The Blood Brain Barrier (BBB)

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Publisher : Springer
ISBN 13 : 3662437872
Total Pages : 169 pages
Book Rating : 4.6/5 (624 download)

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Book Synopsis The Blood Brain Barrier (BBB) by : Gert Fricker

Download or read book The Blood Brain Barrier (BBB) written by Gert Fricker and published by Springer. This book was released on 2014-10-24 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

The Cerebral Circulation

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Publisher : Biota Publishing
ISBN 13 : 1615047239
Total Pages : 82 pages
Book Rating : 4.6/5 (15 download)

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Book Synopsis The Cerebral Circulation by : Marilyn J. Cipolla

Download or read book The Cerebral Circulation written by Marilyn J. Cipolla and published by Biota Publishing. This book was released on 2016-07-28 with total page 82 pages. Available in PDF, EPUB and Kindle. Book excerpt: This e-book will review special features of the cerebral circulation and how they contribute to the physiology of the brain. It describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain microcirculation such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death.

Horse Brain, Human Brain

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Publisher : Trafalgar Square Books
ISBN 13 : 1646010272
Total Pages : 455 pages
Book Rating : 4.6/5 (46 download)

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Book Synopsis Horse Brain, Human Brain by : Janet Jones

Download or read book Horse Brain, Human Brain written by Janet Jones and published by Trafalgar Square Books. This book was released on 2020-09-01 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: An eye-opening game-changer of a book that sheds new light on how horses learn, think, perceive, and perform, and explains how to work with the horse’s brain instead of against it. In this illuminating book, brain scientist and horsewoman Janet Jones describes human and equine brains working together. Using plain language, she explores the differences and similarities between equine and human ways of negotiating the world. Mental abilities—like seeing, learning, fearing, trusting, and focusing—are discussed from both human and horse perspectives. Throughout, true stories of horses and handlers attempting to understand each other—sometimes successfully, sometimes not—help to illustrate the principles. Horsemanship of every kind depends on mutual interaction between equine and human brains. When we understand the function of both, we can learn to communicate with horses on their terms instead of ours. By meeting horses halfway, we achieve many goals. We improve performance. We save valuable training time. We develop much deeper bonds with our horses. We handle them with insight and kindness instead of force or command. We comprehend their misbehavior in ways that allow solutions. We reduce the human mistakes we often make while working with them. Instead of working against the horse’s brain, expecting him to function in unnatural and counterproductive ways, this book provides the information needed to ride with the horse’s brain. Each principle is applied to real everyday issues in the arena or on the trail, often illustrated with true stories from the author’s horse training experience. Horse Brain, Human Brain offers revolutionary ideas that should be considered by anyone who works with horses.

Blood, Brains and Beer

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Author :
Publisher :
ISBN 13 :
Total Pages : 136 pages
Book Rating : 4.X/5 ( download)

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Book Synopsis Blood, Brains and Beer by : David Ogilvy

Download or read book Blood, Brains and Beer written by David Ogilvy and published by . This book was released on 1978 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Angelo Mosso's Circulation of Blood in the Human Brain

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Author :
Publisher : Oxford University Press
ISBN 13 : 0199358990
Total Pages : 241 pages
Book Rating : 4.1/5 (993 download)

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Book Synopsis Angelo Mosso's Circulation of Blood in the Human Brain by : Marcus E. Raichle

Download or read book Angelo Mosso's Circulation of Blood in the Human Brain written by Marcus E. Raichle and published by Oxford University Press. This book was released on 2014-09-17 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern brain imaging is revolutionizing the study of brain function in health and disease. However, few realize that its origins began in the nineteenth century with Dr. Angelo Mosso's pioneering experiments. A foremost Italian physiologist and scientist, Angelo Mosso studied several patients brought to him with head injuries that exposed their live brains to direct, long-term observation. He took advantage of these rare opportunities to document, for the first time, changes in cerebral blood flow in response to different stimuli, behaviors, and emotions, the very same changes that are now the basis for the measurements underlying modern functional brain imaging. Mosso was widely recognized by his contemporaries for his highly original studies, published both in Italian in 1878 and in German in 1881. Yet there has never been a translation through which this groundbreaking work could be appreciated by the English-speaking world. Indeed, Angelo Mosso's sophisticated experiments were to neuroscience what surgeon William Beaumont's in vivo observations were to gastric physiology fifty years earlier. This unique monograph establishes Mosso's rightful role as the pioneer of brain imaging. Through it, the modern reader, whether expert neuroscientist or interested student, can gain a new perspective on the author's remarkable insights: how behaviors as subtle as thinking about a subject or feeling an emotion produce the changes in pulsations of the brain that he observed and recorded for posterity. Special features of this volume include first a brief summary of Mosso's life. Two pioneers of modern brain imaging, Marcus E. Raichle (winner of the Kavli Prize for Neuroscience) and Gordon M. Shepherd (Yale University Professor of Neurobiology) then review Mosso's work and provide extensive commentary to explain its relevance to modern brain science. The authors not only emphasize Mosso's pioneering role in brain imaging, but also his fundamental contribution to the rise of cognitive neuroscience. The English translation (by historian of medicine Christiane Nockels Fabbri) follows, together with all of the plates and illustrations of the original volume. The result is a classic of neuroscience, now available for wide appreciation by neuroscientists, neurologists, psychologists, psychiatrists, historians of science and medicine, and the general public.

Seven and a Half Lessons about the Brain

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Publisher : Houghton Mifflin
ISBN 13 : 0358157145
Total Pages : 197 pages
Book Rating : 4.3/5 (581 download)

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Book Synopsis Seven and a Half Lessons about the Brain by : Lisa Feldman Barrett

Download or read book Seven and a Half Lessons about the Brain written by Lisa Feldman Barrett and published by Houghton Mifflin. This book was released on 2020-11-17 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the author of How Emotions Are Made, a myth-busting primer on the brain, in the tradition of Seven Brief Lessons on Physics and Astrophysics for People in a Hurry

Overloaded

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Publisher : Bloomsbury Publishing
ISBN 13 : 1472969367
Total Pages : 337 pages
Book Rating : 4.4/5 (729 download)

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Book Synopsis Overloaded by : Ginny Smith

Download or read book Overloaded written by Ginny Smith and published by Bloomsbury Publishing. This book was released on 2021-04-01 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: A NEW SCIENTIST BOOK OF THE YEAR From adrenaline to dopamine, our lives are shaped by the chemicals that control us. They are the hormones and neurotransmitters that our brains run on, and Overloaded looks at the roles they play in all aspects of our experiences, from how we make decisions, who we love, what we remember to basic survival drives such as hunger, fear and sleep. Author Ginny Smith explores what these tiny molecules do: what roles do cortisol and adrenaline play in memory formation? How do hormones and neurotransmitters affect the trajectory of our romantic relationships? Ginny meets scientists at the cutting-edge of brain chemistry research who are uncovering unexpected connections between these crucial chemicals. An eye-opening route through the remarkable world of neuro-transmitters, Overloaded unveils the chemicals inside each of us that touch every facet of our lives.

Brains

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Publisher : Harper Collins
ISBN 13 : 0062000306
Total Pages : 193 pages
Book Rating : 4.0/5 (62 download)

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Book Synopsis Brains by : Robin Becker

Download or read book Brains written by Robin Becker and published by Harper Collins. This book was released on 2010-05-18 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: “A witty and unexpected take on the zombie genre; I had a great time.” —Charlaine Harris, #1 New York Times bestselling author of the Sookie Stackhouse novels Subtitled “A Zombie Memoir,” Brains looks at America’s favorite walking-dead flesh-eaters from an audaciously original and deliciously gruesome new perspective. Debut author Robin Becker blazes new ground with this story of former college professor-cum-sentient zombie Jack Barnes, who recounts the tale of the resistance he organized in the wake of the recent zombie apocalypse. World War Z; Shaun of the Dead;Pride, Prejudice, and Zombies… Becker tops them all with Brains—a witty, tasty treat for anyone who every spent a midnight glued to a classic George A. Romero zombie epic!

Discovering the Brain

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Publisher : National Academies Press
ISBN 13 : 0309045290
Total Pages : 195 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Discovering the Brain by : National Academy of Sciences

Download or read book Discovering the Brain written by National Academy of Sciences and published by National Academies Press. This book was released on 1992-01-01 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brainâ€"an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines: How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attentionâ€"and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniquesâ€"what various technologies can and cannot tell usâ€"and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakersâ€"and many scientists as wellâ€"with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."

Am I Just My Brain?

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Publisher : The Good Book Company
ISBN 13 : 1784984035
Total Pages : 146 pages
Book Rating : 4.7/5 (849 download)

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Book Synopsis Am I Just My Brain? by : Sharon Dirckx

Download or read book Am I Just My Brain? written by Sharon Dirckx and published by The Good Book Company. This book was released on 2019-05-01 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: Looking at the body, mind and soul to answer the question: What exactly is a human being? Modern research is uncovering more and more detail of what our brain is and how it works. We are living, thinking creatures who carry around with us an amazing organic supercomputer in our heads. But what is the relationship between our brains and our minds-and ultimately our sense of identity as a person? Are we more than machines? Is free-will an illusion? Do we have a soul? Brain Imaging Scientist Sharon Dirckx lays out the current understanding of who we are from biologists, philosophers, theologians and psychologists, and points towards a bigger picture that suggests answers to the fundamental questions of our existence. Not just "What am I?", but "Who am I?"-and "Why am I?" Read this book to gain valuable insight into what modern research is telling us about ourselves, or to give a sceptical friend to challenge the idea that we are merely material beings living in a material world.

An Introduction to the Blood-brain Barrier

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Publisher : CRC Press
ISBN 13 : 9780849377617
Total Pages : 356 pages
Book Rating : 4.3/5 (776 download)

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Book Synopsis An Introduction to the Blood-brain Barrier by : Davson

Download or read book An Introduction to the Blood-brain Barrier written by Davson and published by CRC Press. This book was released on 1993 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is devoted to exploring the complexities of the blood-brain barrier. The book begins by reviewing the historical experiments that led to the concept of a barrier protecting the brain from variations in the blood. Transport kinetics and carrier-mediated processes are described, and the mechanism by which molecules can cross the barrier is discussed. Ways in which the barrier can be disrupted and opened are covered as well. Subsequent chapters in the book describe the transport of glucose and amino acids into the central nervous systems, cover recent findings by which peptides and proteins are able to gain entry or are excluded from the brain, and analyze models that can be used for investigating how the blood-brain barrier can be disordered in neurological disease processes.

Introduction to the Blood-Brain Barrier

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Publisher : Cambridge University Press
ISBN 13 : 0521581249
Total Pages : 504 pages
Book Rating : 4.5/5 (215 download)

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Book Synopsis Introduction to the Blood-Brain Barrier by : William M. Pardridge

Download or read book Introduction to the Blood-Brain Barrier written by William M. Pardridge and published by Cambridge University Press. This book was released on 1998-08-28 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: The blood-brain barrier serves to protect the brain from toxic substances whilst simultaneously allowing access to essential nutrients and chemical signals. At the interface between brain and body, knowledge of the blood-brain barrier forms an essential component in the complete understanding of a large proportion of medical disciplines. Nevertheless, it seems that ignorance of both the biology of this important membrane and the methodology suitable for its investigation still remains an impediment to progress in many fields, including, for example, the development of new and efficacious neuropharmaceuticals, cerebrovascular disease, Alzheimer's disease, cerebral AIDS and brain tumours. This introduction for both researchers and clinicians across the medical sciences is intended to aid both those beginning work directly in this area and those wishing simply to be better informed when interpreting information where the blood-brain barrier may be involved. Advances in both methodology and biology are detailed in 50 chapters from international authorities.

Neurotoxicology

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Publisher : CRC Press
ISBN 13 : 1420054880
Total Pages : 334 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Neurotoxicology by : G. Jean Harry

Download or read book Neurotoxicology written by G. Jean Harry and published by CRC Press. This book was released on 2016-04-19 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new edition presents an integrated approach to neurotoxicology, the study of organisms' responses to changes in their environment and how interruption of the flow of information by chemical exposure causes a wide range of effects - from learning deficits, sensory disturbances in the extremities, and muscle weakness to seizures and signs simila

Implications of the Blood-Brain Barrier and Its Manipulation

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1461307015
Total Pages : 424 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Implications of the Blood-Brain Barrier and Its Manipulation by : E.A. Neuwelt

Download or read book Implications of the Blood-Brain Barrier and Its Manipulation written by E.A. Neuwelt and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the structure and function of the blood-brain barrier (BBB) and recogniz ing its clinical relevance require a concert of scientific disciplines applied from a view point of integrative physiology rather than from only molecular or analytical approaches. It is this broad scope that is emphasized in this book. In my opinion, four original contributions define the field as it exists today. The first, a monograph by Broman,1 entitled The Permeability of the Cerebrospinal Vessels in Normal and Pathological Conditions, was the model for many subsequent clinical and 3 experimental studies on BBB pathology. Second, experiments by Davson, summarized in his book entitled Physiology of the Ocular and Cerebrospinal Fluids, indicated that passive entry of nonelectrolytes into brain from blood is governed largely by their lipid 4 solubility. This research supported the original suggestion by Gesell and Hertzman that cerebral membranes have the semipermeability properties of cell membranes. The modem era of the barrier was introduced with the 1965 paper by Crone,2 entitled "Facilitated transfer of glucose from blood to brain tissue. " This paper identified stereospecific, facilitated transport of glucose as part of a system of regulatory barrier properties at a time when only a barrier to passive diffusion had been contemplated. Finally, the 1967 paper by Reese and Kamovsky, 11 entitled "Fine structural localization of a blood-brain barrier to exogenous peroxidase," sited the barrier at the continuous layer of cerebrovascular endothelial cells, which are connected by tight junctions.

The Biological Mind

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Publisher : Basic Books
ISBN 13 : 154164431X
Total Pages : 342 pages
Book Rating : 4.5/5 (416 download)

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Book Synopsis The Biological Mind by : Alan Jasanoff

Download or read book The Biological Mind written by Alan Jasanoff and published by Basic Books. This book was released on 2018-03-13 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: A pioneering neuroscientist argues that we are more than our brains To many, the brain is the seat of personal identity and autonomy. But the way we talk about the brain is often rooted more in mystical conceptions of the soul than in scientific fact. This blinds us to the physical realities of mental function. We ignore bodily influences on our psychology, from chemicals in the blood to bacteria in the gut, and overlook the ways that the environment affects our behavior, via factors varying from subconscious sights and sounds to the weather. As a result, we alternately overestimate our capacity for free will or equate brains to inorganic machines like computers. But a brain is neither a soul nor an electrical network: it is a bodily organ, and it cannot be separated from its surroundings. Our selves aren't just inside our heads -- they're spread throughout our bodies and beyond. Only once we come to terms with this can we grasp the true nature of our humanity.

The Neuroscientist Who Lost Her Mind

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Publisher : HarperCollins
ISBN 13 : 1328787273
Total Pages : 213 pages
Book Rating : 4.3/5 (287 download)

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Book Synopsis The Neuroscientist Who Lost Her Mind by : Barbara K. Lipska

Download or read book The Neuroscientist Who Lost Her Mind written by Barbara K. Lipska and published by HarperCollins. This book was released on 2018-04-03 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the tradition of My Stroke of Insight and Brain on Fire, this powerful memoir recounts Barbara Lipska's deadly brain cancer and explains its unforgettable lessons about the brain and mind. Neuroscientist Lipska was diagnosed early in 2015 with metastatic melanoma in her brain's frontal lobe. As the cancer progressed and was treated, she experienced behavioral and cognitive symptoms connected to a range of mental disorders, including dementia and her professional specialty, schizophrenia. Lipska's family and associates were alarmed by the changes in her behavior, which she failed to acknowledge herself. Gradually, after a course of immunotherapy, Lipska returned to normal functioning, amazingly recalled her experience, and through her knowledge of neuroscience identified the ways in which her brain changed during treatment. Lipska admits her condition was unusual; after recovery she was able to return to her research and resume her athletic training and compete in a triathalon. Most patients with similar brain cancers rarely survive to describe their ordeal. Lipska's memoir, coauthored with journalist Elaine McArdle, shows that strength and courage but also an encouraging support network are vital to recovery.

The Concept of a Blood-Brain Barrier

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Author :
Publisher :
ISBN 13 : 9780783732176
Total Pages : 471 pages
Book Rating : 4.7/5 (321 download)

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Book Synopsis The Concept of a Blood-Brain Barrier by : Michael W. Bradbury

Download or read book The Concept of a Blood-Brain Barrier written by Michael W. Bradbury and published by . This book was released on with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: