Biology By Discovery

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Discovery and Explanation in Biology and Medicine

Author : Kenneth F. Schaffner
Publisher : University of Chicago Press
ISBN 13 : 9780226735924
Total Pages : 654 pages
Book Rating : 4.7/5 (359 download)

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Book Synopsis Discovery and Explanation in Biology and Medicine by : Kenneth F. Schaffner

Download or read book Discovery and Explanation in Biology and Medicine written by Kenneth F. Schaffner and published by University of Chicago Press. This book was released on 1993 with total page 654 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kenneth F. Schaffner compares the practice of biological and medical research and shows how traditional topics in philosophy of science—such as the nature of theories and of explanation—can illuminate the life sciences. While Schaffner pays some attention to the conceptual questions of evolutionary biology, his chief focus is on the examples that immunology, human genetics, neuroscience, and internal medicine provide for examinations of the way scientists develop, examine, test, and apply theories. Although traditional philosophy of science has regarded scientific discovery—the questions of creativity in science—as a subject for psychological rather than philosophical study, Schaffner argues that recent work in cognitive science and artificial intelligence enables researchers to rationally analyze the nature of discovery. As a philosopher of science who holds an M.D., he has examined biomedical work from the inside and uses detailed examples from the entire range of the life sciences to support the semantic approach to scientific theories, addressing whether there are "laws" in the life sciences as there are in the physical sciences. Schaffner's novel use of philosophical tools to deal with scientific research in all of its complexity provides a distinctive angle on basic questions of scientific evaluation and explanation.

The Path to the Double Helix

Author : Robert Olby
Publisher : Courier Corporation
ISBN 13 : 0486166597
Total Pages : 562 pages
Book Rating : 4.4/5 (861 download)

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Book Synopsis The Path to the Double Helix by : Robert Olby

Download or read book The Path to the Double Helix written by Robert Olby and published by Courier Corporation. This book was released on 2013-05-13 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by a noted historian of science, this in-depth account traces how Watson and Crick achieved one of science's most dramatic feats: their 1953 discovery of the molecular structure of DNA.

Pattern Discovery in Bioinformatics

Author : Laxmi Parida
Publisher : CRC Press
ISBN 13 : 1420010735
Total Pages : 512 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Pattern Discovery in Bioinformatics by : Laxmi Parida

Download or read book Pattern Discovery in Bioinformatics written by Laxmi Parida and published by CRC Press. This book was released on 2007-07-04 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: The computational methods of bioinformatics are being used more and more to process the large volume of current biological data. Promoting an understanding of the underlying biology that produces this data, Pattern Discovery in Bioinformatics: Theory and Algorithms provides the tools to study regularities in biological data. Taking a systema

Bioinformatics and Drug Discovery

Author : Richard S. Larson
Publisher :
ISBN 13 : 9781617799655
Total Pages : 374 pages
Book Rating : 4.7/5 (996 download)

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Book Synopsis Bioinformatics and Drug Discovery by : Richard S. Larson

Download or read book Bioinformatics and Drug Discovery written by Richard S. Larson and published by . This book was released on 2012 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in drug discovery have been rapid. The second edition of Bioinformatics and Drug Discovery has been completely updated to include topics that range from new technologies in target identification, genomic analysis, cheminformatics, protein analysis, and network or pathway analysis. Each chapter provides an extended introduction that describes the theory and application of the technology. In the second part of each chapter, detailed procedures related to the use of these technologies and software have been incorporated. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Bioinformatics and Drug Discovery, Second Edition seeks to aid scientists in the further study of the rapidly expanding field of drug discovery.

Structural Biology in Drug Discovery

Author : Jean-Paul Renaud
Publisher : John Wiley & Sons
ISBN 13 : 1118900502
Total Pages : 1437 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis Structural Biology in Drug Discovery by : Jean-Paul Renaud

Download or read book Structural Biology in Drug Discovery written by Jean-Paul Renaud and published by John Wiley & Sons. This book was released on 2020-01-09 with total page 1437 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins

Bioinformatics and Computational Biology in Drug Discovery and Development

Author : William T. Loging
Publisher : Cambridge University Press
ISBN 13 : 0521768004
Total Pages : 255 pages
Book Rating : 4.5/5 (217 download)

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Book Synopsis Bioinformatics and Computational Biology in Drug Discovery and Development by : William T. Loging

Download or read book Bioinformatics and Computational Biology in Drug Discovery and Development written by William T. Loging and published by Cambridge University Press. This book was released on 2016-03-17 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive overview of the use of computational biology approaches in the drug discovery and development process.

Biotherapeutics

Author : Lyn Jones
Publisher : Royal Society of Chemistry
ISBN 13 : 1849737150
Total Pages : 331 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Biotherapeutics by : Lyn Jones

Download or read book Biotherapeutics written by Lyn Jones and published by Royal Society of Chemistry. This book was released on 2013-09-06 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates the successful partnership of chemistry and biology to advance successful biotherapeutic modalities. Molecular design to create function is common to both chemical and molecular biology, and this text highlights recent developments from these disciplines that have delivered drugs, clinical candidates or significantly advanced biotherapeutic approaches. Biotherapeutics are often considered to be beyond the reach of the medicinal chemist, but this book demonstrates that chemistry has an essential role in the future success of this area, by explaining and describing the chemical biology technologies that underpin specific therapeutic advances and demonstrating the unique value of molecular design and understanding. Covering topics such as selective protein modification, immunopharmacotherapy, chemically programmed vaccinations, nanobodies and antibodies, this book provides essential reading for medicinal and pharmaceutical chemists working in both industry and academia.

Reinventing Discovery

Author : Michael Nielsen
Publisher : Princeton University Press
ISBN 13 : 0691202842
Total Pages : 272 pages
Book Rating : 4.6/5 (912 download)

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Book Synopsis Reinventing Discovery by : Michael Nielsen

Download or read book Reinventing Discovery written by Michael Nielsen and published by Princeton University Press. This book was released on 2020-04-07 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Reinventing Discovery argues that we are in the early days of the most dramatic change in how science is done in more than 300 years. This change is being driven by new online tools, which are transforming and radically accelerating scientific discovery"--

Bioinformatics and Drug Discovery

Author : Richard S. Larson
Publisher : Humana Press
ISBN 13 : 9781588293466
Total Pages : 444 pages
Book Rating : 4.2/5 (934 download)

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Book Synopsis Bioinformatics and Drug Discovery by : Richard S. Larson

Download or read book Bioinformatics and Drug Discovery written by Richard S. Larson and published by Humana Press. This book was released on 2005-10-01 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: A collection of readily reproducible bioinformatic methods to advance the drug discovery process from gene identification to protein modeling to the identification of specific drug candidates. The authors demonstrate these techniques, including microarray analysis, the analysis of genes as potential drug targets, virtual screening and in silico protein design, and cheminformatics, in a variety of practical situations. Because these technologies are still emergent, each chapter contains an extended introduction that explains the theory and application of the technology and techniques described.

Chemical Biology

Author : Natanya Civjan
Publisher : John Wiley & Sons
ISBN 13 : 1118434501
Total Pages : 657 pages
Book Rating : 4.1/5 (184 download)

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Book Synopsis Chemical Biology by : Natanya Civjan

Download or read book Chemical Biology written by Natanya Civjan and published by John Wiley & Sons. This book was released on 2012-08-07 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: An authoritative look at the application of chemical biology in drug discovery and development Based on the award-winning Wiley Encyclopedia of Chemical Biology published in 2008, this book explores the role of chemical biology in drug discovery and development. The first part of the book reviews key principles and techniques used in the design and evaluation of drug candidates. The second part elucidates biological mechanisms of certain diseases, illuminating approaches to investigate and target these diseases. Comprising carefully selected reprints from the Encyclopedia as well as new contributions from leading scholars in the field, this book provides researchers in academia and industry with important information to aid in the development of novel agents to treat disease. Self-contained articles cover a variety of essential topics, including: The design, development, and optimization of drug candidates The pharmacokinetics and properties of drugs Drug transport and delivery Natural products and natural product models as pharmaceuticals Biological mechanisms underlying health and disease Treatment strategies for a range of diseases, from HIV to schizophrenia Chemical Biology is a top-notch guide and reference for anyone working in the areas of drug discovery and development, including researchers in chemical biology and other fields such as biochemistry, medicine, and pharmaceutical sciences.

Discovery Engineering in Biology

Author : Rebecca Hite
Publisher : National Science Teachers Association
ISBN 13 : 9781681406145
Total Pages : 0 pages
Book Rating : 4.4/5 (61 download)

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Book Synopsis Discovery Engineering in Biology by : Rebecca Hite

Download or read book Discovery Engineering in Biology written by Rebecca Hite and published by National Science Teachers Association. This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Who knew that small, plant-eating mammals called pikas helped scientists find new ways to survive extreme weather events, or that algae could be used as airplane fuel? Your students will learn about amazing scientific advancements like these when you use the lessons in Discovery Engineering in Biology: Case Studies for Grades 6-12. The book is a lively way to blend history, real-world perspectives, 21st-century skills, and engineering into your biology or STEM curriculum. Like Discovery Engineering in Physical Science (see p. XX), this book features case studies about observations and accidental discoveries that led to the invention of new products and problem-solving applications. The 20 lessons are both flexible and easy to use. After reading a historical account of an actual innovation, students explore related activities that connect to such topics as molecules and organisms, ecosystems, heredity, and biological evolution. Then they're prompted to think creatively about science from serendipity. They conduct research, analyze data, and use the engineering design process to develop products or applications of their own. Students are sure to be intrigued by investigations with titles such as "Vindicating Venom: Using Biological Mechanisms to Treat Diseases and Disorders" and "Revealing Repeats: The Accidental Discovery of DNA Fingerprinting." Discovery Engineering in Biology is an engaging way to help students discover that when accidents happen, the outcome can be an incredible innovation"--

Plasmids

Author : Marcelo E. Tolmasky
Publisher : John Wiley & Sons
ISBN 13 : 1555818986
Total Pages : 512 pages
Book Rating : 4.5/5 (558 download)

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Book Synopsis Plasmids by : Marcelo E. Tolmasky

Download or read book Plasmids written by Marcelo E. Tolmasky and published by John Wiley & Sons. This book was released on 2020-07-24 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explore the remarkable discoveries in the rapidly expanding field of plasmid biology Plasmids are integral to biological research as models for innumerable mechanisms of living cells, as tools for creating the most diverse therapies, and as crucial helpers for understanding the dissemination of microbial populations. Their role in virulence and antibiotic resistance, together with the generalization of "omics" disciplines, has recently ignited a new wave of interest in plasmids. This comprehensive book contains a series of expertly written chapters focused on plasmid biology, mechanistic details of plasmid function, and the increased utilization of plasmids in biotechnology and pharmacology that has occurred in the past decade. Plasmids: Biology and Impact in Biotechnology and Discovery serves as an invaluable reference for researchers in the wide range of fields and disciplines that utilize plasmids and can also be used as a textbook for upper-level undergraduate and graduate courses in biotechnology and molecular biology.

Landmark Experiments in Molecular Biology

Author : Michael Fry
Publisher : Academic Press
ISBN 13 : 012802108X
Total Pages : 572 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Landmark Experiments in Molecular Biology by : Michael Fry

Download or read book Landmark Experiments in Molecular Biology written by Michael Fry and published by Academic Press. This book was released on 2016-06-10 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: Landmark Experiments in Molecular Biology critically considers breakthrough experiments that have constituted major turning points in the birth and evolution of molecular biology. These experiments laid the foundations to molecular biology by uncovering the major players in the machinery of inheritance and biological information handling such as DNA, RNA, ribosomes, and proteins. Landmark Experiments in Molecular Biology combines an historical survey of the development of ideas, theories, and profiles of leading scientists with detailed scientific and technical analysis. - Includes detailed analysis of classically designed and executed experiments - Incorporates technical and scientific analysis along with historical background for a robust understanding of molecular biology discoveries - Provides critical analysis of the history of molecular biology to inform the future of scientific discovery - Examines the machinery of inheritance and biological information handling

Serendipity

Author : Royston M. Roberts
Publisher : Wiley
ISBN 13 : 9780471602033
Total Pages : 292 pages
Book Rating : 4.6/5 (2 download)

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Book Synopsis Serendipity by : Royston M. Roberts

Download or read book Serendipity written by Royston M. Roberts and published by Wiley. This book was released on 1991-01-16 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many of the things discovered by accident are important in our everyday lives: Teflon, Velcro, nylon, x-rays, penicillin, safety glass, sugar substitutes, and polyethylene and other plastics. And we owe a debt to accident for some of our deepest scientific knowledge, including Newton's theory of gravitation, the Big Bang theory of Creation, and the discovery of DNA. Even the Rosetta Stone, the Dead Sea Scrolls, and the ruins of Pompeii came to light through chance. This book tells the fascinating stories of these and other discoveries and reveals how the inquisitive human mind turns accident into discovery. Written for the layman, yet scientifically accurate, this illuminating collection of anecdotes portrays invention and discovery as quintessentially human acts, due in part to curiosity, perserverance, and luck.

Undeniable

Author : Douglas Axe
Publisher : HarperCollins
ISBN 13 : 0062349600
Total Pages : 219 pages
Book Rating : 4.0/5 (623 download)

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Book Synopsis Undeniable by : Douglas Axe

Download or read book Undeniable written by Douglas Axe and published by HarperCollins. This book was released on 2016-07-12 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: Named A Best Book of the Year by World Magazine Throughout his distinguished and unconventional career, engineer-turned-molecular-biologist Douglas Axe has been asking the questions that much of the scientific community would rather silence. Now, he presents his conclusions in this brave and pioneering book. Axe argues that the key to understanding our origin is the “design intuition”—the innate belief held by all humans that tasks we would need knowledge to accomplish can only be accomplished by someone who has that knowledge. For the ingenious task of inventing life, this knower can only be God. Starting with the hallowed halls of academic science, Axe dismantles the widespread belief that Darwin’s theory of evolution is indisputably true, showing instead that a gaping hole has been at its center from the beginning. He then explains in plain English the science that proves our design intuition scientifically valid. Lastly, he uses everyday experience to empower ordinary people to defend their design intuition, giving them the confidence and courage to explain why it has to be true and the vision to imagine what biology will become when people stand up for this truth. Armed with that confidence, readers will affirm what once seemed obvious to all of us—that living creatures, from single-celled cyanobacteria to orca whales and human beings, are brilliantly conceived, utterly beyond the reach of accident. Our intuition was right all along.

Systems Biology in Drug Discovery and Development

Author : Qing Yan
Publisher : Humana Press
ISBN 13 : 9781607617990
Total Pages : 0 pages
Book Rating : 4.6/5 (179 download)

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Book Synopsis Systems Biology in Drug Discovery and Development by : Qing Yan

Download or read book Systems Biology in Drug Discovery and Development written by Qing Yan and published by Humana Press. This book was released on 2010-09-21 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to the failing “one-drug-fits-all” model, it has become increasingly necessary to develop personalized medicine that treats whole systems and brings the right drug to the right patient with the right dosages. In Systems Biology in Drug Discovery and Development: Methods and Protocols, leading experts provide a practical, state-of-the-art, and holistic view of the translation of systems biology into better drug discovery and personalized medical practice. While the first part of the book describes cutting-edge technologies and methods in the field, the second part illustrates how the technologies can be applied in science for disease understanding and therapeutic discovery. As a volume in the highly successful Methods in Molecular BiologyTM series, this collection provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and up-to-date, Systems Biology in Drug Discovery and Development: Methods and Protocols covers topics from fundamental concepts to advanced technologies in order to best serve biomedical students and professionals at all levels who are interested in vital integrative studies in molecular biology, genetics, bioinformatics, bioengineering, biochemistry, physiology, pathology, microbiology, immunology, pharmacology, toxicology, drug discovery, and clinical medicine.

First in Fly

Author : Stephanie Elizabeth Mohr
Publisher : Harvard University Press
ISBN 13 : 0674984730
Total Pages : 273 pages
Book Rating : 4.6/5 (749 download)

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Book Synopsis First in Fly by : Stephanie Elizabeth Mohr

Download or read book First in Fly written by Stephanie Elizabeth Mohr and published by Harvard University Press. This book was released on 2018-03-09 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: A single species of fly, Drosophila melanogaster, has been the subject of scientific research for more than one hundred years. Why does this tiny insect merit such intense scrutiny? Drosophila’s importance as a research organism began with its short life cycle, ability to reproduce in large numbers, and easy-to-see mutant phenotypes. Over time, laboratory investigation revealed surprising similarities between flies and other animals at the level of genes, gene networks, cell interactions, physiology, immunity, and behavior. Like humans, flies learn and remember, fight microbial infection, and slow down as they age. Scientists use Drosophila to investigate complex biological activities in a simple but intact living system. Fly research provides answers to some of the most challenging questions in biology and biomedicine, including how cells transmit signals and form ordered structures, how we can interpret the wealth of human genome data now available, and how we can develop effective treatments for cancer, diabetes, and neurodegenerative diseases. Written by a leader in the Drosophila research community, First in Fly celebrates key insights uncovered by investigators using this model organism. Stephanie Elizabeth Mohr draws on these “first in fly” findings to introduce fundamental biological concepts gained over the last century and explore how research in the common fruit fly has expanded our understanding of human health and disease.