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Biomedical Pharmacology And Toxicology Methodological Aspects Of Drug Metabolizing Enzymes
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Book Synopsis Biomedical Pharmacology and Toxicology, Methodological Aspects of Drug Metabolizing Enzymes by : David Zakim
Download or read book Biomedical Pharmacology and Toxicology, Methodological Aspects of Drug Metabolizing Enzymes written by David Zakim and published by Wiley-Interscience. This book was released on 1985-08-13 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: A collection of authoritative reviews on membrane-bound and soluble-fraction epoxide hydrolases; preparation and characterization of sulfotransferases; methods of characterizing the function of VDP-Glucurotransferases; mitochondrial monarmine oxidase; measurement of cytochrome P-450; preparation and characterization of glutathione S-transferases.
Book Synopsis Methodological Aspects of Drug Metabolizing Enzymes by : David Zakim
Download or read book Methodological Aspects of Drug Metabolizing Enzymes written by David Zakim and published by . This book was released on 1985 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Methodological Aspects of Drug Metabolizing Enzymes by : Zakim D Ed
Download or read book Methodological Aspects of Drug Metabolizing Enzymes written by Zakim D Ed and published by . This book was released on 1985 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Aspects of Oxidative Drug Metabolizing Enzymes by : Emel Arinc
Download or read book Molecular Aspects of Oxidative Drug Metabolizing Enzymes written by Emel Arinc and published by Springer. This book was released on 1995-02-17 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the NATO Advanced Study Institute on molecular aspects of drug metabolizing enzymes, held in Kusadasi, Aydin-Turkey, June 20-July 2, 1993
Book Synopsis Current Catalog by : National Library of Medicine (U.S.)
Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 1676 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.
Download or read book Research Awards Index written by and published by . This book was released on 1986 with total page 854 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters by : Shuguang Ma
Download or read book Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters written by Shuguang Ma and published by Elsevier Science. This book was released on 2020-07-24 with total page 708 pages. Available in PDF, EPUB and Kindle. Book excerpt: Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters, Second Edition, is completely updated to provide an overview of the last decade's numerous advances in analytical technologies for detection and quantification of drugs, metabolites, and biomarkers. This new edition goes beyond LC-MS and features all-new chapters on how to evaluate drug absorption, distribution, metabolism, and excretion, potential for hepatic and renal toxicity, immunogenicity of biotherapeutics and translational tools for predicting human dosage, safety and efficacy of small molecules and biologics. This book will be an important handbook and desk reference for pharmacologists, toxicologists, clinical scientists, and students interested in the fields of pharmacology, biochemistry, and drug metabolism. Four sections in the book with 24 chapters give readers an overview of state-of-the-art techniques for identifying and quantifying drugs, metabolites and biomarkers, including a chapter on new approaches for quantification of enzymes and transporters in different tissues Focuses on the role of drug metabolism enzymes, transporters in disposition and drug-drug interactions, as well as strategies for evaluating drug metabolism and safety using advanced liver and kidney models. Discussions on immunogenicity risks of biologics and their evaluation methods have been included Includes several chapters on advanced translational sciences to predict human dosage, pharmacokinetics and efficacy for small molecules and biotherapeutics All chapters are written by experts with a wide range of practical experience from the industry and academia
Book Synopsis Drug-like Properties: Concepts, Structure Design and Methods by : Li Di
Download or read book Drug-like Properties: Concepts, Structure Design and Methods written by Li Di and published by Elsevier. This book was released on 2010-07-26 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. - Serves as an essential working handbook aimed at scientists and students in medicinal chemistry - Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies - Discusses improvements in pharmacokinetics from a practical chemist's standpoint
Author :National Institute of General Medical Sciences (U.S.). Division of Research Grants Publisher : ISBN 13 : Total Pages :346 pages Book Rating :4.3/5 (91 download)
Book Synopsis Subject Index of Current Research Grants and Contracts Administered by the National Institute of General Medical Sciences by : National Institute of General Medical Sciences (U.S.). Division of Research Grants
Download or read book Subject Index of Current Research Grants and Contracts Administered by the National Institute of General Medical Sciences written by National Institute of General Medical Sciences (U.S.). Division of Research Grants and published by . This book was released on 1975 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :National Institutes of Health (U.S.). Division of Research Grants Publisher : ISBN 13 : Total Pages :1224 pages Book Rating :4.3/5 (91 download)
Book Synopsis Research Grants Index by : National Institutes of Health (U.S.). Division of Research Grants
Download or read book Research Grants Index written by National Institutes of Health (U.S.). Division of Research Grants and published by . This book was released on 1975 with total page 1224 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Subject Index of Current Research Grants and Contracts Administered by the National Institute of General Medical Sciences by : National Institute of General Medical Sciences (U.S.)
Download or read book Subject Index of Current Research Grants and Contracts Administered by the National Institute of General Medical Sciences written by National Institute of General Medical Sciences (U.S.) and published by . This book was released on 1976 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis National Library of Medicine Current Catalog by : National Library of Medicine (U.S.)
Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 1000 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The British Library General Catalogue of Printed Books 1986 to 1987 by : British Library
Download or read book The British Library General Catalogue of Printed Books 1986 to 1987 written by British Library and published by K. G. Saur. This book was released on 1988 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Detection of Drugs and Their Metabolites in Oral Fluid by : Robert M. White
Download or read book Detection of Drugs and Their Metabolites in Oral Fluid written by Robert M. White and published by Elsevier. This book was released on 2018-02-23 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: Detection of Drugs and Their Metabolites in Oral Fluid presents the analytical chemistry methods used for the detection and quantification of drugs and their metabolites in human oral fluid. The authors summarize the state of the science, including its strengths, weaknesses, unmet methodological needs, and cutting-edge trends. This volume covers the salient aspects of oral fluid drug testing, including specimen collection and handling, initial testing, point of collection testing (POCT), specimen validity testing (SVT), and confirmatory and proficiency testing. Analytes discussed include amphetamines, cannabinoids, cocaine, opiates, phencyclidine, cannabimimetics, and miscellaneous drugs. This practical guide helps users turn knowledge into practice, moving logically from an outline of the problem, to the evaluation of the appropriateness of oral fluid as a test medium, and finally to a consideration of detection methods and their validation and employment. - Compares different collection and testing systems to assist readers involved in clinical or forensic practice in selecting oral fluid as the matrix of choice - Provides a sound basis for the detection of drugs and their metabolites in oral fluid and the interpretation of both positive and negative - Places the need, or lack thereof, for specimen validity testing and confirmation testing in context with the purposes of oral fluid testing - Describes drugs and drug classes that can be tested, along with useful information on a patient/donor's drug status
Book Synopsis Medical and Health Care Books and Serials in Print by :
Download or read book Medical and Health Care Books and Serials in Print written by and published by . This book was released on 1988 with total page 1440 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Organic Chemistry of Drug Design and Drug Action by : Richard B. Silverman
Download or read book The Organic Chemistry of Drug Design and Drug Action written by Richard B. Silverman and published by Elsevier. This book was released on 2012-12-02 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and includes chapter problems and other elements that make the book more useful for course instruction. - New edition includes new chapter problems and exercises to help students learn, plus extensive references and illustrations - Clearly presents an organic chemist's perspective of how drugs are designed and function, incorporating the extensive changes in the drug industry over the past ten years - Well-respected author has published over 200 articles, earned 21 patents, and invented a drug that is under consideration for commercialization
Book Synopsis Drug Transporters by : Martin F. Fromm
Download or read book Drug Transporters written by Martin F. Fromm and published by Springer Science & Business Media. This book was released on 2010-11-19 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects. This book will give an overview on the transporter families which are most important for drug therapy. Most chapters will focus on one transporter family highlighting tissue expression, substrates, inhibitors, knock-out mouse models and clinical studies.
