Biomedical, Therapeutic and Clinical Applications of Bioactive Glasses

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Publisher : Woodhead Publishing
ISBN 13 : 0081021976
Total Pages : 586 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Biomedical, Therapeutic and Clinical Applications of Bioactive Glasses by : Gurbinder Kaur

Download or read book Biomedical, Therapeutic and Clinical Applications of Bioactive Glasses written by Gurbinder Kaur and published by Woodhead Publishing. This book was released on 2018-09-22 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical, Therapeutic and Clinical Applications of Bioactive Glasses is an essential guide to bioactive glasses, offering an overview of all aspects of the development and utilization of this cutting-edge material. The book covers vital issues, including mesoporosity, encapsulation technologies, scaffold formation and coatings for a number of applications, including drug delivery, encapsulation, scaffolds and coatings. Readers will gain a strong understanding and practical knowledge of the therapeutic aspects of bioceramics, with a focus on glasses from a clinical point-of- view. Researchers, students and scientists involved in bioceramics, bone tissue engineering, regeneration and biomedical engineering will find this to be a comprehensive resource. - Presents detailed coverage of bioactive glasses, including technologies and applications - Includes all the major development areas related to bioactive glasses, enabling readers to understand the latest research - Considers the potential future developments of bioactive glasses as a drug carrier

Bioactive Glasses

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Publisher : Woodhead Publishing
ISBN 13 : 0081009372
Total Pages : 428 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Bioactive Glasses by : Heimo Ylänen

Download or read book Bioactive Glasses written by Heimo Ylänen and published by Woodhead Publishing. This book was released on 2017-09-15 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioactive Glasses: Materials, Properties and Applications, Second Edition provides revised, expanded and updated content on the current status of this unique material, including its properties, technologies and applications. The book is suitable for those active in the biomaterials and bioengineering field, and includes eight new chapters that cover material types, computational modeling, coatings and applications. Chapters deal with the materials and mechanical properties of bioactive glass and the applications of bioactive glasses, covering their uses in wound healing, maxillofacial surgery and bone tissue engineering, among other topics. With its distinguished editor and expert team of international contributors, the book is an invaluable reference for researchers and scientists in the field of biomaterials, both in academia and industry. - Provides a detailed review of bioactive glasses, their properties, technologies and applications - Comprehensively covers the materials and mechanical properties of bioactive glass and their further applications, including wound healing, maxillofacial surgery and bone tissue engineering - Suitable for those active in the biomaterials and bioengineering field

Bioactive Glasses

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Publisher : Royal Society of Chemistry
ISBN 13 : 1782622012
Total Pages : 551 pages
Book Rating : 4.7/5 (826 download)

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Book Synopsis Bioactive Glasses by : Aldo R Boccaccini

Download or read book Bioactive Glasses written by Aldo R Boccaccini and published by Royal Society of Chemistry. This book was released on 2016-11-28 with total page 551 pages. Available in PDF, EPUB and Kindle. Book excerpt: The global ageing society has significantly increased the need for implant materials, which not only replace damaged or lost tissue but are also able to regenerate it. The field of bioactive glasses has been expanding continuously over recent years as they have been shown to bond with hard and soft tissue, release therapeutically active ions, and be capable of enhancing bone formation and regeneration. In addition, they are successfully being used to re-mineralise teeth, thereby making bioactive glasses highly attractive materials in both dentistry and medicine. Understanding the multidisciplinary requirements set by the human body’s environment and the special characteristics of the different families of bioactive glasses is a key in developing new compositions to novel clinical applications. Bioactive Glasses aims to bridge the different scientific communities associated with the field of bioactive glasses with focus on the materials science point of view. Emerging applications covered include soft tissue regeneration, wound healing, vascularisation, cancer treatment and drug delivery devices. This book provides a comprehensive overview of the latest applications of bioactive glasses for material scientists.

Bioceramics and their Clinical Applications

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Author :
Publisher : Elsevier
ISBN 13 : 1845694228
Total Pages : 785 pages
Book Rating : 4.8/5 (456 download)

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Book Synopsis Bioceramics and their Clinical Applications by : Tadashi Kokubo

Download or read book Bioceramics and their Clinical Applications written by Tadashi Kokubo and published by Elsevier. This book was released on 2008-03-25 with total page 785 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioceramics have been used very successfully within the human body for many years. They are commonly used in orthopaedic surgery and dentistry but they are potentially suitable for a wide range of important applications within the medical device industry. This important book reviews the range of bioceramics, their properties and range of clinical uses.Chapters in the first section of the book discusses issues of significance to a range of bioceramics such as their structure, mechanical properties and biological interactions. The second part reviews the fabrication, microstructure and properties of specific bioceramics and glasses, concentrating on the most promising materials. These include alumina and zirconia ceramics, bioactive glasses and bioactive glass-ceramics, calcium sulphate, tricalcium phosphate-based ceramics, hydroxyapatite, tricalcium phosphate/hydroxyapatite biphasic ceramics, si-substrated hydroxyapatite, calcium phosphate cement, calcium phosphate coating, titania-based materials, ceramic-polymer composites, dental ceramics and dental glass-ceramics. The final group of chapters reviews the clinical applications of bioceramics in joint replacement, bone grafts, tissue engineering and dentistry.Bioceramics and their clinical applications is written by leading academics from around the world and it provides an authoritative review of this highly active area of research. This book is a useful resource for biomaterials scientists and engineers, as well as for clinicians and the academic community. - Provides an authoritative review of this highly active area of research - Discusses issues of significance of a range of bioceramics such as their structure, mechanical properties and biological interactions - Reviews the clinical applications of bioceramics in joint replacement, bone grafts, tissue engineering and dentistry

Materials for Biomedical Engineering: Bioactive Materials, Properties, and Applications

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Author :
Publisher : Elsevier
ISBN 13 : 0128184329
Total Pages : 618 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Materials for Biomedical Engineering: Bioactive Materials, Properties, and Applications by : Alexandru Mihai Grumezescu

Download or read book Materials for Biomedical Engineering: Bioactive Materials, Properties, and Applications written by Alexandru Mihai Grumezescu and published by Elsevier. This book was released on 2019-06-18 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: Materials for Biomedical Engineering: Bioactive Materials, Properties, and Applications introduces the reader to a broad range of the different types of bioactive materials used in biomedical engineering. All the main types of bioactive materials are discussed, with an emphasis placed on their synthesis, properties, performance, and potential for biomedical applications. Key chapters on modeling and surface modification and methods provide the step-by-step information needed by researchers. Important applications of bioactive materials, such as drug delivery, cancer therapy and clinical dentistry are also highlighted in detail. Final sections look at future perspectives for bioactive materials in biomedical engineering. - Provides a knowledge of the range of bioactive materials available, enabling the reader to make optimal materials selection decisions - Presents detailed information on current and proposed applications of the latest bioactive materials, thus empowering readers to design innovative products and processes - Covers methods and provides the detailed guidance needed by researchers to replicate key procedures and contribute to further research and discovery in this important field

Green Biocomposites for Biomedical Engineering

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Publisher : Woodhead Publishing
ISBN 13 : 0128215542
Total Pages : 476 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Green Biocomposites for Biomedical Engineering by : Md Enamul Hoque

Download or read book Green Biocomposites for Biomedical Engineering written by Md Enamul Hoque and published by Woodhead Publishing. This book was released on 2021-06-30 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Green Biocomposites for Biomedical Engineering: Design, Properties, and Applications combines emergent research outcomes with fundamental theoretical concepts relevant to processing, properties and applications of advanced green composites in the field of biomedical engineering. The book outlines the design elements and characterization of biocomposites, highlighting each class of biocomposite separately. A broad range of biomedical applications for biocomposites is then covered, with a final section discussing the ethics and safety regulations associated with manufacturing and the use of biocomposites. With contributions from eminent editors and recognized authors around the world, this book is a vital reference for researchers in biomedical engineering, materials science and environmental science, both in industry and academia. - Provides comprehensive information regarding current advances in the interdisciplinary field of eco-friendly green composite materials for biomedical applications - Offers coverage of state-of-the-art physics-based advanced models used in composites - Lists a broad range of characterization techniques and biomedical applications

Chemistry of Medical and Dental Materials

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Publisher : Royal Society of Chemistry
ISBN 13 : 1839161329
Total Pages : 215 pages
Book Rating : 4.8/5 (391 download)

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Book Synopsis Chemistry of Medical and Dental Materials by : John W Nicholson

Download or read book Chemistry of Medical and Dental Materials written by John W Nicholson and published by Royal Society of Chemistry. This book was released on 2020-05-28 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: With synthetic implants such as hip joints, heart valves and dental crowns now routinely used in the human body for medical purposes, study of the metals, ceramics and polymers used in these repairs is more important than ever. The Chemistry of Medical and Dental Materials examines the properties and interactions of these materials within the body at a molecular level, and includes discussion of bioengineering and cell biology, with accounts of the surgical procedures used, as well as extensive coverage of the possible biological reactions to the presence of foreign materials in the body. Acknowledging the substantial growth of the biomaterials field since the first edition, this second edition sees each chapter comprehensively revised and updated. The new edition also includes a new chapter on ethical perspectives, covering issues from animal and human subject testing to the availability of treatments for poorer socio-economic groups. With detailed reviews of the current literature, this book will be a key resource for researchers and practitioners in biomaterials science and dental biomaterials who are involved in the development of new and improved repair materials.

Introduction To Bioceramics, An (2nd Edition)

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Publisher : World Scientific Publishing Company
ISBN 13 : 1908977175
Total Pages : 621 pages
Book Rating : 4.9/5 (89 download)

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Book Synopsis Introduction To Bioceramics, An (2nd Edition) by : Larry L Hench

Download or read book Introduction To Bioceramics, An (2nd Edition) written by Larry L Hench and published by World Scientific Publishing Company. This book was released on 2013-05-06 with total page 621 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the second edition of the classic book An Introduction to Bioceramics which provides a comprehensive overview of all types of ceramic and glass materials that are used in medicine and dentistry. The enormous growth of the field of bioceramics is due to the recognition by the medical and dental community of the importance of bioactive materials to stimulate repair and regeneration of tissues. This edition includes 21 new chapters that document the science and especially the clinical applications of the new generation of bioceramics in the field of tissue regeneration and repair. Important socioeconomic factors influencing the economics and availability of new medical treatments are covered with updates on regulatory procedures for new biomaterials, methods for technology transfer and ethical issues.The book contains 42 chapters that offer the only comprehensive treatment of the science, technology and clinical applications of all types of bioceramic materials used in medicine and dentistry. Each chapter is written by leaders in their specialized fields and is a thorough review of the subject matter, unlike many conference proceedings. All chapters have been edited to reflect the same writing style, making the book an easy read. The completeness of treatment of all types of bioceramics and their clinical applications makes the book unique in the field and invaluable to all readers.

Advanced Techniques in Bone Regeneration

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Publisher : BoD – Books on Demand
ISBN 13 : 9535125389
Total Pages : 388 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Advanced Techniques in Bone Regeneration by : Alessandro Rozim Zorzi

Download or read book Advanced Techniques in Bone Regeneration written by Alessandro Rozim Zorzi and published by BoD – Books on Demand. This book was released on 2016-08-31 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Techniques in Bone Regeneration is a book that brings together over 15 chapters, written by leading practitioners and researchers, of the latest advances in the area, including surgical techniques, new discoveries, and promising methods involving biomaterials and tissue engineering. This book is intended for all who work in the treatment of disorders involving problems with the regeneration of bone tissue, are doctors or dentists, as well as are researchers and teachers involved in this exciting field of scientific knowledge.

Biomaterials in Clinical Practice

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Author :
Publisher : Springer
ISBN 13 : 3319680250
Total Pages : 823 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis Biomaterials in Clinical Practice by : Fatima Zivic

Download or read book Biomaterials in Clinical Practice written by Fatima Zivic and published by Springer. This book was released on 2017-10-20 with total page 823 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the properties of biomaterials that have found wide clinical applications, while also reviewing the state-of-the-art in the development towards future medical applications, starting with a brief introduction to the history of biomaterials used in hip arthroplasty. The book then reviews general types of biomaterials – polymers, ceramics, and metals, as well as different material structures such as porous materials and coatings and their applications – before exploring various current research trends, such as biodegradable and porous metals, shape memory alloys, bioactive biomaterials and coatings, and nanometals used in the diagnosis and therapy of cancer. In turn, the book discusses a range of methods and approaches used in connection with biomaterial properties and characterization – chemical properties, biocompatibility, in vivo behaviour characterisation, as well as genotoxicity and mutagenicity – and reviews various diagnostic techniques: histopathological analysis, imagining techniques, and methods for physicochemical and spectroscopic characterization. Properties of stent deployment procedures in cardiovascular surgeries, from aspects of prediction, development and deployment of stent geometries are presented on the basis of novel modelling approaches. The last part of the book presents the clinical applications of biomaterials, together with case studies in dentistry, knee and hip prosthesis. Reflecting the efforts of a multidisciplinary team of authors, gathering chemical engineers, medical doctors, physicists and engineers, it presents a rich blend of perspectives on the application of biomaterials in clinical practice. The book will provide clinicians with an essential review of currently available solutions in specific medical areas, also incorporating non-medical solutions and standpoints, thus offering them a broader selection of materials and implantable solutions. This work is the result of joint efforts of various academic and research institutions participating in WIMB Tempus project, 543898-TEMPUS-1-2013-1-ES-TEMPUS-JPHES, "Development of Sustainable Interrelations between Education, Research and Innovation at WBC Universities in Nanotechnologies and Advanced Materials where Innovation Means Business", co-funded by the Tempus Programme of the European Union.

Biocompatible Glasses

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Publisher : Springer
ISBN 13 : 331944249X
Total Pages : 338 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Biocompatible Glasses by : Juliana Marchi

Download or read book Biocompatible Glasses written by Juliana Marchi and published by Springer. This book was released on 2016-11-30 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the applications of bioglasses in the biomedical field. It starts with the history and evolution of bioglasses before moving on to the structure and percolation theory, and lastly investigating their current and potential future applications in various fields including dentistry, tissue engineering, bone regeneration, ophthalmology, and drug delivery. The chapters were written by a team of international experts in the field and will be of great interest not only to material scientists, but also to medical doctors and other health sector professionals.

Biomaterials for Precision Cancer Medicine

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Publisher : Elsevier
ISBN 13 : 0323885675
Total Pages : 639 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Biomaterials for Precision Cancer Medicine by : Saeid Kargozar

Download or read book Biomaterials for Precision Cancer Medicine written by Saeid Kargozar and published by Elsevier. This book was released on 2024-10-04 with total page 639 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterials for Precision Cancer Medicine bridges the gap between materials science and medicine, providing insights into novel biomaterial-based treatments for cancer. The book describes the various smart biomaterial-based treatments available, reviewing how they can be designed to target specific tumor types, adapt to changes in the cell microenvironment and offer smart, personalized therapy for different cancer variants, especially those which are drug-resistant. The book provides a materials-focused look at precision cancer medicine, and is thus useful to materials scientists, biomedical engineers, and biomedical scientists – including cancer and genetic specialists – with an interest in alternative cancer therapies. - Reviews the state-of-the-art in precision and translational medicine, setting the scene for the introduction of alternative biomaterial-based therapies - Covers a range of biomaterials for personalized cancer treatment, including polymer-protein conjugates, smart nanoparticles, metal compounds, and more - Addresses preclinical assessment, health risks, challenges and future perspective of precision anti-cancer biomaterials

Bioceramics

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Publisher : Springer Science & Business Media
ISBN 13 : 0387095454
Total Pages : 362 pages
Book Rating : 4.3/5 (87 download)

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Book Synopsis Bioceramics by : Joon Park

Download or read book Bioceramics written by Joon Park and published by Springer Science & Business Media. This book was released on 2009-03-02 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioceramics: Properties, Characterization, and Applications will be a general introduction to the uses of ceramics and glasses in the human body for the purposes of aiding, healing, correcting deformities, and restoring lost function. With over 30 years experience, the author developed the text as an outgrowth of an undergraduate course for senior students in biomedical engineering and will emphasize the fundamentals and applications in modern implant fabrication, and will also deal with tissue engineering scaffolds made of ceramics. Organized as a textbook for the student needing to acquire the core competencies, it will meet the demands of advanced undergraduate or graduate coursework in bioceramics, biomaterials, biomedical engineering, and biophysics.

Nanoengineering of Biomaterials

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Publisher : John Wiley & Sons
ISBN 13 : 3527349049
Total Pages : 1063 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Nanoengineering of Biomaterials by : Sougata Jana

Download or read book Nanoengineering of Biomaterials written by Sougata Jana and published by John Wiley & Sons. This book was released on 2022-04-18 with total page 1063 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive discussion of various types of nanoengineered biomaterials and their applications In Nanoengineering of Biomaterials: Drug Delivery & Biomedical Applications, an expert team of chemists delivers a succinct exploration of the synthesis, characterization, in-vitro and in-vivo drug molecule release, pharmacokinetic activity, pharmacodynamic activity, and the biomedical applications of several types of nanoengineered biomaterials. The editors have also included resources to highlight the most current developments in the field. The book is a collection of valuable and accessible reference sources for researchers in materials chemistry and related disciplines. It uses a functions-directed approach to using organic and inorganic source compounds that translate into biological systems as scaffolds, micelles, dendrimers, and other delivery systems. Nanoengineering of Biomaterials offers readers up-to-date chemistry and material science insights that are readily transferrable to biomedical systems. The book also includes: Thorough introductions to alginate nanoparticle delivery of therapeutics and chitosan-based nanomaterials in biological applications Comprehensive explorations of nanostructured carrageenan as a drug carrier, gellan gum nanoparticles in drug delivery, and guar-gum nanoparticles in the delivery of bioactive molecules Practical discussions of protein-based nanoparticles for drug delivery, solid lipid nanoparticles as drug carriers, and pH-responsive nanoparticles in therapy In-depth examinations of stimuli-responsive nano carriers in drug targeting Perfect for pharmaceutical chemists, materials scientists, polymer chemists, life scientists, and medicinal chemists, Nanoengineering of Biomaterials: Drug Delivery and Biomedical Applications is also an indispensable resource for biologists and bioengineers seeking a one-stop reference on the transferability of materials chemistry and nanotechnology to biomedicine.

Applications of Biomedical Engineering in Dentistry

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Author :
Publisher : Springer Nature
ISBN 13 : 3030215830
Total Pages : 477 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Applications of Biomedical Engineering in Dentistry by : Lobat Tayebi

Download or read book Applications of Biomedical Engineering in Dentistry written by Lobat Tayebi and published by Springer Nature. This book was released on 2019-08-27 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers readers a valuable overview of recent advances in biomedical engineering, as applied to the modern dentistry. It begins by studying the biomaterials in dentistry, and materials used intraoperatively during oral and maxillofacial surgery procedures. Next, it considers the subjects in which biomedical engineers can be influential, such as 3-dimensional (3D) imaging, laser and photobiomodulation, surface modification of dental implants, and bioreactors. Hard and soft tissue engineerings in dentistry are discussed, and some specific and essential methods such as 3D-printing are elaborated. Presenting particular clinical functions of regenerative dentistry and tissue engineering in treatment of oral and maxillofacial soft tissues is the subject of a separate chapter. Challenges in the rehabilitation handling of large and localized oral and maxillofacial defects is a severe issue in dentistry, which are considered to understand how bioengineers help with treatment methods in this regard. Recent advances in nanodentistry is discussed followed by a chapter on the applications of stem cell-encapsulated hydrogel in dentistry.Periodontal regeneration is a challenging issue in dentistry, and thus, is going to be considered separately to understand the efforts and achievements of tissue engineers in this matter. Oral mucosa grafting is a practical approach in engineering and treatment of tissues in ophthalmology, which is the subject of another chapter. Microfluidic approaches became more popular in biomedical engineering during the last decade; hence, one chapter focuses on the advanced topic of microfluidics technologies using oral factors as saliva-based studies. Injectable gels in endodontics is a new theme in dentistry that bioengineering skills can advance its development, specifically by producing clinically safe and effective gels with regeneration and antibacterial properties. Engineered products often need to be tested in vivo before being clinical in dentistry; thus, one chapter is dedicated to reviewing applicable animal models in dental research. The last chapter covers the progress on the whole tooth bioengineering as a valuable and ultimate goal of many dental researchers. Offers readers an interdisciplinary approach that relates biomedical engineering and restorative dentistry Discusses recent technological achievements in engineering with applications in dentistry Provides useful tool to dental companies for future product planning, specifically to biomedical engineers engaged in dental research

Racing for the Surface

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Author :
Publisher : Springer Nature
ISBN 13 : 3030344711
Total Pages : 808 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Racing for the Surface by : Bingyun Li

Download or read book Racing for the Surface written by Bingyun Li and published by Springer Nature. This book was released on 2020-02-28 with total page 808 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the key basics of tissue engineering as well as the latest advances in the integration of both antimicrobial and osteoinductive properties. Topics covered include osteoconductive and osteoinductive biomaterials (calcium phosphate, bone morphogenetic protein, peptides, antibodies, bioactive glasses, nanomaterials, etc.) and scaffolds. Research integrating both antimicrobial/biofilm-inhibiting and osteoinductive/osteoconductive properties and their co-delivery is detailed and their roles in clinical success are discussed. Combined with its companion volume, Racing for the Surface: Antimicrobial and Interface Tissue Engineering, this book bridges the gap between infection and tissue engineering, and is an ideal book for academic researchers, clinicians, industrial engineers and scientists, governmental representatives in national laboratories, and advanced undergraduate students and post-doctoral fellows who are interested in tissue engineering and regeneration, infection, and biomaterials and devices.

Tissue Engineering Using Ceramics and Polymers

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Author :
Publisher : Woodhead Publishing
ISBN 13 : 0128205792
Total Pages : 890 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Tissue Engineering Using Ceramics and Polymers by : Aldo R. Boccaccini

Download or read book Tissue Engineering Using Ceramics and Polymers written by Aldo R. Boccaccini and published by Woodhead Publishing. This book was released on 2021-10-27 with total page 890 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tissue Engineering Using Ceramics and Polymers, Third Edition is a valuable reference tool for both academic researchers and scientists involved in biomaterials or tissue engineering, including the areas of bone and soft-tissue reconstruction, repair and organ regeneration. With its distinguished editors and international team of contributors, this book reviews the latest research and advances in this thriving area and how they can be used to develop treatments for disease states. New sections cover nanobiomaterials, drug delivery, advanced imaging and MRI for tissue engineering, and characterization of vascularized scaffolds. Technology and research in the field of tissue engineering has drastically increased within the last few years to the extent that almost every tissue and organ of the human body could potentially be regenerated with the aid of biomaterials. - Provides updated and new information on ceramic and polymer biomaterials for tissue engineering - Presents readers with systematic coverage of the processing, characterization and modeling of each material - Includes content that will be relevant to a range of readers, including biomedical engineers, materials scientists, and those interested in regenerative medicine