Biomarkers Of Toxic Metals

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Biomarkers of Toxic Metals

Author : Vanda Maria Falcão Espada Lopes de Andrade
Publisher : CRC Press
ISBN 13 : 1000954331
Total Pages : 302 pages
Book Rating : 4.0/5 (9 download)

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Book Synopsis Biomarkers of Toxic Metals by : Vanda Maria Falcão Espada Lopes de Andrade

Download or read book Biomarkers of Toxic Metals written by Vanda Maria Falcão Espada Lopes de Andrade and published by CRC Press. This book was released on 2023-08-04 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: The current exposure of human populations to toxic metals makes the prevention and control of such exposures crucial. Biomarkers are undoubtably recognized as vital tools to achieve these goals. This book is for researchers, toxicologists, physicians, pharmacologists and those working in governmental regulatory agencies and other public health fields. The first part of this book covers general aspects of biomarkers of toxic metals, while parts 2 and 3 cover biomarkers of xenobiotic metals and essential metals with potential for toxicity, respectively. In part 4, novel approaches to metal biomarkers are focused.

Biomarkers of Toxic Metals

Author :
Publisher :
ISBN 13 : 9781032039381
Total Pages : 0 pages
Book Rating : 4.0/5 (393 download)

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Book Synopsis Biomarkers of Toxic Metals by :

Download or read book Biomarkers of Toxic Metals written by and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The first part of this book will cover general aspects of biomarkers of toxic metals, such as metal pollution and public health impacts, biomarkers' relevance, and contribution through environmental, occupational, and clinical fields to public health. Parts II and III will cover biomarkers of xenobiotic metals, and biomarkers of essential metals with potential for toxicity, respectively. Metal toxicokinetic, toxic effects and biomarkers of exposure, susceptibility and effect will be depicted. In part IV, novel approaches to metal toxicity and their biomarkers will be focused, in the perspectives of "real life" chronic exposure to metal mixtures and multi-biomarkers approaches"--

Biomarkers of Toxic Metals

Author : ‏ Vanda Maria Falcão Espada Lopes de Andrade
Publisher :
ISBN 13 : 9781032039404
Total Pages : 0 pages
Book Rating : 4.0/5 (394 download)

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Book Synopsis Biomarkers of Toxic Metals by : ‏ Vanda Maria Falcão Espada Lopes de Andrade

Download or read book Biomarkers of Toxic Metals written by ‏ Vanda Maria Falcão Espada Lopes de Andrade and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The first part of this book will cover general aspects of biomarkers of toxic metals, such as metal pollution and public health impacts, biomarkers' relevance, and contribution through environmental, occupational, and clinical fields to public health. Parts II and III will cover biomarkers of xenobiotic metals, and biomarkers of essential metals with potential for toxicity, respectively. Metal toxicokinetic, toxic effects and biomarkers of exposure, susceptibility and effect will be depicted. In part IV, novel approaches to metal toxicity and their biomarkers will be focused, in the perspectives of "real life" chronic exposure to metal mixtures and multi-biomarkers approaches"

Issue Paper on the Human Health Effects of Metals

Author :
Publisher :
ISBN 13 :
Total Pages : 52 pages
Book Rating : 4.:/5 (31 download)

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Book Synopsis Issue Paper on the Human Health Effects of Metals by :

Download or read book Issue Paper on the Human Health Effects of Metals written by and published by . This book was released on 2004 with total page 52 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Handbook on the Toxicology of Metals

Author : Gunnar F. Nordberg
Publisher : Academic Press
ISBN 13 : 0123973392
Total Pages : 1544 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Handbook on the Toxicology of Metals by : Gunnar F. Nordberg

Download or read book Handbook on the Toxicology of Metals written by Gunnar F. Nordberg and published by Academic Press. This book was released on 2014-08-07 with total page 1544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook on the Toxicology of Metals, Fourth Edition bridges the gap between established knowledgebase and new advances in metal toxicology to provide one essential reference for all those involved in the field. This book provides comprehensive coverage of basic toxicological data, emphasizing toxic effects primarily in humans, but also those of animals and biological systems in vitro. The fourth edition also contains several new chapters on important topics such as nanotoxicology, metals in prosthetics and dental implants, gene-environment interaction, neurotoxicology, metals in food, renal, cardiovascular, and diabetes effects of metal exposures and more. Volume I covers “General Considerations and Volume II is devoted to “Specific Metals. A multidisciplinary resource with contributions from internationally-recognized experts, the fourth edition of the Handbook on the Toxicology of Metals is a prominent and indispensable reference for toxicologists, physicians, pharmacologists, engineers, and all those involved in the toxicity of metals. Contains 61 peer reviewed chapters dealing with the effects of metallic elements and their compounds on biological systems Includes information on sources, transport and transformation of metals in the environment and on certain aspects of the ecological effects of metals to provide a basis for better understanding of the potential for adverse effects on human health Covers the toxicology of metallic nanomaterials in a new comprehensive chapter Metal toxicology in developing countries is dealt with in another new chapter emphasizing the adverse effects on human health by the inadequate handling of "ewaste Other new chapters in the 4th edition include: Toxic metals in food; Toxicity of metals released from medical devices; Gene-environment interactions; Neurotoxicology of metals; Cardiovascular disease; Renal effects of exposure to metals; Gold and gold mining; Iridium; Lanthanum; Lithium and Rhodium

Biomarkers of Environmental Toxicants

Author : Kun Lu
Publisher : Mdpi AG
ISBN 13 : 9783039367368
Total Pages : 292 pages
Book Rating : 4.3/5 (673 download)

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Book Synopsis Biomarkers of Environmental Toxicants by : Kun Lu

Download or read book Biomarkers of Environmental Toxicants written by Kun Lu and published by Mdpi AG. This book was released on 2020-10-02 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomarkers of environmental toxicants are measures of exposures, some of which can serve to assess disease risk and inter-individual susceptibilities. Metabolites, protein and DNA adducts also serve to elucidate the mechanisms of the bioactivation and detoxication of reactive toxicant intermediates. Some environmental chemicals act as modulators of gene and protein activity, and induce the dysbiosis of the microbiome, which impacts the metabolome and overall health. In this Special Issue on "Biomarkers of Environmental Toxicants", review articles and original research studies are featured, covering the latest bioanalytical, biochemical and mass spectrometry-based technologies, to monitor exposures through targeted and non-targeted methods, and mechanistic studies that examine the biological effects of environmental toxicants in cells and humans. Diverse topics, such as exposome, microbiome, DNA/protein adducts and t-RNA modifications, as well as important environment toxicants, including heavy metals, benzene, phthalates, aldehydes, glycidol, tobacco smoke and aristolochic acids, are covered. Novel analytical methods, such as protein adductomics, DNA adduct analysis in formalin-fixed paraffin-embedded tissues, site-specific mutagenesis assay and accelerator mass spectrometry, are also included. This collection provides a valuable update of the most recent biochemical and analytical tools that employ biomarkers in toxicology research, biomarker discovery, and exposure and risk assessment in population-based studies.

Use of Biomarkers for Environmental Quality Assessment

Author : Jean-Claude Amiard
Publisher : CRC Press
ISBN 13 : 100044564X
Total Pages : 353 pages
Book Rating : 4.0/5 (4 download)

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Book Synopsis Use of Biomarkers for Environmental Quality Assessment by : Jean-Claude Amiard

Download or read book Use of Biomarkers for Environmental Quality Assessment written by Jean-Claude Amiard and published by CRC Press. This book was released on 2021-05-30 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work is primarily designed for any person or organization in charge of assessment of the quality of natural resources and of pollution prevention.

Biomarkers in Toxicology

Author : Ramesh C Gupta
Publisher : Academic Press
ISBN 13 : 0124046495
Total Pages : 1149 pages
Book Rating : 4.1/5 (24 download)

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Book Synopsis Biomarkers in Toxicology by : Ramesh C Gupta

Download or read book Biomarkers in Toxicology written by Ramesh C Gupta and published by Academic Press. This book was released on 2014-01-25 with total page 1149 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomarkers in Toxicology is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This book includes both vertebrate and non-vertebrate species models for toxicological testing and development of biomarkers. Divided into several key sections, this reference volume contains chapters devoted to topics in molecular-cellular toxicology, as well as a look at the latest cutting-edge technologies used to detect biomarkers of exposure and effects. Each chapter also contains several references to the current literature and important resources for further reading. Given this comprehensive treatment, Biomarkers in Toxicology is an essential reference for all those interested in biomarkers across several scientific and biomedical fields. Written by international experts who have evaluated the expansive literature to provide you with one resource covering all aspects of toxicology biomarkers Identifies and discusses the most sensitive, accurate, unique and validated biomarkers used as indicators of exposure and effect of chemicals of different classes Covers special topics and applications of biomarkers, including chapters on molecular toxicology biomarkers, biomarker analysis for nanotoxicology, development of biomarkers for drug efficacy evaluation and much more

Neurotoxicity of Metals

Author : Michael Aschner
Publisher : Springer
ISBN 13 : 9783319601885
Total Pages : 383 pages
Book Rating : 4.6/5 (18 download)

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Book Synopsis Neurotoxicity of Metals by : Michael Aschner

Download or read book Neurotoxicity of Metals written by Michael Aschner and published by Springer. This book was released on 2017-09-18 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assembles international authorities to address contemporary research in metal neurotoxicity. Essential and non-essential metals play an important role in neurodevelopmental and neurodegenerative diseases. Recent developments in understanding the role of metals in the etiology of these disorders have led to rapid growth in clarifying the pathology of some of the most devastating diseases we face and in identifying potential new therapies. Few books or periodicals have been wholly dedicated to the topic of metals, and this collection is intended to serve as a resource for all researchers interested in metals and their role in health and disease.

Evaluation of Methods for the Treatment of Hair Samples as Accurate Biomarkers of Exposure to Toxic Metals

Author : Elizabeth M. Peacock-Villada
Publisher :
ISBN 13 :
Total Pages : 110 pages
Book Rating : 4.:/5 (242 download)

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Book Synopsis Evaluation of Methods for the Treatment of Hair Samples as Accurate Biomarkers of Exposure to Toxic Metals by : Elizabeth M. Peacock-Villada

Download or read book Evaluation of Methods for the Treatment of Hair Samples as Accurate Biomarkers of Exposure to Toxic Metals written by Elizabeth M. Peacock-Villada and published by . This book was released on 2005 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Animal Biomarkers as Pollution Indicators

Author : David B. Peakall
Publisher : Springer Science & Business Media
ISBN 13 : 9401123462
Total Pages : 312 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Animal Biomarkers as Pollution Indicators by : David B. Peakall

Download or read book Animal Biomarkers as Pollution Indicators written by David B. Peakall and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ecotoxicology is a relatively new scientific discipline. Indeed, it might be argued that it is only during the last 5-10 years that it has come to merit being regarded as a true science, rather than a collection of procedures for protecting the environment through management and monitoring of pollutant discharges into the environment. The term 'ecotoxicology' was first coined in the late sixties by Prof. Truhaut, a toxicologist who had the vision to recognize the importance of investigating the fate and effects of chemicals in ecosystems. At that time, ecotoxicology was considered a sub-discipline of medical toxicology. Subsequently, several attempts have been made to portray ecotoxicology in a more realistic light. Notably, both F. Moriarty (1988) and F. Ramade (1987) emphasized in their books the broad basis of ecotoxicology, encompassing chemical and radiation effects on all components of ecosystems. In doing so, they and others have shifted concern from direct chemical toxicity to man, to the far more subtle effects that pollutant chemicals exert on natural biota. Such effects potentially threaten the existence of all life on Earth. Although I have identified the sixties as the era when ecotoxicology was first conceived as a coherent subject area, it is important to acknowledge that studies that would now be regarded as ecotoxicological are much older. Wherever people's ingenuity has led them to change the face of nature significantly, it has not escaped them that a number of biological con sequences, often unfavourable, ensue.

Toxicology of Metals

Author : Robert A. Goyer
Publisher : Springer
ISBN 13 : 9783642791642
Total Pages : 0 pages
Book Rating : 4.7/5 (916 download)

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Book Synopsis Toxicology of Metals by : Robert A. Goyer

Download or read book Toxicology of Metals written by Robert A. Goyer and published by Springer. This book was released on 2011-11-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: An insight into new advances of current interest in metal toxicology, such as mechanisms important in risk-assessment for human health. The book also has chapters on emerging conceptual problems including resistance to metal toxicity effects on gene expression, alongside principles regarding drug-chelation of metals, the potential use of prophyrins as indicators of metal exposure and toxicity. The toxicology of specific metals of major public health concern are discussed in depth, such as mercury, aluminum, arsenic, chromium, and cadmium. Of interest to basic scientists as well as public health administrators.

Cellular Effects of Heavy Metals

Author : Gaspar Banfalvi
Publisher : Springer Science & Business Media
ISBN 13 : 9400704283
Total Pages : 348 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Cellular Effects of Heavy Metals by : Gaspar Banfalvi

Download or read book Cellular Effects of Heavy Metals written by Gaspar Banfalvi and published by Springer Science & Business Media. This book was released on 2011-03-02 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: The term “heavy metals” is used as a group name of toxic metals and metalloids (semimetals) causing contaminations and ecotoxicity. In strict chemical sense the density of heavy metals is higher than 5 g/cm3. From biological point of view as microelements they can be divided into two major groups. a. For their physiological function organisms and cells require essential microelements such as iron, chromium (III), cobalt, copper, manganese, molidenium, zinc. b. The other group of heavy metals is toxic to the health or environment. Of highest concern are the emissions of As, Cd, Co, Cu, Hg, Mn, Ni, Pb, Sn, Tl. The toxicity of heavy metals is well known at organizational level, while less attention has been paid to their cellular effects. This book describes the toxicity of heavy metals on microorganisms, yeast, plant and animal cells. Other chapters of the book deal with their genotoxic, mutagenic and carcinogenic effects. The toxicity of several metals touch upon the aspects of environmental hazard, ecosystems and human health. Among the cellular responses of heavy metals irregularities in cellular mechanisms such as gene expression, protein folding, stress signaling pathways are among the most important ones. The final chapters deal with biosensors and removal of heavy metals. As everybody is eating, drinking and exposed to heavy metals on a daily basis, the spirit of the book will attract a wide audience.

Identifying Biomarkers and Mechanisms of Toxic Metal Stress with Global Proteomics

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (16 download)

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Book Synopsis Identifying Biomarkers and Mechanisms of Toxic Metal Stress with Global Proteomics by :

Download or read book Identifying Biomarkers and Mechanisms of Toxic Metal Stress with Global Proteomics written by and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Hg is a wide-spread contaminant in the environment and is toxic in all of its various forms. Data suggest that RHg+ and Hg2+ are toxic in two ways. At low levels, Hg species appear to disrupt membrane-bound respiration causing a burst of reactive oxygen species (ROS) that further damage the cell. At higher Hg concentrations, RHg+ and Hg2+ may form adducts with cysteine- and selenocysteine-containing proteins in all cellular compartments resulting in their inactivation. Although these mechansims for toxicity are generally accepted, the most sensitive targets associated with these mechanisms are not well understood. In this collaborative project involving three laboratories at three institutions, the overall goal was to develop of a mass spectrometry-based global proteomics methodology that could be used to identify Hg-adducted (and ideally, ROS-damaged) proteins in order to address these types of questions. The two objectives of this overall collaborative project were (1) to identify, quantify, and compare ROS- and Hg-damaged proteins in cells treated with various Hg species and concentrations to test this model for two mechanisms of Hg toxicity, and (2) to define the cellular roles of the ubiquitous bacterial mercury resistance (mer) locus with regards to how the proteins of this pathway interact to protect other cell proteins from Hg damage. The specific objectives and accomplishments of the Miller lab in this project included: (1) Development of algorithms for analysis of the Hg-proteomic mass spectrometry data to identify mercury adducted peptides and other trends in the data. (2) Investigation of the role of mer operon proteins in scavenging Hg(II) from other mer pathway proteins as a means of protecting cellular proteins from damage.

Molecular Biological Markers for Toxicology and Risk Assessment

Author : Bruce A. Fowler
Publisher : Academic Press
ISBN 13 : 0128019018
Total Pages : 166 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Molecular Biological Markers for Toxicology and Risk Assessment by : Bruce A. Fowler

Download or read book Molecular Biological Markers for Toxicology and Risk Assessment written by Bruce A. Fowler and published by Academic Press. This book was released on 2016-06-10 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Biological Markers for Toxicology and Risk Assessment provides an introduction to the exciting field of biomarkers and their use in toxicology and risk assessment. In recent years, new classes of molecular biomarkers capable of detecting early manifestations of ongoing chemical-induced cell injury and cell death have been developed as a result of advances in analytical chemistry, molecular biology, and computational modeling. The interplay between these emergent tools of science has resulted in new insights into initial mechanisms of chemical-induced toxicity and carcinogenicity. Molecular Biological Markers for Toxicology and Risk Assessment guides the reader through a broad range of molecular biological markers, including the "omic" biomarkers, and provides an examination of the various elements in the evolution of these modern tools. It then explores possible ways in which these markers may be applied to advance the field of chemical risk assessment. Since molecular biomarkers and related technologies are inherently complex, the book concludes with a section on risk communication in order that readers may appreciate both the strengths and limitations of molecular biological marker approaches to risk assessment practice. Introduces the use of molecular biomarkers to detect toxic effects of chemicals as early as possible Provides an accessible overview of this emerging, interdisciplinary field, to best inform decision making in chemical and pharmaceutical safety Includes a section on risk communication of these complex concepts, essential for effective risk assessment Provides new insights into the initial mechanisms of chemical-induced toxicity and carcinogenicity

Toxicology of Metals

Author : N. Ballatori
Publisher : Berlin ; New York : Springer-Verlag
ISBN 13 :
Total Pages : 502 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Toxicology of Metals by : N. Ballatori

Download or read book Toxicology of Metals written by N. Ballatori and published by Berlin ; New York : Springer-Verlag. This book was released on 1995 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: The toxicology of metals has been concerned in the past with effects that produced clinical signs and symptoms. However, this view of metal toxicology has expanded in recent years due principally to two advances. There has been a considerable increase in our knowledge of the biochemical effects of metals. In addition, biomarkers of toxicity can now be recognized that identify toxicity at levels of exposure that do not produce overt clinical effects. Thus, the toxicology of metals is now focused on nonclinical events that reflect adverse health effects. This new awareness has produced the challenge of determining the lowest adverse level of exposure. With increasing analytical sensitivity and methodologies to detect small changes at the molecular level, the lowest level of exposure of some toxic metals, like lead, is very small. Indeed, for metals in which there is no biologic requirement, it may be questioned whether there is a level of exposure that does not produce some degree of toxicity. For essential metals, the question is being asked as to the levels at which exposure exceeds biologic require ments and excess exposure becomes toxic. The appropriateness of health decisions and the formation of public policy are dependent on the availability of current scientific information that addresses these questions. The information in this volume is intended to be a resource for this purpose as well as a reference for students of toxicology and other health professionals.

Biomarkers: A Pragmatic Basis for Remediation of Severe Pollution in Eastern Europe

Author : David B. Peakall
Publisher : Springer Science & Business Media
ISBN 13 : 9401145504
Total Pages : 450 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Biomarkers: A Pragmatic Basis for Remediation of Severe Pollution in Eastern Europe by : David B. Peakall

Download or read book Biomarkers: A Pragmatic Basis for Remediation of Severe Pollution in Eastern Europe written by David B. Peakall and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many areas of Eastern Europe have been polluted to an extent unknown in the West. Four such sites - Kola Peninsula, northern Bohemia, upper Vistula Basin, and Katowice - have been identified and detailed accounts of the pollution at these sites are given. The current status of the use of biomarkers in hazard assessment is given by several scientists from NATO countries. Four working groups, comprising scientists working on the polluted sites and western scientists with expertise in biomarkers, examine the use of biomarkers to assess the environmental health of each of these areas and make recommendations on the future direction of remedial action in these areas.