Biomarkers And Biosensors

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Biomarkers and Biosensors

Author : Ajit Sadana
Publisher : Newnes
ISBN 13 : 0444537953
Total Pages : 703 pages
Book Rating : 4.4/5 (445 download)

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Book Synopsis Biomarkers and Biosensors by : Ajit Sadana

Download or read book Biomarkers and Biosensors written by Ajit Sadana and published by Newnes. This book was released on 2014-12-08 with total page 703 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomarkers and Biosensors offers thorough coverage of biomarker/biosensor interaction, current research trends, and future developments in applications of drug discovery. This book is useful to researchers in this field as well as clinicians interested in new developments in early detection and diagnosis of disease or the mode of operation of biomarkers. Biomarkers and Biosensors also emphasizes kinetics, and clearly delineates how this influences the biomarker market. - Offers thorough coverage of the kinetics of biomarker interaction with the biosensor surface - Provides evidence-based approach to evaluate effectiveness - Provides pharmaceutical chemists the possibilities and methodology in assessing the effectiveness of new drugs - Provides the information needed for the selection of the best biomarker for a specific application

Electrochemical Biosensors

Author : Serge Cosnier
Publisher : CRC Press
ISBN 13 : 9814411477
Total Pages : 405 pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis Electrochemical Biosensors by : Serge Cosnier

Download or read book Electrochemical Biosensors written by Serge Cosnier and published by CRC Press. This book was released on 2015-01-26 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since four decades, rapid detection and monitoring in clinical and food diagnostics and in environmental and biodefense have paved the way for the elaboration of electrochemical biosensors. Thanks to their adaptability, ease of use in relatively complex samples, and their portability, electrochemical biosensors now are one of the mainstays of analy

The Detection of Biomarkers

Author : Sibel A. Ozkan
Publisher : Academic Press
ISBN 13 : 0128230754
Total Pages : 615 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis The Detection of Biomarkers by : Sibel A. Ozkan

Download or read book The Detection of Biomarkers written by Sibel A. Ozkan and published by Academic Press. This book was released on 2021-12-05 with total page 615 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reliable, precise and accurate detection and analysis of biomarkers remains a significant challenge for clinical researchers. Methods for the detection of biomarkers are rather complex, requiring pre-treatment steps before analysis can take place. Moreover, comparing various biomarker assays and tracing research progress in this area systematically is a challenge for researchers. The Detection of Biomarkers presents developments in biomarker detection, including methods tools and strategies, biosensor design, materials, and applications. The book presents methods, materials and procedures that are simple, precise, sensitive, selective, fast and economical, and therefore highly practical for use in clinical research scenarios. This volume situates biomarker detection in its research context and sets out future prospects for the area. Its 20 chapters offer a comprehensive coverage of biomarkers, including progress on nanotechnology, biosensor types, synthesis, immobilization, and applications in various fields. The book also demonstrates, for students, how to synthesize and immobilize biosensors for biomarker assay. It offers researchers real alternative and innovative ways to think about the field of biomarker detection, increasing the reliability, precision and accuracy of biomarker detection. - Locates biomarker detection in its research context, setting out present and future prospects - Allows clinical researchers to compare various biomarker assays systematically - Presents new methods, materials and procedures that are simple, precise, sensitive, selective, fast and economical - Gives innovative biomarker assays that are viable alternatives to current complex methods - Helps clinical researchers who need reliable, precise and accurate biomarker detection methods

Advanced Biosensors for Health Care Applications

Author : Raju Khan
Publisher : Elsevier
ISBN 13 : 0128165227
Total Pages : 433 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Advanced Biosensors for Health Care Applications by : Raju Khan

Download or read book Advanced Biosensors for Health Care Applications written by Raju Khan and published by Elsevier. This book was released on 2019-06-15 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Biosensors for Health Care Applications highlights the different types of prognostic and diagnostic biomarkers associated with cancer, diabetes, Alzheimer's disease, brain and retinal diseases, cardiovascular diseases, bacterial infections, as well as various types of electrochemical biosensor techniques used for early detection of the potential biomarkers of these diseases. Many advanced nanomaterials have attracted intense interests with their unique optical and electrical properties, high stability, and good biocompatibility. Based on these properties, advanced nanoparticles have been used as biomolecular carriers, signal producers, and signal amplifiers in biosensor design. Recent studies reported that there are several diagnostic methods available, but the major issue is the sensitivity and selectivity of these approaches. This book outlines the need of novel strategies for developing new systems to retrieve health information of patients in real time. It explores the potential of nano-multidisciplinary science in the design and development of smart sensing technology using micro-nanoelectrodes, novel sensing materials, integration with MEMS, miniaturized transduction systems, novel sensing strategy, that is, FET, CMOS, System-on-a-Chip (SoC), Diagnostic-on-a-Chip (DoC), and Lab-on-a-Chip (LOC), for diagnostics and personalized health-care monitoring. It is a useful handbook for specialists in biotechnology and biochemical engineering. - Describes advanced nanomaterials for biosensor applications - Relates the properties of available nanomaterials to specific biomarkers applications - Includes diagnosis and electrochemical studies based on biosensors - Explores the potential of nano-multidisciplinary science to design and develop smart sensing technologies - Describes novel strategies for developing a new class of assay systems to retrieve the desired health information

Biosensor Based Advanced Cancer Diagnostics

Author : Raju Khan
Publisher : Academic Press
ISBN 13 : 0128236515
Total Pages : 439 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Biosensor Based Advanced Cancer Diagnostics by : Raju Khan

Download or read book Biosensor Based Advanced Cancer Diagnostics written by Raju Khan and published by Academic Press. This book was released on 2021-08-25 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: Early diagnosis of cancer and other non-oncological disorders gives a significant advantage for curing the disease and improving patient's life expectancy. Recent advances in biosensor-based techniques which are designed for specific biomarkers can be exploited for early diagnosis of diseases. Biosensor Based Advanced Cancer Diagnostics covers all available biosensor-based approaches and comprehensive technologies; along with their application in diagnosis, prognosis and therapeutic management of various oncological disorders. Besides this, current challenges and future aspects of these diagnostic approaches have also been discussed. This book offers a view of recent advances and is also helpful for designing new biosensor-based technologies in the field of medical science, engineering and biomedical technology. Biosensor Based Advanced Cancer Diagnostics helps biomedical engineers, researchers, molecular biologists, oncologists and clinicians with the development of point of care devices for disease diagnostics and prognostics. It also provides information on developing user friendly, sensitive, stable, accurate, low cost and minimally invasive modalities which can be adopted from lab to clinics. This book covers in-depth knowledge of disease biomarkers that can be exploited for designing and development of a range of biosensors. The editors have summarized the potential cancer biomarkers and methodology for their detection, plus transferring the developed system to clinical application by miniaturization and required integration with microfluidic systems. - Covers design and development of advanced platforms for rapid diagnosis of cancerous biomarkers - Takes a multidisciplinary approach to sensitive transducers development, nano-enabled advanced imaging, miniaturized analytical systems, and device packaging for point-of-care applications - Offers an insight into how to develop cost-effective diagnostics for early detection of cancer

Nanobiosensors

Author : Aiguo Wu
Publisher : John Wiley & Sons
ISBN 13 : 3527345108
Total Pages : 412 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Nanobiosensors by : Aiguo Wu

Download or read book Nanobiosensors written by Aiguo Wu and published by John Wiley & Sons. This book was released on 2020-06-02 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Containing cutting edge research on the hot topic of nanobiosensor, this book will become highly read Biosensor research has recently re-emerged as most vibrant area in recent years particularly after the advent of novel nanomaterials of multidimensional features and compositions. Nanomaterials of different types and striking properties have played a positive role in giving the boost and accelerated pace to biosensors development technology. Nanobiosensors - From Design to Applications covers several aspects of biosensors beginning from the basic concepts to advanced level research. It will help to bridge the gap between various aspects of biosensors development technology and applications. It covers biosensors related material in broad spectrum such as basic concepts, biosensors & their classification, biomarkers & their role in biosensors, nanostructures-based biosensors, applications of biosensors in human diseases, drug detection, toxins, and smart phone based biosensors. Nanobiosensors - From Design to Applications will prove a source of inspiration for research on biosensors, their local level development and consequently using for practical application in different industries such as food, biomedical diagnosis, pharmaceutics, agriculture, drug discovery, forensics, etc. * Discusses the latest technology and advances in the field of nanobiosensors and their applications in human diseases, drug detection, toxins * Offers a broad and comprehensive view of cutting-edge research on advanced materials such as carbon materials, nitride based nanomaterials, metal and metal oxide based nanomaterials for the fast-developing nanobiosensors research * Goes to a wide scientific and industry audience Nanobiosensors - From Design to Applications is a resource for polymer chemists, spectroscopists, materials scientists, physical chemists, surface chemists, and surface physicists.

Biosensors and Nanotechnology

Author : Zeynep Altintas
Publisher : John Wiley & Sons
ISBN 13 : 1119065011
Total Pages : 421 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Biosensors and Nanotechnology by : Zeynep Altintas

Download or read book Biosensors and Nanotechnology written by Zeynep Altintas and published by John Wiley & Sons. This book was released on 2017-12-18 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a broad range of information from basic principles to advanced applications of biosensors and nanomaterials in health care diagnostics This book utilizes a multidisciplinary approach to provide a wide range of information on biosensors and the impact of nanotechnology on the development of biosensors for health care. It offers a solid background on biosensors, recognition receptors, biomarkers, and disease diagnostics. An overview of biosensor-based health care applications is addressed. Nanomaterial applications in biosensors and diagnostics are included, covering the application of nanoparticles, magnetic nanomaterials, quantum dots, carbon nanotubes, graphene, and molecularly imprinted nanostructures. The topic of organ-specific health care systems utilizing biosensors is also incorporated to provide deep insight into the very recent advances in disease diagnostics. Biosensors and Nanotechnology: Applications in Health Care Diagnostics is comprised of 15 chapters that are presented in four sections and written by 33 researchers who are actively working in Germany, the United Kingdom, Italy, Turkey, Denmark, Finland, Romania, Malaysia and Brazil. It covers biomarkers in healthcare; microfluidics in medical diagnostics; SPR-based biosensor techniques; piezoelectric-based biosensor technologies; MEMS-based cell counting methods; lab-on-chip platforms; optical applications for cancer cases; and more. Discusses the latest technology and advances in the field of biosensors and their applications for healthcare diagnostics Particular focus on biosensors for cancer Summarizes research of the last 30 years, relating it to state-of-the-art technologies Biosensors and Nanotechnology: Applications in Health Care Diagnostics is an excellent book for researchers, scientists, regulators, consultants, and engineers in the field, as well as for graduate students studying the subject.

Biosensors – Recent Advances and Future Challenges

Author : Paolo Bollella
Publisher : MDPI
ISBN 13 : 3039438875
Total Pages : 504 pages
Book Rating : 4.0/5 (394 download)

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Book Synopsis Biosensors – Recent Advances and Future Challenges by : Paolo Bollella

Download or read book Biosensors – Recent Advances and Future Challenges written by Paolo Bollella and published by MDPI. This book was released on 2021-01-27 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present book is devoted to all aspects of biosensing in a very broad definition, including, but not limited to, biomolecular composition used in biosensors (e.g., biocatalytic enzymes, DNAzymes, abiotic nanospecies with biocatalytic features, bioreceptors, DNA/RNA, aptasensors, etc.), physical signal transduction mechanisms (e.g., electrochemical, optical, magnetic, etc.), engineering of different biosensing platforms, operation of biosensors in vitro and in vivo (implantable or wearable devices), self-powered biosensors, etc. The biosensors can be represented with analogue devices measuring concentrations of analytes and binary devices operating in the YES/NO format, possibly with logical processing of input signals. Furthermore, the book is aimed at attracting young scientists and introducing them to the field, while providing newcomers with an enormous collection of literature references.

Advanced Biosensors for Virus Detection

Author : Raju Khan
Publisher : Academic Press
ISBN 13 : 0323859895
Total Pages : 478 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Advanced Biosensors for Virus Detection by : Raju Khan

Download or read book Advanced Biosensors for Virus Detection written by Raju Khan and published by Academic Press. This book was released on 2022-03-04 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Biosensors for Virus Detection: Smart Diagnostics to Combat Against the SARS-CoV2 Pandemic covers the development of biosensor-based approaches for the diagnosis and prognosis of viral infections, specifically coronaviruses. The book discusses wide-ranging topics of available biosensor-based technologies and their application for early viral detection. Sections cover the emergence of SARS-CoV, MERS-CoV and SARS-CoV2, the global health response, the impact on affected populations, state-of-the art biomarkers, and risk factors. Specific focus is given to COVID-19, with coverage of genomic profiling, strain variation and the pathogenesis of SARS-CoV2. In addition, current therapeutics, nano-abled advancements and challenges in the detection of SARS-CoV2 and COVID-19 management are discussed, along with the role of nanomaterials in the development of biosensors and how biosensors can be scaled up for clinical applications and commercialization. - Deals with biosensors-based approaches that could be exploited to design and develop high throughput, rapid and cost-effective diagnostics technologies for the early detection of viral infections - Illustrates the development of multiplexed, miniaturized analytical systems for point-of-care applications - Provides information about fabrication protocols for various biosensor based diagnostic approaches that could be directly implemented to develop a novel biosensor - Includes the past, present and future status of biosensors, along with information about biosensors currently under clinical trials

Commercial Biosensors and Their Applications

Author : Mustafa Kemal Sezgintürk
Publisher : Elsevier
ISBN 13 : 0128196858
Total Pages : 376 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Commercial Biosensors and Their Applications by : Mustafa Kemal Sezgintürk

Download or read book Commercial Biosensors and Their Applications written by Mustafa Kemal Sezgintürk and published by Elsevier. This book was released on 2020-06-12 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Commercial Biosensors and Their Applications: Clinical, Food, and Beyond offers professionals an in-depth look at some of the most significant applications of commercially available biosensor-based instrumentation in the clinical, food quality control, bioprocess monitoring, and bio threat fields. Featuring contributions by an international team of scientists, this book provides readers with an unparalleled opportunity to see how their colleagues around the world are using these powerful tools. This book is an indispensable addition to the reference libraries of biosensor technologists, analytical chemists, clinical chemists, biochemists, physicians, medical doctors, engineers, and clinical biochemists. The book discusses the need for portable, rapid, and smart biosensing devices and their use as cost-effective, in situ, real-time analytical tools in a variety of fields. - Devotes several chapters to applications of biosensors to clinical samples, exploring how biosensors are currently used for in-home diabetes monitoring, point-of-care diagnostics, non-invasive sensing, and biomedical research - Includes a section on food applications covering how biosensors can detect genetically modified organisms, toxins, allergens, hormones, microorganisms, species-specificity, pesticides, insecticides, and related components - Discusses nanobiosensor and applications, including a chapter on nanotechnological approaches and materials in commercial biosensors

Medical Biosensors for Point of Care (POC) Applications

Author : Roger Narayan
Publisher : Woodhead Publishing
ISBN 13 : 0081000782
Total Pages : 318 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Medical Biosensors for Point of Care (POC) Applications by : Roger Narayan

Download or read book Medical Biosensors for Point of Care (POC) Applications written by Roger Narayan and published by Woodhead Publishing. This book was released on 2016-08-21 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical Biosensors for Point of Care (POC) Applications discusses advances in this important and emerging field which has the potential to transform patient diagnosis and care. Part 1 covers the fundamentals of medical biosensors for point-of-care applications. Chapters in part 2 go on to look at materials and fabrication of medical biosensors while the next part looks at different technologies and operational techniques. The final set of chapters provide an overview of the current applications of this technology. Traditionally medical diagnostics have been dependent on sophisticated technologies which only trained professionals were able to operate. Recent research has focused on creating point-of-care diagnostic tools. These biosensors are miniaturised, portable, and are designed to be used at the point-of-care by untrained individuals, providing real-time and remote health monitoring. - Provides essential knowledge for designers and manufacturers of biosensors for point-of-care applications - Provides comprehensive coverage of the fundamentals, materials, technologies, and applications of medical biosensors for point-of-care applications - Includes contributions from leading international researchers with extensive experience in developing medical biosensors - Discusses advances in this important and emerging field which has the potential to transform patient diagnosis and care

Biosensors and Molecular Technologies for Cancer Diagnostics

Author : Keith E. Herold
Publisher : Taylor & Francis
ISBN 13 : 1439841667
Total Pages : 841 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Biosensors and Molecular Technologies for Cancer Diagnostics by : Keith E. Herold

Download or read book Biosensors and Molecular Technologies for Cancer Diagnostics written by Keith E. Herold and published by Taylor & Francis. This book was released on 2012-05-29 with total page 841 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bridging the gap between research and clinical application, Biosensors and Molecular Technologies for Cancer Diagnostics explores the use of biosensors as effective alternatives to the current standard methods in cancer diagnosis and detection. It describes the major aspects involved in detecting and diagnosing cancer as well as the basic elements

Wearable Physical, Chemical and Biological Sensors

Author : Eden Morales-Narvaez
Publisher : Elsevier
ISBN 13 : 012823234X
Total Pages : 330 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Wearable Physical, Chemical and Biological Sensors by : Eden Morales-Narvaez

Download or read book Wearable Physical, Chemical and Biological Sensors written by Eden Morales-Narvaez and published by Elsevier. This book was released on 2022-02-22 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Wearable Physical, Chemical and Biological Sensors introduces readers of all backgrounds—chemistry, electronics, photonics, biology, microfluidics, materials, and more—to the fundamental principles needed to develop wearable sensors for a host of different applications. The capability to continuously monitor organ-related biomarkers, environmental exposure, movement disorders, and other health conditions using miniaturized devices that operate in real time provides numerous benefits, such as avoiding or delaying the onset of disease, saving resources allocated to public health, and making better decisions on medical diagnostics or treatment. Worn like glasses, masks, wristwatches, fitness bands, tattoo-like devices, or patches, wearables are being boosted by the Internet of Things in combination with smart mobile devices. Besides, wearables for smart agriculture are also covered. Written by experts in their respective fields, Wearable Physical, Chemical and Biological Sensors provides insights on how to design, fabricate, and operate these sensors. - Provides a holistic view of the field, covering physical, chemical, and biosensing approaches along with the advantages of their various functionalities - Covers all necessary elements for developing wearable sensors, including materials, biorecognition elements, transductions systems, signal amplification strategies, and system design considerations - Each chapter includes examples, summaries, and references for further reading

3D Cell-Based Biosensors in Drug Discovery Programs

Author : William S. Kisaalita
Publisher : CRC Press
ISBN 13 : 1420073508
Total Pages : 404 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis 3D Cell-Based Biosensors in Drug Discovery Programs by : William S. Kisaalita

Download or read book 3D Cell-Based Biosensors in Drug Discovery Programs written by William S. Kisaalita and published by CRC Press. This book was released on 2010-06-22 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in genomics and combinatorial chemistry during the past two decades inspired innovative technologies and changes in the discovery and pre-clinical development paradigm with the goal of accelerating the process of bringing therapeutic drugs to market. Written by William Kisaalita, one of the foremost experts in this field, 3D Cell-Based Bio

Smart Biosensors in Medical Care

Author : Jyotismita Chaki
Publisher : Academic Press
ISBN 13 : 0128209364
Total Pages : 250 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Smart Biosensors in Medical Care by : Jyotismita Chaki

Download or read book Smart Biosensors in Medical Care written by Jyotismita Chaki and published by Academic Press. This book was released on 2020-02-18 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Smart Biosensors in Medical Care discusses the characteristics of biosensors and their potential applications in healthcare. This book is aimed at professionals, scientists and engineers who are interested in integrating biosensors into medical care systems for patients. It also provides fundamental and foundational knowledge for undergraduate and post graduate students. The book presents a comprehensive view of up-to-date requirements in hardware and communication, offers future perspectives on next-generation medical care systems, and includes global case studies of recent system operations in healthcare. Sections cover smart biosensors, such as wearable, implantable, patch based, and enzyme based for medical care. Advances in ubiquitous sensing applications for healthcare is a series which covers new systems based on ubiquitous sensing for healthcare (USH). Volumes in this series cover a wide range of interdisciplinary areas, including wireless sensors networks, wireless body area networks, Big data, Internet-of-Things (IoT), security, monitoring, real time data collection, data management, systems design/analysis, and much more. - Covers the basics of biosensor based medical care data analysis and management - Discusses data transmission techniques, presenting applications with extensive studies for biosensor based medical healthcare systems - Offers solutions to the challenges of designing biosensor based medical healthcare systems

Biosensors for Medical Applications

Author : Séamus Higson
Publisher : Elsevier
ISBN 13 : 0857097180
Total Pages : 356 pages
Book Rating : 4.8/5 (57 download)

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Book Synopsis Biosensors for Medical Applications by : Séamus Higson

Download or read book Biosensors for Medical Applications written by Séamus Higson and published by Elsevier. This book was released on 2012-08-21 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical sensors are an essential tool in the detection and monitoring of a wide range of medical conditions from cancer to Parkinson's disease. Biosensors for medical applications provides a comprehensive review of established, cutting edge and future trends in biomedical sensors and their applications.Part one focuses on key principles and transduction approaches, reviewing electrochemical, piezoelectric and nano-sized biosensors. Impedence interrogated affinity biosensors for medical applications and practical applications of enzyme biosensors are explored, before part two goes on to review specific medical applications. Biosensors for DNA and RNA detection and characterization, disease biomarker detection, and the use of affibodies as an alternative to antibodies in cancer marker biosensors are investigated, along with biosensors for drug testing and discovery, non-invasive measurements, and wearable biosensors for medical applications.With its distinguished editor and international team of expert contributors, Biosensors for medical applications is an essential guide for all those involved in the research, design, production and use of medical biosensors. - Provides a comprehensive review of established, cutting edge and future trends in biomedical sensors and their applications - Examines key principles and transduction approaches, reviewing electrochemical, piezoelectric and nano-sized biosensors - Reviews biosensors for DNA and RNA detection and characterisation, disease biomarker detection, and the use of affibodies as an alternative to antibodies in cancer marker biosensors

Biomarkers

Author : Vishal S. Vaidya
Publisher : John Wiley & Sons
ISBN 13 : 9780470918555
Total Pages : 632 pages
Book Rating : 4.9/5 (185 download)

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Book Synopsis Biomarkers by : Vishal S. Vaidya

Download or read book Biomarkers written by Vishal S. Vaidya and published by John Wiley & Sons. This book was released on 2010-10-28 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an introduction to the field of biomarkers, how they have been and can be used, and how different approaches can be used to identify, characterize, and monitor biomarkers. The book has chapters on topics including HIV, Cancer, Parkinson’s, vascular injury, environmental exposure. A following section discusses the technologies (diagnostics and assays) to detect biomarkers and authors have emphasized the preclinical and clinical manifestation of the injury/disease process.