Imaging Mass Spectrometry

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Publisher : Springer Science & Business Media
ISBN 13 : 4431094253
Total Pages : 252 pages
Book Rating : 4.4/5 (31 download)

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Book Synopsis Imaging Mass Spectrometry by : Mitsutoshi Setou

Download or read book Imaging Mass Spectrometry written by Mitsutoshi Setou and published by Springer Science & Business Media. This book was released on 2010-01-29 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Addressing the widespread need for a practical guide to imaging mass spectrometry (IMS), this book presents the protocols of IMS technology. As that technology expands, research groups around the world continue its development. Pharmaceutical companies are using IMS for drug analyses to study pharmacokinetics and medical properties of drugs. Drug research and disease-related biomarker screening are experiencing greater use of this technology, with a concurrent increase in the number of researchers in academia and industry interested in wider applications of IMS. Intended for beginners or those with limited experience with IMS technology, this book provides practical details and instructions needed for immediate know-how, including the preparation of animal tissue samples, the application of a matrix, instrumental operations, and data analysis, among others. By describing the foundations of IMS, this volume contributes to the ongoing development of the field and to progress in human health.

Medical Informatics

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Publisher : Springer Science & Business Media
ISBN 13 : 038725739X
Total Pages : 656 pages
Book Rating : 4.3/5 (872 download)

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Book Synopsis Medical Informatics by : Hsinchun Chen

Download or read book Medical Informatics written by Hsinchun Chen and published by Springer Science & Business Media. This book was released on 2006-07-19 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensively presents the foundations and leading application research in medical informatics/biomedicine. The concepts and techniques are illustrated with detailed case studies. Authors are widely recognized professors and researchers in Schools of Medicine and Information Systems from the University of Arizona, University of Washington, Columbia University, and Oregon Health & Science University. Related Springer title, Shortliffe: Medical Informatics, has sold over 8000 copies The title will be positioned at the upper division and graduate level Medical Informatics course and a reference work for practitioners in the field.

A Conceptual Change Rationale for the Design and Classroom Implementation of Biomap

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Publisher :
ISBN 13 :
Total Pages : 1224 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis A Conceptual Change Rationale for the Design and Classroom Implementation of Biomap by : Sharolyn Joy Belzer

Download or read book A Conceptual Change Rationale for the Design and Classroom Implementation of Biomap written by Sharolyn Joy Belzer and published by . This book was released on 1995 with total page 1224 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Emerging Safety Science

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Publisher : National Academies Press
ISBN 13 : 0309110122
Total Pages : 150 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Emerging Safety Science by : Institute of Medicine

Download or read book Emerging Safety Science written by Institute of Medicine and published by National Academies Press. This book was released on 2008-05-08 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the costs of new drug development have skyrocketed. The average cost of developing a new approved drug is now estimated to be $1.3 billion (DiMasi and Grabowski, 2007). At the same time, each year fewer new molecular entities (NMEs) are approved. DiMasi and Grabowski report that only 21.5 percent of the candidate drugs that enter phase I clinical testing actually make it to market. In 2007, just 17 novel drugs and 2 novel biologics were approved. In addition to the slowing rate of drug development and approval, recent years have seen a number of drugs withdrawn from the market for safety reasons. According to the Government Accountability Office (GAO), 10 drugs were withdrawn because of safety concerns between 2000 and March 2006 (GAO, 2006). Finding ways to select successful drug candidates earlier in development could save millions or even billions of dollars, reduce the costs of drugs on the market, and increase the number of new drugs with improved safety profiles that are available to patients. Emerging scientific knowledge and technologies hold the potential to enhance correct decision making for the advancement of candidate drugs. Identification of safety problems is a key reason that new drug development is stalled. Traditional methods for assessing a drug's safety prior to approval are limited in their ability to detect rare safety problems. Prior to receiving U.S. Food and Drug Administration (FDA) approval, a drug will have been tested in hundreds to thousands of patients. Generally, drugs cannot confidently be linked to safety problems until they have been tested in tens of thousands to hundreds of thousands of people. With current methods, it is unlikely that rare safety problems will be identified prior to approval. Emerging Safety Science: Workshop Summary summarizes the events and presentations of the workshop.

A Short History of the Future

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Publisher : University of Chicago Press
ISBN 13 : 9780226869032
Total Pages : 348 pages
Book Rating : 4.8/5 (69 download)

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Book Synopsis A Short History of the Future by : W. Warren Wagar

Download or read book A Short History of the Future written by W. Warren Wagar and published by University of Chicago Press. This book was released on 1999-08 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Narrated by a far-future historian, Peter Jensen leaves an account of the world from the 1990s to the opening of the 23rd century as a gift to his granddaughter. A combination of fiction and scholarship, this third edition of Wagar's speculative history of the future alternates between descriptions of world events and intimate glimpses of this historian's family into the first centuries of the new millennium.

Lipidomics

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Publisher : John Wiley & Sons
ISBN 13 : 3527655964
Total Pages : 507 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Lipidomics by : Kim Ekroos

Download or read book Lipidomics written by Kim Ekroos and published by John Wiley & Sons. This book was released on 2012-09-04 with total page 507 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on the practical applications, this user-oriented guide presents current technologies and strategies for systems-level lipid analysis, going beyond basic research to concentrate on commercial uses of lipidomics in biomarker and diagnostic development, as well as within pharmaceutical drug discovery and development. The editor and authors have experience of the most recent analytical instruments and techniques, allowing them to provide here first-hand practical experience for newcomers to the field. The first half of the book covers current methodologies, ranging from global to targeted lipidomics and shotgun approaches, while the second part discusses the role of lipidomics in biomedical and pharmaceutical research, covering such diverse fields as inflammation, metabolic syndrome, cardiovascular and neurological disease. Both small and large-scale, high-throughput approaches are discussed, resulting in an invaluable source for academic and industrial research and development.

Phenotypic Drug Discovery

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Publisher : Royal Society of Chemistry
ISBN 13 : 1788018761
Total Pages : 273 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis Phenotypic Drug Discovery by : Angelique Augustin

Download or read book Phenotypic Drug Discovery written by Angelique Augustin and published by Royal Society of Chemistry. This book was released on 2020-12-10 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phenotypic drug discovery has been highlighted in the past decade as an important strategy in the discovery of novel medical entities. This book aims to equip researchers with a thought-provoking guide to the application and development of contemporary phenotypic drug discovery for clinical success.

Advances in Ecology Environment and Conservation Research and Application: 2011 Edition

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Publisher : ScholarlyEditions
ISBN 13 : 1464921326
Total Pages : 595 pages
Book Rating : 4.4/5 (649 download)

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Book Synopsis Advances in Ecology Environment and Conservation Research and Application: 2011 Edition by :

Download or read book Advances in Ecology Environment and Conservation Research and Application: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 595 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Ecology Environment and Conservation Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Ecology Environment and Conservation. The editors have built Advances in Ecology Environment and Conservation Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Ecology Environment and Conservation in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Ecology Environment and Conservation Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Data Integration in the Life Sciences

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Publisher : Springer
ISBN 13 : 3540318798
Total Pages : 355 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Data Integration in the Life Sciences by : Bertram Ludäscher

Download or read book Data Integration in the Life Sciences written by Bertram Ludäscher and published by Springer. This book was released on 2005-08-25 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: The workshop was organized by the San Diego Supercomputer Center (SDSC) and took place July 20 –22, 2005 at the University of California, San Diego.

Conservation in the Internet Age

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Publisher : Island Press
ISBN 13 : 1597268518
Total Pages : 393 pages
Book Rating : 4.5/5 (972 download)

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Book Synopsis Conservation in the Internet Age by : James N. Levitt

Download or read book Conservation in the Internet Age written by James N. Levitt and published by Island Press. This book was released on 2013-04-16 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the earliest days of our nation, new communications and transportation networks have enabled vast changes in how and where Americans live and work. Transcontinental railroads and telegraphs helped to open the West; mass media and interstate highways paved the way for suburban migration. In our own day, the internet and advanced logistics networks are enabling new changes on the landscape, with both positive and negative impacts on our efforts to conserve land and biodiversity. Emerging technologies have led to tremendous innovations in conservation science and resource management as well as education and advocacy efforts. At the same time, new networks have been powerful enablers of decentralization, facilitating sprawling development into previously undesirable or inaccessible areas. Conservation in the Internet Age offers an innovative, cross-disciplinary perspective on critical changes on the land and in the field of conservation. The book: provides a general overview of the impact of new technologies and networks explores the potentially disruptive impacts of the new networks on open space and biodiversity presents case studies of innovative ways that conservation organizations are using the new networks to pursue their missions considers how rapid change in the Internet Age offers the potential for landmark conservation initiatives Conservation in the Internet Age is the first book to examine the links among land use, technology, and conservation from multiple perspectives, and to suggest areas and initiatives that merit further investigation. It offers unique and valuable insight into the challenges facing the land and biodiversity conservation community in the early twenty-first century, and represents an important new work for policymakers, conservation professionals, and academics in planning, design, conservation and resource management, policy, and related fields.

Proteome Research

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Publisher : Springer Science & Business Media
ISBN 13 : 9783540712411
Total Pages : 268 pages
Book Rating : 4.7/5 (124 download)

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Book Synopsis Proteome Research by : M.R. Wilkins

Download or read book Proteome Research written by M.R. Wilkins and published by Springer Science & Business Media. This book was released on 2008-02-05 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteomics is a multifaceted, interdisciplinary field which studies the complexity and dynamics of proteins in biological systems. It combines powerful separation and analytical technology with advanced informatics to understand the function of proteins in the cell and in the body. This book provides a clear conceptual description of each facet of proteomics, describes recent advances in technology and thinking in each area, and provides details of how these have been applied to a variety of biological problems. It is written by expert practitioners in the field, from industry, research institutions, and the clinic. It provides junior and experienced researchers with an invaluable proteomic reference, and gives fascinating glimpses of the future of this dynamic field.

Controlling Salmonella in Poultry Production and Processing

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Publisher : CRC Press
ISBN 13 : 1439821119
Total Pages : 310 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Controlling Salmonella in Poultry Production and Processing by : Ph.D., Scott M. Russell

Download or read book Controlling Salmonella in Poultry Production and Processing written by Ph.D., Scott M. Russell and published by CRC Press. This book was released on 2012-02-16 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Salmonella is a major pathogen that can result in deadly foodborne illness. The Centers for Disease Control and Prevention (CDC) estimates that there are 1.4 million cases of Salmonella poisoning each year in the United States from a variety of causes, with undercooked poultry and eggs being the prime culprits. Therefore, intervention strategies ar

High-Throughput Screening in Drug Discovery

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Publisher : John Wiley & Sons
ISBN 13 : 3527609369
Total Pages : 362 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis High-Throughput Screening in Drug Discovery by : Jörg Hüser

Download or read book High-Throughput Screening in Drug Discovery written by Jörg Hüser and published by John Wiley & Sons. This book was released on 2006-12-13 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Backed by leading authorities, this is a professional guide to successful compound screening in pharmaceutical research and chemical biology, including the chemoinformatic tools needed for correct data evaluation. Chapter authors from leading pharmaceutical companies as well as from Harvard University discuss such factors as chemical genetics, binding, cell-based and biochemical assays, the efficient use of compound libraries and data mining using cell-based assay results. For both academics and professionals in the pharma and biotech industries working on small molecule screening.

Metabolomics Perspectives

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Publisher : Academic Press
ISBN 13 : 0323850634
Total Pages : 685 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Metabolomics Perspectives by : Jacopo Troisi

Download or read book Metabolomics Perspectives written by Jacopo Troisi and published by Academic Press. This book was released on 2022-03-15 with total page 685 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolomics Perspectives: From Theory to Practical Application is an expertly written volume, which provides a thorough description of the current state-of-the-art in the metabolomics field. The philosophy behind the book is to guide the reader in a step-by-step exploration of metabolomics experiments, ranging from sample preparation to data extraction, analysis and interpretation, and to discuss the main current applications and future perspectives of this emerging science. Armed with critical insights, coupled with a clear writing, the book consists of three main sections. The first one introduces the pivotal theoretical fundamentals and provides a comprehensive overview of the "wet" laboratory workflow, including protocol instructions and a detailed description of experimental methods and analytical techniques. The second section covers a wide range of topics in the context of data analysis, including guidance in exploratory analysis, supervised and unsupervised machine learning approaches and validation and optimization methods. In addition to the several examples reported in the text, the book features an R package, specifically designed to perform all the described algorithms, which is hosted on a companion website (www.metabolomicsperspectives.com) together with several sets of available metabolomic data. Finally, an extensive dissertation describes the latest advances and the major fields of interest for metabolomics applications, highlighting their crucial potentials for future biomedical research. Thus, this book represents a must-read for both experienced researchers, interested in metabolomics, and newcomers to the field. - Provides an in-depth description of the metabolomics experimental workflow and its applications in life science and biomedical research - Features chapter contributions from the greatest international experts in the field - Includes an R package and several sets of metabolomics data, hosted on a companion website

Human-based Systems for Translational Research

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Publisher : Royal Society of Chemistry
ISBN 13 : 1782620133
Total Pages : 297 pages
Book Rating : 4.7/5 (826 download)

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Book Synopsis Human-based Systems for Translational Research by : Robert Coleman

Download or read book Human-based Systems for Translational Research written by Robert Coleman and published by Royal Society of Chemistry. This book was released on 2014-12-08 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a history and discussion of the use of human tissues as an alternative to animal-based testing for assessing the efficacy and safety of new medicines. Beginning by providing a historical background to animal-based testing, this text then describes in detail the issues relating to access to human cells and tissue and the rules and regulations governing their use. The book illustrates what is currently possible in humanising medicines research and development, and suggests more rational and reliable means of developing safe and effective drugs for the future than those on which we currently rely. Early chapters establish the need to generate more data in human-derived test systems, and the need for resources such as tissue banks and standardised processes whilst highlighting the barriers that have prevented such developments so far. Subsequent chapters explore the alternatives to current animal toxicology studies, including stem cells and computational models, with balanced views of the technical challenges and opportunities these offer. In addition, useful information on computational methods and pharmacokinetics are included. This book is an essential read for anyone engaged in translational drug discovery who wishes to consolidate their understanding and broaden their awareness of the key issues involved in accessing primary human tissue and the advantages of doing so.

Marine Biomedicine

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Publisher : CRC Press
ISBN 13 : 1466582138
Total Pages : 613 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Marine Biomedicine by : Bill J. Baker

Download or read book Marine Biomedicine written by Bill J. Baker and published by CRC Press. This book was released on 2015-11-05 with total page 613 pages. Available in PDF, EPUB and Kindle. Book excerpt: Marine Biomedicine: From Beach to Bedside assesses current efforts in marine biomedicine and evaluates the implications of recent advances on the future of the field.Richly illustrated in full color to enhance reader comprehension, the book covers four sections. The first one addresses the technology that has recently been brought to bear on the st

Mass Spectrometry Imaging in Food Analysis

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Publisher : CRC Press
ISBN 13 : 0429765304
Total Pages : 215 pages
Book Rating : 4.4/5 (297 download)

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Book Synopsis Mass Spectrometry Imaging in Food Analysis by : Leo M.L. Nollet

Download or read book Mass Spectrometry Imaging in Food Analysis written by Leo M.L. Nollet and published by CRC Press. This book was released on 2020-04-29 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: Food contains various compounds and many technologies exist to analyze those molecules of interest. However, the analysis of the spatial distribution of those compounds using conventional technology, such as liquid chromatography-mass spectrometry or gas chromatography-mass spectrometry is difficult. Mass spectrometry imaging (MSI) is a mass spectrometry technique to visualize the spatial distribution of molecules, as biomarkers, metabolites, peptides or proteins by their molecular masses. Despite the fact that MSI has been generally considered a qualitative method, the signal generated by this technique is proportional to the relative abundance of the analyte and so quantification is possible. Mass Spectrometry Imaging in Food Analysis, a volume in the Food Analysis and Properties Series, explains how the novel use of matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) will be an ideal complementary approach. MALDI-MSI is a two-dimensional MALDI-MS technology that can detect compounds in a tissue section without extraction, purification, separation, or labeling. It can be used to visualize the spatial distribution of biomolecules in foods. Features: Explains the novel use of matrix-assisted laser desorption/ionization mass spectrometry imaging in food analysis Describes how MALDI-MSI will be a useful technique for optical quality assurance. Shows how MALDI-MSI detects food contaminants and residues Covers the historical development of the technology While there are a multitude of books on mass spectrometry, none focus on food applications and thus this book is ideally suited to food scientists, food industry personnel engaged in product development, research institutions, and universities active in food analysis or chemical analysis. Also available in the Food Analysis and Properties Series: Food Aroma Evolution: During Food Processing, Cooking, and Aging, edited by Matteo Bordiga and Leo M.L. Nollet (ISBN: 9781138338241) Ambient Mass Spectroscopy Techniques in Food and the Environment, edited by Leo M.L. Nollet and Basil K. Munjanja (ISBN: 9781138505568) Hyperspectral Imaging Analysis and Applications for Food Quality, edited by N.C. Basantia, Leo M.L. Nollet, and Mohammed Kamruzzaman (ISBN: 9781138630796) For a complete list of books in this series, please visit our website at: www.crcpress.com/Food-Analysis--Properties/book-series/CRCFOODANPRO