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Bone Metastasis For Solid Tumors From Mechanisms To Clinical Treatment
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Book Synopsis Bone Metastasis for Solid Tumors: from Mechanisms to Clinical Treatment by : Dianwen Song
Download or read book Bone Metastasis for Solid Tumors: from Mechanisms to Clinical Treatment written by Dianwen Song and published by Frontiers Media SA. This book was released on 2022-01-27 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Bone Metastasis written by Gurmit Singh and published by Springer Science & Business Media. This book was released on 2007-10-28 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: A state-of-the-art review of the molecular underpinnings of bone-seeking cancers, current treatment approaches for them, and future therapeutic strategies. The authors illuminate the role of various autocrine, paracrine, and immunological factors involved in the progression and establishment of bone metastases, highlighting the physiological processes that lead to bone degradation, pain, angiogenesis, and dysregulation of bone turnover. They also discuss the various strategies that appear to have promise and are currently deployed in treatment or are at the experimental stage.
Book Synopsis Bone Metastases by : Vassilios Vassiliou
Download or read book Bone Metastases written by Vassilios Vassiliou and published by Springer Science & Business Media. This book was released on 2013-11-19 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this book serves both as an introductory and reference book focusing on the field of metastatic bone disease. Featuring contributions from experts in the field, this volume describes the molecular and cellular mechanisms involved in the formation of bone metastases, presents the newer advances made in the understanding of the clinical picture and symptoms of patients, analyses the role of bone markers in research and clinical practice and deals with all aspects of imaging modalities applied for the detection and evaluation of bone metastases. Moreover, the use of all available treatment methods, such as radiotherapy, surgery and systemic treatments for the management of patients with metastatic bone disease is discussed in detail. Overall this volume presents a thorough overview of all aspects of metastatic bone disease and provides a comprehensive and concise information resource for researchers, oncologists, orthopaedic surgeons and clinicians dealing with patients with metastatic bone disease.
Book Synopsis Experimental and Clinical Metastasis by : Julia V. Burnier
Download or read book Experimental and Clinical Metastasis written by Julia V. Burnier and published by Springer Science & Business Media. This book was released on 2013-01-04 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metastatic disease is the most lethal aspect of human malignancies, making the understanding and continued research of the process of metastasis a crucial step in treating cancer. The proposed book, entitled “Experimental and Clinical Metastasis: A Comprehensive Review” aims to provide a clear and extensive review of the clinical and experimental implications of metastatic disease. This work focuses on recent contributions to the field of metastasis, and will highlight crucial findings in the molecular understanding of disseminated disease as well as standard and personalized medicine currently being investigated in the clinic. Topics will include, among many, gene properties of metastatic cells, molecular mechanisms of tumour growth and spread, animal models of metastasis, and clinical implications, markers and treatment for metastatic disease. With the participation of worldwide experts in the field of oncology, from major academic and government centres, this book will provide a leading manual for the study of the metastatic process, from benchside science to bedside care. In this light, the proposed book will facilitate classroom learning for both medical and graduate students, as well as serve as a tool for physicians and researchers interested in the metastatic process. In addition, this book will include the latest advances in basic science as well as leading technologies and theories of targeting metastatic cells. Most importantly, not only will basic and clinical aspects be discussed, but furthermore, the translational aspect of research in metastatic diseases will be emphasized.
Book Synopsis Bone Metastasis and Molecular Mechanisms by : Gurmit Singh
Download or read book Bone Metastasis and Molecular Mechanisms written by Gurmit Singh and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: Patients with advanced breast or prostate cancers usually develop bone metastases. The principal complications resulting from metastatic bone disease are pain, spinal cord compression, pathologic fractures and bone marrow suppression. Improving the management of bone metastases is crucial to quality of life for patients with breast and prostate cancer. Advances in understanding of the molecular mechanisms underlying the pathophysiology of bone metastasis are driving the development of new therapeutic strategies.
Book Synopsis Bone metastasis in the milieu of Osteoimmunology by : Jawed A. Siddiqui
Download or read book Bone metastasis in the milieu of Osteoimmunology written by Jawed A. Siddiqui and published by Frontiers Media SA. This book was released on 2023-09-01 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone metastases are common in many cancers and associated with skeletal-related events such as spinal cord compression, fractures, pain, disability, and impaired quality of life. Bone metastasis is most prominent in breast, prostate, and lung cancer patients and is the leading cause of cancer-associated death. Osteoblasts and osteoclasts control each other’s functions to maintain normal bone homeostasis. In addition, bone remodeling is governed by the balanced activity of the bone and immune cells. Bone metastasis is a multistage process, and the bone microenvironment influences the seeding and colonization of the disseminated cancer cells. Disruption of bone homeostasis and immune population provides fertile soil to facilitate cancer cell seeding. Despite the advancement of our understanding to treat primary tumors, most of the treatments for bone metastasis are palliative. Proper understanding of the immune component of the bone and their involvement in bone metastasis niche formation will help to explore future directions of bone metastasis research.
Book Synopsis Principles of Bone Biology by : John P. Bilezikian
Download or read book Principles of Bone Biology written by John P. Bilezikian and published by Academic Press. This book was released on 2008-09-29 with total page 2074 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders. Provides a "one-stop" shop. There is no need to search through many research journals or books to glean the information one wants...it is all in one source written by the experts in the field The essential resource for anyone involved in the study of bones and bone diseases Takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics Readers can easily search and locate information quickly as it will be online with this new edition
Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.
Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Book Synopsis Hypercalcemia of Malignancy by : Friedhelm Raue
Download or read book Hypercalcemia of Malignancy written by Friedhelm Raue and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hypercalcemia is the most common life-threatening metabolic disorder associated with cancer. The pathophysiological, epidemiological and clinical aspects of hypercalcemia of malignancy are presented in this issue, with a focus on the recently discovered humoral factor responsible for the development of hypercalcemia. With a better understanding of the pathophysiology of this condition and the development of new potent drugs, capable of inhibiting bone resorption, especially bisphosphonates, the clinician will be more successful in correcting hypercalcemia in the great majority of patients.
Download or read book Bone Metastasis written by F. William Orr and published by Berlin : Springer. This book was released on 1996 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Management of Bone Metastases by : Vincenzo Denaro
Download or read book Management of Bone Metastases written by Vincenzo Denaro and published by Springer. This book was released on 2018-07-25 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: This highly informative book provides a comprehensive, up-to-date and practical reference for daily clinical practice in the management of patients affected by bone metastases. Written by renowned orthopedic surgeons and leading doctors in the respective fields of expertise, it offers a transversal review of the current medical and surgical treatments to allow a real interdisciplinary approach to the oncologic patient according to the highest current standards. The book illustrates all the fundamental medical treatments for metastatic bone diseases and provides an overview of pathology issues related to this condition. An entire section is devoted to main different methods of patients approach. It also provides guidance on all current surgical procedures and minimally invasive treatment techniques. Using a common language and recognizing the different osteoncologic competences, this work allows surgeons, oncologists, radiologists, pathologists and physiatricians to update their expertise and broaden their understanding of how a real team approach can improve the management of these oncology patients.
Book Synopsis Metastatic Cancer: Clinical and Biological Perspectives by : Rahul Jandial
Download or read book Metastatic Cancer: Clinical and Biological Perspectives written by Rahul Jandial and published by CRC Press. This book was released on 2013-08-08 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most cancer deaths are a result of metastasis. The spread of a primary tumor to colonize neighboring and distant organs is the relentless endgame that defines the neoplastic process. Patients who have been diagnosed with cancer are treated to prevent both the recurrence of the tumor at the site of origin and metastasis that would re-stage them as advanced stage IV cancer. Historically and still with some types of cancer, stage IV is perceived by patients as “terminal.” Fortunately, recent molecular therapies have extended the lives of patients with advanced cancer and reassuringly people living with metastatic disease increasingly visit our clinics. What is the path forward? Given that the consilience of science and medicine is a dynamic art from which therapies arise, it would be misguided to consider any single work adequate at capturing the horizon for research. So with humility we constructed this text as primer for scientists. It begins with a broad introduction to the clinical management of common cancers. This is intended to serve as a foundation for investigators to consider when developing basic science hypotheses. Unquestionably, medical and surgical care of cancer patients reveals biology and dictates how novel therapeutics will ultimately be evaluated in clinical trials. The second section of this text offers provocative and evolving insights that underscore the breadth of science involved in the elucidation of cancer metastasis biology. The text concludes with information that integrates scientific and clinical foundations to highlight translational research. This book serves as a framework for scientists to conceptualize clinical and translational knowledge on the complexity of disease that is metastatic cancer.
Book Synopsis Bone Metastases from Prostate Cancer by : Francesco Bertoldo
Download or read book Bone Metastases from Prostate Cancer written by Francesco Bertoldo and published by Springer. This book was released on 2016-11-07 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents up-to-date information on one of the hottest topics in prostate cancer, namely bone metastases. The most recent developments with respect to biology, pathology, diagnosis, and treatment are described, providing readers with an excellent understanding of the mechanisms of metastasis formation, the characteristics of metastases, their aggressiveness, and prognostic factors for treatment response. The coverage includes discussion of all of the best available options (laboratory, radiology, and nuclear medicine) for achieving early diagnosis and both established and novel therapeutic approaches. Detailed information is provided on hormonal manipulations, bone-targeted agents, vaccines, taxanes, and other treatments that are enriching the therapeutic armamentarium. The editors can be considered leaders in the field, with great experience in diagnostic and clinical oncology and research, and the authors are experts in diverse specialties. This ensures a multidisciplinary approach, mirroring the current situation in which treatment in patients with bone metastases is undertaken by a team of specialists and health professionals in a variety of fields.
Book Synopsis Introduction to Cancer Metastasis by : Aamir Ahmad
Download or read book Introduction to Cancer Metastasis written by Aamir Ahmad and published by Academic Press. This book was released on 2016-11-14 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to Cancer Metastasis provides, in one place, an overview of organ-specific cancer metastasis and the most common sites of cancer metastasis. Through specific chapters on individual primary cancers, their metastasis, and chapters on common metastatic sites, this volume comprehensively informs readers about the broader knowledge base in cancer metastasis. The process of metastasis is particularly responsible for making cancer so lethal. This volume explores both metastasis from sites of origin and common metastatic sites, thus increasing understanding of both perspectives. Includes basic biology and translational approaches to organ-specific cancer sites Provides readers with information on emerging therapeutic targets for cancer metastasis Contains contributions from leading researchers around the globe
Book Synopsis Mechanisms of Bone Metastasis from Breast Cancer Using a Clinically Relevant Model by :
Download or read book Mechanisms of Bone Metastasis from Breast Cancer Using a Clinically Relevant Model written by and published by . This book was released on 2001 with total page 62 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone metastases develop in 70% of breast cancer patients who are left untreated or for whom treatment fails. Once the tumor has metastasised, the disease is hard to control and treatment options are limited. A lack of knowledge of the metastasis process and the genes that control it precludes the use of rational drug design. Breast cancer metastasis to bone is poorly understood largely due to a dearth of model systems available to study this process. We have developed a murine model of breast cancer that actively mimics the human disease. After implantation of tumor cells into the mammary gland, a primary tumour develops and subsequently metastasises to the lymph nodes, lung and bone. The resulting bone lysis, paralysis, hypercalcaemia and elevated plasma parathyroid hormone-related protein (PTHrP) are all hallmarks of the human disease. We have used the 3 years of DOD funding to develop and characterize the model and to seek the genes that regulate metastasis to bone. By differential gene expression analysis using two clones that are both metastatic but differ in their ability to metastasise to bone, we have identified candidate genes for bone tumor homing and growth. We have also determined the expression patterns and function of genes already proposed by others to play a role in breast cancer metastasis.
Book Synopsis Prevention of Bone Metastases by : Markus Joerger
Download or read book Prevention of Bone Metastases written by Markus Joerger and published by Springer Science & Business Media. This book was released on 2012-01-05 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone metastases continue to be a major cause of morbidity in cancer patients, but improved understanding of the biology of bone metastases has led to the identification of drugs that are of potential value in not only their treatment but also their prevention. This book, written by recognized experts in the field, provides a detailed overview of current knowledge on this subject. One important focus of the book is the efficacy of bisphosphonates in preventing bone metastases in patients with breast, lung, and prostate cancer and disease progression in cases of multiple myeloma. The combined use of bisphosphonates and cytostatics is also discussed, with a report on first clinical data. Further topics addressed include the significance of the bone microenvironment, special issues in the elderly patient, the use of bone turnover markers, and initial findings obtained with denosumab.
Book Synopsis MRI-Guided Focused Ultrasound Surgery by : Ferenc A. Jolesz
Download or read book MRI-Guided Focused Ultrasound Surgery written by Ferenc A. Jolesz and published by CRC Press. This book was released on 2007-09-26 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: MRI-Guided Focused Ultrasound Surgery will be the first publication on this new technology, and will present a variety of current and future clinical applications in tumor ablation treatment. This source helps surgeons and specialists evaluate, analyze, and utilize MRI-guided focused ultrasound surgery - bridging the gap between phase 3 clinical tr
