ischemia event. Experimentally, the author was able to model hypoxic preconditioning in animal model. Increasing knowledge of this endogenous neuroprotectin by ischemic tolerance may help to minimize neuronal damage following ischemic stroke and hypoxic encephalopathy. This book is, therefore, the first overview of this important topic and will certainly influence further investigations in clinical and neuroscience research.

Neonatal Encephalopathy and Neurologic Outcome

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Author : American College of Obstetricians and Gy
Publisher : American College of Obstetricians and Gynecologists Women's Health Care Physicians
ISBN 13 : 9781934984307
Total Pages : 0 pages
Book Rating : 4.9/5 (843 download)

Book Synopsis Neonatal Encephalopathy and Neurologic Outcome by : American College of Obstetricians and Gy

Download or read book Neonatal Encephalopathy and Neurologic Outcome written by American College of Obstetricians and Gy and published by American College of Obstetricians and Gynecologists Women's Health Care Physicians. This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significantly revised and updated, the new second edition updates the science on neonatal encephalopathy presented in the 1st edition. The new 2nd edition recommends a broad evaluation of all potential contributing factors in every case of neonatal encephalopathy, including maternal medical history, obstetric and intrapartum factors, and placental pathology. This recommendation is a shift from the 2003 report, which focused on determining whether or not a hypoxic-ischemic event was the cause of neonatal encephalopathy. Includes new sections on - Placental pathology - Focal ischemic stroke - Neonatal interventions - Patient safety - Significant advances in neuroimaging This report will assist the clinician in evaluating a newborn with encephalopathy to assist in defining both the cause and timing.

Machine Learning, Big Data, and IoT for Medical Informatics

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Author : Pardeep Kumar
Publisher : Academic Press
ISBN 13 : 0128217812
Total Pages : 460 pages
Book Rating : 4.1/5 (282 download)

Book Synopsis Machine Learning, Big Data, and IoT for Medical Informatics by : Pardeep Kumar

Download or read book Machine Learning, Big Data, and IoT for Medical Informatics written by Pardeep Kumar and published by Academic Press. This book was released on 2021-06-13 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Machine Learning, Big Data, and IoT for Medical Informatics focuses on the latest techniques adopted in the field of medical informatics. In medical informatics, machine learning, big data, and IOT-based techniques play a significant role in disease diagnosis and its prediction. In the medical field, the structure of data is equally important for accurate predictive analytics due to heterogeneity of data such as ECG data, X-ray data, and image data. Thus, this book focuses on the usability of machine learning, big data, and IOT-based techniques in handling structured and unstructured data. It also emphasizes on the privacy preservation techniques of medical data. This volume can be used as a reference book for scientists, researchers, practitioners, and academicians working in the field of intelligent medical informatics. In addition, it can also be used as a reference book for both undergraduate and graduate courses such as medical informatics, machine learning, big data, and IoT. - Explains the uses of CNN, Deep Learning and extreme machine learning concepts for the design and development of predictive diagnostic systems. - Includes several privacy preservation techniques for medical data. - Presents the integration of Internet of Things with predictive diagnostic systems for disease diagnosis. - Offers case studies and applications relating to machine learning, big data, and health care analysis.

Cerebrovascular and Neurodegenerative Diseases – New Insights into Molecular Cell Biology and Therapeutic Targets

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Author : Sikha Saha
Publisher : Frontiers Media SA
ISBN 13 : 2889634426
Total Pages : 317 pages
Book Rating : 4.8/5 (896 download)

Book Synopsis Cerebrovascular and Neurodegenerative Diseases – New Insights into Molecular Cell Biology and Therapeutic Targets by : Sikha Saha

Download or read book Cerebrovascular and Neurodegenerative Diseases – New Insights into Molecular Cell Biology and Therapeutic Targets written by Sikha Saha and published by Frontiers Media SA. This book was released on 2020-01-30 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Brain Neurotrauma

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Author : Firas H. Kobeissy
Publisher : CRC Press
ISBN 13 : 1466565993
Total Pages : 718 pages
Book Rating : 4.4/5 (665 download)

Book Synopsis Brain Neurotrauma by : Firas H. Kobeissy

Download or read book Brain Neurotrauma written by Firas H. Kobeissy and published by CRC Press. This book was released on 2015-02-25 with total page 718 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the contribution from more than one hundred CNS neurotrauma experts, this book provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma including biomarker studies, experimental models, diagnostic methods, and neurotherapeutic intervention strategies in brain injury research. It discusses neurotrauma mechanisms, biomarker discovery, and neurocognitive and neurobehavioral deficits. Also included are medical interventions and recent neurotherapeutics used in the area of brain injury that have been translated to the area of rehabilitation research. In addition, a section is devoted to models of milder CNS injury, including sports injuries.

New Perspectives of Central Nervous System Injury and Neuroprotection

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Author :
Publisher : Academic Press
ISBN 13 : 012387016X
Total Pages : 419 pages
Book Rating : 4.1/5 (238 download)

Book Synopsis New Perspectives of Central Nervous System Injury and Neuroprotection by :

Download or read book New Perspectives of Central Nervous System Injury and Neuroprotection written by and published by Academic Press. This book was released on 2012-10-22 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: Central nervous system (CNS) diseases such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis affect a large number of populations worldwide for which no suitable cure is currently available. In addition, stroke, nanoparticle intoxication, diabetes, hypertension, and psychostimulant abuse either alone or in combination are capable of inducing potential brain damage. Thus, there is an urgent need to expand our knowledge to find suitable therapeutic strategies to enhance neurorepair processes in such diseases.This volume presents neuroprotection and novel therapeutic strategies developed in the last 5 years by 12 world leaders in the field. The term neuroprotection means rescuing neuronal and non-neuronal cells together. The cerebral endothelium that constitutes the anatomical and physiological site of the blood-brain barrier (BBB) is one of the most important non-neural cells in the CNS. Any distortion of the BBB leads to brain diseases and restoration of the barrier results in neuroprotection. Thus, the BBB appears to be the "gateway" for neurological diseases and neurorepair. However, to treat brain tumors or infarcts, new therapeutic strategies are needed to enhance brain drug delivery using nanotechnology. In addition, apart from conventional drugs, restoration of BBB function could also be achieved by means of antibodies directed against specific proteins, neurotransmitters or exogenous supplement of neurotrophic factors. Since co-morbidity factors e.g., hypertension, diabetes, and exposure of nanoparticles could complicate the pathogenesis of neurological disorders either an enhanced dose of the drug or nanodelivery of a combination of several drugs is needed to achieve neuroprotection.This volume of International Review of Neurobiology is the first to discuss novel therapeutic strategies in situations of neurological disorders in combination with different co-morbidity factors. Reviews written by experts in such a way that provides basic knowledge for beginners and advanced information for researchers and experts New aspects of Neurodegenerative diseases such as; Alzheimer’s Disease, Parkinson’s Disease, Amyotrophic Lateral Sclerosis are presented with the latest therapeutic measures Exacerbation of brain pathology in hypertension or diabetes is discussed for the first time

Brain Repair After Stroke

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Author : Steven C. Cramer
Publisher : Cambridge University Press
ISBN 13 : 1139490656
Total Pages : 307 pages
Book Rating : 4.1/5 (394 download)

Book Synopsis Brain Repair After Stroke by : Steven C. Cramer

Download or read book Brain Repair After Stroke written by Steven C. Cramer and published by Cambridge University Press. This book was released on 2010-10-28 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Increasing evidence identifies the possibility of restoring function to the damaged brain via exogenous therapies. One major target for these advances is stroke, where most patients can be left with significant disability. Treatments have the potential to improve the victim's quality of life significantly and reduce the time and expense of rehabilitation. Brain Repair After Stroke reviews the biology of spontaneous brain repair after stroke in animal models and in humans. Detailed chapters cover the many forms of therapy being explored to promote brain repair and consider clinical trial issues in this context. This book provides a summary of the neurobiology of innate and treatment-induced repair mechanisms after hypoxia and reviews the state of the art for human therapeutics in relation to promoting behavioral recovery after stroke. Essential reading for stroke physicians, neurologists, rehabilitation physicians and neuropsychologists.

Emerging Strategies in Neuroprotection

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Author : Manangos
Publisher : Springer Science & Business Media
ISBN 13 : 1468467964
Total Pages : 371 pages
Book Rating : 4.4/5 (684 download)

Book Synopsis Emerging Strategies in Neuroprotection by : Manangos

Download or read book Emerging Strategies in Neuroprotection written by Manangos and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: SOLOMON H. SNYDER Receptor Research Reaches Neurology: Relevance to Neurodegenerative Diseases and Stroke President George Bush has heralded the 1990s as the decade of the brain, based largely on the rapid escalation of advances in the molecular neuro sciences and the likelihood that these will bear therapeutic fruit before the turn of the century. There is little doubt that the 1970s and 1980s have witnessed more remarkable advances in the molecular neurosciences than all of the preceding hundred years. Identification of receptor sites for drugs and neurotransmitters along with simple, sensitive, and specific means of monitoring them has made it possible to elucidate the mechanism of action for many known drugs and to identify new chemical entities as potential therapeutic agents. At the same time, the numbers of distinct neurotrans mitters have multiplied. Prior to 1970 only the biogenic amines were well accepted as transmitters. The early 1970s witnessed the gradual acceptance of amino acids as major excitatory and inhibitory neurotransmitters. Identification of opiate receptors and the subsequent identification of the enkephalins as their endogenous ligands led to an appreciation of peptides as putative transmitters and the accumulation of as many as a hundred neuropeptides by the decade's end. In the 1980s the revolutions of molecular biology have been applied aggressively to the neurosciences with molecular cloning for neuropeptide precursors, many important neurochemical en zymes, and receptors for numerous transmitters.

Oxidative Stress and Neurodegenerative Disorders

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Author : G. Ali Qureshi
Publisher : Elsevier
ISBN 13 : 0080489494
Total Pages : 795 pages
Book Rating : 4.0/5 (84 download)

Book Synopsis Oxidative Stress and Neurodegenerative Disorders by : G. Ali Qureshi

Download or read book Oxidative Stress and Neurodegenerative Disorders written by G. Ali Qureshi and published by Elsevier. This book was released on 2007-03-22 with total page 795 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders.* Contains the latest information on the subject of neurodegenerative disorders* Reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems

2-Oxoglutarate-Dependent Oxygenases

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Author : Christopher Schofield
Publisher : Royal Society of Chemistry
ISBN 13 : 1782621954
Total Pages : 508 pages
Book Rating : 4.7/5 (826 download)

Book Synopsis 2-Oxoglutarate-Dependent Oxygenases by : Christopher Schofield

Download or read book 2-Oxoglutarate-Dependent Oxygenases written by Christopher Schofield and published by Royal Society of Chemistry. This book was released on 2015-04-23 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the discovery of the first examples of 2-oxoglutarate-dependent oxygenase-catalysed reactions in the 1960s, a remarkably broad diversity of alternate reactions and substrates has been revealed, and extensive advances have been achieved in our understanding of the structures and catalytic mechanisms. These enzymes are important agrochemical targets and are being pursued as therapeutic targets for a wide range of diseases including cancer and anemia. This book provides a central source of information that summarizes the key features of the essential group of 2-oxoglutarate-dependent dioxygenases and related enzymes. Given the numerous recent advances and biomedical interest in the field, this book aims to unite the latest research for those already working in the field as well as to provide an introduction for those newly approaching the topic, and for those interested in translating the basic science into medicinal and agricultural benefits. The book begins with four broad chapters that highlight critical aspects, including an overview of possible catalytic reactions, structures and mechanisms. The following seventeen chapters focus on carefully selected topics, each written by leading experts in the area. Readers will find explanations of rapidly evolving research, from the chemistry of isopenicillin N synthase to the oxidation mechanism of 5-methylcytosine in DNA by ten-eleven-translocase oxygenases.

Neuroinflammation in Stroke

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Author : Ulrich Dirnagl
Publisher : Springer Science & Business Media
ISBN 13 : 3662054264
Total Pages : 248 pages
Book Rating : 4.6/5 (62 download)

Book Synopsis Neuroinflammation in Stroke by : Ulrich Dirnagl

Download or read book Neuroinflammation in Stroke written by Ulrich Dirnagl and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: The successful treatment of acute stroke remains one of the major challenges in clinical medicine. Over the last decades, the understanding of stroke pathophysiology has greatly improved, while the therapeutic options in stroke therapy remain very limited. Today, hyperacute mechanisms of damage, such as excitotoxicity, can be discriminated from delayed ones, such as inflammation and apoptosis. Targeting of inflammation has already been successfully applied in various stroke models, but translation into a clinically efficacious strategy has not been achieved so far. In this book, leading experts in basic cerebrovascular research as well as stroke treatment review the current evidence for and against an important role for inflammation in stroke, and explore the potential of treating or modulating inflammation in stroke therapy.

Translational Research in Traumatic Brain Injury

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Author : Daniel Laskowitz
Publisher : CRC Press
ISBN 13 : 1498766579
Total Pages : 388 pages
Book Rating : 4.4/5 (987 download)

Book Synopsis Translational Research in Traumatic Brain Injury by : Daniel Laskowitz

Download or read book Translational Research in Traumatic Brain Injury written by Daniel Laskowitz and published by CRC Press. This book was released on 2016-04-21 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme

Neuro-inflammation in Neuronal Death and Repair

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Author : Giacinto Bagetta
Publisher : Elsevier
ISBN 13 : 0080550568
Total Pages : 499 pages
Book Rating : 4.0/5 (85 download)

Book Synopsis Neuro-inflammation in Neuronal Death and Repair by : Giacinto Bagetta

Download or read book Neuro-inflammation in Neuronal Death and Repair written by Giacinto Bagetta and published by Elsevier. This book was released on 2007-07-25 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroinflammation has been implicated recently in the pathogenesis of many neurodegenerative diseases. The cross-talk between neurons and non-neuronal cells seems to be a critical step in the progression of neurodegeneration and molecules that have a beneficial role may turn into harmful players. Thus, matrix metalloproteinases (MMPs), which are involved in axonal growth and regeneration as well as synaptic plasticity, may also have detrimental effects. Recent evidence has linked MMPs to conditions like ischemia, multiple sclerosis, Alzheimer's disease and suggested that, together with their role in the degradation of extracellular macromolecules, MMPs could work as important signalling molecules from injured neurons to the microglia. Thus, MMP-3 has been shown to induce the release of pro-inflammatory cytokines from microglia via activation of ERK and NF-kB-dependent pathways. Increasing evidence highlights the importance of a balanced cross-talk between neurons and non-neuronal cells and indicates that the presence of reactive astrocytes, the activation of microglia and the release of inflammatory mediators may contribute to the progression of many central nervous system disorders, independently of the nature of the primary pathogenic event. However, many aspects still remain controversial and much more effort is needed to understand the role of neuroinflammatory mediators and processes in these conditions. This volume brings together renowned, international scientists to discuss current knowledge and views on the mechanisms of neuroinflammation, on its role in the context of different neurodegenerative diseases (i.e. Alzheimer's, prion disease, HIV-associated dementia, multiple sclerosis, pain) and on the potential approaches for future therapeutic strategies.

Neonatal Hematology and Transfusion Medicine, An Issue of Clinics in Perinatology

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Author : Robert D. Christensen
Publisher : Elsevier Health Sciences
ISBN 13 : 0323402658
Total Pages : 241 pages
Book Rating : 4.3/5 (234 download)

Book Synopsis Neonatal Hematology and Transfusion Medicine, An Issue of Clinics in Perinatology by : Robert D. Christensen

Download or read book Neonatal Hematology and Transfusion Medicine, An Issue of Clinics in Perinatology written by Robert D. Christensen and published by Elsevier Health Sciences. This book was released on 2015-11-12 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in neonatal hematology, largely made by the authors of these chapters, are likely to generate wide spread and long-term improvements in outcomes, as well as reductions in costs of care. Publication of these advances in a single volume will facilitate dissemination of these techniques and practices. The advances include neuroprotection from erythropoietic stimulators, improved guidelines for platelet transfusions, evidence-based guidelines for FFP administration, improved diagnostic methods for genetic causes of severe neonatal jaundice, more accurate definitions of hematological perturbations in necrotizing enterocolitis and sepsis, and reduction in transfusions and in IVH rates by cord milking/delayed clamping.

Index Medicus

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Author :
Publisher :
ISBN 13 :
Total Pages : 1504 pages
Book Rating : 4.:/5 (319 download)

Book Synopsis Index Medicus by :

Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 1504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.