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Biology Of Negative Strand Rna Viruses The Power Of Reverse Genetics
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Book Synopsis Biology of Negative Strand RNA Viruses: The Power of Reverse Genetics by : Yoshihiro Kawaoka
Download or read book Biology of Negative Strand RNA Viruses: The Power of Reverse Genetics written by Yoshihiro Kawaoka and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Negative-strand RNA viruses, so named because of the polarity of their genomic RNA to mRNA, include important human and non-human pathogens. This volume covers major advances in reverse genetics techniques over the past decade, state-of-the-art basic science and the clinical implications of experimental findings. This should rekindle interest in negative-strand RNA viruses among readers, including those in other disciplines, leading to further progress in understanding these important viruses and in developing effective measures of control.
Book Synopsis Reverse Genetics of RNA Viruses by : Anne Bridgen
Download or read book Reverse Genetics of RNA Viruses written by Anne Bridgen and published by John Wiley & Sons. This book was released on 2012-10-07 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reverse genetics, the genetic manipulation of RNA viruses to create a wild-type or modified virus, has led to important advances in our understanding of viral gene function and interaction with host cells. Since many severe viral human and animal pathogens are RNA viruses, including those responsible for polio, measles, rotaviral diarrhoea and influenza infections, it is also an extremely powerful technique with important potential application for the prevention and control of a range of human and animal viral diseases. Reverse Genetics of RNA Viruses provides a comprehensive account of the very latest developments in reverse genetics of RNA viruses through a wide range of applications within each of the core virus groups including; positive sense, negative sense and double stranded RNA viruses. Written by a team of international experts in the field, it provides a unique insight into how the field has developed, what problems are being addressed now and where applications may lead in the future. It will prove invaluable to bioscience, medical and veterinary students, those starting research in this area as well as other researchers and teachers needing to update their knowledge of this fast-moving field. An authoritative, comprehensive overview of reverse genetics in RNA Viruses. Includes numerous examples of cutting- edge applications of reverse genetics within each of the RNA viral groups. Written by a team of international experts, including some of the leading researchers in the field.
Book Synopsis Reverse Genetics of RNA Viruses by : Daniel R. Pérez
Download or read book Reverse Genetics of RNA Viruses written by Daniel R. Pérez and published by Springer Nature. This book was released on 2023-12-08 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition volume expands on the previous edition with new and updated chapters that highlight the latest methods and approaches for the manipulation of RNA viruses. The chapters in this book explore the fundamental role in studying RNA viruses; identifying markers of host range, disease, and transmission; and aid readers with the further development of in silico computational biology tools and artificial intelligence algorithms that can help predict the emergence of certain pathogens. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Reverse Genetics of RNA Viruses: Methods and Protocols, Second Edition is a valuable resource for researchers who are interested in learning more about this developing field.
Book Synopsis Negative Strand RNA Virus by : Ming Luo
Download or read book Negative Strand RNA Virus written by Ming Luo and published by World Scientific. This book was released on 2011 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: Negative strand RNA viruses have a unique mechanism of replication. Their genome is a single strand RNA that has to be transcribed as soon as the virus enters the host in order to carry out viral replication. As a result, a viral-specific RNA polymerase is packaged in the virion and is ready for transcription after virus entry. This novel replication mechanism dictates the assembly and RNA synthesis of negative strand RNA viruses. In recent years, many discoveries have been made with regard to the entry, replication and assembly of this class of viruses. This book will present updated coverage of the fundamental knowledge about negative strand RNA viruses.
Download or read book RNA Viruses written by Alan Cann and published by OUP Oxford. This book was released on 2000-05-04 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: RNA Viruses: A Practical Approach is wide ranging in scope, from emerging technology such as reverse genetics and retrovirus vectors, to money saving tips - how to make your own silica particles for high efficiency RNA extraction and liposomes for cell transfection! Chapter one covers the fundamentals of investigating RNA virus genome structure at a molecular level. Chapters two and three describe techniques for mutagenesis of RNA genomes and analysis of transcription. Chapter four deals with RNA virus-encoded proteinases, an important aspect of the control of RNA virus gene expression. Chapter five considers retrovirus oncogenesis and chapter six analysis of RNA virus quasispecies. Chapter seven describes systems for investigation of in vitro replication of positive-stranded viruses and chapter eight the packaging of RNA virus genomes. In addition to the technical aspects of reverse genetics and retrovirus vectors, both of the final two chapters also consider ethical aspects of these new technologies.
Book Synopsis Coronavirus Replication and Reverse Genetics by : Luis Enjuanes
Download or read book Coronavirus Replication and Reverse Genetics written by Luis Enjuanes and published by Springer Science & Business Media. This book was released on 2005-10-25 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human coronaviruses caused the SARS epidemic that infected more than 8000 people, killing about ten percent of them in 32 countries. This book provides essential information on these viruses and the development of vaccines to control coronavirus infections.
Book Synopsis Reverse Genetics of Negative Stranded RNA Viruses by : Fundación Juan March. Instituto de Estudios e Investigaciones
Download or read book Reverse Genetics of Negative Stranded RNA Viruses written by Fundación Juan March. Instituto de Estudios e Investigaciones and published by . This book was released on 1993 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book RNA Genetics written by Esteban Domingo and published by CRC Press. This book was released on 2018-02-06 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: First Published in 2018. Routledge is an imprint of Taylor & Francis, an Informa company.
Download or read book RNA Genetics written by Esteban Domingo and published by CRC Press. This book was released on 2018-01-18 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the basic features of virus replication, and points out how these features lead into the diverse biologies and genetics of the various viruses.
Book Synopsis Coronavirus Replication and Reverse Genetics by : Luis Enjuanes
Download or read book Coronavirus Replication and Reverse Genetics written by Luis Enjuanes and published by . This book was released on 2005 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Coronaviruses are the RNA viruses with the largest genome known to date (27 to 32 kb). Members of this virus family affect most domestic animal species, causing important socio-economical losses, and also infect humans. Human coronaviruses were known to cause the winter common cold, a mild infection without important pathological consequences except in immuno-compromised patients. Recently, two new human coronaviruses have emerged, one causing the Severe and Acute Respiratory Syndrome (SARS) that infected more than 8000 individuals, leading to more than 800 deaths in 32 countries. This epidemic mobilized the World Health Organization, which launched travel restrictions to certain parts of the world for the first time in the last 50 years. The fact that coronaviruses, as many other viruses, crossed the species barrier to infect humans has posed a serious challenge to scientists involved in animal and human health. Control of coronavirus-induced diseases can only be the consequence of research on virus molecular biology and pathogenesis. This book contains information on virus genome structure, mechanism of replication and transcription, and the development of tools that make possible reverse genetic studies to understand virus-host interactions and the molecular basis of virus pathogenesis. The book also provides essential information for the development of classical and recombinant vaccines to control coronavirus infections.
Book Synopsis Quasispecies and RNA Virus Evolution by : Esteban Domingo
Download or read book Quasispecies and RNA Virus Evolution written by Esteban Domingo and published by . This book was released on 2001 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Genetic Diversity of RNA Viruses by : John J. Holland
Download or read book Genetic Diversity of RNA Viruses written by John J. Holland and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many RNA viruses have been known for decades to be genetically and biologically quite variable. Some well-known examples are influenza viruses, foot and mouth disease viruses, and Newcastle disease virus. During the past decade, it has become clear that most, it not all. , RNA viruses (riboviruses and retroviruses) are much more mutable than was recognized previously, and that this great mutability generates extremely complex populations consisting of indeterminate mixtures of related variants (Le. , "mutant swarms" or "quasispecies" populations). This is also true of DNA viruses (such as hepatitis DNA genomes via RNA transcripts B virus) which replicate their that are reverse-transcribed back to DNA. This hypermutability of RNA replicons provides great biological adaptability for RNA virus genomes. It also allows (but does not necessitate) RNA viruses, so that they can extremely rapid evolution of evolve over a million times more quickly than their eukaryotic DNA-based hosts. The genetics of RNA replicons is so unusual (and often counterintuitive) that it has many important biological conse quences which are neither readily apparent nor widely under stood. Failure to understand the distinctive aspects of RNA genetics frequently generates confusion and controversy and can adversely impact vaccine and antiviral drug programs and other applications of medical virology. The 14 chapters in this volume describe advances in a number of significant areas of RNA virus genetics and evolution.
Book Synopsis Workshop on Reverse Genetics of Negative Stranded RNA Viruses by :
Download or read book Workshop on Reverse Genetics of Negative Stranded RNA Viruses written by and published by . This book was released on 1993 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Positive-strand RNA Viruses by : Margo A. Brinton
Download or read book Positive-strand RNA Viruses written by Margo A. Brinton and published by Springer. This book was released on 1994 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis New Aspects of Positive-strand RNA Viruses by : Margo A. Brinton
Download or read book New Aspects of Positive-strand RNA Viruses written by Margo A. Brinton and published by ASM Press. This book was released on 1990 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: General overviews and minireviews on specific viruses and properties combine to present a broad range of current findings.
Book Synopsis Development and Applications of a New Reverse Genetics Method for the Generation of Single-stranded Positive-sense RNA Viruses by : Fabien Aubry
Download or read book Development and Applications of a New Reverse Genetics Method for the Generation of Single-stranded Positive-sense RNA Viruses written by Fabien Aubry and published by . This book was released on 2014 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reverse genetics has become a key methodology for producing genetically modified RNA viruses and deciphering cellular and viral biological properties, but the most commonly used methods, based on the preparation of plasmid-based complete viral genomes, are laborious and unpredictable. The first part of this thesis presents studies relating to the development of a new reverse genetics system, designated the ISA (Infectious-Subgenomic-Amplicons) method, which enabled the generation of both wild-type and genetically modified infectious viruses belonging to three different families of positive, single stranded RNA viruses within days with great control of the viral sequences. In the second part of this thesis, we applied for the first time to an arbovirus (CHIKV), codon re-encoding - a recently developed and very exciting method for the development of live attenuated vaccines. Using a random codon re-encoding approach which randomly attributed nucleotide codons based on their corresponding amino acid sequence, we identified major fitness losses of CHIKV in both primate and arthropod cells. The decrease of replicative fitness correlated with the extent of re-encoding, an observation that may assist in the modulation of viral attenuation. Detailed analysis of these observed replicative fitness losses indicated that they are the consequence of several independent re-encoding induced events. Using the experience acquired on the CHIKV, we successfully transposed this attenuation mechanism to JEV and improved our control of the attenuation process by using a combination of de novo synthesis and the ISA method.
Book Synopsis The Molecular Biology of the Positive Strand RNA Viruses by : D. J. Rowlands
Download or read book The Molecular Biology of the Positive Strand RNA Viruses written by D. J. Rowlands and published by . This book was released on 1987 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt:
